Cyclophil ME 50 Tablet 5's
MRP ₹294
(Inclusive of all Taxes)
₹44.1 Cashback (15%)
Extra 15% Off with Bank Offers
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Genuine Products
Synonym :
CYCLOSPORIN
Composition :
CYCLOSPORINE-50MG
Manufacturer/Marketer :
Biocon Ltd
Consume Type :
ORAL
Return Policy :
Not Returnable
Expires on or after :
About Cyclophil ME 50 Tablet
Cyclophil ME 50 Tablet belongs to a group of medications called 'immunosuppressants,' primarily used to prevent organ rejection after a transplant. It is also used to treat symptoms associated with psoriasis and rheumatoid arthritis.
Cyclophil ME 50 Tablet contains 'cyclosporine,' which works by suppressing the immune system, thereby stopping your body from rejecting a new organ. It also reduces rapid skin cell growth and lowers pain and inflammation in the joints.
Cyclophil ME 50 Tablet may cause side effects like headaches, vomiting, nausea, loss of appetite and diarrhoea. Most of these side effects do not require medical attention and resolve over time. However, consult your doctor if the side effects persist or worsen.
To treat your condition effectually, continue taking Cyclophil ME 50 Tablet for as long as your doctor has prescribed. Inform your doctor about your health condition and any medications you are taking to help rule out any potential/unpleasant side effects.
Uses of Cyclophil ME 50 Tablet
Cyclophil ME 50 Tablet is used to prevent organ rejection and treat psoriasis and rheumatoid arthritis. The detailed uses of Cyclophil ME 50 Tablet are as follows:
- Treatment of Organ Transplant Rejection: Cyclophil ME 50 Tablet is used in the prevention of organ transplant rejection after liver, kidney, pancreas, lungs, heart, skin, and bone marrow transplants.
- Treatment of Psoriasis: Cyclophil ME 50 Tablet is used in the treatment of psoriasis. It helps reduce rapid skin cell growth and inflammation caused by psoriasis.
- Treatment of Rheumatoid Arthritis: Cyclophil ME 50 Tablet is used in the treatment of rheumatoid arthritis. It helps reduce pain and inflammation in the joints and slows down joint damage.
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Directions for Use
- Cyclophil ME 50 Tablet can be taken with or without food. However, avoid taking it with grapefruit, pineapple, or papaya juice, as they may increase the amount of this medication in your blood.
- It is usually taken 2 times a day or as prescribed by your doctor.
- Swallow the whole capsule with a glass of water.
- Do not crush, chew, or open it.
Medicinal Benefits
- Cyclophil ME 50 Tablet suppresses the immune system to prevent the rejection of transplanted organs (e.g., kidney, liver, heart).
- It is also used in bone marrow and stem cell transplantation to prevent graft rejection.
- Cyclophil ME 50 Tablet helps control immune overactivity in various autoimmune conditions by blocking immune cells that attack the body’s own tissues.
- It reduces rapid skin cell growth and inflammation in severe psoriasis, leading to clearer skin and symptom relief.
- This medicine reduces joint pain, inflammation, and slows down joint damage in patients with active rheumatoid arthritis unresponsive to other therapies.
- It may also be used to treat severe atopic dermatitis, especially in patients who do not respond adequately to topical treatments.
- Helps manage severe inflammatory eye diseases that can threaten vision by reducing immune-mediated damage.
- It is used in certain cases of nephrotic syndrome (a kidney disorder causing excess protein loss in urine), especially when other treatments fail.
How Cyclophil ME 50 Tablet Works
Cyclophil ME 50 Tablet contains 'cyclosporine,' which works by suppressing the immune system, thereby stopping your body from rejecting a new organ. It also reduces rapid skin cell growth and the production of interleukins (molecules involved in inflammation). Additionally, it also reduces pain and inflammation in the joints and slows down the joint damage caused by an overactive immune system.
Storage
• Store in a cool and dry place away from sunlight.• Keep Cyclophil ME 50 Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Cyclophil ME 50 Tablet
- Limit intake of full-fat dairy products, red meat and processed foods rich in saturated fats.
- Avoid foods with label “partially hydrogenated oils”.
- Eat more vegetables, fruits, oats, whole grains, lentils and beans to increase fiber intake.
- Include foods rich in monounsaturated fats like nuts, avocados, olive oil, and oily fish.
- Limit consumption of egg yolks.
- Exercise for at least 30 minutes 5 days a week.
- Aim for weight loss and maintain healthy weight.
- Quit smoking as smoking raises the risk of heart disease associated with cholesterol.
- Limit alcohol consumption as excessive drinking may raise cholesterol levels.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
- Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
- Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
- Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
- Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
- Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
- Monitor UTI symptoms and report any changes to your doctor.
- If antibiotics are prescribed, take them as directed and complete the full course.
- Rest well; get enough sleep.
- Eat a balanced diet and drink enough water.
- Manage stress with yoga and meditation.
- Limit alcohol and caffeine.
- Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
- Inform your doctor immediately if you experience a fever after starting a new medication.
- Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
- Monitor your body temperature to monitor fever progression.
- Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
- Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
- Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
- If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
- Limit processed foods and eat more vegetables and fruits.
- Exercise at least 30 minutes every day.
- Maintain a healthy weight.
- Quit smoking as it can worsen kidney damage.
- Control your blood pressure and blood glucose.
- Limit salt intake and alcohol consumption.
- Increased creatinine levels must be corrected immediately with the help of a doctor.
- Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
- Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
- Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
- Avoid smoking and drinking alcohol.
- Regular cleansing will help get rid of dead skin cells and stop ingrown hairs.
- Keep your hormones in balance by managing your stress, eating well and exercising regularly.
- Shaving, waxing, and bleaching are ways to get rid of extra hair.
What if I have taken an overdose of Cyclophil ME 50 Tablet
Take Cyclophil ME 50 Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. Symptoms of overdose may include headache, drowsiness, vomiting, increased heart rate, and liver and kidney toxicity. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
Drug Warnings
- Do not take Cyclophil ME 50 Tablet if you are allergic to any of the components.
- Let your doctor know before using Cyclophil ME 50 Tablet if you have/had liver or kidney problems, epilepsy, high blood pressure, low levels of magnesium, high levels of potassium, cancer, or infection.
- Cyclophil ME 50 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.
- Before taking Cyclophil ME 50 Tablet, inform your doctor if you have any type of cancer.
- Consult your doctor before taking Cyclophil ME 50 Tablet if you are pregnant or planning for pregnancy.
- Cyclophil ME 50 Tablet should not be taken by breastfeeding mothers as it passes into breast milk.
- Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.
Drug-Drug Interactions
Critical
Critical
Drug-Drug Interactions
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Critical
How does the drug interact with Cyclophil ME 50 Tablet:
Coadministration of pitavastatin with Cyclophil ME 50 Tablet may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Pitavastatin with Cyclophil ME 50 Tablet is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
Coadministration of pitavastatin with Cyclophil ME 50 Tablet may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Pitavastatin with Cyclophil ME 50 Tablet is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
Critical
How does the drug interact with Cyclophil ME 50 Tablet:
Combining Cyclophil ME 50 Tablet and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Cyclophil ME 50 Tablet and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
Combining Cyclophil ME 50 Tablet and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).
How to manage the interaction:
Taking Cyclophil ME 50 Tablet and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
Critical
How does the drug interact with Cyclophil ME 50 Tablet:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.
How to manage the interaction:
Taking Cyclophil ME 50 Tablet with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.
How to manage the interaction:
Taking Cyclophil ME 50 Tablet with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with Cyclophil ME 50 Tablet:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.
How to manage the interaction:
Taking Cyclophil ME 50 Tablet with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
Taking cyclosporine with cidofovir can increase the risk of kidney problems.
How to manage the interaction:
Taking Cyclophil ME 50 Tablet with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
Critical
How does the drug interact with Cyclophil ME 50 Tablet:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.
How to manage the interaction:
Taking Cyclophil ME 50 Tablet with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.
How to manage the interaction:
Taking Cyclophil ME 50 Tablet with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinIohexol
Severe
How does the drug interact with Cyclophil ME 50 Tablet:
Coadministration of iohexol with Cyclophil ME 50 Tablet may increases the risk of kidney problems.
How to manage the interaction:
Although there is a possible interaction between iohexol and Cyclophil ME 50 Tablet, they can be taken together if your doctor has prescribed them. However, contact your doctor immediately if experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not stop using any medications without talking to a doctor.
Coadministration of iohexol with Cyclophil ME 50 Tablet may increases the risk of kidney problems.
How to manage the interaction:
Although there is a possible interaction between iohexol and Cyclophil ME 50 Tablet, they can be taken together if your doctor has prescribed them. However, contact your doctor immediately if experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Cyclophil ME 50 Tablet:
Coadministration of posaconazole and Cyclophil ME 50 Tablet together can enhance the effects of Cyclophil ME 50 Tablet.
How to manage the interaction:
Although using posaconazole and Cyclophil ME 50 Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor immediately if you experience any symptoms such as nausea, dizziness, weakness, vomiting, diarrhea, abdominal pain, or headache. Do not stop taking any medications without consulting a doctor.
Coadministration of posaconazole and Cyclophil ME 50 Tablet together can enhance the effects of Cyclophil ME 50 Tablet.
How to manage the interaction:
Although using posaconazole and Cyclophil ME 50 Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor immediately if you experience any symptoms such as nausea, dizziness, weakness, vomiting, diarrhea, abdominal pain, or headache. Do not stop taking any medications without consulting a doctor.
Severe
How does the drug interact with Cyclophil ME 50 Tablet:
Coadministration of docetaxel with Cyclophil ME 50 Tablet may significantly increase the blood levels of docetaxel.
How to manage the interaction:
Although there is a possible interaction between deferasirox and Cyclophil ME 50 Tablet, they can be taken together if your doctor has prescribed them. Contact your doctor immediately if experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
Coadministration of docetaxel with Cyclophil ME 50 Tablet may significantly increase the blood levels of docetaxel.
How to manage the interaction:
Although there is a possible interaction between deferasirox and Cyclophil ME 50 Tablet, they can be taken together if your doctor has prescribed them. Contact your doctor immediately if experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Cyclophil ME 50 Tablet:
When etanercept is taken with cyclosporine, it can increase the risk of infections.
How to manage the interaction:
Although taking etanercept and Cyclophil ME 50 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, contact a doctor immediately if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
When etanercept is taken with cyclosporine, it can increase the risk of infections.
How to manage the interaction:
Although taking etanercept and Cyclophil ME 50 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, contact a doctor immediately if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Cyclophil ME 50 Tablet:
Using Cyclophil ME 50 Tablet with amiloride can result in increased potassium levels in the blood.
How to manage the interaction:
Although taking amiloride and Cyclophil ME 50 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor, if you have symptoms such as a slow, rapid, or irregular heartbeat, rapid breathing, numbness or tingling, or pain in the muscles or weakness. Do not discontinue any medications without a doctor's advice.
Using Cyclophil ME 50 Tablet with amiloride can result in increased potassium levels in the blood.
How to manage the interaction:
Although taking amiloride and Cyclophil ME 50 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor, if you have symptoms such as a slow, rapid, or irregular heartbeat, rapid breathing, numbness or tingling, or pain in the muscles or weakness. Do not discontinue any medications without a doctor's advice.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Diet & Lifestyle Advise
- Physical activity helps strengthen muscles and relieve joint stiffness. Gentle activities, such as 20-30 minutes of walking or swimming, would be helpful.
- Practising yoga may also help improve joint flexibility and manage pain.
- Maintain a healthy weight by engaging in regular low-impact exercises and eating a balanced diet.
- Get adequate sleep, as rest can help reduce inflammation and swelling.
- Follow heat or cold therapy by applying a cold or hot compress to the joints for 15-20 minutes regularly.
- De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
- Acupuncture, massage, and physical therapy may also be helpful.
- Eat foods rich in antioxidants, such as berries, spinach, kidney beans, and dark chocolate.
- Foods containing flavonoids can help reduce inflammation. These include soy, berries, broccoli, grapes, and green tea.
- Avoid smoking and alcohol consumption.
Habit Forming
No
Therapeutic Class
IMMUNOSUPPRESSANTS
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Alcohol
Caution
You are recommended to avoid alcohol consumption while taking Cyclophil ME 50 Tablet. It could lead to increased dizziness and drowsiness.
Pregnancy
Caution
It is not known whether Cyclophil ME 50 Tablet will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.
Breast Feeding
Unsafe
It is not recommended to take Cyclophil ME 50 Tablet while you are breastfeeding. Cyclophil ME 50 Tablet passes into breast milk.
Driving
Caution
Drive or operate machinery only if you are alert.
Liver
Caution
Take Cyclophil ME 50 Tablet only if prescribed by the doctor, especially if you are dealing with Liver diseases/conditions, as your doctor may adjust the dose as required.
Kidney
Consult your doctor
Please consult your doctor if you have kidney impairment before taking Cyclophil ME 50 Tablet.
Children
Unsafe
Cyclophil ME 50 Tablet should not be given to children, as the efficacy and safety have not been established.
Heart
Please consult your doctor if you have a history of heart disease before taking Cyclophil ME 50 Tablet. Your doctor will prescribe it only if the benefits outweigh the risks.
Geriatrics
Caution
Cyclophil ME 50 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Talk to your doctor if you have any concerns.
FAQs
Country of origin
INDIA
Manufacturer/Marketer address
20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - CYC0052
Disclaimer
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Author Details
Reference
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/050715s035,050716s038lbl.pdf
- https://www.mayoclinic.org/drugs-supplements/cyclosporine-oral-route/description/drg-20075815
- https://medlineplus.gov/druginfo/meds/a601207.html
- https://www.drugs.com/disease-interactions/cyclosporine.html
- https://www.medicines.org.uk/emc/files/pil.5300.pdf
- https://www.webmd.com/drugs/2/drug-5645-9108/cyclosporine-oral/cyclosporine-oral/details
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