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compositionComposition:NINTEDANIB-150MG
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Denine-150 Softgel Capsule 10's is used to treat idiopathic pulmonary fibrosis (a disease that causes scarring of the lungs). It contains Nintedanib, which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. In some cases, this medicine may cause side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NINTEDANIB-150MG

Manufacturer/Marketer :

Zorvia Healthcare Ltd

Consume Type :

Oral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Denine-150 Softgel Capsule 10's

Denine-150 Softgel Capsule 10's is a prescription medicine used to treat adults with chronic lung conditions that cause progressive scarring, such as idiopathic pulmonary fibrosis. This medicine is designed to help slow down the decline in lung function by targeting the pathways that lead to lung tissue stiffening. By reducing this scarring process, it helps preserve your remaining lung function and capacity.

To achieve the best results, you must take Denine-150 Softgel Capsule 10's consistently every day exactly as your doctor directs. It is highly recommended to take this capsule with food and a full glass of water to help manage common stomach-related side effects. Incorporating healthy habits, such as stopping smoking and staying well-hydrated, can also support your overall lung health during treatment.

The most common side effects associated with this medication include diarrhoea, nausea, and stomach pain. It is important to watch for these symptoms and consult your doctor immediately if you experience severe diarrhoea, signs of liver damage, or unusual bleeding.

Do not take this if you are pregnant, planning to become pregnant, or have severe liver damage. Before starting this treatment, you must tell your doctor if you have a history of heart disease, liver problems, high blood pressure, or bleeding disorders.

Denine-150 Softgel Capsule 10's may interact with certain medicines, including blood thinners, and smoking may reduce the amount of medicine in your body. Older adults can generally use this medicine, but they may need closer monitoring because liver problems and other health conditions are more common with age. Tell your doctor if you have any liver problems. People with mild liver impairment may need a lower dose and closer monitoring, while Denine-150 Softgel Capsule 10's is generally not recommended for those with moderate or severe liver impairment. If you are pregnant, planning a pregnancy, or breastfeeding, consult your doctor before starting treatment.

Uses of Denine-150 Softgel Capsule 10's

Your doctor may prescribe this medicine to treat several conditions, including:

  • Idiopathic Pulmonary Fibrosis (IPF): Denine-150 Softgel Capsule 10's helps slow the progressive scarring and stiffening of the lungs, making it easier to maintain your breathing capacity over time.
  • Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD): Denine-150 Softgel Capsule 10's reduces the rate of decline in lung function in patients who have lung scarring related to autoimmune connective tissue diseases.
  • Chronic Fibrosing Interstitial Lung Diseases (ILDs) with a Progressive Phenotype: Denine-150 Softgel Capsule 10's helps manage various long-term lung conditions where scarring continues to worsen despite other treatments, helping to preserve vital lung volume.

Key Benefits

The primary benefit of Denine-150 Softgel Capsule 10's is its ability to protect and preserve your lung function over time. By targeting the underlying chemical signals that cause tissue scarring, this medicine helps you maintain your breathing capacity and perform daily tasks more comfortably.

  • Slower disease progression: It significantly reduces the speed at which lung scarring worsens, allowing you to maintain your active daily routines for a longer period.
  • Lower risk of sudden worsening: It helps lower the risk of sudden, severe breathing crises, which are medically known as acute exacerbations.
  • Better control over breathing decline: Regular use helps stabilise your overall lung health, giving you more predictability in managing your symptoms.

Directions for Use

  • Denine-150 Softgel Capsule 10's should be taken with meals to enhance its effectiveness.
  • It is recommended to take Denine-150 Softgel Capsule 10's twice daily or as advised by your doctor.
  • Swallow Denine-150 Softgel Capsule 10's as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Denine-150 Softgel Capsule 10's Works

Denine-150 Softgel Capsule 10's contains nintedanib, which works by blocking certain proteins called tyrosine kinases. These proteins send signals that encourage cells in the lungs to grow and produce collagen, a major part of scar tissue. Too much scar tissue can make the lungs thick and stiff, making it harder to breathe. By blocking these signals, nintedanib helps slow the buildup of scar tissue and the decline in lung function. It does not remove existing lung scarring or cure the condition, but it may help preserve lung function for longer.
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Alcohol

Caution

It is not known if alcohol interacts with Denine-150 Softgel Capsule 10's. However, as a precautionary measure, you are recommended not to consume alcohol with the Denine-150 Softgel Capsule 10's to avoid unpleasant side effects.

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Pregnancy

Unsafe

Denine-150 Softgel Capsule 10's is listed as pregnancy category D. Because Denine-150 Softgel Capsule 10's can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Denine-150 Softgel Capsule 10's.

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Breast Feeding

Consult your doctor

Consult your doctor if you are breastfeeding; your doctor will decide whether Denine-150 Softgel Capsule 10's can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Denine-150 Softgel Capsule 10's may significantly influence your ability to drive and use machines. You should not drive or operate machinery if you feel sick.

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Liver

Consult your doctor

Dose adjustment may be needed. Denine-150 Softgel Capsule 10's is not recommended for patients with severe hepatic impairment. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Consult your doctor

Dose adjustment may be needed. Denine-150 Softgel Capsule 10's is not recommended for patients with an end-stage renal disease requiring dialysis. Please consult your doctor if you have kidney impairment or any concerns.

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Children

Unsafe

Denine-150 Softgel Capsule 10's is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Inform your doctor if you have any existing heart disease. Your doctor will prescribe this medicine only if the potential benefits outweigh the risks.

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Geriatrics

Caution

Denine-150 Softgel Capsule 10's should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Denine-150 Softgel Capsule 10's.

What if I have taken an overdose of Denine-150 Softgel Capsule 10's

If you take more than your prescribed dose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Stay hydrated by drinking water throughout the day, which helps prevent dehydration if you experience diarrhoea.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating small portions of bland foods throughout the day can make eating easier.
  • Avoid smoking completely: Smoking speeds up lung damage and can significantly reduce how well Denine-150 Softgel Capsule 10's works in your body.
  • Get regular liver tests: Attend all scheduled appointments for blood tests, as your doctor needs to monitor your liver health closely during treatment.
  • Avoid grapefruit and grapefruit juice: This fruit can affect how your body processes the medicine, potentially increasing the risk of side effects.
health query

Have a query?

How Soon It Starts Working

The time required for Denine-150 Softgel Capsule 10's to start to work: The exact onset time of Denine-150 Softgel Capsule 10's has not been clinically established. 

The time for which the effects of Denine-150 Softgel Capsule 10's last: The duration of Denine-150 Softgel Capsule 10's’s effect is clinically not established.

What if you forget to take Denine-150 Softgel Capsule 10's

If you miss a dose, skip the missed dose entirely and take your next capsule at your next regularly scheduled time. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Denine-150 Softgel Capsule 10's at room temperature, specifically between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original blister pack or container to protect it from direct light and moisture.

Drug Warnings

  • Use reliable birth control: Women who can get pregnant must use highly effective birth control during treatment and for at least 3 months after stopping Denine-150 Softgel Capsule 10's, as it can cause severe harm to an unborn baby.
  • Watch for unusual bleeding: Tell your doctor immediately if you notice blood in your stool, cough up blood, or experience frequent nosebleeds.
  • Monitor your blood pressure: This medication can raise your blood pressure, so check it regularly at home and share the results with your doctor.
  • Check your skin and eyes: Regularly look for signs of yellowing (jaundice), which could indicate a liver problem.
  • Tell all your healthcare providers: Inform your dentist or surgeon that you take Denine-150 Softgel Capsule 10's before any procedure, as it can affect wound healing.

verifiedApollotooltip

The following medicines may interact with Denine-150 Softgel Capsule 10's and require closer monitoring or dose adjustments:

  • Blood thinners: Taking this medicine with anticoagulants (such as warfarin) can increase your risk of serious bleeding.
  • Enzyme blockers: Strong CYP3A4 inhibitors (like ketoconazole or erythromycin) can increase the levels of Denine-150 Softgel Capsule 10's in your blood, making side effects more likely.
  • Enzyme inducers: Medicines like rifampicin can lower the level of Denine-150 Softgel Capsule 10's in your blood, making it less effective.
  • Laxatives: Combining this medicine with laxatives can worsen severe diarrhoea.

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verifiedApollotooltip

Certain foods or drinks may affect the safety or tolerability of Denine-150 Softgel Capsule 10's. Important interactions include:

  • Alcohol: Alcohol may increase the risk of liver problems and worsen side effects such as nausea, dizziness, or stomach discomfort. Ask your doctor whether it is safe to drink alcohol during treatment.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Denine-150 Softgel Capsule 10's is used to treat idiopathic pulmonary fibrosis (IPF), a disease marked by a progressive decline in lung function.
Denine-150 Softgel Capsule 10's helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helping you breathe better.
Avoid smoking before starting the treatment while taking Denine-150 Softgel Capsule 10's as smoking might alter the effectiveness of Denine-150 Softgel Capsule 10's.
Denine-150 Softgel Capsule 10's should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking Denine-150 Softgel Capsule 10's until your doctor asks you to stop it.
If you have any surgery, including dental surgery, please inform your doctor if you are taking Denine-150 Softgel Capsule 10's as your doctor might stop Denine-150 Softgel Capsule 10's before undergoing surgery.
In elderly patients, the risk of side effects is higher if you are taking Denine-150 Softgel Capsule 10's. For the patients who are elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.
It is not recommended to discontinue the Denine-150 Softgel Capsule 10's without consulting your healthcare provider. Abruptly stopping the medication can lead to disease progression or other complications. Consult your healthcare provider for personalised guidance if you have concerns or experience side effects.
If you forget to take a dose of Denine-150 Softgel Capsule 10's, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for the missed one, as this can increase the risk of side effects.
Common side effects of Denine-150 Softgel Capsule 10's may include nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity in some individuals. Most of these side effects do not require medical attention and will resolve gradually over time. However, if you experience these side effects persistently, inform your doctor.
Denine-150 Softgel Capsule 10's is not recommended for use in patients with severe liver impairment. Please consult your doctor if you have a liver impairment or any concerns before Denine-150 Softgel Capsule 10's.
Yes, you should always take Denine-150 Softgel Capsule 10's with food. This helps to reduce common stomach-related side effects like nausea and diarrhoea. Talk to your doctor or pharmacist if you struggle to manage stomach issues.
If you develop diarrhoea, drink plenty of fluids to avoid dehydration and contact your doctor immediately. They may recommend an over-the-counter anti-diarrhoeal medicine or adjust your dose. Talk to your doctor or pharmacist before taking any new medicine.
No, Denine-150 Softgel Capsule 10's does not cure lung scarring, and it cannot reverse scar tissue that has already formed. Instead, it works to slow down the progression of the disease and preserve your remaining lung function. Talk to your doctor or pharmacist for more information.
You should limit or avoid alcohol while taking Denine-150 Softgel Capsule 10's because both alcohol and this medicine can put stress on your liver, increasing your risk of liver damage. Talk to your doctor or pharmacist about safe alcohol limits.
Your doctor will order regular blood tests to monitor your liver function. Since this medicine can cause liver damage, checking your blood helps ensure the medicine is safe for you to continue. Talk to your doctor or pharmacist if you have concerns about these tests.
No, you should not take Denine-150 Softgel Capsule 10's if you are pregnant or planning to become pregnant, as it can cause severe harm to an unborn baby. Women who can get pregnant must use highly effective birth control during treatment and for at least 3 months after. Talk to your doctor or pharmacist about safe options.

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Country of origin

India

Manufacturer/Marketer address

Suite 4, 10th Floor, Centaurus, Central Avenue, Hiranandani Estate, Ghodbunder Road, Thane West, Maharashtra-400607
Other Info - DEN0597
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