Apollo
logo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
Select Delivery Location
compositionComposition:DACARBAZINE-500MG
prescription
Prescription Medicine
info
image icons

Dacarb 500 mg Injection is used to treat skin cancer. It contains Dacarbazine, an alkylating agent that inhibits the DNA and RNA transcription essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells. Dacarb 500 mg Injection may cause certain side effects, such as nausea, vomiting, headache, dizziness, and pain at the injection site.

Read more
Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
OffersOffers & Discounts

Get Free delivery (₹99) with circle icon

Join Circle
coupon
Get 18% Off with Coupons
coupon
Extra 10% Off with Bank Offers
bank offer
bank offer
bank offer

More about the Product

Composition :

DACARBAZINE-500MG

Manufacturer/Marketer :

Getwell Life Sciences India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Dacarb 500 mg Injection

Dacarb 500 mg Injection is a prescription injection used to treat certain types of cancers, including advanced skin cancer (metastatic malignant melanoma) and lymph system cancer (Hodgkin's lymphoma). It works by targeting and slowing the growth of cancer cells in the body. This medication is always given under the direct supervision of a healthcare professional in a medical setting.

Your treatment schedule is carefully planned by your doctor and is typically given in cycles, meaning you will receive the injection for a few days followed by a rest period. Consistency in attending your scheduled clinic visits is vital to ensure the medication works effectively. Because this treatment can affect your appetite and hydration, eating small, frequent meals and staying well-hydrated are helpful lifestyle adjustments during therapy.

Some people may experience temporary side effects like nausea, vomiting, or loss of appetite during their treatment. If you notice serious symptoms such as unusual bruising, signs of an infection like a fever, or severe abdominal pain, you must contact your doctor immediately.

Before starting treatment, talk to your doctor if you have a history of liver disease, kidney problems, or low blood cell counts. This medicine should not be given if you have severe bone marrow suppression, are pregnant, or are breastfeeding.

This medicine can interact with other drugs, including vaccines and medications that affect your immune system, which may increase your risk of infections. It is important to consult your healthcare team if you are an older adult, planning to start a family, or nursing, as special precautions are required.

Uses of Dacarb 500 mg Injection

Dacarb 500 mg Injection helps treat certain types of cancer by slowing or stopping the growth of cancer cells. Your doctor may prescribe it for the following conditions:

  • Malignant melanoma: This medicine is used to treat advanced skin cancer that has spread to other parts of the body. It helps by targeting and slowing down the rapid multiplication of abnormal skin cancer cells.
  • Hodgkin's lymphoma: This medicine is used as part of a combination chemotherapy plan to treat cancer of the lymphatic system, helping to destroy cancer cells in the lymph nodes and promote remission.

Key Benefits

Using Dacarb 500 mg Injection as prescribed helps treat certain types of cancer by slowing their growth and supporting cancer treatment. Here are the key benefits you can expect:

  • Helps control cancer growth: Dacarb 500 mg Injection helps destroy cancer cells, which may slow the spread of advanced cancers, reduce tumour size, and relieve cancer-related symptoms.
  • Supports combination chemotherapy: When used as part of a combination chemotherapy regimen, it helps improve the chances of achieving remission in certain cancers, such as Hodgkin's lymphoma.
  • Improves quality of life: By helping control cancer and its symptoms, Dacarb 500 mg Injection may improve daily comfort and overall wellbeing during treatment.
  • Allows recovery between treatment cycles: Treatment is given in cycles, allowing healthy cells time to recover between doses and helping patients better manage treatment-related fatigue.
Side effects of Dacarb 500 mg Injection
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Dacarb 500 mg Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Dacarb 500 mg Injection Works

Dacarb 500 mg Injection contains dacarbazine, an alkylating agent used to treat certain types of cancer. Dacarb 500 mg Injection works by binding directly to the DNA of cancer cells. DNA is the genetic blueprint that cells need to grow, divide, and survive. By damaging this genetic material, the medicine prevents cancer cells from multiplying and triggers their natural breakdown. Because cancer cells divide much faster than most normal cells, they are especially sensitive to this DNA damage. Once the medicine enters your bloodstream, it travels throughout the body to target these rapidly dividing abnormal cells, helping to halt the progression of the disease.
bannner image

Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Dacarb 500 mg Injection to prevent serious side effects.

bannner image

Pregnancy

Unsafe

Dacarb 500 mg Injection is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Dacarb 500 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

bannner image

Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Dacarb 500 mg Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

bannner image

Driving

Caution

Dacarb 500 mg Injection will be administered in the hospital setting. Hence, driving is not recommended.

bannner image

Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Dacarb 500 mg Injection. It may cause hepatic necrosis when administered with other antineoplastics. Hence, Dacarb 500 mg Injection should be used with caution in patients with liver problems. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Dacarb 500 mg Injection. It should be used with caution in patients with renal impairment. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

bannner image

Children

Consult your doctor

Limited information is available for the use of Dacarb 500 mg Injection in children. It will be administered to the children only if clearly needed. If administered, careful monitoring of the child is needed.

bannner image

Heart

Caution

If you have a history of heart disease, please inform the doctor before receiving Dacarb 500 mg Injection.

bannner image

Geriatrics

Consult your doctor

Limited information available about the use of Dacarb 500 mg Injection in geriatric patients. Please consult your physician.

What if I have taken an overdose of Dacarb 500 mg Injection

Because this medication is prepared and given by trained medical professionals, an overdose is extremely rare. However, if you suspect an error or experience severe side effects immediately after an injection, seek immediate medical attention or notify the hospital staff right away.

Diet & Lifestyle Advise

  • Manage Nausea: Eat small, frequent meals throughout the day instead of three large ones. Stick to bland foods like dry toast, crackers, or rice, and avoid greasy, highly spiced, or very sweet foods.
  • Stay Hydrated: Drink plenty of fluids (such as water, clear broths, or decaffeinated teas) between meals, especially on treatment days, to help protect your kidneys and prevent dehydration.
  • Prioritise Skin and Sun Protection: This medication can make your skin highly sensitive to sunlight. Wear protective clothing, a wide-brimmed hat, and apply a broad-spectrum sunscreen with high SPF when outdoors, and avoid direct sun exposure as much as possible.
  • Prevent Infections: Since your white blood cell count may drop, wash your hands frequently with soap and water, avoid close contact with people who are sick, and avoid eating raw or undercooked foods.
health query

Have a query?

How Soon It Starts Working

The time required for Dacarb 500 mg Injection to start to work: The exact onset time of Dacarb 500 mg Injection has not been clinically established. The time for which the effects of Dacarb 500 mg Injection last: The duration of Dacarb 500 mg Injection’s effect is clinically not established.

What if you forget to take Dacarb 500 mg Injection

Since this medicine is given by a healthcare professional in a clinic, it is highly unlikely that you will miss a dose. However, if you miss an appointment or need to reschedule your infusion, contact your oncology clinic immediately to set up a new appointment. Do not try to make up for it without medical guidance.

Storage

•Store unopened Dacarb 500 mg Injection vials in a refrigerator at 2°C to 8°C. Do not freeze the medicine.
icon image

Keep Refrigerated. Do not freeze.

Drug Warnings

  • Watch the Injection Site: Tell your nurse immediately if you feel any burning, stinging, pain, or coldness around your IV line during the infusion. This could mean the medicine is leaking out of the vein into the surrounding tissue, which requires immediate medical intervention.
  • Monitor Your Temperature: Check your temperature regularly. A fever is often the first sign of a low white blood cell count and must be treated as a medical emergency.
  • Avoid Live Vaccines: Do not get any live vaccines (such as the measles, mumps, or shingles vaccines) while receiving this treatment, as your weakened immune system may not be able to handle the vaccine safely.
  • Use Effective Contraception: Both men and women should use highly effective birth control during treatment and for several months afterward, as this medication can cause severe harm to an unborn baby.
  • Check Solution Appearance: Before the injection is given, ensure the medical staff inspects the vial; the solution should be clear and free of particles. If it appears dark pink or has sediment, it should not be used.

Drug-Drug Interactions

verifiedApollotooltip
  • Immunosuppressants and Corticosteroids: Combining these with Dacarb 500 mg Injection can further weaken your immune system, severely increasing your risk of dangerous infections.
  • Live Vaccines: Receiving a live vaccine while on this medicine can lead to a severe, potentially life-threatening vaccine-induced infection.
  • Phenytoin: This medication may decrease the absorption or effectiveness of phenytoin (a seisure medicine), potentially increasing your risk of seizures.
DacarbazineBaricitinib
Severe
DacarbazineKetoconazole
Severe

Drug-Drug Interactions

Login/Sign Up

DacarbazineBaricitinib
Severe
How does the drug interact with Dacarb 500 mg Injection:
Coadministration of Dacarb 500 mg Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Baricitinib and Dacarb 500 mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
DacarbazineKetoconazole
Severe
How does the drug interact with Dacarb 500 mg Injection:
When Dacarb 500 mg Injection is taken with Ketoconazole, it can increase the risk of liver damage.

How to manage the interaction:
There may be a possibility of interaction between Dacarb 500 mg Injection and Ketoconazole, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
DacarbazineTofacitinib
Severe
How does the drug interact with Dacarb 500 mg Injection:
Taking Dacarb 500 mg Injection with Tofacitinib may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Dacarb 500 mg Injection and Tofacitinib, but it can be taken if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
DacarbazineCladribine
Severe
How does the drug interact with Dacarb 500 mg Injection:
The combined use of cladribine with Dacarb 500 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Dacarb 500 mg Injection and Cladribine, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
DacarbazineEtanercept
Severe
How does the drug interact with Dacarb 500 mg Injection:
When Etanercept is used with Dacarb 500 mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Dacarb 500 mg Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
DacarbazineClozapine
Severe
How does the drug interact with Dacarb 500 mg Injection:
Combining Dacarb 500 mg Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Although taking Dacarb 500 mg Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
DacarbazineInfliximab
Severe
How does the drug interact with Dacarb 500 mg Injection:
When Dacarb 500 mg Injection is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Infliximab and Dacarb 500 mg Injection, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
DacarbazineThalidomide
Severe
How does the drug interact with Dacarb 500 mg Injection:
Taking thalidomide together with Dacarb 500 mg Injection may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Dacarb 500 mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Dacarb 500 mg Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Dacarb 500 mg Injection is used to treat Metastatic Malignant Melanoma and Hodgkin’s Disease.
Dacarb 500 mg Injection contains Dacarbazine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.
Dacarb 500 mg Injection may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.
Dacarb 500 mg Injection is administered intravenously by a trained healthcare professional. Hence, do not self-administer.
Dacarb 500 mg Injection is not a potent vesicant. Dacarb 500 mg Injection is a chemotherapeutic medicine used in the treatment of skin cancer.
Dacarb 500 mg Injection may cause hair loss. Tell your doctor if it is severe or does not go away.
The common side effects of Dacarb 500 mg Injection may include nausea, vomiting, headache, dizziness, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
You should avoid direct sun exposure as much as possible because this medication can make your skin extremely sensitive to sunlight, increasing your risk of severe sunburns. Always wear protective clothing and apply a high-SPF sunscreen when you must go outside. Talk to your doctor about safe sun practices.
Tell your healthcare provider or nurse immediately if you feel any burning, stinging, pain, or swelling at the injection site during the infusion. This could indicate the medicine is leaking into surrounding tissues. Talk to your doctor or nurse right away if this occurs.
No, you should avoid getting live vaccines while receiving this treatment because your immune system is weakened, which increases the risk of getting sick from the vaccine. Always consult your healthcare provider before getting any vaccine. Talk to your doctor for a safe vaccination schedule.
This medicine can temporarily lower your white blood cells, red blood cells, and platelets. This can make you more prone to infections, fatigue, and easy bruising or bleeding. Your doctor will monitor your blood counts regularly. Talk to your doctor if you notice any unusual symptoms.
It is highly recommended to avoid alcohol during your treatment, as both alcohol and this medicine can strain your liver and worsen side effects like nausea and vomiting. Talk to your doctor or pharmacist about safe lifestyle choices during chemotherapy.
No, this medication can cause severe harm to an unborn baby and can affect fertility in both men and women. You must use highly effective birth control during treatment and for a specified time after your final dose. Talk to your doctor if you are planning to start a family.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

305, Bakshi House, 40-41, Nehru Place ., New Delhi- 110 017
Other Info - DAC0061
whatsapp Floating Button
Buy Now