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compositionComposition:DACTINOMYCIN-0.5MG
prescription
Prescription Medicine
info
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DACTINOGET 0.5MG INJECTION VIAL belongs to the group of medicines called antibiotics indicated in the treatment of Wilms' tumour (kidney cancer), rhabdomyosarcoma (muscle cancer), Ewing's sarcoma (bone cancer), melanoma (skin cancer), and cancer of the uterus and testis. It contains Dactinomycin, which works by slowing or stopping the growth of cancer cells. It prevents the reproduction of abnormal cells associated with cancer, thus helping treat cancer.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DACTINOMYCIN-0.5MG

Manufacturer/Marketer :

Adonis Laboratories Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About DACTINOGET 0.5MG INJECTION VIAL

DACTINOGET 0.5MG INJECTION VIAL is an injection used to treat several types of cancer, including Wilms tumour (a type of kidney cancer), rhabdomyosarcoma (cancer in muscle tissue), and Ewing's sarcoma (bone cancer). It is a chemotherapy medicine designed to stop cancer cells from multiplying. Your medical team will determine if this treatment is appropriate for your specific condition.

Because this medication is given in specific cycles, keeping your scheduled appointments is essential for it to work effectively. It is injected directly into a vein by a healthcare provider, meaning food does not affect how it is absorbed. Making simple changes, like eating small meals throughout the day and drinking plenty of water, can help manage side effects and support your body during treatment.

While this medicine is highly effective, it can cause common side effects like nausea, vomiting, and temporary hair loss. You must contact your doctor immediately if you experience severe symptoms, such as yellowing of your skin or eyes, severe stomach pain, or signs of an infection like a fever. Your healthcare team will monitor you closely throughout your treatment.

Do not take this if you have a severe active infection, or if you have had a life-threatening allergic reaction to this medicine in the past. Talk to your doctor if you have pre-existing liver disease, kidney issues, or low blood cell counts before starting treatment. Knowing your complete health history helps your doctor manage your therapy safely.

Certain medications, live vaccines, and radiation therapy can interact with this medicine, which is why your healthcare team needs a complete list of everything you take. If you are pregnant, planning to become pregnant, or breastfeeding, you should not receive this medicine as it can harm the baby. Older adults and children may require special monitoring during treatment.

Uses of DACTINOGET 0.5MG INJECTION VIAL

DACTINOGET 0.5MG INJECTION VIAL is used to treat several types of cancer. The detailed uses of DACTINOGET 0.5MG INJECTION VIAL are as follows:

  • Wilms tumour: This medicine helps by shrinking tumours in the kidneys, often used alongside surgery or radiation to treat this childhood cancer.
  • Rhabdomyosarcoma: It targets and slows down the growth of fast-dividing cancer cells in the muscles and soft tissues.
  • Ewing's sarcoma: It works to control tumour growth in the bones and surrounding tissues, helping to prevent the cancer from spreading.
  • Gestational trophoblastic neoplasia: It treats rare tumours that develop in the uterus during pregnancy by destroying abnormal placental cells.

Key Benefits

DACTINOGET 0.5MG INJECTION VIAL helps treat certain types of cancer by slowing or stopping the growth and division of cancer cells. With regular use as prescribed, it helps reduce tumour size, control disease progression, and support better treatment outcomes.

  • Helps Shrink Tumours: By preventing cancer cells from multiplying, this medicine helps reduce tumour size, which may improve symptoms and, in some cases, make surgical removal easier.
  • Slows the Spread of Cancer: This medicine helps limit the growth and spread of cancer cells to other parts of the body, supporting effective disease control and improving the chances of successful treatment.
  • Supports Comprehensive Cancer Care: When used as part of a combination treatment plan, this medicine helps improve overall treatment outcomes, supports remission when achievable, and contributes to better long-term disease management.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication, to improve effectiveness.
  • DACTINOGET 0.5MG INJECTION VIAL will be administered by a healthcare professional.
  • Do not self-administer it.

How DACTINOGET 0.5MG INJECTION VIAL Works

DACTINOGET 0.5MG INJECTION VIAL contains dactinomycin, which works to look at how cancer cells grow. Cancer cells divide much faster than normal cells, which requires them to constantly copy their genetic material (DNA) and make new proteins. This rapid division is what allows tumours to grow and spread. This medicine works by binding directly to the DNA inside the cancer cells. This physical block prevents the cells from reading their genetic instructions and making the RNA and proteins they need to survive and multiply. Unable to repair themselves or divide, the cancer cells eventually break down and die, helping to halt the progression of the disease.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with DACTINOGET 0.5MG INJECTION VIAL. Please consult the doctor.

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Pregnancy

Unsafe

DACTINOGET 0.5MG INJECTION VIAL should not be used during pregnancy as it may cause foetal harm. Consult the doctor if you are pregnant, planning for pregnancy or if you think you are pregnant.

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Breast Feeding

Unsafe

Avoid breastfeeding while on treatment with DACTINOGET 0.5MG INJECTION VIAL.

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Driving

Caution

DACTINOGET 0.5MG INJECTION VIAL may affect your alertness. Drive or operate heavy machinery only if you are alert.

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Liver

Caution

If you have a history of liver problems, inform the doctor before receiving DACTINOGET 0.5MG INJECTION VIAL.

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Kidney

Caution

If you have a history of kidney problems, inform the doctor before receiving DACTINOGET 0.5MG INJECTION VIAL.

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Children

Safe if prescribed

DACTINOGET 0.5MG INJECTION VIAL is safe for use in children if prescribed by the doctor.

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Heart

Safe if prescribed

DACTINOGET 0.5MG INJECTION VIAL may be given to heart patients if clearly indicated, but doctors monitor closely for blood-related and systemic side effects. Your treatment plan will be tailored to minimize risks based on your heart health.

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Geriatrics

Caution

DACTINOGET 0.5MG INJECTION VIAL may be used in geriatric patients, but with caution due to increased sensitivity to side effects like myelosuppression, liver toxicity, and infection risk. Since clinical studies haven’t included enough elderly subjects to confirm safety, doctors typically monitor closely and adjust treatment based on individual tolerance.

What if I have taken an overdose of DACTINOGET 0.5MG INJECTION VIAL

Because healthcare professionals calculate and inject this medicine, an overdose is highly unlikely. However, if you suspect an error or experience severe, sudden symptoms after your treatment, seek immediate medical attention or contact emergency services.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water and clear fluids on your treatment days to help your kidneys flush out the waste products of broken-down cells.
  • Protect your skin: This medicine makes your skin more sensitive to sunlight, and it can cause severe reactions on skin previously treated with radiation. Wear protective clothing and apply broad-spectrum sunscreen when outdoors.
  • Practice gentle mouth care: Use a soft-bristled toothbrush and rinse your mouth with water or a mild baking soda wash. Avoid commercial mouthwashes containing alcohol, which can worsen mouth sores.
  • Avoid crowds and sick people: This medication temporarily lowers your white blood cell count, making it harder for your body to fight off infections. Wash your hands frequently and avoid close contact with anyone who has a cold or flu.
  • Eat small, frequent meals: To manage nausea and keep your strength up, opt for small portions of bland foods throughout the day rather than three large meals.
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How Soon It Starts Working

The time required for DACTINOGET 0.5MG INJECTION VIAL to start to work: DACTINOGET 0.5MG INJECTION VIAL ideally shows its action within few hours after administration. The time for which the effects of DACTINOGET 0.5MG INJECTION VIAL last: The duration of action for DACTINOGET 0.5MG INJECTION VIAL is unknown.

What if you forget to take DACTINOGET 0.5MG INJECTION VIAL

Since this medication is injected by a healthcare provider in a clinical setting, missing a dose means missing a scheduled appointment. Contact your oncology clinic immediately to report the missed session and reschedule your appointment as soon as possible to keep your treatment on track.

Storage

•The vials of this medication are stored before use at controlled room temperature, specifically between 20°C and 25°C (68°F to 77°F).
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Report injection site discomfort immediately: If you feel any burning, stinging, coldness, or pain near your IV line during the infusion, tell your nurse immediately to prevent tissue damage.
  • Check your temperature daily: Keep a reliable thermometer at home and check your temperature regularly. A fever is a medical emergency when your white blood cells are low.
  • Avoid live vaccines: Do not receive live vaccines (such as the measles, mumps, or rubella vaccine) during your treatment, as your weakened immune system may not handle them safely.
  • Use effective birth control: Both men and women should use highly reliable birth control during treatment and for several months afterwards to prevent pregnancy, as this medicine can cause severe birth defects.
  • Monitor for skin changes: Let your doctor know if you notice redness or peeling in areas that received radiation therapy in the past, as this medicine can reactivate skin inflammation in those spots.

Drug-Drug Interactions

verifiedApollotooltip
  • Live Vaccines: May increase the risk of severe, active infections when taken while your immune system is suppressed by chemotherapy.
  • Other Chemotherapy Drugs: Combining this medicine with other cancer treatments can increase the risk of liver damage and bone marrow suppression.
DactinomycinTofacitinib
Severe
DactinomycinEtanercept
Severe

Drug-Drug Interactions

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DactinomycinTofacitinib
Severe
How does the drug interact with Dactinoget 0.5mg Injection Vial:
Taking Tofacitinib with Dactinoget 0.5mg Injection Vial may increase the risk of serious infection.

How to manage the interaction:
Taking Dactinoget 0.5mg Injection Vial with Tofacitinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any complications, infections, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning when you pee, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
DactinomycinEtanercept
Severe
How does the drug interact with Dactinoget 0.5mg Injection Vial:
When Etanercept is used with Dactinoget 0.5mg Injection Vial, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Dactinoget 0.5mg Injection Vial and Etanercept, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
DactinomycinClozapine
Severe
How does the drug interact with Dactinoget 0.5mg Injection Vial:
Combining Dactinoget 0.5mg Injection Vial with Clozapine can increase the risk of risk.

How to manage the interaction:
Although taking Dactinoget 0.5mg Injection Vial and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you experience symptoms such as infection, fever, sore throat, muscle aches, or weight loss, it is important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
DactinomycinInfliximab
Severe
How does the drug interact with Dactinoget 0.5mg Injection Vial:
Combining Infliximab with Dactinoget 0.5mg Injection Vial can increase the risk and severity of side effects.

How to manage the interaction:
Although taking Infliximab and Dactinoget 0.5mg Injection Vial together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, a sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
DactinomycinCladribine
Severe
How does the drug interact with Dactinoget 0.5mg Injection Vial:
The combined use of cladribine with Dactinoget 0.5mg Injection Vial can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Dactinoget 0.5mg Injection Vial with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without talking to a doctor.
DactinomycinThalidomide
Severe
How does the drug interact with Dactinoget 0.5mg Injection Vial:
Taking thalidomide together with Dactinoget 0.5mg Injection Vial may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Dactinoget 0.5mg Injection Vial together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
DactinomycinBaricitinib
Severe
How does the drug interact with Dactinoget 0.5mg Injection Vial:
Coadministration of baricitinib and Dactinoget 0.5mg Injection Vial can raise your risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Dactinoget 0.5mg Injection Vial if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

  • No clinically significant food interactions are known with DACTINOGET 0.5MG INJECTION VIAL when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

DACTINOGET 0.5MG INJECTION VIAL is indicated in the treatment of Wilms' tumour (kidney cancer), rhabdomyosarcoma (muscle cancer), Ewing's sarcoma (bone cancer), melanoma (skin cancer), and cancer of the uterus and testis.
DACTINOGET 0.5MG INJECTION VIAL works by slowing or stopping the growth of cancer cells. Thereby, it helps treat cancer.
DACTINOGET 0.5MG INJECTION VIAL may affect blood cell count, leading to an increased risk of infections. Wash your hands frequently and avoid contact with sick people. Consult the doctor if you develop signs of infection.
Avoid live vaccines during treatment with DACTINOGET 0.5MG INJECTION VIAL because your immune system may be weakened. This includes live vaccines such as the nasal-spray flu vaccine. Some non-live vaccines, such as the injectable flu vaccine, may be appropriate but may not work as effectively during treatment. Always consult your doctor before receiving any vaccination.
DACTINOGET 0.5MG INJECTION VIAL may cause fertility problems as a side effect. Consult the doctor if you have any concerns regarding this.
This medicine is injected directly into a vein (intravenously) by a trained healthcare professional in a hospital or clinic setting. It is not available as an oral tablet or for self-injection at home. Talk to your doctor if you have questions about your treatment schedule.
Tell your healthcare provider or nurse immediately. Burning, stinging, or pain during the infusion can mean the medicine is leaking out of the vein, which can cause severe skin and tissue damage. Quick action is needed to stop the injection and protect your tissues.
Yes, temporary hair loss is a common side effect of this treatment. Your hair will typically begin to grow back after your chemotherapy cycles are fully completed. Talk to your doctor if you need support or resources for managing hair loss.
It is best to avoid alcohol during your treatment. Both alcohol and this medicine can put extra stress on your liver, increasing the risk of liver damage. Talk to your doctor or pharmacist about what is safe for you.
No, you should avoid getting pregnant during treatment. This medicine can cause severe harm or birth defects to an unborn baby. Both male and female patients must use highly effective birth control during treatment and for a specified time afterwards. Talk to your doctor for specific advice on family planning.
Low blood counts can cause symptoms like unusual tiredness, shortness of breath, easy bruising, nosebleeds, or frequent infections with fevers. Your medical team will perform regular blood tests throughout your treatment to monitor your blood cell levels. Talk to your doctor if you experience any of these symptoms.
Radiation recall is a severe, sunburn-like skin reaction that can happen in areas that previously received radiation therapy when you take certain chemotherapy medicines. This medicine is known to cause this reaction in some patients. Talk to your doctor if you notice redness, blistering, or peeling skin.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

R-4, Khirki Main Road, Malviya Nagar New Delhi- 110 017, (India)
Other Info - DAC0017
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