About ENALAPRILAT
ENALAPRILAT is an anti-hypertensive medicine primarily used in the treatment of Hypertension. It is used when the oral treatment is not effective. Hypertension (high blood pressure) is a serious condition in which the force exerted by the blood against the artery walls becomes high, and this hardens the heart to pump blood.
ENALAPRILAT contains Enalaprilat, which belongs to the class of Angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing the production of certain substances responsible for increased blood pressure.
ENALAPRILAT may cause certain common side effects such as cough, dizziness, headache, nausea, light-headedness, difficulty breathing, vomiting, confusion, sore throat, chest pain, abdominal pain, diarrhoea, decreased blood pressure, nervousness, injection site reactions, and hoarseness. These side effects do not require medical attention and usually resolve after some time. ENALAPRILAT will be administered by a trained healthcare professional. Do not self-administer.
Avoid receiving ENALAPRILAT and inform your doctor if you are allergic to it. ENALAPRILAT is contraindicated in patients with angioedema related to previous treatment with an angiotensin-converting enzyme inhibitor and hereditary or idiopathic angioedema. This medicine should be used with caution if you have/had any conditions such as congestive heart failure, liver or kidney disease, and peripheral oedema (swelling of hands/legs). It is not recommended to take this medicine during pregnancy and breastfeeding.
Uses of ENALAPRILAT
Hypertension.
Medicinal Benefits
ENALAPRILAT contains Enalaprilat, which belongs to the Angiotensin-converting enzyme (ACE) inhibitors class. It works by reducing the production of certain substances that cause an increase in blood pressure. It allows the blood to flow more smoothly and makes the heart more efficient at pumping blood throughout the body. ENALAPRILAT helps reduce high BP and the risk of heart attack, stroke and angina (chest pain).
Directions for Use
Storage
Side Effects of ENALAPRILAT
- Headache
- Diarrhoea
- Dizziness
- Nausea
- Cough
- Hoarseness
- Abdominal pain
- Nervousness
- Pain at the site of injection
- Chest pain
- Upper respiratory tract infections
In-Depth Precautions and Warning
Drug Warnings
Avoid receiving ENALAPRILAT and inform your doctor if an allergic reaction occurs. ENALAPRILAT is contraindicated in patients with angioedema related to previous treatment with an angiotensin-converting enzyme inhibitor and hereditary or idiopathic angioedema. ENALAPRILAT is not recommended for use in children as the safety and efficacy are not established. On rare occasions, ACE inhibitors have been linked to a syndrome that begins with cholestatic jaundice, advances to fulminant hepatic necrosis, and occasionally results in death. When jaundice or significant elevations in hepatic enzymes occur in patients taking ACE inhibitors, the medication should be stopped, and appropriate medical attention should be given. Before receiving ENALAPRILAT, caution should be exercised in patients with congestive heart failure, liver disease, kidney disease, hyperkalaemia, angioedema, cough, and peripheral oedema (swelling of hands/legs). In some patients, this medicine may cause head and neck angioedema, severe anaphylactic reactions, hypotension, hepatic failure, and neutropenia. Hence, inform your doctor about your complete medication and medical history. Avoid consumption of alcohol during the treatment. If you are pregnant or breastfeeding, inform your doctor beforehand.
Drug Interactions
Drug-Drug Interactions: ENALAPRILAT may have interaction with heart failure medicines (sacubitril, valsartan), NSAIDs (aspirin, naproxen, indomethacin, ibuprofen), anti-gout medicines (allopurinol), anti-diabetic medicines (sitagliptin, metformin, insulin glargine), diuretics (furosemide), anti-hypertensive medication (aliskiren), potassium supplements.
Drug-Drug Interactions: Avoid consuming potassium-rich foods such as potassium-containing salt substitutes or over-the-counter potassium supplements. Avoid smoking and alcohol consumption.
Drug-Drug Interactions: ENALAPRILAT may have interactions with angioedema (swelling), congestive heart failure (heart problems), angioedema, low blood pressure, liver disease and kidney dysfunction.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeDo not consume alcohol while on treatment with ENALAPRILAT as it may worsen the side effects like dizziness and also may increase blood pressure.
Pregnancy
unsafeThe use of ENALAPRILAT is contraindicated during the second and third trimester of pregnancy. It may cause harm to the developing fetus. Inform your doctor if you are pregnant before receiving ENALAPRILAT.
Breast Feeding
unsafeENALAPRILAT may be excreted in human milk. Therefore, it is not recommended for breastfeeding mothers as it may be unsafe for the baby. Inform your doctor if you are breastfeeding before receiving ENALAPRILAT. Your doctor will decide whether you stop breastfeeding or discontinue the use of ENALAPRILAT based on the benefits and risks.
Driving
cautionENALAPRILAT may cause dizziness. Hence, do not drive or operate machines after receiving this medicine.
Liver
cautionIf you have a pre-existing or a history of liver disease, inform your doctor before receiving ENALAPRILAT. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Elderly patients with liver impairment should start the treatment with a lower dose.
Kidney
cautionIf you have a pre-existing or a history of kidney disease, inform your doctor before receiving ENALAPRILAT. ENALAPRILAT may cause renal failure in some patients. Hence, inform your doctor if the patient develops any symptoms. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Elderly patients with renal impairment should start the treatment with a lower dose.
Children
unsafeENALAPRILAT is not recommended for use in children as the safety and efficacy are not established for this age group.
Habit Forming
Diet & Lifestyle Advise
- Try to maintain your weight under control with a BMI of 19.5-24.9.
- Doing regular physical activity or exercise for at least 30 minutes most days of the week can help you lower your raised blood pressure.
- Opt for a diet rich in whole grains, fruits, veggies and low-fat dairy products.
- Reduce the intake of table salt in your daily diet to 2300 mg per day for better results.
- Quitting smoking and alcohol consumption is the best strategy to lower the risk of heart disease.
- Avoid chronic stress, as it can raise your blood pressure.
- Monitor your blood pressure daily, and if there is too much fluctuation, then immediately contact your doctor.
Special Advise
- Sudden withdrawal may worsen angina (chest pain). However, if you experience chest pain, consult your doctor immediately.
- Frequent monitoring of blood pressure is important while receiving this medicine.
- Abnormal liver and kidney tests must be reported to the doctor.
- Your doctor may suggest a blood test for serum electrolytes (sodium, potassium), and a CBC to check for the occurrence of hyponatremia and hypokalaemia.
Patients Concern
Disease/Condition Glossary
Hypertension: Also called high blood pressure, is a serious condition in which the force exerted by the blood against the artery walls becomes high. This hardens the heart to pump blood. Raised blood pressure can cause chest pain (angina), heart attack (when the blood supply to the heart is blocked), stroke (brain damage) and kidney failure. ENALAPRILAT is used in treating hypertension and thus helps reduce further risk. The blood pressure can be diagnosed with the help of a blood pressure monitor called a sphygmomanometer.
