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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cycloxan Tablet is used to treat cancer and nephrotic syndrome (kidney disease). It contains Cyclophosphamide that stops the growth and multiplication of cancer cells. In some cases, this medicine may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Not Returnable

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About Cycloxan Tablet

Cycloxan Tablet is used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia,  nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Cycloxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Cycloxan Tablet contains ‘Cyclophosphamide’, an alkylating agent that damages the genetic material of cancer cells to stop their growth and multiplication. Thus, Cycloxan Tablet helps treat cancer by killing the cancer cells.
 
You are advised to take Cycloxan Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Do not be reluctant to talk with your doctor if you experience any of these side effects persistently.
 
Do not take Cycloxan Tablet if you are allergic to any of its components; or if you have bladder obstruction or other urination problems. Avoid taking Cycloxan Tablet if you are pregnant or breastfeeding. Cycloxan Tablet may cause dizziness, so drive only if you are alert. Cycloxan Tablet should be given to children only if prescribed by the doctor. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Cycloxan Tablet

Cycloxan Tablet is used for the treatment of cancer and nephrotic syndrome (kidney disease). The detailed uses of Cycloxan Tablet are as follows:
•Cancer treatment: Cycloxan Tablet is used to treat various cancers, including lymphomas, leukemia, and breast cancer, by slowing or stopping cancer cell growth.
•Autoimmune disorders: Cycloxan Tablet helps manage autoimmune diseases like lupus and rheumatoid arthritis by suppressing the immune response and reducing inflammation.
•Organ Transplantation: Cycloxan Tablet is used in organ transplant patients to prevent rejection by suppressing the immune system.
•Nephrotic Syndrome: Cycloxan Tablet is used to treat nephrotic syndrome, especially in cases resistant to standard treatments, by reducing proteinuria and improving kidney function.
•Scleroderma Treatment: Cycloxan Tablet is involved in managing scleroderma by alleviating symptoms and slowing disease progression through immune system suppression.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush or chew it. Oral liquid: Check the label for directions before use and take the prescribed dose using the dosing syringe or medicine spoon.

Medicinal Benefits

Cycloxan Tablet belongs to the group of anti-cancer medicines used to treat malignant diseases such as Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma(cancer of plasma cells), Burkitt’s lymphoma, leukaemia (blood cancer), neuroblastoma (nerve tissue cancer), retinoblastoma (eye cancer), adenocarcinoma of the ovary (ovarian cancer), mycosis fungoides (T-cell lymphoma), rhabdomyosarcoma (soft tissue cancer), osteosarcoma (bone cancer), and breast carcinoma. Additionally, Cycloxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in pediatric patients. Cycloxan Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Cycloxan Tablet helps to treat cancer by killing the cancer cells.

How Cycloxan Tablet Works

Cycloxan Tablet contains ‘Cyclophosphamide’, an alkylating agent that damages the genetic material of cancer cells to stop their growth and multiplication. Thus, Cycloxan Tablet helps treat cancer by killing the cancer cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Cycloxan Tablet
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
  • Stay hydrated to support kidney and bladder health.
  • Rest on your back as advised by your doctor.
  • Limit physical strain for 1-2 weeks.
  • Avoid strenuous activities like running and contact sports.
  • Quit smoking to improve overall health.
  • Use pain medication responsibly.
  • Avoid foods that can irritate the urinary track, such as spicy or acidic foods.
  • Remember to consult your doctor for personalized advice and guidance on managing your symptoms and developing a treatment plan.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • If you are concerned about impaired spermatogenesis, talk to your doctor. They may adjust the dose if necessary or prescribe alternative medication.
  • Limit exposure to environmental toxins, smoking, and excessive alcohol consumption.
  • Regularly monitor hormone levels, such as testosterone and follicle-stimulating hormone (FSH), to detect any changes.
  • Ensure adequate zinc and folate intake, as these nutrients are essential for spermatogenesis.
  • Consume omega-3 fatty acid-rich foods or supplements, such as fish oil, to support reproductive health.

What if I have taken an overdose of Cycloxan Tablet

Take Cycloxan Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include black/tarry stools, red urine, unusual bleeding/bruising, unusual tiredness/weakness, signs of infection (sore throat, cough, fever), chest pain, and swelling in the ankles, feet or legs. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Cycloxan Tablet if you are allergic to any of its contents; or have urinary flow obstruction, bone marrow suppression, or infections. Talk to your doctor if you have myelosuppression, immunosuppression, infections, diabetes, heart, lung, liver, or kidney problems. Inform your doctor if you are receiving any radiotherapy or chemotherapy. Avoid taking Cycloxan Tablet if you are pregnant or breastfeeding. Cycloxan Tablet may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Drug-Drug Interactions

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CyclophosphamideNalidixic acid
Critical
CyclophosphamideCidofovir
Critical

Drug-Drug Interactions

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CyclophosphamideNalidixic acid
Critical
How does the drug interact with Cycloxan Tablet:
Co-administration of Nalidixic acid with Cycloxan Tablet may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Cycloxan Tablet and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideCidofovir
Critical
How does the drug interact with Cycloxan Tablet:
Co-administration of Cycloxan Tablet and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideLeflunomide
Severe
How does the drug interact with Cycloxan Tablet:
Taking Cycloxan Tablet with Leflunomide may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Cycloxan Tablet can be taken with Leflunomide if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideTenofovir alafenamide
Severe
How does the drug interact with Cycloxan Tablet:
Co-administration of Tenofovir alafenamide may cause kidney problems, and combining it with Cycloxan Tablet may increase the risk.

How to manage the interaction:
Although there is a possible interaction, Cycloxan Tablet can be taken with Tenofovir alafenamide if prescribed by the doctor. Consult the doctor if you develop signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop any medication without consulting a doctor.
CyclophosphamideThalidomide
Severe
How does the drug interact with Cycloxan Tablet:
Taking Cycloxan Tablet with Thalidomide may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Cycloxan Tablet can be taken with Thalidomide if prescribed by the doctor. However, consult the doctor if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue any medications without a doctor's advice.
CyclophosphamideDeferiprone
Severe
How does the drug interact with Cycloxan Tablet:
Co-administration of Cycloxan Tablet and Deferiprone may increase the risk of serious and potential infections.

How to manage the interaction:
Co-administration of Cycloxan Tablet with Deferiprone can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CyclophosphamideGolimumab
Severe
How does the drug interact with Cycloxan Tablet:
Co-administration of Golimumab with Cycloxan Tablet may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Cycloxan Tablet with Golimumab can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideCertolizumab
Severe
How does the drug interact with Cycloxan Tablet:
When Cycloxan Tablet is taken with Certolizumab, may increase the risk or severity of infections.

How to manage the interaction:
There may be a possibility of interaction between Cycloxan Tablet and Certolizumab, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
CyclophosphamideTofacitinib
Severe
How does the drug interact with Cycloxan Tablet:
Taking Cycloxan Tablet with Tofacitinib may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Cycloxan Tablet can be taken with Tofacitinib if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideInfliximab
Severe
How does the drug interact with Cycloxan Tablet:
When Cycloxan Tablet is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although taking Infliximab and Cycloxan Tablet together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.
  • Stay protected from the sun. Avoid tanning beds and cover up with clothing, sunscreen, and sunglasses.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Cycloxan Tablet Substitute

Substitutes safety advice
  • Adcyclo 50 Tablet 10's

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    3.83per tablet
  • Cycloglob 50mg Tablet

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    3.42per tablet
  • Bdcyclo Tablet

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    3.24per tablet
  • Endoxan Tablet 10's

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    3.83per tablet
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Alcohol

Consult your doctor

It is not known if alcohol affects Cycloxan Tablet . Please consult your doctor.

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Pregnancy

Unsafe

Cyclophosphamide belongs to pregnancy category D. Cycloxan Tablet should not be taken during pregnancy as it might cause fetal harm. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnant.

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Breast Feeding

Unsafe

Cycloxan Tablet passes into breastmilk. Avoid breastfeeding while taking Cycloxan Tablet .

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Driving

Caution

Cycloxan Tablet may cause dizziness. Drive or operate heavy machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Cycloxan Tablet should be used with caution in patients with renal impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Cycloxan Tablet should be given to children only if prescribed by a doctor.

FAQs

Cycloxan Tablet is used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia, nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Cycloxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.

Cycloxan Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Cycloxan Tablet helps to treat cancer by killing the cancer cells.

Do not stop taking Cycloxan Tablet on your own. You are advised to take Cycloxan Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Cycloxan Tablet .

Cycloxan Tablet might interfere with oogenesis (development of ovum) and spermatogenesis (development of sperm) and could impair fertility. Before starting treatment with Cycloxan Tablet , talk to your doctor regarding cryopreservation/freezing of eggs/sperm if you consider becoming parents.

Cycloxan Tablet might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding, or bruising or if the wounds do not heal properly.

No, it is not safe to father a child while taking Cycloxan Tablet . Use effective contraception while taking Cycloxan Tablet and for at least four months after treatment. Women of childbearing age taking Cycloxan Tablet should use highly effective contraceptives while taking Cycloxan Tablet up to 1 year after the treatment.

Cycloxan Tablet might cause myelosuppression/bone marrow suppression leading to a decrease in white blood cells. This could lead to an increased risk of infections. Regular blood tests while taking Cycloxan Tablet are advised.

During treatment with Cycloxan Tablet , stay protected from sun and avoid excessive sun exposure. It’s best to use sunscreen, sunglasses and protective clothing to prevent skin damage, if your immune system is weakened.

Cancer treatments like chemotherapy and radiation therapy can increase the chance of developing other cancers, which may appear years after treatment with Cycloxan Tablet . The use of Cycloxan Tablet is associated with a higher risk of bladder cancer. Rarely, it may also increase the risk of other cancers like acute leukaemia, and ureter cancer.

Cycloxan Tablet is a chemotherapy medicine which belongs to the class of alkylating agents. It works by destroying cancer cells.

Yes, Cycloxan Tablet may be used to treat nephrotic syndrome in children, especially in cases where the condition has not improved, or has recurred after using other medications. It is also an option for children who have experienced severe side effects from other treatments. However, its safety and effectiveness for nephrotic syndrome in adults have not been established.

Cycloxan Tablet may cause weight loss due to decreased appetite and may be due to underlying cancer. Consult a doctor if you experience significant weight loss.

Cycloxan Tablet may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. However, if these side effects persist or worsen, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Biochem Pharma, Lg 113 / A, Xth Central Mall, Mahavir Nagar, 90Ft Road, Next To D Mart, Kandivali - West, Mumbai - 400067.
Other Info - CYC0025

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