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  3. DACAREX 200MG INJECTION

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DACAREX 200MG INJECTION, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

DACAREX 200MG INJECTION is used to treat skin cancer. It contains Dacarbazine, an alkylating agent that inhibits the DNA and RNA transcription essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells. DACAREX 200MG INJECTION may cause certain side effects, such as nausea, vomiting, headache, dizziness, and pain at the injection site.

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Composition :

DACARBAZINE-200MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About DACAREX 200MG INJECTION

DACAREX 200MG INJECTION is a chemotherapeutic medicine used in the treatment of skin cancer. Cancer is a condition where the cells grow and reproduce uncontrollably in a specific body part. These cancerous cells can attack and destroy surrounding healthy tissue and organs. DACAREX 200MG INJECTION is used in the treatment of metastatic malignant melanoma. It is a serious condition in which the cancer grows in melanocytes and also spreads to other parts of the body. DACAREX 200MG INJECTION is also used as a second-line therapy in the treatment of Hodgkin’s Disease when used in combination with other approved drugs.

DACAREX 200MG INJECTION contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

DACAREX 200MG INJECTION may cause certain side effects, such as nausea, vomiting, headache, dizziness, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. DACAREX 200MG INJECTION is a parenteral preparation. A trained healthcare professional will administer it. 

DACAREX 200MG INJECTION should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including medications you take, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease or heart problems. DACAREX 200MG INJECTION may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, careful monitoring of blood and liver functioning should be done during the entire treatment. This medicine is known to cause fetal harm if used in pregnancy. Hence, inform your doctor if you are pregnant, planning to become pregnant and breastfeeding before taking DACAREX 200MG INJECTION.

Uses of DACAREX 200MG INJECTION

DACAREX 200MG INJECTION is used in the treatment of advanced cancers. The detailed uses of DACAREX 200MG INJECTION are as follows:

  • Treats melanoma: DACAREX 200MG INJECTION is indicated for metastatic melanoma, a type of skin cancer that has spread to other parts of the body.
  • Manages soft tissue sarcoma: DACAREX 200MG INJECTION is used in the treatment of advanced soft tissue sarcomas to slow cancer progression.
  • Treats Hodgkin lymphoma: DACAREX 200MG INJECTION is a part of combination chemotherapy regimens for managing advanced Hodgkin lymphoma.

Have a query?

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • DACAREX 200MG INJECTION will be administered by the doctor or healthcare professional.
  • Do not self-administer.

Medicinal Benefits

DACAREX 200MG INJECTION contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

How DACAREX 200MG INJECTION Works

DACAREX 200MG INJECTION contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep DACAREX 200MG INJECTION out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Dacarex 200mg Injection
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

What if I have taken an overdose of DACAREX 200MG INJECTION

Since DACAREX 200MG INJECTION is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

DACAREX 200MG INJECTION should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease or cardiac disorders. DACAREX 200MG INJECTION may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women and breastfeeding mothers. Hence, inform your doctor if you are pregnant, planning to become pregnant and breastfeeding. It is unknown whether DACAREX 200MG INJECTION can be administered to children or not. If administered, close monitoring of the child is needed. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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DacarbazineKetoconazole
Severe
DacarbazineInfliximab
Severe

Drug-Drug Interactions

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DacarbazineKetoconazole
Severe
How does the drug interact with Dacarex 200mg Injection:
When Dacarex 200mg Injection is taken with Ketoconazole, it can increase the risk of liver damage.

How to manage the interaction:
There may be a possibility of interaction between Dacarex 200mg Injection and Ketoconazole, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
DacarbazineInfliximab
Severe
How does the drug interact with Dacarex 200mg Injection:
When Dacarex 200mg Injection is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Infliximab and Dacarex 200mg Injection, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
DacarbazineThalidomide
Severe
How does the drug interact with Dacarex 200mg Injection:
Taking thalidomide together with Dacarex 200mg Injection may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Dacarex 200mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
DacarbazineBaricitinib
Severe
How does the drug interact with Dacarex 200mg Injection:
Coadministration of Dacarex 200mg Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Baricitinib and Dacarex 200mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
DacarbazineClozapine
Severe
How does the drug interact with Dacarex 200mg Injection:
Combining Dacarex 200mg Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Although taking Dacarex 200mg Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
DacarbazineEtanercept
Severe
How does the drug interact with Dacarex 200mg Injection:
When Etanercept is used with Dacarex 200mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Dacarex 200mg Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
DacarbazineTofacitinib
Severe
How does the drug interact with Dacarex 200mg Injection:
Taking Dacarex 200mg Injection with Tofacitinib may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Dacarex 200mg Injection and Tofacitinib, but it can be taken if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
DacarbazineCladribine
Severe
How does the drug interact with Dacarex 200mg Injection:
The combined use of cladribine with Dacarex 200mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Dacarex 200mg Injection and Cladribine, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid going out in the hot sun, as it can harm your skin.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with DACAREX 200MG INJECTION to prevent serious side effects.

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Pregnancy

Unsafe

DACAREX 200MG INJECTION is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving DACAREX 200MG INJECTION. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving DACAREX 200MG INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

DACAREX 200MG INJECTION will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving DACAREX 200MG INJECTION. It may cause hepatic necrosis when administered with other antineoplastics. Hence, DACAREX 200MG INJECTION should be used with caution in patients with liver problems. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving DACAREX 200MG INJECTION. It should be used with caution in patients with renal impairment. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Consult your doctor

Limited information is available for the use of DACAREX 200MG INJECTION in children. It will be administered to the children only if clearly needed. If administered, careful monitoring of the child is needed.

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Heart

If you have a history of heart disease, please inform the doctor before receiving DACAREX 200MG INJECTION.

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Geriatrics

Consult your doctor

Limited information available about the use of DACAREX 200MG INJECTION in geriatric patients. Please consult your physician.

FAQs

DACAREX 200MG INJECTION is used to treat Metastatic Malignant Melanoma and Hodgkin’s Disease.

DACAREX 200MG INJECTION contains Dacarbazine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

DACAREX 200MG INJECTION may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

DACAREX 200MG INJECTION is administered intravenously by a trained healthcare professional. Hence, do not self-administer.

DACAREX 200MG INJECTION is not a potent vesicant. DACAREX 200MG INJECTION is a chemotherapeutic medicine used in the treatment of skin cancer.

DACAREX 200MG INJECTION works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

DACAREX 200MG INJECTION may cause hair loss. Tell your doctor if it is severe or does not go away.

The common side effects of DACAREX 200MG INJECTION may include nausea, vomiting, headache, dizziness, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - DAC0002

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:51 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=26e91082-7698-4680-beab-07c47802f0f9
  2. https://reference.medscape.com/drug/dtic-dome-dacarbazine-342215
  3. https://www.lls.org/drug/dacarbazine
  4. https://www.drugs.com/pro/dacarbazine.html#s-34068-7

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