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compositionComposition:PYRIMETHAMINE-25MG+SULPHADOXINE-500MG
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Prescription Medicine
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Croydoxin FM 25 mg/500 mg Tablet is an antimalarial medicine used in the treatment of malaria. It contains Pyrimethamine and Sulphadoxine. Pyrimethamine works by killing the parasite and stops the infection from spreading. Sulphadoxine helps prevent the parasite from producing folinic acid, which is necessary for their multiplication. Common side effects of this medicine are nausea, dizziness, vomiting, headache, diarrhoea, anorexia, body pain, and stomach discomfort.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PYRIMETHAMINE-25MG+SULPHADOXINE-500MG

Manufacturer/Marketer :

GlaxoSmithKline Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Croydoxin FM 25 mg/500 mg Tablet

Croydoxin FM 25 mg/500 mg Tablet is a prescription tablet used to treat and prevent certain types of malaria, a serious infection spread by mosquito bites. It works by targeting the parasites responsible for the infection to clear them from your body. Doctors typically prescribe this medication for individuals travelling to or living in areas where malaria is common.

You should take Croydoxin FM 25 mg/500 mg Tablet exactly as prescribed by your doctor, often as a single dose or a specific short schedule. It is best taken with a full glass of water after a meal to reduce the risk of an upset stomach. Staying well-hydrated and using insect repellent are key lifestyle habits that support this treatment.

While taking Croydoxin FM 25 mg/500 mg Tablet, some people may experience mild side effects like nausea, vomiting, or a temporary loss of appetite. However, you must contact your doctor immediately if you experience severe skin rashes, a sore throat, fever, or unusual paleness and fatigue. These can be signs of rare but serious blood or skin reactions that require urgent medical attention.

Do not take this if you have severe kidney or liver damage or a history of blood disorders like anaemia caused by folate deficiency. It is also important to tell your doctor if you have asthma or a known allergy to sulfa medicines. Pregnant women near their due date and infants under two months of age should not take this medicine.

Croydoxin FM 25 mg/500 mg Tablet can interact with other medications, such as folic acid supplements or certain blood thinners, which may lower its effectiveness or increase side effects. You should avoid drinking alcohol while taking this medicine, as it can increase the risk of liver damage. If you are pregnant, breastfeeding, or elderly, talk to your doctor or pharmacist to weigh the benefits and risks before starting this treatment.

Uses of Croydoxin FM 25 mg/500 mg Tablet

Croydoxin FM 25 mg/500 mg Tablet is used to treat and prevent certain types of malaria. The detailed uses of Croydoxin FM 25 mg/500 mg Tablet are as follows:

  • Malaria treatment: Croydoxin FM 25 mg/500 mg Tablet is prescribed to treat active, uncomplicated malaria infections caused by certain malaria parasites, helping to clear the infection from the bloodstream.
  • Malaria prevention (prophylaxis): It is used in specific high-risk regions to prevent malaria infection in travellers or vulnerable populations, stopping the parasites from multiplying if you are bitten by an infected mosquito.

Key Benefits

Croydoxin FM 25 mg/500 mg Tablet helps treat and prevent malaria by stopping malaria parasites from multiplying in the body. It supports rapid symptom relief during infection and provides important protection when used for malaria prevention during travel to high-risk areas.

  • Treats Malaria Effectively: By rapidly clearing malaria parasites from the blood, Croydoxin FM 25 mg/500 mg Tablet helps reduce fever, chills, body aches, and other symptoms of malaria.
  • Supports Faster Recovery: As parasite levels fall, symptoms usually improve within a few days, helping restore energy and overall well-being.
  • Easy-to-Complete Treatment Course: Croydoxin FM 25 mg/500 mg Tablet is often prescribed as a short treatment course, which can make it easier to complete the full regimen successfully.
  • Provides Protection During Travel: When used for malaria prevention, Croydoxin FM 25 mg/500 mg Tablet helps reduce the risk of developing malaria and offers important protection against serious malaria-related complications during travel to endemic regions.
Side effects of Croydoxin FM 25 mg/500 mg Tablet
  • Eat foods rich in vitamins C and E, and healthy fats.
  • Consider soft foods like smoothies, soups, and scrambled eggs.
  • Take supplements like vitamins C and E, zinc, and omega-3 fatty acids under medical supervision.
  • Include anti-inflammatory foods like omega-3 rich foods, berries, leafy greens, and spices.
  • Avoid allergens and consider an elimination diet.
  • Practice gentle skin care with non-irritating cleansers and moisturizers.
  • Keep skin well-moisturized with fragrance-free products.
  • Monitor for complications like infection and temperature regulation.
  • Let your doctor know if there are unsual symptoms after taking the medication, such as red patches on your skin.
  • Your doctor may change your medication, lower the dose, or stop the treatment to help manage the symptoms.
  • Avoid heavy physical activity and get plenty of rest to prevent further worsening of the symptoms.
  • Apply cold packs to the affected areas for relief.
  • Keep yourself hydrated or take supplements to get enough vitamins.
  • Over-the-counter pain relievers can help with discomfort.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Directions for Use

  • Croydoxin FM 25 mg/500 mg Tablet can be taken with meals to reduce stomach upset.
  • Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow the whole tablet with a glass of water.
  • Do not break, chew, or crush it.

How Croydoxin FM 25 mg/500 mg Tablet Works

Croydoxin FM 25 mg/500 mg Tablet is a combination of two active ingredients that work together to stop malaria parasites from growing. Malaria parasites need folic acid (a type of vitamin B) to replicate and survive in your red blood cells. The two components of Croydoxin FM 25 mg/500 mg Tablet block two different steps in the parasite's folic acid production process. The first active ingredient, pyrimethamine, which prevents the parasite from utilising an essential enzyme needed to create folic acid. The second active ingredient, sulphadoxine, blocks a later step in the same pathway, completely cutting off the parasite's ability to produce the proteins it needs to multiply. By attacking the parasite at two separate points, Croydoxin FM 25 mg/500 mg Tablet effectively starves and kills the infection while minimising the chance of the parasites becoming resistant to the treatment.
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Alcohol

Consult your doctor

The interaction of Croydoxin FM 25 mg/500 mg Tablet with alcohol is unknown. Please consult your doctor.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Croydoxin FM 25 mg/500 mg Tablet. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Pyrimethamine is excreted in human milk. Therefore, if you are breastfeeding, inform your doctor before receiving Croydoxin FM 25 mg/500 mg Tablet. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Croydoxin FM 25 mg/500 mg Tablet may decrease alertness or make you feel sleepy and dizzy. So, do not drive or operate heavy machinery after taking Croydoxin FM 25 mg/500 mg Tablet until you are alert.

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Liver

Caution

Croydoxin FM 25 mg/500 mg Tablet should be used with caution if you have a pre-existing or a history of liver disease. Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Croydoxin FM 25 mg/500 mg Tablet should be used with caution if you have a pre-existing or a history of kidney disease. Your doctor may adjust the dose based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your child's doctor will decide the dose of this medicine based on the age and condition of the child.

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Heart

Caution

Please inform your doctor if you have heart problems before taking Croydoxin FM 25 mg/500 mg Tablet, as there is limited information available on its safety in such cases.

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Geriatrics

Caution

Geriatric patients may take Croydoxin FM 25 mg/500 mg Tablet with caution, as age-related risks like anemia or drug interactions require medical supervision.

What if I have taken an overdose of Croydoxin FM 25 mg/500 mg Tablet

If you suspect an overdose, seek immediate medical attention. Symptoms of an overdose may include severe vomiting, seizures, or extreme dizziness.

Diet & Lifestyle Advise

  • Avoid mosquito bites: Even while taking preventive medication, protect yourself by sleeping under insecticide-treated bed nets, using insect repellent containing DEET, and wearing long-sleeved shirts and long pants.
  • Increase fluid intake: Drink plenty of water and clear fluids while taking Croydoxin FM 25 mg/500 mg Tablet to help your kidneys flush out the medicine safely and prevent crystals from forming in your urine.
  • Limit direct sun exposure: This medication can make your skin more sensitive to sunlight. Wear sunscreen, protective clothing, and sunglasses when outdoors to avoid severe sunburn.
  • Avoid alcohol: Do not drink alcohol during your treatment, as it can strain your liver and increase the risk of liver damage when combined with this medication.
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Have a query?

How Soon It Starts Working

The time required for Croydoxin FM 25 mg/500 mg Tablet to start to work: The time required for Croydoxin FM 25 mg/500 mg Tablet to show its action is not clinically established. The time for which the effects of Croydoxin FM 25 mg/500 mg Tablet last: The duration of action for Croydoxin FM 25 mg/500 mg Tablet is not clinically established.

What if you forget to take Croydoxin FM 25 mg/500 mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, talk to your doctor or pharmacist.

Storage

•Store Croydoxin FM 25 mg/500 mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Watch for skin changes: Stop taking Croydoxin FM 25 mg/500 mg Tablet and seek emergency medical help at the very first sign of a skin rash, redness, or blistering.
  • Check the packaging: Ensure the blister pack is fully sealed and intact before taking your tablet; do not use if the foil is broken or damaged.
  • Stay hydrated: Ensure you are passing light-coloured, clear urine throughout the day to confirm your kidneys are well-hydrated.
  • Complete the course: If prescribed a multi-day course, finish all tablets exactly as directed, even if you start feeling better, to ensure the malaria parasite is completely cleared.
  • Avoid folic acid supplements: Unless specifically directed by your doctor, do not take folic acid supplements during your treatment, as they can interfere with how Croydoxin FM 25 mg/500 mg Tablet fights the parasite.

Drug-Drug Interactions

verifiedApollotooltip
  • Folic acid or folate supplements: May reduce the effectiveness of Croydoxin FM 25 mg/500 mg Tablet in killing malaria parasites.
  • Blood thinners (like warfarin): Croydoxin FM 25 mg/500 mg Tablet may increase the effect of these medicines, raising the risk of bleeding.
  • Seizure medications: Some anti-seizure drugs may lower the levels of this medicine in your body or increase the risk of side effects.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Highly fortified folic acid foods: Consuming large amounts of foods heavily enriched with folic acid may lower the medication's ability to block parasite growth.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- MALARIALS]

FAQs

Croydoxin FM 25 mg/500 mg Tablet is used to treat Malaria and Toxoplasmosis.
Croydoxin FM 25 mg/500 mg Tablet works by killing the parasite and stopping the infection from spreading.
No, do not stop taking Croydoxin FM 25 mg/500 mg Tablet. It is recommended to take this medicine for the entire prescribed duration, even when symptoms improve or resolve. Failure to do so might result in drug resistance, and treating any subsequent infection with the same medicine would be very difficult.
Do not take Croydoxin FM 25 mg/500 mg Tablet if you are near your due date (late pregnancy), as it can cause serious blood issues in the newborn. In early pregnancy, it should only be taken if clearly prescribed by a specialist to treat or prevent malaria. Talk to your doctor to understand the risks and benefits.
You should avoid taking folic acid supplements while using Croydoxin FM 25 mg/500 mg Tablet unless your doctor specifically tells you to. Folic acid can interfere with how this medicine works, making it less effective at killing the malaria parasites. Talk to your doctor or pharmacist for guidance.
Drinking plenty of water helps your kidneys process and safely eliminate the active ingredients in Croydoxin FM 25 mg/500 mg Tablet. This prevents the formation of crystals in your urine, which can irritate or damage your kidneys. Talk to your doctor if you experience decreased urination.
It is highly recommended to avoid alcohol while taking Croydoxin FM 25 mg/500 mg Tablet. Both alcohol and this medication can put stress on your liver, and combining them increases the risk of liver damage. Talk to your doctor if you have concerns about alcohol use.
If you vomit within an hour of taking your tablet, you may need to take another dose, as the medicine may not have been fully absorbed. However, you should contact your healthcare provider immediately before taking an extra dose to get specific instructions. Talk to your doctor.
Croydoxin FM 25 mg/500 mg Tablet can be used in children, but the dosage must be carefully calculated by a pediatrician based on the child's body weight. It should never be given to infants under two months of age. Talk to your doctor to get the correct prescription.
Croydoxin FM 25 mg/500 mg Tablet is highly effective against specific types of malaria parasites, particularly Plasmodium falciparum. However, in some parts of the world, malaria parasites have developed resistance to this medicine, meaning it may not work for all strains. Talk to your doctor or travel clinic to ensure this is the right medication for your destination.

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Country of origin

India
Other Info - CR26190
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