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compositionComposition:DARBEPOETIN ALFA-40MCG
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Neph-Darb 40 Injection is used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). It helps to reverse anaemia and reduce the need for blood transfusion. It contains Darbepoetin alfa, which works by providing signals to the bone marrow to make more red blood cells. In chronic kidney disease, when the kidney fails to produce sufficient erythropoietin protein that aids in the formation of red blood cells, this medicine stimulates the production of this protein in the bone marrow. It may cause common side effects such as shortness of breath, cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DARBEPOETIN ALFA-40MCG

Manufacturer/Marketer :

EVERVITAL LIFESCIENCES

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Neph-Darb 40 Injection

Neph-Darb 40 Injection is an injectable medicine prescribed to treat anaemia, which is a condition characterised by a low red blood cell count. It is commonly used for patients with long-term kidney disease or those receiving chemotherapy for certain types of cancer. By helping your body produce more red blood cells, this treatment reduces the severe tiredness and weakness associated with anaemia.

This medicine is injected either under the skin or directly into a vein, and it must be used consistently as scheduled by your healthcare provider. Your food intake does not affect how this medicine works, but eating a balanced diet rich in iron can support your body's red blood cell production. Regularly monitoring your nutritional intake helps achieve the best results from your treatment.

While using Neph-Darb 40 Injection , some people may experience common side effects like headaches or mild discomfort at the injection site. However, if you develop serious symptoms such as sudden shortness of breath, chest pain, or a severe headache, you must contact your doctor immediately. Do not delay seeking medical care if you experience these issues.

Before starting Neph-Darb 40 Injection , tell your doctor if you have a history of high blood pressure, heart disease, stroke, or seizures. Do not take this if you have uncontrolled high blood pressure or if you have ever developed a condition called pure red cell aplasia (a severe stop in red blood cell production) after using similar medicines.

Certain medications, such as those that suppress your immune system, can interact with this injection, so provide your doctor with a complete list of your current medicines. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, talk to your doctor or pharmacist to ensure this treatment is safe for your specific situation.

Uses of Neph-Darb 40 Injection

Neph-Darb 40 Injection is used to treat anaemia. The detailed uses of Neph-Darb 40 Injection are as follows:

  • Anaemia due to chronic kidney disease: Neph-Darb 40 Injection helps by stimulating your body to produce more red blood cells, which prevents severe fatigue and weakness caused by failing kidneys.
  • Anaemia due to chemotherapy: For patients undergoing cancer treatments, this injection helps rebuild red blood cell levels that have been lowered by chemotherapy drugs.
     

Key Benefits

Neph-Darb 40 Injection helps treat anaemia by stimulating your body to produce more red blood cells, improving oxygen delivery to your tissues. With regular treatment, it helps restore energy levels, reduces the need for blood transfusions, and makes everyday activities easier by easing symptoms of low red blood cell counts.

  • Improves energy and reduces fatigue: By increasing the oxygen-carrying red blood cells in your body, this medicine helps reduce the constant tiredness and weakness associated with anaemia.
  • Reduces the need for blood transfusions: By encouraging your body to naturally make its own red blood cells, it lowers the frequency of requiring external blood transfusions.
  • Supports daily activities: Improved red blood cell counts mean your muscles and organs get the oxygen they need, helping you manage your daily routine with less physical strain.
Side effects of Neph-Darb 40 Injection 0.4 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Neph-Darb 40 Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Neph-Darb 40 Injection Works

Neph-Darb 40 Injection contains darbepoetin alfa. It works by mimicking the action of a natural hormone in your body called erythropoietin, which is produced by healthy kidneys. This hormone sends a signal to your bone marrow, the soft tissue inside your bones, to produce more red blood cells. When kidneys are damaged or when chemotherapy suppresses bone marrow function, your body cannot produce enough of this hormone, leading to anaemia. When you inject Neph-Darb 40 Injection , it binds to specific receptors in the bone marrow, triggering the division and growth of red blood cells. This safely and gradually increases your red blood cell count, helping your body transport oxygen more efficiently.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Neph-Darb 40 Injection as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking Neph-Darb 40 Injection if you are pregnant unless prescribed by a doctor as Neph-Darb 40 Injection is a pregnancy category C drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Neph-Darb 40 Injection ; your doctor will decide whether Neph-Darb 40 Injection can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Neph-Darb 40 Injection causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Neph-Darb 40 Injection should not be given to children as the safety and efficacy have not been established.

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Heart

Unsafe

Neph-Darb 40 Injection is not recommended for use in cardiac patients due to the cardiovascular effects.

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Geriatrics

Consult your doctor

Neph-Darb 40 Injection can be given in geriatric patients if prescribed by the physician.

What if I have taken an overdose of Neph-Darb 40 Injection

If you suspect an overdose or have injected too much of this medicine, seek immediate medical attention or call an emergency helpline. An overdose can cause your red blood cell count to rise too quickly, which can lead to serious heart or blood vessel complications.

Diet & Lifestyle Advise

  • Eat iron-rich foods: To make red blood cells, your body needs plenty of iron. Include foods like red meat, beans, lentils, spinach, and iron-fortified cereals in your meals.
  • Check your iron levels: Your doctor may recommend taking an iron supplement. Ensure you take it exactly as prescribed, as Neph-Darb 40 Injection cannot work effectively if your body's iron stores are low.
  • Monitor your blood pressure: Because this medicine can raise your blood pressure, check it regularly at home and keep a log for your doctor.
  • Avoid dehydration: Drink plenty of water throughout the day to support healthy blood circulation.
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Have a query?

How Soon It Starts Working

The time required for Neph-Darb 40 Injection to start to work: The time required for Neph-Darb 40 Injection to show its action is unknown. The time for which the effects of Neph-Darb 40 Injection last: The duration of action for Neph-Darb 40 Injection is unknown.

What if you forget to take Neph-Darb 40 Injection

If you miss a dose, contact your doctor or pharmacist immediately to get a rescheduled timing. Do not inject a double dose to make up for a missed one.

Storage

• Store Neph-Darb 40 Injection in a refrigerator between 2°C and 8°C. • Do not freeze the medicine, and do not use it if it has been frozen.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Never shake the vial or syringe, as vigorous shaking can damage the medicine and make it ineffective.
  • Do not use the medicine if you notice any cloudiness, discolouration, or floating particles in the liquid.
  • Always change the location where you inject the medicine each time to prevent skin irritation or thickening.
  • Keep all appointments for blood tests, as your doctor needs to check your haemoglobin levels regularly to ensure your dose is safe and effective.
  • Avoid driving or operating machinery if you feel dizzy or experience headaches after your injection.

Drug-Drug Interactions

verifiedApollotooltip
  • Cyclosporine: This medicine binds to red blood cells. When used together, your doctor may need to monitor your blood levels of cyclosporine and adjust the dose if necessary.
  • Other medicines that stimulate red blood cell production: Combining these can cause your blood counts to rise too rapidly, increasing the risk of serious side effects.
     
Darbepoetin alfaThalidomide
Severe
Darbepoetin alfaCarfilzomib
Severe

Drug-Drug Interactions

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Darbepoetin alfaThalidomide
Severe
How does the drug interact with Neph-Darb 40 Injection 0.4 ml:
Taking thalidomide together with Neph-Darb 40 Injection 0.4 ml may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction between Thalidomide and Neph-Darb 40 Injection 0.4 ml, but it can be taken if your doctor has advised it. However, if you experience chest pain shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
Darbepoetin alfaCarfilzomib
Severe
How does the drug interact with Neph-Darb 40 Injection 0.4 ml:
Combining Neph-Darb 40 Injection 0.4 ml with Carfilzomib can increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction between Carfilzomib and Neph-Darb 40 Injection 0.4 ml, you can take these medicines together if prescribed by your doctor. However, if you experience chest pain; shortness of breath; difficulty breathing; coughing up blood; sudden loss of vision; pain, redness, or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
Darbepoetin alfaLenalidomide
Severe
How does the drug interact with Neph-Darb 40 Injection 0.4 ml:
Taking Neph-Darb 40 Injection 0.4 ml with Lenalidomide can increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and Neph-Darb 40 Injection 0.4 ml, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Darbepoetin alfaPomalidomide
Severe
How does the drug interact with Neph-Darb 40 Injection 0.4 ml:
Taking Neph-Darb 40 Injection 0.4 ml with Pomalidomide can increase the risk of dangerous blood clots.

How to manage the interaction:
Although there is a possible interaction between Pomalidomide and Neph-Darb 40 Injection 0.4 ml, you can take these medicines together if prescribed by a doctor. However, If you experience chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Neph-Darb 40 Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ERYTHROPOIESIS STIMULATING AGENTS (ESAs)]

FAQs

Neph-Darb 40 Injection is used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Neph-Darb 40 Injection helps to reverse anaemia and reduce the need for blood transfusion.
It is suggested to store the Neph-Darb 40 Injection in the refrigerator and protect it from light. However, a person should not freeze it.
It is advised to tell your doctor about your medical conditions like heart disease, high blood pressure, kidney disease, a stroke, heart attack, or blood clot, a seizure, a latex allergy to avoid any type of medical condition.
A person who is allergic to any chemical compound present in Neph-Darb 40 Injection or have uncontrolled/untreated high blood pressure, or ever had pure red cell aplasia (a type of anaemia) caused by using darbepoetin alfa, or epoetin alfa is not allowed to take a name.
Consult your doctor before taking Neph-Darb 40 Injection if you are pregnant or planning for pregnancy. Your doctor will prescribe Neph-Darb 40 Injection only if the benefits outweigh the risks.
Neph-Darb 40 Injection contains a protein "Darbepoetin alfa", which works by providing signals to the bone marrow to make more red blood cells. As in chronic kidney disease, the kidney gets damaged and doesn't filter the blood in the way it should be leading to anemia.
Neph-Darb 40 Injection may cause side effects such as injection site pain, cough, low blood pressure, headache, diarrhoea, body pains, shortness of breath or stomach pain. If these side effects persist or worsen, please consult your doctor.
After beginning treatment with Neph-Darb 40 Injection , it takes around 2 to 6 weeks for increase in haemoglobin level in blood.
Neph-Darb 40 Injection is used only if anaemia is due to chronic (long term) kidney disease and chemotherapy for some types of cancer (except for bone marrow and blood cells).
Neph-Darb 40 Injection may cause high blood pressure particularly in patients with long term kidney disease due to the rapid increase of red blood cells in the initial 3 months after starting Neph-Darb 40 Injection .
Neph-Darb 40 Injection is not used in the treatment of cancer. It is used in treatment of anemia (low levels of healthy red blood cells) in patients receiving chemotherapy for some types of cancer (except for bone marrow or blood cells cancer).
Neph-Darb 40 Injection should be used with extreme caution as it can cause serious side effects and can even be life-threatening. The patient should follow doctor’s recommendations strictly.
If you have deficiencies of folic acid, vitamin B12 or iron, you may not respond to Neph-Darb 40 Injection . It is important that you take measures to correct these deficiencies. Other reasons may be infections, bleeding, inflammation and bone marrow fibrosis. If you have any concerns, consult your doctor.
Neph-Darb 40 Injection is usually not recommended for children as the safety and effectiveness were not established. However, if you have any concerns regarding the use of Neph-Darb 40 Injection for children, please consult your doctor.
Yes, you can inject it at home once a healthcare provider has trained you on how to prepare and inject it safely. Do not attempt to self-inject until you are confident in the process. Talk to your doctor or pharmacist if you need a demonstration.
This injection prompts your body to build new red blood cells, which requires a large amount of iron. If your iron levels are low, the medicine will not work as effectively. Talk to your doctor or pharmacist about the right iron supplement for you.
If the injection has been frozen, do not use it, even if it has thawed out. Freezing destroys the active components of the medicine, making it unsafe and ineffective. Dispose of it safely and use a new syringe. Talk to your doctor or pharmacist if you need assistance with replacement.
Your doctor will likely order blood tests weekly or bi-weekly when you start treatment and then monthly once your red blood cell levels stabilise. These tests help ensure you are receiving the correct dose. Talk to your doctor about your blood test schedule.
A sudden, severe headache can be a warning sign of a dangerous rise in blood pressure. You should seek immediate medical help or contact your doctor right away if this occurs. Talk to your doctor about how to manage blood pressure spikes.

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Reference

  1. U.S. Food and Drug Administration (FDA). Darbamg071902Lb [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Darbepoetin Alfa Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Darbepoetin alfa. 2001. [Accessed on 23 Jan. 2019]Check here
  4. Darbepoetin alfa. 2001. [Accessed on 07 Apr. 2019]Check here
  5. Drugs and Lactation Database (LactMed®) [Internet]. 2006. [Accessed on 17 Jun. 2023]Check here
  6. John Powell and Cheryle Gurk-Turner. Darbepoetin alfa (Aranesp). NIH National Library of Medicine, National center for biotechnology information. PubMed Central. July 2002. [Accessed on 4th June 2022]Check here
  7. Amgen Technology (Ireland) Unlimited Company. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 4th June 2022] ,Check here

Country of origin

India

Manufacturer/Marketer address

Shop No. 12, Aura Biplex, Habitat Co - Op Housing Society, Behind Kalyan Jewellers, S V Road, Borivali (W), Mumbai - 400092
Other Info - NEP0252

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