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compositionComposition:DACOMITINIB-45MG
prescription
Prescription Medicine
info
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Dacenza 45 mg Tablet 30's is an anti-cancer medicine used to treat non-small cell lung cancer (NSCLC). It consists of Dacominitib, which belongs to the class of medicines known as kinase inhibitors. It works by stopping the action of an enzyme (tyrosine kinase) that causes the multiplication of cancerous cells; this prevents the abnormal growth of cancer cells and thus reduces the spread of cancer to other parts of the body.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DACOMITINIB-45MG

Manufacturer/Marketer :

Adley Oncology

Consume Type :

Oral

Return Policy :

Not Returnable

About Dacenza 45 mg Tablet 30's

Dacenza 45 mg Tablet 30's is a prescription medicine used to treat a specific type of advanced lung cancer known as non-small cell lung cancer. It is specifically prescribed for patients whose tumour cells have certain abnormal epidermal growth factor receptor (EGFR) proteins.

To get the best results, you must take this medicine consistently once every day at the same time, either with or without food. Maintaining a balanced diet, staying well-hydrated, and avoiding direct sun exposure can support your body during this treatment.

While taking this medicine, you may experience common side effects like diarrhoea, skin rash, dry skin, or nail changes. It is crucial to contact your healthcare provider immediately if you experience severe diarrhoea, sudden breathing difficulties, or yellowing of your skin or eyes.

Do not take this if you are allergic to any of the ingredients in this medicine. Before starting, tell your doctor if you have a history of lung inflammation, liver disease, or frequent severe diarrhoea.

This medicine can interact with certain acid-reducing medications, which can make it less effective. Pregnant or breastfeeding women should not use this medication as it may harm the baby, and elderly individuals should use it under close medical supervision. Talk to your doctor or pharmacist if you take other medications, smoke, or drink alcohol regularly.

Uses of Dacenza 45 mg Tablet 30's

Dacenza 45 mg Tablet 30's may be prescribed to treat the following condition:

  • Non-small cell lung cancer (NSCLC): Dacenza 45 mg Tablet 30's is used as a first-line treatment for adults with advanced or metastatic non-small cell lung cancer that has specific abnormal epidermal growth factor receptor (EGFR) genes. It works by targeting these abnormal proteins to help slow down the spread of cancer cells.

Key Benefits

Dacenza 45 mg Tablet 30's is a targeted cancer medicine used to treat certain types of non-small cell lung cancer with specific epidermal growth factor receptor (EGFR) mutations. It works by blocking signals that cancer cells use to grow and multiply, helping slow disease progression.

  • Helps Control Cancer Growth: Blocks EGFR signalling pathways involved in the growth and multiplication of cancer cells.
  • Delays Disease Progression: Helps slow the growth or spread of certain EGFR-mutated lung cancers, potentially extending the period before the disease worsens.
  • Supports Tumour Control: By interfering with cancer cell signalling, it may help reduce or stabilise tumour growth in eligible patients.
  • Provides Targeted Treatment: Specifically targets abnormal EGFR signalling, offering a treatment approach tailored to cancers with certain EGFR mutations.
  • Convenient Oral Treatment: Taken as an oral tablet, allowing treatment to be administered at home without the need for routine intravenous chemotherapy infusions.
Side effects of Dacenza 45mg Tab
  • Include omega-3 rich foods like fatty fish, ground flax, flaxseed oil, and walnuts.
  • Consume calcium-rich dairy products for bone health.
  • Eat green and leafy vegetables for essential nutrients.
  • Include lean protein sources like eggs and whole grains.
  • Use herbs and spices for added flavor and nutrition.
  • Choose fortified foods for extra nutritional benefits.
  • Get plenty of sleep for overall health and well-being.
  • Exercise regularly to maintain a healthy weight.
  • Follow a proper diet; avoid sugary snacks and drinks.
  • Manage stress with yoga or meditation.
  • Limit alcohol consumption.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.
  • Dehydration would need immediate medical attention if its severe where medical help can save you from crisis.
  • In case the level of dehydration is from mild to moderate, drink plenty of water for an immediate relief.
  • Seek a place where the surrounding temperature is less and try to stay away from heat and humidity.
  • Lie down by keeping a cool and wet towel on your forehead to prevent high temperature in your body to avoid dehydration.
  • Talk to your medical practitioner and use oral rehydrating salts to replace the lost salts from your body.

Directions for Use

  • Dacenza 45 mg Tablet 30's can be taken with or without food as advised by your doctor.
  • It is recommended to take Dacenza 45 mg Tablet 30's once daily or as advised by your doctor.
  • Swallow Dacenza 45 mg Tablet 30's as a whole with a full glass of water.
  • Do not chew, crush, or break it.

How Dacenza 45 mg Tablet 30's Works

Dacenza 45 mg Tablet 30's contains dacomitinib. It belongs to a class of medications called tyrosine kinase inhibitors. In certain lung cancers, a protein called the Epidermal Growth Factor Receptor (EGFR) is overactive, causing cancer cells to grow and divide uncontrollably. Dacenza 45 mg Tablet 30's works by binding to and blocking these abnormal EGFR proteins. By shutting down this signalling pathway, the medicine helps stop the growth and spread of cancer cells, encouraging them to die off and helping to keep the disease under control.
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Alcohol

Consult your doctor

It is unknown whether alcohol may interact with Dacenza 45 mg Tablet 30's. However, as a precautionary measure, it is advisable not to take or limit alcohol. Consult your doctor for more information.

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Pregnancy

Unsafe

Dacenza 45 mg Tablet 30's is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Dacenza 45 mg Tablet 30's. You should not become pregnant while you are taking Dacenza 45 mg Tablet 30's and for at least 17 days after your last dose.

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Breast Feeding

Unsafe

It is not known whether Dacenza 45 mg Tablet 30's is present in human milk. However, you should not breastfeed while taking this medicine and, for 17 days after your last dose.

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Driving

Unsafe

Dacenza 45 mg Tablet 30's may cause blurred vision as a side effect. Hence, try to avoid driving, operating machinery, or engaging in any activity that needs clear vision until you are able to see clearly while you are on treatment with Dacenza 45 mg Tablet 30's.

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Liver

Caution

If you have mild to moderate liver problems, inform your doctor before taking Dacenza 45 mg Tablet 30's. The dose of this medicine has to be adjusted in case you have severe liver disease.

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Kidney

Caution

Inform your doctor before receiving Dacenza 45 mg Tablet 30's if you have a history of kidney diseases. No dose adjustments are required in mild to moderate renal impairment.

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Children

Unsafe

Dacenza 45 mg Tablet 30's is not recommended for children as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please consult your doctor before receiving Dacenza 45 mg Tablet 30's if you have pre-existing heart problems. Your doctor will prescribe Dacenza 45 mg Tablet 30's if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Dacenza 45 mg Tablet 30's to geriatric patients. Your doctor will prescribe Dacenza 45 mg Tablet 30's if the benefits outweigh the risks.

What if I have taken an overdose of Dacenza 45 mg Tablet 30's

If you accidentally take too much of this medicine, seek emergency medical attention or contact a poison control centre immediately.

Diet & Lifestyle Advise

  • Manage diarrhoea early: Stay hydrated by drinking plenty of water, clear broths, or electrolyte solutions. Keep anti-diarrhoea medication on hand as recommended by your doctor.
  • Protect your skin: Use a gentle, alcohol-free moisturiser twice daily. Wear broad-spectrum sunscreen (SPF 30 or higher) and protective clothing when outdoors, as this medicine makes your skin highly sensitive to sunlight.
  • Gentle nail care: Keep your nails trimmed straight across. Avoid biting your nails or cutting your cuticles, and wear protective gloves when doing dishes or cleaning.
  • Soothe your mouth: Brush your teeth with a soft-bristled toothbrush and rinse your mouth regularly with a salt and baking soda solution. Avoid spicy, acidic, or very hot foods that can irritate mouth sores.
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How Soon It Starts Working

The time required for Dacenza 45 mg Tablet 30's to start to work: The time required for Dacenza 45 mg Tablet 30's to show its action is not clinically established. The time for which the effects of Dacenza 45 mg Tablet 30's last: The duration of action for Dacenza 45 mg Tablet 30's is not clinically established.

What if you forget to take Dacenza 45 mg Tablet 30's

If you miss a dose, do not take a double dose to make up for it. Skip the missed dose and take your next dose at your regularly scheduled time the following day. Talk to your doctor or pharmacist if you miss multiple doses.

Storage

• Store Dacenza 45 mg Tablet 30's tablets at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Watch for lung symptoms: Seek immediate emergency medical care if you develop sudden shortness of breath, a dry cough, or a fever, as these can be signs of serious lung inflammation.
  • Avoid PPI acid reducers: Do not take proton pump inhibitors (such as omeprazole or pantoprazole) while taking Dacenza 45 mg Tablet 30's, as they can significantly lower the absorption and effectiveness of your cancer medicine.
  • Monitor your liver: Your doctor will perform regular blood tests to check for signs of liver damage while you are taking this medicine.
  • Use reliable birth control: Both men and women should use effective birth control during treatment and for at least 17 days after the final dose to prevent pregnancy.
  • Report skin changes: Let your healthcare team know at the first sign of a rash or skin irritation so they can help you manage it before it becomes severe.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines before using Dacenza 45 mg Tablet 30's:

  • Proton Pump Inhibitors (PPIs): Medicines like omeprazole, lansoprazole, or esomeprazole lower stomach acid, which drastically reduces how much of Dacenza 45 mg Tablet 30's your body can absorb. Avoid these during treatment.
  • H2 Blockers and Antacids: Medications like famotidine or calcium carbonate can interfere with absorption. Take them at least 2 hours before or 10 hours after your Dacenza 45 mg Tablet 30's dose.
  • CYP2D6 Substrates: This medicine can increase the levels of certain drugs processed by the liver (such as certain antidepressants or heart medicines), potentially raising the risk of their side effects.
DacomitinibEsomeprazole
Severe
DacomitinibAtomoxetine
Severe

Drug-Drug Interactions

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DacomitinibEsomeprazole
Severe
How does the drug interact with Dacenza 45mg Tab:
Esomeprazole can make Dacenza 45mg Tab less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Co-administration of Esomeprazole with Dacenza 45mg Tab can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
DacomitinibAtomoxetine
Severe
How does the drug interact with Dacenza 45mg Tab:
Taking Atomoxetine and Dacenza 45mg Tab may significantly increase the blood levels of atomoxetine. This can increase side effects (dizziness, dry mouth, loss of appetite, sleep disturbances, and heart palpitations).

How to manage the interaction:
Although taking Atomoxetine and Dacenza 45mg Tab together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience dizziness, dry mouth, loss of appetite, sleep disturbances, and rapid heartbeats, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
DacomitinibPantoprazole
Severe
How does the drug interact with Dacenza 45mg Tab:
Taking Pantoprazole can make Dacenza 45mg Tab less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Pantoprazole with Dacenza 45mg Tab together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
DacomitinibLansoprazole
Severe
How does the drug interact with Dacenza 45mg Tab:
Co-administration of Lansoprazole can make Dacenza 45mg Tab less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Co-administration of Lansoprazole with Dacenza 45mg Tab can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting to a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Dacenza 45 mg Tablet 30's when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Dacenza 45 mg Tablet 30's is used to treat Non-small cell lung cancer (NSCLC).
Dacenza 45 mg Tablet 30's contains Dacominitib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.
The most common sign of lung cancer is a cough that lasts long and gets worse with time. Sometimes, a patient may notice blood in the cough. Chest pain is also a sign of lung cancer, followed by coughing.
Yes, you can take Dacenza 45 mg Tablet 30's with or without food. It is important to take it at the same time every day to maintain consistent medicine levels in your body. Talk to your doctor or pharmacist if you experience nausea.
Skin rashes are very common with this medicine. Apply a mild, fragrance-free moisturiser daily and avoid direct sun exposure. Contact your doctor immediately if the rash becomes painful, blistered, or covers a large area.
Yes, but timing is critical. Take local antacids at least 2 hours before or 10 hours after taking Dacenza 45 mg Tablet 30's to ensure your body can absorb the cancer medicine properly. Talk to your doctor or pharmacist for specific advice.
You should continue taking Dacenza 45 mg Tablet 30's for as long as your doctor prescribes it, which is typically until the cancer starts growing again or if you experience side effects that cannot be managed. Never stop taking it without consulting your healthcare team.
Yes, some patients may experience mild hair thinning or hair loss during treatment. If this concerns you, talk to your doctor or pharmacist about gentle hair care strategies.
While there is no direct interaction, alcohol can worsen side effects like dehydration from diarrhoea or liver strain. It is best to limit or avoid alcohol during cancer treatment. Talk to your doctor or pharmacist about what is safe for you.
No, Dacenza 45 mg Tablet 30's can cause harm to an unborn baby. You must use highly effective birth control during treatment and for at least 17 days after your last dose. If you suspect you are pregnant, contact your doctor immediately.
Regular blood tests are necessary to monitor your liver function and check for signs of liver damage or other changes in your body. Always attend your scheduled lab appointments and talk to your doctor about your results.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

SCO-184, Sector - 5, Panchkula -134114 Haryana (INDIA)
Other Info - DAC0087
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