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  1. Home
  2. Medicine

  3. Culactone 20mg/50mg Tablet

Prescription drug
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Culactone 20mg/50mg Tablet, Pack of 1 Tablet
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Extra 15% Off with Bank Offers

Composition :

FUROSEMIDE-20MG + SPIRONOLACTONE-50MG

Manufacturer/Marketer :

Cubit Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

About Culactone 20mg/50mg Tablet

Culactone 20mg/50mg Tablet used to treat oedema. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease.

Culactone 20mg/50mg Tablet works by increasing the amount of urine that is passed out from the kidneys. Thus, it lowers high blood pressure and reduces the risk of heart attack, stroke, or chest pain.

In some cases, Culactone 20mg/50mg Tablet may cause side effects such as low blood pressure (hypotension), dehydration, electrolyte disturbances (potassium and sodium), headache, nausea, or dizziness. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Inform your doctor if you are suffering from any kidney, liver or heart disease. If you are pregnant or breastfeeding, please tell your doctor. Reducing the amount of table salt (sodium chloride) in your diet often relieves body swelling.

Uses of Culactone 20mg/50mg Tablet

Culactone 20mg/50mg Tablet is used in the treatment of oedema (fluid overload). The detailed uses of Culactone 20mg/50mg Tablet are as follows:

  • Oedema Treatment: Culactone 20mg/50mg Tablet helps to treat oedema by reducing excess fluid accumulation in the body's tissues, often associated with conditions like heart failure, liver cirrhosis, or kidney disorders.
  • Improvement in heart and kidney function: Culactone 20mg/50mg Tablet helps to improve heart and kidney function by reducing excess fluid in the body, preventing complications like swelling, shortness of breath, and strain on the heart and kidneys.

Have a query?

Directions for Use

  • Take Culactone 20mg/50mg Tablet with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Swallow Culactone 20mg/50mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Culactone 20mg/50mg Tablet is used to treat oedema (fluid retention).
  • It helps the body lose excess fluids by increasing urine production.
  • Reduces swelling (oedema) associated with heart, liver, kidney, or lung disorders.
  • Maintains potassium balance in the body.

How Culactone 20mg/50mg Tablet Works

Culactone 20mg/50mg Tablet works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Culactone 20mg/50mg Tablet
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.

What if I have taken an overdose of Culactone 20mg/50mg Tablet

Do not take more than the prescribed dose of Culactone 20mg/50mg Tablet as it may cause serious side effects. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Culactone 20mg/50mg Tablet should not be given to people allergic to any of its components, who have low blood pressure (less than 90 mmHg), have had a heart attack, have kidney disease (with creatinine clearance less than 30 mL/min), have liver disease, or are pregnant or breastfeeding.
  • Culactone 20mg/50mg Tablet is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem).
  • Culactone 20mg/50mg Tablet may cause vocal changes, so special attention must be given to the patients using Culactone 20mg/50mg Tablet and whose voice is significant for their work (like actors, singers, or teachers).
  • Hypovolaemia or dehydration with electrolyte and acid-base disturbances must be corrected before using Culactone 20mg/50mg Tablet.
  • Try not to stop taking Culactone 20mg/50mg Tablet on your own, as doing so may raise your blood pressure, thereby increasing the risk of getting heart disease and stroke.

Drug-Drug Interactions

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SpironolactoneEplerenone
Critical
SpironolactoneAmiloride
Critical

Drug-Drug Interactions

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SpironolactoneEplerenone
Critical
How does the drug interact with Culactone 20mg/50mg Tablet:
Combining Eplerenone with Spiranolactone may significantly increase potassium levels in the blood which can lead to kidney issues and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Culactone 20mg/50mg Tablet and eplerenone, it is not recommended as it can lead to an interaction. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
SpironolactoneAmiloride
Critical
How does the drug interact with Culactone 20mg/50mg Tablet:
Coadministration of Amiloride with Culactone 20mg/50mg Tablet may increase potassium levels in the blood.

How to manage the interaction:
Taking Amiloride with Culactone 20mg/50mg Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. Do not stop taking any medication without doctor's advice.
FurosemideZiprasidone
Critical
How does the drug interact with Culactone 20mg/50mg Tablet:
Taking Ziprasidone with Culactone 20mg/50mg Tablet can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Culactone 20mg/50mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting. Do not discontinue any medications without consulting a doctor.
SpironolactoneTelmisartan
Severe
How does the drug interact with Culactone 20mg/50mg Tablet:
Taking Culactone 20mg/50mg Tablet with telmisartan may increase potassium levels in the blood.

How to manage the interaction:
Although there is a possible interaction, telmisartan can be taken with Culactone 20mg/50mg Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of high potassium such as nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Maintain adequate fluid intake during treatment with these medications. Do not discontinue the medications without consulting a doctor.
SpironolactonePerindopril
Severe
How does the drug interact with Culactone 20mg/50mg Tablet:
Using perindopril together with Culactone 20mg/50mg Tablet may cause hyperkalemia (high potassium level in blood).

How to manage the interaction:
Although taking Culactone 20mg/50mg Tablet and perindopril together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as weakness, confusion, numbness or tingling, and uneven heartbeats. Do not stop using any medications without consulting doctor.
SpironolactoneTacrolimus
Severe
How does the drug interact with Culactone 20mg/50mg Tablet:
Taking Culactone 20mg/50mg Tablet with tacrolimus may increase potassium levels in the blood and even kidney and heart problems.

How to manage the interaction:
Although taking Culactone 20mg/50mg Tablet and tacrolimus together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without consulting doctor.
SpironolactoneQuinapril
Severe
How does the drug interact with Culactone 20mg/50mg Tablet:
Using quinapril together with Culactone 20mg/50mg Tablet may cause hyperkalemia (increase the levels of potassium in your blood).

How to manage the interaction:
Although taking Culactone 20mg/50mg Tablet and quinapril together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as weakness, confusion, numbness or tingling, and uneven heartbeat. Do not stop using any medications without consulting doctor.
SpironolactoneCaptopril
Severe
How does the drug interact with Culactone 20mg/50mg Tablet:
Combining Culactone 20mg/50mg Tablet with Captopril may significantly increase potassium levels in the blood which can lead to kidney issues and irregular heart rhythm.

How to manage the interaction:
Taking Captopril with Culactone 20mg/50mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. Do not stop taking any medication without doctor's advise.
SpironolactoneTrimethoprim
Severe
How does the drug interact with Culactone 20mg/50mg Tablet:
Taking Culactone 20mg/50mg Tablet with trimethoprim may increase potassium levels in the blood.

How to manage the interaction:
Although taking Culactone 20mg/50mg Tablet and trimethoprim together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without consulting doctor.
SpironolactoneEnalapril
Severe
How does the drug interact with Culactone 20mg/50mg Tablet:
Coadministration of enalapril with Culactone 20mg/50mg Tablet may increase the risk of hyperkalemia (high potassium levels in the blood), hypotension, syncope (fainting), and renal failure due to additive or synergistic effects. If you are elderly, dehydrated, or have a history of renal or heart illness, your risk is enhanced.

How to manage the interaction:
Although taking Enalapril together with Culactone 20mg/50mg Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, coconut water, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are high in antioxidants.
  • Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.
  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.
  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
  • Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
  • Avoid consumption of too much salt or salty food.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Regular physical activity or exercise, like walking, improves your blood flow.
  • When possible, elevate your legs or the swollen area on a chair or pillows.
  • Avoid standing or sitting for extended periods of time.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Culactone 20mg/50mg Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

You are recommended not to consume alcohol along with Culactone 20mg/50mg Tablet to avoid unpleasant side effects.

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Pregnancy

Unsafe

Culactone 20mg/50mg Tablet must not be taken during pregnancy.

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Breast Feeding

Unsafe

Breastfeeding must be avoided during treatment with Culactone 20mg/50mg Tablet.

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Driving

Unsafe

It is not recommended to drive after taking Culactone 20mg/50mg Tablet as it may occasionally cause drowsiness due to orthostatic hypotension (sudden drop in blood pressure on standing from a lying position).

bannner image

Liver

Caution

Culactone 20mg/50mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending upon your current liver conditions.

bannner image

Kidney

Caution

Culactone 20mg/50mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Your doctor may adjust your dose depending upon your current kidney conditions.

bannner image

Children

Unsafe

Culactone 20mg/50mg Tablet is not recommended for children below 12 years of age.

FAQs

Culactone 20mg/50mg Tablet is used to treat hypertension (high blood pressure and oedema (fluid retention). It helps to remove excess water from the body.

Culactone 20mg/50mg Tablet works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease.

No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it.

You should closely monitor your blood pressure, renal function and electrolytes within 4-6 weeks of commencing therapy. Besides this, frequent checks of the potassium level are required in patients with kidney failure and with creatinine clearance below 60 ml/min.

If your leg (foot, ankle) or any other body part is swelling, you need to visit a physician or cardiologist who could perform an ultrasound examination of your leg veins and an ultrasound of your heart (echocardiogram-ECG).

Store Culactone 20mg/50mg Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Do not take Culactone 20mg/50mg Tablet if you are allergic to any of its components, have low blood pressure (less than 90 mm of Hg), have had a heart attack, or have kidney disease (with creatinine clearance less than 30 mL/min). Besides this, it is contraindicated in cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem).

Culactone 20mg/50mg Tablet is a combination medicine used to treat oedema (fluid overload) and hypertension (high blood pressure).

Yes, Culactone 20mg/50mg Tablet is safe if taken in the dose and duration prescribed by the doctor.

Culactone 20mg/50mg Tablet may cause dizziness as a side effect. Do not drive or operate machinery if you experience dizziness.

Culactone 20mg/50mg Tablet contains furosemide which may increase uric acid levels leading to gout. Consult the doctor if you experience sudden severe pain in a joint (usually your big toe).

Country of origin

India

Manufacturer/Marketer address

1, Cubit House, 13/369, Panchratna Estate, B/H Ankoor Oil Factory, Opp. Bhagyoday Hotel, Changodar, Ahmedabad-382210 (Guj.) India.
Other Info - CU52778

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 29, 2025 | 9:19 AM IST

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Reference

  1. https://www.sanofi.in/-/media/Project/One-Sanofi-Web/Websites/Asia-Pacific/Sanofi-IN/Home/science-and-innovation/for-healthcare-professionals/product-information/Lasilactone_PI_201801.pdf
  2. https://www.drugs.com/uk/lasilactone-20mg-50mg-capsules-leaflet.html
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