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  3. Crizalk 200 mg Capsule 60's

Crizalk 200 mg Capsule 60's, Pack of 1 Capsule
Crizalk 200 mg Capsule 60's, Pack of 1 Capsule
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Crizalk 200 mg Capsule is an anti-cancer medicine used in the treatment of Non-small cell lung cancer (NSCLC). This medicine contains crizotinib which works by stopping the tyrosine kinase enzyme and stops the cancerous cell growth. Common side effects include visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness.
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Composition :

CRIZOTINIB-200MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Crizalk 200 mg Capsule

Crizalk 200 mg Capsule belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

Crizalk 200 mg Capsule contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. Crizalk 200 mg Capsule is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Always use this medicine exactly as your doctor has told you. You must keep to your doctor's instructions to get the maximum benefit. Sometimes, you may experience specific common side effects, such as visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Crizalk 200 mg Capsule if you are allergic to Crizalk 200 mg Capsule or any of its ingredients. Crizalk 200 mg Capsule may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Crizalk 200 mg Capsule as it could lead to increased dizziness. Crizalk 200 mg Capsule is not recommended for children as safety and effectiveness have not been established. Inform your healthcare professional if you are a pregnant or breastfeeding woman so that your doctor decides whether Crizalk 200 mg Capsule can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. While on Crizalk 200 mg Capsule treatment, you should avoid eating grapefruit or consuming grapefruit juice since they may alter the amount of Crizalk 200 mg Capsule in your body.

Uses of Crizalk 200 mg Capsule

Treatment of Non-small cell lung cancer (NSCLC)

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Crizalk 200 mg Capsule contains the active substance Crizotinib, a medicine used to treat adults with non-small cell lung cancer (NSCLC). Crizalk 200 mg Capsule is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase. It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth.

How Crizalk 200 mg Capsule Works

Crizalk 200 mg Capsule contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. Crizalk 200 mg Capsule is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Storage

Store in a cool and dry place away from sunlight
Side effects of Crizalk 200 mg Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Crizalk 200 mg Capsule

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Do not take Crizalk 200 mg Capsule if you are allergic to Crizalk 200 mg Capsule or any of its ingredients. Crizalk 200 mg Capsule may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol along with Crizalk 200 mg Capsule as it could lead to increased dizziness. Crizalk 200 mg Capsule is not recommended for children as safety and effectiveness have not been established. Consult your doctor if you are a pregnant or breastfeeding woman; your doctor will decide whether the Crizalk 200 mg Capsule can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. It is essential to take Crizalk 200 mg Capsule every day, as long as your doctor prescribes it. Contact your doctor immediately if you cannot take medicine as your doctor prescribed or feel you do not need it anymore. Do not stop taking this medicine on your own. People with liver, kidney or heart disorders, lung inflammation, stomach or intestine problems, and vision disorders should consult the doctor before taking the Crizalk 200 mg Capsule .

Drug-Drug Interactions

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CrizotinibZiprasidone
Critical
CrizotinibNorfloxacin
Severe

Drug-Drug Interactions

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CrizotinibZiprasidone
Critical
How does the drug interact with Crizalk 200 mg Capsule:
Coadministration of Crizalk 200 mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Crizalk 200 mg Capsule is not recommended,but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CrizotinibNorfloxacin
Severe
How does the drug interact with Crizalk 200 mg Capsule:
Coadministration of Norfloxacin with Crizalk 200 mg Capsule can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin with Crizalk 200 mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
CrizotinibPrimaquine
Severe
How does the drug interact with Crizalk 200 mg Capsule:
Taking primaquine and Crizalk 200 mg Capsule together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Primaquine and Crizalk 200 mg Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
CrizotinibRanolazine
Severe
How does the drug interact with Crizalk 200 mg Capsule:
When Crizalk 200 mg Capsule is taken with Ranolazine, may increase the blood levels and effects of ranolazine. High blood levels of ranolazine can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Crizalk 200 mg Capsule with Ranolazine can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
CrizotinibAmitriptyline
Severe
How does the drug interact with Crizalk 200 mg Capsule:
Coadministration of Amitriptyline and Crizalk 200 mg Capsule may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Crizalk 200 mg Capsule may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
CrizotinibGatifloxacin
Severe
How does the drug interact with Crizalk 200 mg Capsule:
Taking Gatifloxacin with Crizalk 200 mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin with Crizalk 200 mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibOlaparib
Severe
How does the drug interact with Crizalk 200 mg Capsule:
Using Crizalk 200 mg Capsule and olaparib can increase the blood levels of olaparib. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Crizalk 200 mg Capsule and olaparib can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
CrizotinibLevofloxacin
Severe
How does the drug interact with Crizalk 200 mg Capsule:
Although it is a very rare adverse effect, taking levofloxacin with Crizalk 200 mg Capsule increases the risk of an abnormal heart rhythm. If you're dealing with other heart illnesses, electrolyte imbalances (for example, magnesium or potassium loss likely due to serious or prolonged diarrhoea or vomiting), you may be at greater risk.

How to manage the interaction:
Concomitant administration of levofloxacin with Crizalk 200 mg Capsule can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting your doctor.
CrizotinibCeritinib
Severe
How does the drug interact with Crizalk 200 mg Capsule:
Taking Crizalk 200 mg Capsule with Ceritinib may significantly increase the blood levels and effects of Crizalk 200 mg Capsule.

How to manage the interaction:
Co-administration of Ceritinib with Crizalk 200 mg Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms like an irregular heart rhythm, dizziness, fainting, or a fast or pounding heartbeat, it is important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
CrizotinibIbrutinib
Severe
How does the drug interact with Crizalk 200 mg Capsule:
Taking Ibrutinib with Crizalk 200 mg Capsule may increase the levels of Ibrutinib.

How to manage the interaction:
Although there is a possible interaction between Ibrutinib and Crizalk 200 mg Capsule, you can take these medicines together if prescribed by a doctor. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow a pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Caution

Consuming alcohol while using Crizalk 200 mg Capsule is not recommended since it may produce side effects or make you more sensitive to the effects of alcohol.

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Pregnancy

Caution

Crizalk 200 mg Capsule is not typically recommended during the pregnancy. Please consult the healthcare professional if you have any concerns regarding this.

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Breast Feeding

Caution

Crizalk 200 mg Capsule is not typically recommended if you are a nursing woman. Please consult the healthcare professional if you have any concerns regarding this.

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Driving

Caution

Do not drive, or you should take special care when driving and using machines as patients taking Crizalk 200 mg Capsule may experience visual disturbances, dizziness, and tiredness.

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Liver

Caution

Caution should be taken while using Crizalk 200 mg Capsule in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Caution should be taken while using Crizalk 200 mg Capsule in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

It is not recommended for children as the safety and efficacy have not been established.

Have a query?

FAQs

Crizalk 200 mg Capsule belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults.

Crizotinib is the active ingredient in Crizalk 200 mg Capsule . It works by inhibiting an enzyme called tyrosine kinase and causing cancer cells to die. Crizalk 200 mg Capsule is only provided to individuals whose condition is caused by an ALK tyrosine kinase gene mutation.

In elderly patients, the risk of side effects is more if you take the Crizalk 200 mg Capsule . For the elderly, it might require dose adjustment, or your doctor might prescribe any other medication safe for the elderly.

No, avoid smoking before starting the treatment and while taking Crizalk 200 mg Capsule as smoking might alter the effectiveness of Crizalk 200 mg Capsule .

Take the missed dose as soon as you remember. Skip the missing dose and return to your regular dosing plan if it is time for the next dose. Do not take a double dose to make up for a missing dose.

Crizalk 200 mg Capsule may cause visual disturbances such as flashes of light, blurred vision, or double vision as a temporary side effect. If it continues or worsens your condition, seek medical advice immediately.

Crizalk 200 mg Capsule should be taken orally. Swallow it as a whole with a glass of water. Do not chew, crush or break it.

The side effects of Crizalk 200 mg Capsule include dizziness, diarrhoea, visual disturbances or stomach upset, including vomiting, nausea, and tiredness. Consult the doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18Th Floor , Plot No. C-70, €˜G’ Block , Bandra Kurla Complex, Bandra East , Mumbai - 400051
Other Info - CRI0083

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jan 1, 2025 | 2:46 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.2857.pdf
  2. https://www.medicines.org.uk/emc/product/2857/smpc#gref
  3. https://www.nhs.uk/conditions/lung-cancer/
  4. https://pubmed.ncbi.nlm.nih.gov/24756793/
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