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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Dapahenz-S 10/50 Tablet is used to treat type-2 diabetes mellitus. It contains Dapagliflozin and Sitagliptin. Dapagliflozin lowers blood glucose levels and increases glucose excretion in the urine. By improving insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces. Thus, it helps control blood sugar levels. Common side effects of this medicine include diarrhoea, hypoglycaemia, headache, nausea, and vomiting.

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Manufacturer/Marketer :

La Renon Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Dapahenz-S 10/50 Tablet

Dapahenz-S 10/50 Tablet is used to treat Type 2 diabetes. Type 2 diabetes is a common condition that causes the level of glucose (sugar) in the blood to become too high. It's a lifelong condition that can affect your everyday life. You may need to change your diet, take medicines and have regular check-ups to lead a normal life.

Dapahenz-S 10/50 Tablet contains Dapagliflozin and Sitagliptin. This medicine works by increasing the removal of sugar by your kidneys. Linagliptin works by increasing levels of natural substances called incretins. Incretins help regulate blood sugar levels by stimulating insulin release, particularly after meals. They also decrease the amount of sugar your liver makes.

Not everyone who is taking Dapahenz-S 10/50 Tablet will get these side effects. In some cases, you may experience certain common side effects, such as frequent urination, dizziness, or light-headedness. To reduce the risk of dizziness and light-headedness, get up slowly when rising from a sitting or lying position. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. The dosage is based on your medical condition and response to treatment. To help you remember, take it at the same time each day. Tell your doctor if your condition does not improve or worsens (if your blood sugar is too high or too low).

Before taking this medication, tell your doctor or pharmacist if you are allergic to empagliflozin or linagliptin; or have other allergies. Dapahenz-S 10/50 Tablet should not be stopped even if you feel better, without consulting your doctor as your sugar level keeps changing. If you stop taking Dapahenz-S 10/50 Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss, kidney damage, and nerve damage. Dapahenz-S 10/50 Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Consult the doctor if you are pregnant or breastfeeding.

It is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, limb loss, and sexual dysfunction. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

Uses of Dapahenz-S 10/50 Tablet

Dapahenz-S 10/50 Tablet is used in the treatment of Type-2 diabetes mellitus. The detailed uses of Dapahenz-S 10/50 Tablet are as follows:
• Control blood sugar levels: Dapahenz-S 10/50 Tablet helps lower elevated blood glucose in adults with type 2 diabetes, especially when diet, exercise, and other medications alone are not enough.
• Combination therapy: Dapahenz-S 10/50 Tablet improves insulin sensitivity, reduce glucose production in the liver, and increase glucose excretion through urine.
• Reduce risk of diabetes-related complications: By maintaining better glycemic control, Dapahenz-S 10/50 Tablet may help lower the risk of long-term complications like kidney damage, nerve issues, and cardiovascular events.

Directions for Use

• Take Dapahenz-S 10/50 Tablet with or without food or as advised by a doctor. • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety. • Swallow the medicine as a whole with glass of water. • Do not crush, break, or chew it.

Medicinal Benefits

  • Dapahenz-S 10/50 Tablet helps treat type 2 diabetes, along with a balanced diet and regular exercise. It works by removing excess sugar from the body through urine.
  • It helps control the rise of blood sugar levels in your body after a meal.
  • Dapahenz-S 10/50 Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.
  • This medicine is also used to treat chronic kidney disease in adults with reduced kidney function. It helps protect your kidneys from losing their function, which may help some people live longer.

How Dapahenz-S 10/50 Tablet Works

Dapahenz-S 10/50 Tablet contains Dapagliflozin (sodium-glucose cotransporter-2 inhibitors) and Sitagliptin (dipeptidyl peptidase-4 inhibitor). Dapagliflozin lowers blood glucose levels and increases the excretion of glucose in the urine. By increasing insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces. Thus, Dapahenz-S 10/50 Tablet helps control blood sugar levels.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Dapahenz-S 10/50 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Dapahenz-S 10/50 Tablet may include hypoglycemia and severe gastrointestinal problems. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Before taking this medication, tell your doctor or pharmacist if you are allergic to empagliflozin or Linagliptin; or have any other allergies. Dapahenz-S 10/50 Tablet should not be stopped even if you feel better, without consulting your doctor as your sugar level keeps changing. If you stop taking Dapahenz-S 10/50 Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy). Please inform your doctor if you have heart disease. Dapahenz-S 10/50 Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease.

Inform your doctor if you are pregnant or breastfeeding before taking Dapahenz-S 10/50 Tablet . It may be harder to control your blood sugar when your body is stressed (such as when you have a fever, infection, injury, or surgery). Also, if you eat less or cannot eat due to these conditions or any illness, this can lead to other side effects while taking this medication. Consult your doctor because this may require changing your treatment plan and medications. Before surgery, tell your doctor or dentist about all the products you use (including prescription, nonprescription, and herbal products).

Store Dapahenz-S 10/50 Tablet at room temperature. You are advised not to chew, crush or break the medicine. Keep the medicine out of reach of children. Do not take more than the recommended dose of medicine, as it can cause undesirable effects. It is always important to check for the expiry of the medicine. Discard the medicine if it reaches the expiry date. Be alert for signs of low blood sugar (hypoglycemia), such as sweating, dizziness, dry mouth, dry skin, fast heartbeat, shivering, intense thirst, or frequent urination. If you experience any of these symptoms, take honey or sugar candies right away.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Dapahenz-S 10/50 Tablet:
Co-administration of Dapahenz-S 10/50 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Taking Dapahenz-S 10/50 Tablet with Gatifloxacin is not recommended as it can lead to a possible interaction, However, it can be taken if advised by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dapahenz-S 10/50 Tablet:
Co-administration of Dapahenz-S 10/50 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Gatifloxacin can be taken with Dapahenz-S 10/50 Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremor, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue the medication without consulting a doctor.
SitagliptinIvacaftor
Severe
How does the drug interact with Dapahenz-S 10/50 Tablet:
When Dapahenz-S 10/50 Tablet is taken with Ivacaftor, the amount of Dapahenz-S 10/50 Tablet in the blood can go up.

How to manage the interaction:
Taking Dapahenz-S 10/50 Tablet with Ivacaftor together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dapahenz-S 10/50 Tablet:
Co-administration of Dapahenz-S 10/50 Tablet with Aliskiren may increase the risk of dehydration and low blood pressure.

How to manage the interaction:
If you are supposed to use Dapahenz-S 10/50 Tablet and Aliskiren together, a doctor may adjust the dose and monitor you more frequently. However, if you experience dizziness, fainting, headache, lightheadedness, and/or changes in pulse or heart rate, contact a doctor. Do not discontinue the medication without consulting a doctor.
SitagliptinTirzepatide
Moderate
How does the drug interact with Dapahenz-S 10/50 Tablet:
As tirzepatide and Dapahenz-S 10/50 Tablet both work through similar pathways in the body, it is possible that using them together may result in an increase in side effects.

How to manage the interaction:
It is essential to inform your doctor about all other medications you are taking, including vitamins and herbal supplements. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat foods rich in healthy carbohydrates and fibre, fruits, whole grains, and vegetables.
  • Try eating food at regular intervals. Do not skip meals. Also, try not to overeat.
  • Follow a healthy diet and walk/exercise for at least 45 minutes.
  • Maintain a healthy weight by exercising regularly.
  • Rest properly and avoid stress by doing meditation or yoga.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS
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Alcohol

Unsafe

Avoid consumption of alcohol during treatment with Dapahenz-S 10/50 Tablet as it may cause serious side effects.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before starting treatment with Dapahenz-S 10/50 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Limited data is available on the effect of Dapahenz-S 10/50 Tablet on breastfeeding. Hence, if you are a nursing mother, inform your doctor before taking Dapahenz-S 10/50 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Dapahenz-S 10/50 Tablet may occasionally cause dizziness. Hence, drive only if you are alert after taking this medicine.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before taking Dapahenz-S 10/50 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Dapahenz-S 10/50 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Dapahenz-S 10/50 Tablet is not recommended for use in children below 12 years of age as the safety and efficacy are not established.

Have a query?

FAQs

Dapahenz-S 10/50 Tablet is used to treat type-2 diabetes mellitus. Type-2 diabetes mellitus (also known as non-insulin-dependent diabetes or adult-onset diabetes) is a medical condition in which blood glucose levels are above normal due to insulin deficiency, insulin resistance, or both.

Low-fibre diets, high-fat diets, sugary diets, obesity, smoking, stress, lack of exercise, age, genetic factors, and certain medical conditions are the common causes of diabetes.

Dapahenz-S 10/50 Tablet is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin lowers blood glucose levels and increases the excretion of glucose in the urine. By increasing insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces.

Country of origin

India

Manufacturer/Marketer address

Behind Rajpath Club, Kensville Road, Opp. Infostretch Building, Off S.G. Highway, Ahmedabad- 380059, Gujarat- India
Other Info - DAP0441

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