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compositionComposition:DAPAGLIFLOZIN-10MG+METFORMIN-500MG
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Prescription Medicine
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Dapaclan M 10/500 Tab is used to treat type 2 diabetes mellitus. It contains Metformin and Dapagliflozin which work by eliminating excess sugars from the body through urine and restoring the body's response to insulin. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, headache, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DAPAGLIFLOZIN-10MG+METFORMIN-500MG

Manufacturer/Marketer :

MERAKI HEALTH

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Dapaclan M 10/500 Tab

Dapaclan M 10/500 Tab is a prescription oral tablet used to manage high blood sugar in adults with type 2 diabetes. By combining two distinct blood sugar-lowering actions, this medication helps control glucose levels and supports long-term diabetes management. It is prescribed alongside a personalised diet and physical activity plan to achieve the best therapeutic results.

To ensure its effectiveness, you should take Dapaclan M 10/500 Tab consistently at the same times every day as directed by your healthcare provider. It is generally recommended to take this tablet with food, which helps minimise the chance of experiencing a temporary upset stomach. Combining this medication with healthy lifestyle choices, such as eating high-fibre foods and engaging in regular exercise, significantly enhances your blood sugar control.

While many patients tolerate this medicine well, some may experience mild side effects like a temporary upset stomach or mild urinary tract infections. It is critical to contact your doctor immediately if you experience signs of rare but serious issues, such as severe dehydration, unusual muscle pain, or rapid, deep breathing. Your healthcare provider will monitor your progress to ensure the medicine is working safely for you.

Do not take this if you have severe kidney disease, liver damage, or a history of diabetic ketoacidosis. Before starting Dapaclan M 10/500 Tab , it is highly important to discuss your complete medical history with your doctor, especially if you have heart failure, moderate kidney issues, or a history of frequent urinary tract infections. Your doctor will evaluate if this specific combination is safe for your organs.

This medication can interact with other substances, such as iodinated contrast dyes used in medical scans or heavy alcohol consumption, both of which can increase the risk of a rare but serious metabolic condition. If you are pregnant, breastfeeding, planning a pregnancy, or are an elderly patient, you must consult your healthcare provider to discuss alternative options. Always disclose all prescription and over-the-counter medicines you are currently taking.

Uses of Dapaclan M 10/500 Tab

Dapaclan M 10/500 Tab is used to treat Type 2 diabetes mellitus. The detailed uses of Dapaclan M 10/500 Tab are as follows: 

  • Type 2 Diabetes Mellitus: Dapaclan M 10/500 Tab is used to improve blood sugar control in adults when lifestyle changes or other single medications do not provide adequate control.
  • Reduction of Cardiovascular Risks: In patients with type 2 diabetes and established heart disease, this combination helps lower the risk of hospitalisation due to heart failure.

Key Benefits

Dapaclan M 10/500 Tab helps maintain healthy blood sugar levels while providing long-term benefits for your overall health. With regular use, it supports steady energy levels, reduces the risk of diabetes-related complications, and promotes heart and kidney health.

  • Helps Maintain Stable Blood Sugar and Energy Levels: By keeping your blood sugar within a healthy range, this medicine helps reduce the sluggishness and fatigue associated with high blood glucose, supporting consistent energy throughout the day.
  • Protects Against Long-Term Diabetes Complications: Consistent blood sugar control helps lower the risk of complications such as kidney damage, vision loss, and nerve damage in the hands and feet, supporting long-term health.
  • Supports Heart and Kidney Health: One of the active ingredients helps remove excess sodium and water from the body, reducing strain on the heart while supporting cardiovascular and kidney health.

Directions for Use

  • Take Dapaclan M 10/500 Tab with meals or as advised by your doctor.
  • It is advised to take Dapaclan M 10/500 Tab once daily; however, follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew or break it.

How Dapaclan M 10/500 Tab Works

Dapaclan M 10/500 Tab combines two different active ingredients that target blood sugar through separate pathways in the body. The first active ingredient, dapagliflozin, belongs to a class of medicines called SGLT2 inhibitors. It works directly on your kidneys to block the reabsorption of glucose, allowing your body to flush out excess sugar through your urine. The second active ingredient, metformin, is a biguanide that works in three distinct ways. First, it reduces the amount of glucose that your liver produces and releases into your bloodstream. Second, it slows down the absorption of sugar from the food you eat. Third, it improves your body's sensitivity to insulin, helping your muscles use glucose more efficiently. Together, these two mechanisms provide a coordinated approach to keeping your blood sugar levels stable throughout the day and night.
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Alcohol

Unsafe

It is advised to avoid alcohol intake since it may worsen the side effects like lactic acidosis and increase the risk of developing low blood sugar levels.

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Pregnancy

Unsafe

Dapagliflozin in Dapaclan M 10/500 Tab is not recommended during the second or third trimester of pregnancy. Your doctor may suggest other medications to control your blood sugar levels. Please consult your doctor before starting Dapaclan M 10/500 Tab if you are pregnant or planning to conceive.

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Breast Feeding

Unsafe

Dapaclan M 10/500 Tab may be unsafe to use during breastfeeding since it is excreted into the breast milk. Please seek medical advice for further information.

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Driving

Unsafe

Your driving may be affected if your blood sugar levels are too high or too low. Do not drive or operate machinery if you also experience blurred vision, dizziness or drowsiness due to extremely low or high blood sugar.

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Liver

Consult your doctor

Let your doctor know if you have any history of liver diseases or hepatic impairment when prescribed Dapaclan M 10/500 Tab .

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Kidney

Unsafe

Dapaclan M 10/500 Tab is contraindicated in patients with severe renal impairment/kidney diseases. Let your doctor know if you have any history of kidney diseases when you are prescribed Dapaclan M 10/500 Tab .

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Children

Unsafe

Dapaclan M 10/500 Tab is not recommended for people younger than 18 years of age.

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Heart

Caution

Please inform your doctor if you have a history of heart disease before using Dapaclan M 10/500 Tab . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Dapaclan M 10/500 Tab should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Dapaclan M 10/500 Tab

In case of an accidental overdose, seek immediate medical attention. An overdose can cause dangerously low blood sugar or a serious metabolic condition. Watch for symptoms such as severe nausea, rapid breathing, dizziness, or extreme weakness, and seek emergency help right away.

Diet & Lifestyle Advise

  • Stay adequately hydrated: Because this medicine removes sugar and fluid through your urine, make sure to drink plenty of water throughout the day to prevent dehydration.
  • Follow a low-glycemic diet: Focus on whole foods, lean proteins, high-fibre vegetables, and complex carbohydrates while limiting sugary snacks, white bread, and sodas.
  • Maintain a consistent exercise routine: Aim for at least 150 minutes of moderate aerobic activity, like brisk walking, per week to help your muscles use glucose more effectively.
  • Monitor your blood sugar: Check your blood sugar levels regularly as advised by your doctor, and keep a log of the readings to share at your next medical appointment.
  • Perform daily foot self-checks: Diabetes can affect blood flow and nerve endings in your feet. Inspect your feet daily for any cuts, blisters, redness, or swelling.
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How Soon It Starts Working

The time required for Dapaclan M 10/500 Tab to start to work: Dapaclan M 10/500 Tab ideally shows its action within a few hours after administration. 

The time for which the effects of Dapaclan M 10/500 Tab last: The effect of Dapaclan M 10/500 Tab lasts for 24 hours.

What if you forget to take Dapaclan M 10/500 Tab

If you miss a dose of Dapaclan M 10/500 Tab , take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

• Store Dapaclan M 10/500 Tab tablets at room temperature, buy preserving them between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Hydration is key: Keep a water bottle with you and drink fluids regularly to prevent dry mouth and dizziness.
  • Limit alcohol: Avoid drinking heavy amounts of alcohol while taking this medicine, as it can significantly increase your risk of lactic acidosis.
  • Check prior to medical scans: Tell your medical team you take Dapaclan M 10/500 Tab before any scan requiring iodinated contrast dye, as you may need to temporarily pause the medicine.
  • Watch for yeast infections: Be alert to itching, burning, or discharge in genital areas, and seek prompt treatment if these symptoms develop.
  • Inform surgeons before procedures: If you are planning to have surgery, talk to your doctor, as you may need to stop taking Dapaclan M 10/500 Tab several days before the operation to avoid complications.

verifiedApollotooltip
  • Contrast Media (Iodinated Dyes): May increase the risk of kidney issues and lactic acidosis; the medication is usually stopped temporarily before and after the procedure.
  • Diuretics (Water Pills): May increase the risk of dehydration and low blood pressure when combined with Dapaclan M 10/500 Tab .
  • Insulin and Sulfonylureas: May increase the risk of low blood sugar when combined with this medicine, requiring a dose adjustment of your other diabetes medications.

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verifiedApollotooltip

Alcohol: Avoid excessive alcohol consumption, as it can dangerously increase the risk of lactic acidosis and alter blood sugar control.

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Dapaclan M 10/500 Tab belongs to the class of antidiabetic drugs, primarily used to treat type 2 diabetes mellitus with a proper diet and exercise. Dapaclan M 10/500 Tab also lowers the risk of heart failure in type 2 diabetic patients with heart diseases.
Dapaclan M 10/500 Tab contains two antidiabetic medicines: Metformin and Dapagliflozin. These drugs lower the blood sugar levels in type 2 diabetes mellitus by eliminating excess sugars through urine and also by increasing the activity of insulin.
Dapaclan M 10/500 Tab may cause low blood sugar levels (hypoglycaemia) and can make you hungry, dizzy, irritable, confused, anxious, or shaky. Hence, it is advised to take Dapaclan M 10/500 Tab with a meal. To immediately treat hypoglycaemia, it is advised to eat or drink fast-acting sugar sources like fruit juices, hard candy, raisins or non-diet soda.
Your doctor may advise Dapaclan M 10/500 Tab with or without other medications to control your blood sugar levels. However, it is advised to maintain a proper diet and exercise to achieve the controlled blood sugar levels while using Dapaclan M 10/500 Tab with or without other antidiabetic drugs.
Dapaclan M 10/500 Tab should be used with caution in heart, kidney or liver diseases, breathing problems (asthma, obstructive lung disease), blood disorders (anaemia, vitamin B12 deficiency), dehydration, alcohol use, low blood pressure, pancreas problems/surgery, and yeast infection of genitals. Dapaclan M 10/500 Tab is contraindicated in patients with severe renal impairment and metabolic acidosis/diabetic ketoacidosis.
While using Dapaclan M 10/500 Tab , if you experience vomiting, stomach/abdominal pain, muscle cramps, sick feeling, severe tiredness, difficulty in breathing, or reduced body temperature and heartbeat, it is important to seek immediate medical help since these are the symptoms of lactic acidosis. Lactic acidosis is a rare but serious complication caused due to accumulation of metformin. It is a medical emergency and needs immediate treatment. Please consult your doctor for further information.
It is not recommended to use Dapaclan M 10/500 Tab along with water pills/diuretics. Simultaneous use of Dapaclan M 10/500 Tab and water pills causes dehydration and may increase the risk of lactic acidosis.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
The side effects of Dapaclan M 10/500 Tab include headache, nausea, vomiting, diarrhoea, runny or stuffy nose, sore throat and genital infections. If these side effects persist or worsen, please consult your doctor.
You are recommended to consult your doctor before taking Dapaclan M 10/500 Tab with insulin as it may increase the risk of hypoglycemia (low blood sugar). You may need a dose adjustment or regular monitoring of blood sugar to use these medicines safely.
No, avoid taking Dapaclan M 10/500 Tab if you have any kidney problems, as it works by excreting excess sugar through urine.
No, usually Dapaclan M 10/500 Tab does not cause loss of body weight. On the other hand, rapid loss of body weight is a sign of a Diabetic ketoacidosis, a serious medical condition.
No, Dapaclan M 10/500 Tab is only useful in type 2 diabetes mellitus, in which the body either produces less amount of insulin or cannot utilise it.
No, this medicine is generally not recommended during pregnancy. If you are planning a pregnancy or become pregnant, talk to your doctor to switch to a safer blood sugar-lowering treatment.
Persistent, severe diarrhoea can lead to dehydration and increase the risk of side effects. Stop taking the medicine temporarily and talk to your doctor or pharmacist immediately.
It is highly recommended to limit or avoid alcohol, especially heavy drinking, because it increases the risk of a rare but life-threatening condition called lactic acidosis. Talk to your doctor about safe alcohol limits.
One of the active ingredients causes your body to pass more sugar and water out through your urine. Drinking plenty of water prevents dehydration and reduces the risk of urinary tract infections. Talk to your doctor if you struggle to stay hydrated.
You must inform your surgeon or radiologist that you are taking Dapaclan M 10/500 Tab . You may need to stop taking the medicine temporarily before major surgery or scans involving iodinated contrast dyes. Talk to your doctor for specific instructions.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Dapagliflozin And Metformin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.7612 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Dapagliflozin and metformin HCl extended-release. 2014. [Accessed on 29 Apr. 2019]Check here
  5. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). February 2013. [Accessed on 27th June 2022]Check here
  6. AstraZeneca UK Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 27th June 2022]Check here
  7. AstraZeneca Pharmaceuticals LP. Dapagliflozin and Metformin. [Revised in April 2022] [Accessed on 27th June 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Plot No. 2-10-85/11, Mahalaxmi Nagar , Cherlapally, Kapra (M), Medchal-Malkajgiri (Dist) Hyderabad-500051 Telangana
Other Info - DAP0403
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