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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cyramza 500 Injection is used for treating Colorectal Cancer, Stomach Cancer, Hepatocellular cancer and Non-small cell lung cancer. It contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death. Thus, it treats certain cancers. Cyramza 500 Injection may cause side effects, such as abdominal pain, dry mouth, mouth sores, increased blood pressure, diarrhoea, fatigue, nausea, headache, nose bleeds, vomiting, tiredness, and injection site reactions.

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Whats That

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Composition :

RAMUCIRUMAB-500MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Cyramza 500 Injection

Cyramza 500 Injection is an anti-cancer medicine used alone or in combination with other combination medicines for the treatment of metastatic gastric or gastroesophageal junction adenocarcinoma, hepatocellular cancer, colorectal cancer, and non-small cell lung cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. It can also be used when the cancer has spread to other parts of the body.

Cyramza 500 Injection contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Cyramza 500 Injection may cause some side effects, such as abdominal pain, dry mouth, mouth sores, increased blood pressure, diarrhoea, fatigue, nausea, headache, nose bleeds, vomiting, tiredness, and injection site reactions. If the side effects persist or bother you, please consult your doctor. Cyramza 500 Injection will be administered by a doctor experienced in the administration of cancer medicine. Do not self-administer.

Avoid taking it and inform your doctor if you are allergic to Cyramza 500 Injection or its components. Inform your doctor if you have any cardiovascular conditions, heart attack, stroke, increased blood pressure, any planned surgery, lung problems, or liver/kidney disease, as it can cause adverse effects. Cyramza 500 Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Cyramza 500 Injection

Cyramza 500 Injection is used in the treatment of Colorectal Cancer, Stomach Cancer, Hepatocellular cancer and Non-small cell lung cancer. The detailed uses of Cyramza 500 Injection are as follows:<br/>• Stomach and gastroesophageal junction cancer: Cyramza 500 Injection is used for treating stomach and gastroesophageal junction cancer that has progressed after initial therapy. It may be administered alone or with paclitaxel to help slow the disease and improve survival outcomes.<br/>• Non-small cell lung cancer (NSCLC): Cyramza 500 Injection is used for non-small cell lung cancer (NSCLC) in patients who no longer respond to prior chemotherapy. It works in combination with other drugs to inhibit tumor growth by targeting blood vessel formation.<br/>• Colorectal cancer: Cyramza 500 Injection is used to treat metastatic colorectal cancer that is resistant to earlier lines of treatment. It helps reduce the blood supply to tumors, thereby controlling disease spread and progression.<br/>• Liver cancer (hepatocellular carcinoma): Cyramza 500 Injection is indicated for liver cancer (hepatocellular carcinoma) in patients previously treated with sorafenib. It is especially beneficial in cases with elevated AFP levels and helps limit further tumor advancement.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Cyramza 500 Injection is administered by the doctor or nurse.• Avoid self-administration.

Medicinal Benefits

Cyramza 500 Injection contains Trastuzumab, which is used for treating patients with different types of cancer. This medicine works by inhibiting the excess production of a human vascular endothelial growth factor receptor 2, which is responsible for the growth and spread of cancer cells. This causes inhibition of the cancer cell growth and, finally, initiation of programmed cell death.

How Cyramza 500 Injection Works

Cyramza 500 Injection contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Storage

• Store in a cool and dry place away from sunlight.• Keep Cyramza 500 Injection out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Cyramza 500 Injection

As Cyramza 500 Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Cyramza 500 Injection should be avoided if you are allergic to it or any other components of this medicine. Before taking Cyramza 500 Injection, inform your doctor if you have any history of cardiovascular conditions, heart attack, stroke, increased blood pressure, any planned surgery, lung problems, or liver or kidney disease, as it can cause adverse effects. Cyramza 500 Injection may cause Cyramza 500 Injection may cause reversible posterior leukoencephalopathy syndrome, arterial thromboembolic events, hypertension, an increased risk of hemorrhage, infusion-related reactions, gastrointestinal perforation, and clinical deterioration in patients with cirrhosis during the treatment. Hence, careful observation should be performed for any reactions in the patient. Cyramza 500 Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Cyramza 500 Injection is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Cyramza 500 Injection 50 ml:
Coadministration of ketorolac with Cyramza 500 Injection 50 ml can cause bleeding.

How to manage the interaction:
Although there is a interaction between Ketorolac and Cyramza 500 Injection 50 ml, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cyramza 500 Injection 50 ml:
Coadministration of Piroxicam with Cyramza 500 Injection 50 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Piroxicam with Cyramza 500 Injection 50 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cyramza 500 Injection 50 ml:
Using Cyramza 500 Injection 50 ml together with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Fondaparinux and Cyramza 500 Injection 50 ml, but it can be taken if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Cyramza 500 Injection 50 ml:
Combined use of aspirin with Cyramza 500 Injection 50 ml may result in gut ulcers and bleeding.

How to manage the interaction:
There may be a possibility of interaction between Aspirin and Cyramza 500 Injection 50 ml, but it can be taken if prescribed by a doctor. However, if you notice unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cyramza 500 Injection 50 ml:
Taking Dabigatran etexilate with Cyramza 500 Injection 50 ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Cyramza 500 Injection 50 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cyramza 500 Injection 50 ml:
The use of Cyramza 500 Injection 50 ml together with clopidogrel may raise the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Clopidogrel and Cyramza 500 Injection 50 ml, you can take these medicines together if prescribed by your doctor. If you notice these signs, contact your doctor immediately - feeling dizzy or lightheaded, dark or bloody stools, coughing, intense headaches, or weakness. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Cyramza 500 Injection 50 ml:
Co-administration of Diclofenac and Cyramza 500 Injection 50 ml can cause bleeding and ulcers.

How to manage the interaction:
Co-administration of Diclofenac and Cyramza 500 Injection 50 ml can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cyramza 500 Injection 50 ml:
Using Cyramza 500 Injection 50 ml together with apixaban may increase the risk of bleeding.

How to manage the interaction:
Even though combining Cyramza 500 Injection 50 ml and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
How does the drug interact with Cyramza 500 Injection 50 ml:
Co-administration of Prasugrel with Cyramza 500 Injection 50 ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Prasugrel with Cyramza 500 Injection 50 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Caution

It is unknown whether Cyramza 500 Injection interacts with alcohol. Consult your doctor for more information.

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Pregnancy

Unsafe

Cyramza 500 Injection is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Cyramza 500 Injection. You should not become pregnant while you are receiving Cyramza 500 Injection for at least three months from the last dose of Cyramza 500 Injection. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Cyramza 500 Injection should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least two months from the last dose of medicine.

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Driving

Caution

Cyramza 500 Injection will be administered to hospitalized patients. Driving is not recommended.

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Liver

Safe if prescribed

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Cyramza 500 Injection. Based on population PK analysis, no dose adjustment is advised for patients with mild liver impairment. Patients with Child-Pugh B or C cirrhosis who received single-agent Cyramza 500 Injection reported clinical deterioration.

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Kidney

Safe if prescribed

Hence, if you have a pre-existing or a history of kidney disease, inform your doctor. Based on population PK analysis, no dose adjustment is advised for patients with kidney impairment.

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Children

Unsafe

Cyramza 500 Injection is not recommended for use in children as the safety and efficacy are not established.

Have a query?

FAQs

Cyramza 500 Injection is used to treat Colorectal Cancer, Stomach Cancer, Hepatocellular cancer and Non-small cell lung cancer.

Cyramza 500 Injection contains Ramucirumab, which works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Inform your doctor whether you have received any other cancer treatment. Cyramza 500 Injection may cause reversible posterior leukoencephalopathy syndrome, arterial thromboembolic events, hypertension, infusion-related reactions, gastrointestinal perforation, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, lung problems, are pregnant, are planning to become pregnant, or are breastfeeding before receiving Cyramza 500 Injection.

Country of origin

India

Manufacturer/Marketer address

Plot# 92, Sector 32, Institutional Area, Gurgaon-122001, Haryana, India
Other Info - CYR0011

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Keep Refrigerated. Do not freeze.Prepaid payment required.

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