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compositionComposition:RAMUCIRUMAB-500MG
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Prescription Medicine
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Cyramza 500 Injection is used for treating Colorectal Cancer, Stomach Cancer, Hepatocellular cancer and Non-small cell lung cancer. It contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death. Thus, it treats certain cancers. Cyramza 500 Injection may cause side effects, such as abdominal pain, dry mouth, mouth sores, increased blood pressure, diarrhoea, fatigue, nausea, headache, nose bleeds, vomiting, tiredness, and injection site reactions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RAMUCIRUMAB-500MG

Manufacturer/Marketer :

Eli Lilly and Company (India) Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cyramza 500 Injection

Cyramza 500 Injection is a specialised prescription medication used to treat certain advanced cancers, including cancers of the stomach, gastro-oesophageal junction, lungs, colon, rectum, and liver. It belongs to a class of targeted therapies that work by stopping cancer cells from growing and spreading. This medicine is prescribed when other standard treatments have not worked or have stopped working.

This treatment is given as an intravenous infusion, typically once every two or three weeks depending on your specific treatment plan. It is highly important to receive these infusions consistently on the schedule set by your oncologist to get the best results. While undergoing therapy, eating a balanced diet rich in protein and drinking plenty of fluids can help your body manage treatment stress and maintain your energy levels.

While taking Cyramza 500 Injection, you may experience common side effects such as high blood pressure, headaches, or feeling very tired. However, you must contact your healthcare team immediately if you experience serious side effects, such as severe bleeding, persistent stomach pain, or chest tightness during or after an infusion.

Talk to your doctor before starting this medicine if you have a history of high blood pressure, thyroid issues, liver damage, or blood clots. Do not take this if you have unhealed wounds or are scheduled to have a major surgery in the near future, as it can severely interfere with wound healing.

This medicine can interact with blood thinners, increasing your risk of bleeding, so inform your doctor about all drugs you take. Additionally, pregnant or breastfeeding individuals must not receive Cyramza 500 Injection due to the risk of serious harm to the baby, and elderly patients should consult their doctor for personalised monitoring.

Uses of Cyramza 500 Injection

The following are the approved therapeutic uses of Cyramza 500 Injection in different types of advanced cancers:

  • Advanced Stomach or Gastro-oesophageal Junction Cancer: Cyramza 500 Injection helps by slowing down tumour progression in patients whose cancer has spread or returned after initial chemotherapy.
  • Non-Small Cell Lung Cancer: When combined with other targeted therapies or chemotherapy, it helps manage advanced lung cancer that has spread to other parts of the body.
  • Metastatic Colorectal Cancer: It is used in combination with chemotherapy to treat colon or rectal cancer that has worsened after previous treatments.
  • Hepatocellular Carcinoma (Liver Cancer): It serves as a treatment option for people with advanced liver cancer who have high levels of a protein called alpha-fetoprotein in their blood.

Key Benefits

Cyramza 500 Injection offers significant benefits by directly targeting the physical processes that allow advanced cancers to grow and spread in the body.

  • Slowing Cancer Progression: By targeting the blood supply of tumours, this medicine helps delay the growth and spread of advanced cancers, providing more time under disease control.
  • An Alternative When Other Treatments Fail: It offers a viable and effective option for patients whose cancers have become resistant to standard first-line chemotherapy regimens.
  • Targeted Action: Because it specifically targets the signals that create tumour blood vessels, it focuses directly on the tumour environment rather than damaging all rapidly dividing healthy cells in the body.
Side effects of Cyramza 500 Injection 50 ml

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Cyramza 500 Injection is administered by the doctor or nurse.
  • Avoid self-administration.

How Cyramza 500 Injection Works

Cyramza 500 Injection contains ramucirumab, a monoclonal antibody that helps slow the growth and spread of certain types of cancer. Cyramza 500 Injection works by binding to vascular endothelial growth factor receptor-2 (VEGFR-2), a receptor found on the surface of blood vessel cells. This blocks the action of growth signals that normally stimulate the formation of new blood vessels needed to supply tumours with oxygen and nutrients. By preventing the growth of new blood vessels, Cyramza 500 Injection reduces the tumour's blood supply, which helps slow or stop its growth and may limit its spread to other parts of the body. Together, these actions help control tumour growth, support cancer treatment, and improve treatment outcomes when used alone or in combination with other anticancer medicines.
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Alcohol

Caution

It is unknown whether Cyramza 500 Injection interacts with alcohol. Consult your doctor for more information.

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Pregnancy

Unsafe

Cyramza 500 Injection is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Cyramza 500 Injection. You should not become pregnant while you are receiving Cyramza 500 Injection for at least three months from the last dose of Cyramza 500 Injection. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Cyramza 500 Injection should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least two months from the last dose of medicine.

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Driving

Caution

Cyramza 500 Injection will be administered to hospitalized patients. Driving is not recommended.

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Liver

Safe if prescribed

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Cyramza 500 Injection. Based on population PK analysis, no dose adjustment is advised for patients with mild liver impairment. Patients with Child-Pugh B or C cirrhosis who received single-agent Cyramza 500 Injection reported clinical deterioration.

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Kidney

Safe if prescribed

Hence, if you have a pre-existing or a history of kidney disease, inform your doctor. Based on population PK analysis, no dose adjustment is advised for patients with kidney impairment.

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Children

Unsafe

Cyramza 500 Injection is not recommended for use in children as the safety and efficacy are not established.

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Heart

Caution

Cyramza 500 Injection can be used in patients with heart problems, but only with extreme caution and close monitoring.

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Geriatrics

Caution

Geriatric patients can receive Cyramza 500 Injection, but only with careful medical evaluation and monitoring.

What if I have taken an overdose of Cyramza 500 Injection

Since a trained healthcare professional prepares and gives this medicine, an overdose is highly unlikely. However, if you suspect there has been an administration error or if you experience severe symptoms immediately after an infusion, notify your healthcare provider or seek emergency medical attention right away.

Diet & Lifestyle Advise

  • Monitor your blood pressure: Check your blood pressure daily at home and keep a log. Report any sudden or high readings to your medical team.
  • Practice gentle dental hygiene: Use an extra-soft toothbrush and avoid flossing aggressively to prevent gum bleeding, as Cyramza 500 Injection can increase bleeding risks.
  • Plan around surgeries: Always inform your dentist or surgeon that you are receiving Cyramza 500 Injection. You will need to stop using the medicine temporarily before and after any surgical procedures to ensure proper wound healing.
  • Stay hydrated: Drink plenty of water and clear broths, especially if you experience diarrhoea, to protect your kidneys and prevent dehydration.
  • Eat smaller, frequent meals: If you experience nausea or loss of appetite, consuming small portions of bland foods throughout the day can help maintain your strength.
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How Soon It Starts Working

The time required for Cyramza 500 Injection to start to work: The time required for Cyramza 500 Injection to show its action is not clinically established. The time for which the effects of Cyramza 500 Injection last: The duration of action for Cyramza 500 Injection is not clinically established.

What if you forget to take Cyramza 500 Injection

Because this medication is scheduled and given by medical professionals at a clinic, missing a dose is uncommon. If you miss an appointment or need to delay your infusion, contact your doctor or oncology clinic immediately to reschedule. Do not try to double your dose at your next visit.

Storage

•Cyramza 500 Injection is stored and handled exclusively by the healthcare facility where you receive your treatment.•It must be kept refrigerated at a temperature of 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the infusion solution: Ensure the solution is clear and colourless to slightly yellow before the infusion begins. It should not be used if it contains visible particles.
  • Report unhealed wounds: Inform your healthcare provider about any unhealed cuts, ulcers, recent surgeries, or dental wounds before receiving an infusion, as this medicine may delay wound healing.
  • Watch for infusion reactions: Tell your nurse immediately if you experience chills, shivering, dizziness, difficulty breathing, or any unusual symptoms during the infusion.
  • Avoid certain pain relievers unless approved: Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, unless your oncologist advises it, as they may increase the risk of bleeding.
  • Attend routine monitoring tests: Keep all scheduled appointments for urine tests, as your doctor will regularly check for protein in your urine to monitor your kidney health.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Cyramza 500 Injection and increase the risk of complications:

  • Blood Thinners (like warfarin or heparin): May significantly increase the risk of serious, internal bleeding when used together with Cyramza 500 Injection.
  • NSAIDs (like ibuprofen or naproxen): Can raise the risk of stomach irritation and severe bleeding.
RamucirumabApixaban
Severe
RamucirumabKetorolac
Severe

Drug-Drug Interactions

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RamucirumabApixaban
Severe
How does the drug interact with Cyramza 500 Injection 50 ml:
Using Cyramza 500 Injection 50 ml together with apixaban may increase the risk of bleeding.

How to manage the interaction:
Even though combining Cyramza 500 Injection 50 ml and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
RamucirumabKetorolac
Severe
How does the drug interact with Cyramza 500 Injection 50 ml:
Coadministration of ketorolac with Cyramza 500 Injection 50 ml can cause bleeding.

How to manage the interaction:
Although there is a interaction between Ketorolac and Cyramza 500 Injection 50 ml, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
RamucirumabDiclofenac
Severe
How does the drug interact with Cyramza 500 Injection 50 ml:
Co-administration of Diclofenac and Cyramza 500 Injection 50 ml can cause bleeding and ulcers.

How to manage the interaction:
Co-administration of Diclofenac and Cyramza 500 Injection 50 ml can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
RamucirumabDabigatran etexilate
Severe
How does the drug interact with Cyramza 500 Injection 50 ml:
Taking Dabigatran etexilate with Cyramza 500 Injection 50 ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Cyramza 500 Injection 50 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
RamucirumabPrasugrel
Severe
How does the drug interact with Cyramza 500 Injection 50 ml:
Co-administration of Prasugrel with Cyramza 500 Injection 50 ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Prasugrel with Cyramza 500 Injection 50 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
RamucirumabFondaparinux
Severe
How does the drug interact with Cyramza 500 Injection 50 ml:
Using Cyramza 500 Injection 50 ml together with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Fondaparinux and Cyramza 500 Injection 50 ml, but it can be taken if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
RamucirumabClopidogrel
Severe
How does the drug interact with Cyramza 500 Injection 50 ml:
The use of Cyramza 500 Injection 50 ml together with clopidogrel may raise the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Clopidogrel and Cyramza 500 Injection 50 ml, you can take these medicines together if prescribed by your doctor. If you notice these signs, contact your doctor immediately - feeling dizzy or lightheaded, dark or bloody stools, coughing, intense headaches, or weakness. Do not discontinue any medications without consulting your doctor.
RamucirumabAspirin
Severe
How does the drug interact with Cyramza 500 Injection 50 ml:
Combined use of aspirin with Cyramza 500 Injection 50 ml may result in gut ulcers and bleeding.

How to manage the interaction:
There may be a possibility of interaction between Aspirin and Cyramza 500 Injection 50 ml, but it can be taken if prescribed by a doctor. However, if you notice unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.
RamucirumabPiroxicam
Severe
How does the drug interact with Cyramza 500 Injection 50 ml:
Coadministration of Piroxicam with Cyramza 500 Injection 50 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Piroxicam with Cyramza 500 Injection 50 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Cyramza 500 Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Cyramza 500 Injection is used to treat Colorectal Cancer, Stomach Cancer, Hepatocellular cancer and Non-small cell lung cancer.
Cyramza 500 Injection contains Ramucirumab, which works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.
Inform your doctor whether you have received any other cancer treatment. Cyramza 500 Injection may cause reversible posterior leukoencephalopathy syndrome, arterial thromboembolic events, hypertension, infusion-related reactions, gastrointestinal perforation, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, lung problems, are pregnant, are planning to become pregnant, or are breastfeeding before receiving Cyramza 500 Injection.
No, Cyramza 500 Injection is not a classic chemotherapy drug. It is a targeted therapy (a monoclonal antibody) that specifically blocks the blood supply to cancer cells, whereas chemotherapy generally targets all rapidly dividing cells. Talk to your doctor to understand how this differs from your other treatments.
The infusion typically takes about 60 minutes. However, it may take longer if you experience any mild side effects or reactions during the administration. Talk to your doctor or nurse about what to expect on your treatment day.
Most people can drive after the infusion, but some may feel fatigued, dizzy, or weak. It is best to have someone drive you to and from your first few appointments until you know how the medicine affects you. Talk to your doctor if you feel unsure.
On its own, Cyramza 500 Injection does not typically cause hair loss. However, because it is often given in combination with traditional chemotherapy drugs, you may still experience hair loss from those other medications. Talk to your doctor to clarify the side effects of your specific combination regimen.
You must inform your dentist that you are taking Cyramza 500 Injection before scheduling any invasive procedures. Because this medicine interferes with wound healing and increases bleeding risks, you will likely need to temporarily pause the medication before and after the dental work. Talk to your oncologist to coordinate the timing.
No, you should not receive Cyramza 500 Injection if you are pregnant, as it can cause severe harm to an unborn baby. You should use highly effective birth control during treatment and for at least 3 months after your last dose. Talk to your doctor if you have concerns about fertility or pregnancy.
Cyramza 500 Injection can cause a significant increase in blood pressure by narrowing blood vessels. Your healthcare team will check your blood pressure before every infusion and may prescribe blood pressure medication if it becomes too high. Talk to your doctor if you notice high readings at home.
Mild nosebleeds can happen, but you should notify your healthcare team about any bleeding. If the nosebleed is severe, frequent, or hard to stop, seek emergency medical care immediately. Talk to your doctor or pharmacist about safe ways to manage dry nasal passages.

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Country of origin

India

Manufacturer/Marketer address

Plot# 92, Sector 32, Institutional Area, Gurgaon-122001, Haryana, India
Other Info - CYR0011
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