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  3. Darnesp 40 Injection 0.4 ml

Darnesp 40 Injection 0.4 ml, Pack of 1 INJECTION
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Darnesp 40 Injection is used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). It helps to reverse anaemia and reduce the need for blood transfusion. It contains Darbepoetin alfa, which works by providing signals to the bone marrow to make more red blood cells. In chronic kidney disease, when the kidney fails to produce sufficient erythropoietin protein that aids in the formation of red blood cells, this medicine stimulates the production of this protein in the bone marrow. It may cause common side effects such as shortness of breath, cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain.
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Composition :

DARBEPOETIN ALFA-40MCG

Manufacturer/Marketer :

Adonis Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Darnesp 40 Injection

Darnesp 40 Injection belongs to the class of medication called 'blood-forming agent'  primarily used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Darnesp 40 Injection helps to reverse anaemia and reduce the need for blood transfusion. Anaemia occurs when the body has a lower amount of red blood cells or haemoglobin. In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia.

Darnesp 40 Injection contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. Darnesp 40 Injection is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, Darnesp 40 Injection stimulates the production of this protein in the bone marrow. 

Darnesp 40 Injection will be injected by the healthcare provider. Do not self-administer. The most common side effects of Darnesp 40 Injection are shortness of breath,  cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain. Most of these sides effects of Darnesp 40 Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you have uncontrolled/untreated high blood pressure or red cell aplasia (a type of anaemia) due to darbepoetin alfa or epoetin alfa, please inform your doctor before taking Darnesp 40 Injection to avoid any complications. Also, mention all the other medications you are taking to affect the way Darnesp 40 Injection works. Inform your doctor immediately, if you feel weak, lightheaded, tired, or short of breath, or if your skin looks pale as it may be signs that the body has stopped responding to Darnesp 40 Injection . 

Uses of Darnesp 40 Injection

Treatment of Anaemia (in cancer and chronic kidney disease)

Directions for Use

Darnesp 40 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Darnesp 40 Injection is a human-made form of naturally occurring erythropoiesis-stimulating protein or erythropoietin (a hormone produced by the kidney's specialized cells and is responsible for protecting red blood cells against destruction and also stimulates the cells of bone marrow to produce more amount of red blood cells). Deficiency of erythropoietin happens when a person is suffering from chronic kidney diseases, which in turn cause low red blood cells count causing anaemia.  This medicine is primarily indicated for treating anaemia (low red blood cell count) in persons with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer except for bone marrow or blood cells' cancer. Darnesp 40 Injection contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. 

How Darnesp 40 Injection Works

Darnesp 40 Injection contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. Darnesp 40 Injection is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, Darnesp 40 Injection stimulates the production of this protein in the bone marrow.

Storage

Store in a cool and dry place away from sunlight
Side effects of Darnesp 40 Injection 0.4 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.

What if I have taken an overdose of Darnesp 40 Injection

Do not use more than the prescribed dose of Darnesp 40 Injection as it may cause overdose and lead to severe hypertension (high blood pressure). If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Darnesp 40 Injection can enhance the risk of serious heart problems including heart attack so tell your doctor immediately if you notice shortness of breath, sudden numbness or weakness, chest pain, or trouble speaking or understanding. This medicine may also shorten survival time in some people with certain types of cancer. Inform your doctor before taking Darnesp 40 Injection if you have heart disease, high blood pressure, kidney disease, stroke, heart attack, blood clot, seizure, or latex allergy. Do not take Darnesp 40 Injection if you are pregnant or breastfeeding unless prescribed by the doctor. Darnesp 40 Injection may affect a person's ability to drive as it may cause convulsion during initial days of treatment, so a person taking Darnesp 40 Injection should avoid driving or operating any machine. Darnesp 40 Injection should not be given to children below 12 years of age, as safety and effectiveness have not been established. Avoid consuming alcohol along with Darnesp 40 Injection as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions

verifiedApollotooltip
Darbepoetin alfaCarfilzomib
Severe
Darbepoetin alfaPomalidomide
Severe

Drug-Drug Interactions

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Darbepoetin alfaCarfilzomib
Severe
How does the drug interact with Darnesp 40 Injection 0.4 ml:
Combining Darnesp 40 Injection 0.4 ml with Carfilzomib can increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction between Carfilzomib and Darnesp 40 Injection 0.4 ml, you can take these medicines together if prescribed by your doctor. However, if you experience chest pain; shortness of breath; difficulty breathing; coughing up blood; sudden loss of vision; pain, redness, or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
Darbepoetin alfaPomalidomide
Severe
How does the drug interact with Darnesp 40 Injection 0.4 ml:
Taking Darnesp 40 Injection 0.4 ml with Pomalidomide can increase the risk of dangerous blood clots.

How to manage the interaction:
Although there is a possible interaction between Pomalidomide and Darnesp 40 Injection 0.4 ml, you can take these medicines together if prescribed by a doctor. However, If you experience chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Darbepoetin alfaThalidomide
Severe
How does the drug interact with Darnesp 40 Injection 0.4 ml:
Taking thalidomide together with Darnesp 40 Injection 0.4 ml may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction between Thalidomide and Darnesp 40 Injection 0.4 ml, but it can be taken if your doctor has advised it. However, if you experience chest pain shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
Darbepoetin alfaLenalidomide
Severe
How does the drug interact with Darnesp 40 Injection 0.4 ml:
Taking Darnesp 40 Injection 0.4 ml with Lenalidomide can increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and Darnesp 40 Injection 0.4 ml, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Limit the consumption of fluids, salt, potassium, phosphorous, and other electrolytes.
  • Eat a low-protein diet, and get enough calories from the foods if you are losing weight.
  • Eat foods that are high in vitamin B12, iron, and folic acid can fulfil the deficiencies of happed in kidney disease.
  • Include a little number of healthy fats in your diet that give you enough energy to be active during the day; however, try to limit fats that make you fatty. Try to include olive oil, peanut oil, and corn oil into your diet.
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

ERYTHROPOIESIS STIMULATING AGENTS (ESAs)

Darnesp 40 Injection Substitute

Substitutes safety advice

  • Cresp 40 Injection 0.4 ml

    by Others

    ₹2723.20per tablet

  • Dargen 40 PFS Injection 0.4 ml

    by AYUR

    ₹2729.70per tablet

  • Juvobin 40 Injection 0.4 ml

    by AYUR

    ₹2275.20per tablet

  • Neph-Darb 40 Injection 0.4 ml

    by Others

    ₹2296.00per tablet

  • Zynesp 40 Injection 1's

    by AYUR

    ₹2285.30per tablet

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Darnesp 40 Injection as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking Darnesp 40 Injection if you are pregnant unless prescribed by a doctor as Darnesp 40 Injection is a pregnancy category C drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Darnesp 40 Injection ; your doctor will decide whether Darnesp 40 Injection can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Darnesp 40 Injection causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Darnesp 40 Injection should not be given to children as the safety and efficacy have not been established.

FAQs

Darnesp 40 Injection is used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Darnesp 40 Injection helps to reverse anaemia and reduce the need for blood transfusion.

It is suggested to store the Darnesp 40 Injection in the refrigerator and protect it from light. However, a person should not freeze it.

It is advised to tell your doctor about your medical conditions like heart disease, high blood pressure, kidney disease, a stroke, heart attack, or blood clot, a seizure, a latex allergy to avoid any type of medical condition.

A person who is allergic to any chemical compound present in Darnesp 40 Injection or have uncontrolled/untreated high blood pressure, or ever had pure red cell aplasia (a type of anaemia) caused by using darbepoetin alfa, or epoetin alfa is not allowed to take a name.

Consult your doctor before taking Darnesp 40 Injection if you are pregnant or planning for pregnancy. Your doctor will prescribe Darnesp 40 Injection only if the benefits outweigh the risks.

Darnesp 40 Injection contains a protein "Darbepoetin alfa", which works by providing signals to the bone marrow to make more red blood cells. As in chronic kidney disease, the kidney gets damaged and doesn't filter the blood in the way it should be leading to anemia.

Darnesp 40 Injection may cause side effects such as injection site pain, cough, low blood pressure, headache, diarrhoea, body pains, shortness of breath or stomach pain. If these side effects persist or worsen, please consult your doctor.

After beginning treatment with Darnesp 40 Injection , it takes around 2 to 6 weeks for increase in haemoglobin level in blood.

Darnesp 40 Injection is used only if anaemia is due to chronic (long term) kidney disease and chemotherapy for some types of cancer (except for bone marrow and blood cells).

Darnesp 40 Injection may cause high blood pressure particularly in patients with long term kidney disease due to the rapid increase of red blood cells in the initial 3 months after starting Darnesp 40 Injection .

Darnesp 40 Injection is not used in the treatment of cancer. It is used in treatment of anemia (low levels of healthy red blood cells) in patients receiving chemotherapy for some types of cancer (except for bone marrow or blood cells cancer).

Darnesp 40 Injection should be used with extreme caution as it can cause serious side effects and can even be life-threatening. The patient should follow doctor’s recommendations strictly.

If you have deficiencies of folic acid, vitamin B12 or iron, you may not respond to Darnesp 40 Injection . It is important that you take measures to correct these deficiencies. Other reasons may be infections, bleeding, inflammation and bone marrow fibrosis. If you have any concerns, consult your doctor.

Darnesp 40 Injection is usually not recommended for children as the safety and effectiveness were not established. However, if you have any concerns regarding the use of Darnesp 40 Injection for children, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

C-6, Groma House, Apmc Market ,Sector 19, Vashi, Navi Mumbai €“ 400 703
Other Info - DAR0114

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icon image

Keep Refrigerated. Do not freeze.

Author Details

Doctor imageDoctor badge

Written By

Veda Maddala

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:49 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/darbamg071902LB.pdf
  2. https://www.drugs.com/mtm/darbepoetin-alfa.html
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