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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Denotec 120 mg Injection 1.7 ml is used to treat osteoporosis, bone loss, giant cell tumours of the bone, high calcium levels and reduce the risk of fractures. It contains denosumab, which blocks a receptor that causes bone loss; thereby increasing bone density, and strengthening the bone. It slows the tumour growth by blocking certain receptors in the tumour cells. In some cases, this medicine may cause side effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

DENOSUMAB-120MG

Manufacturer/Marketer :

Hetero Healthcare Ltd

Consume Type :

Parenteral

Return Policy :

Not Returnable

About Denotec 120 mg Injection 1.7 ml

Denotec 120 mg Injection 1.7 ml belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Denotec 120 mg Injection 1.7 ml is also used to treat bone loss due to reduced testosterone level caused by surgery, due to the treatment with medicines such as glucocorticoids and in patients with prostate cancer. Denotec 120 mg Injection 1.7 ml may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumour of the bone, and to treat high calcium levels caused by cancer.
 
Denotec 120 mg Injection 1.7 ml contains Denosumab, which works by blocking a receptor in the body that causes bone loss, thereby treating bone loss. Denotec 120 mg Injection 1.7 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the growth of the tumour. Denotec 120 mg Injection 1.7 ml helps treat high calcium levels by decreasing bone breakdown, as a breakdown of the bones releases calcium. Denotec 120 mg Injection 1.7 ml makes the bones stronger and less likely to break.
 
Denotec 120 mg Injection 1.7 ml will be administered by a healthcare professional; do not self-administer. Sometimes, you may experience common side effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. You should talk to your doctor if the side effects persist or worsen.
 
Denotec 120 mg Injection 1.7 ml might cause jaw osteonecrosis; therefore, maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Denotec 120 mg Injection 1.7 ml. Avoid taking Denotec 120 mg Injection 1.7 ml if you are pregnant. Consult your doctor before taking Denotec 120 mg Injection 1.7 ml if you are breastfeeding. Denotec 120 mg Injection 1.7 ml is not recommended for children below 18 years as safety and effectiveness have not been established. To rule out any interactions, keep your doctor informed about your health condition and medicines.

Uses of Denotec 120 mg Injection 1.7 ml

Denotec 120 mg Injection 1.7 ml used to treat osteoporosis, bone loss, giant cell tumour of the bone, and high calcium levels. The detailed uses of Denotec 120 mg Injection 1.7 ml are as follows:

  • Management of Osteoporosis: Denotec 120 mg Injection 1.7 ml treats osteoporosis in postmenopausal women, increasing bone density and reducing fracture risk.
  • Giant cell tumour of the bone treatment: Denotec 120 mg Injection 1.7 ml is prescribed for the treatment of giant cell tumour of the bone, which helps by reducing tumour size and slowing its growth.
  • Increases bone mass: Denotec 120 mg Injection 1.7 ml increases bone mass in patients at high risk for fracture, including those undergoing androgen deprivation therapy for prostate cancer or adjuvant aromatase inhibitor therapy for breast cancer.
  • Hypercalcemia Treatment: Denotec 120 mg Injection 1.7 ml treats hypercalcemia caused by cancer, helping normalise calcium levels in the blood.
  • Paget’s Disease: Denotec 120 mg Injection 1.7 ml treats Paget’s disease by alleviating bone pain and complications caused by enlarged and deformed bones.

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Directions for Use

  • Your doctor will determine the dosage and timing of Denotec 120 mg Injection 1.7 ml based on your health condition. Usually, it is given once every 6 months.
  • Denotec 120 mg Injection 1.7 ml is administered subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area by the doctor or nurse in a hospital setting.
  • Do not self-administer it.

Key Benefits

Denotec 120 mg Injection 1.7 ml belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Denotec 120 mg Injection 1.7 ml is also used to treat bone loss due to reduced hormone levels caused by surgery or due to treatment with medicines in patients with prostate cancer. It is also used to treat bone loss occurring due to long-term treatment with glucocorticoids in patients who are at an increased risk of fractures. Denotec 120 mg Injection 1.7 ml may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone and to treat high calcium levels caused by cancer. Denotec 120 mg Injection 1.7 ml binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. It decreases bone breakdown, increases bone density, and strengthens the bone. Denotec 120 mg Injection 1.7 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the growth of the tumour. Denotec 120 mg Injection 1.7 ml helps treat high calcium levels by decreasing bone breakdown, as the breakdown of the bones releases calcium. Denotec 120 mg Injection 1.7 ml makes the bones stronger and less likely to break.

How Denotec 120 mg Injection 1.7 ml Works

Denotec 120 mg Injection 1.7 ml contains Denosumab, which works by blocking a receptor in the body that causes bone loss, thereby treating bone loss. Denotec 120 mg Injection 1.7 ml treats giant cell tumours of bone (GCTB) by blocking specific receptors in the tumour cells, thereby slowing the growth of the tumour. Denotec 120 mg Injection 1.7 ml helps treat high calcium levels by decreasing bone breakdown, as a breakdown of the bones releases calcium. Denotec 120 mg Injection 1.7 ml makes the bones stronger and less likely to break.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Denotec 120 mg Injection 1.7 ml

It is unlikely to overdose on parenteral medication as a healthcare professional administers it. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Do not take Denotec 120 mg Injection 1.7 ml if you are allergic to any of its components or have hypocalcaemia (low levels of calcium in the blood). Inform your doctor if you have low levels of calcium, kidney dysfunction, liver problems, poor dental health, gum problems, weak immune system, hypoparathyroidism (decreased function of the parathyroid gland), malabsorption, latex allergy, undergone thyroid surgery, planned dental procedure, if you are taking glucocorticoids, or cannot take calcium and vitamin D supplements. Avoid taking Denotec 120 mg Injection 1.7 ml if you are pregnant. Consult your doctor if you are breastfeeding. Denotec 120 mg Injection 1.7 ml is not recommended for children below 18 years as safety and effectiveness have not been established.

Diet & Lifestyle Advise

  • Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
  • Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
  • Snack on calcium-rich nuts like Brazil nuts or almonds.
  • Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
  • Avoid or reduce the intake of caffeine, soft drinks, and alcohol as they may inhibit calcium absorption.
  • Replace the meat with tofu or tempeh for extra calcium in your food.

Habit Forming

No

Therapeutic Class

[MONOCLONAL ANTIBODIES]

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Alcohol

Safe if prescribed

It is not known if alcohol interacts with Denotec 120 mg Injection 1.7 ml, so please consult a doctor.

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Pregnancy

Consult your doctor

Denotec 120 mg Injection 1.7 ml is not recommended during pregnancy as it might cause foetal harm. If you are a woman of child-bearing potential, use effective contraception during the treatment with Denotec 120 mg Injection 1.7 ml and for 5 months after discontinuation. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Consult your doctor

Consult your doctor if you are breastfeeding; your doctor will decide if breastfeeding mothers can take Denotec 120 mg Injection 1.7 ml or not.

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Driving

Safe if prescribed

Denotec 120 mg Injection 1.7 ml generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Consult your doctor

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Denotec 120 mg Injection 1.7 ml is not recommended for children below 18 years as safety and effectiveness were not established.

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Heart

Denotec 120 mg Injection 1.7 ml should be administered with caution in patients with heart problems. Therefore, please talk to your doctor before receiving Denotec 120 mg Injection 1.7 ml.

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Geriatrics

Consult your doctor

Denotec 120 mg Injection 1.7 ml should be administered with caution in older adults. Always seek medical advice before receiving it.

FAQs

Denotec 120 mg Injection 1.7 ml is used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. It is also used to treat bone loss and reduce the risk of fractures.

Denotec 120 mg Injection 1.7 ml binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreases bone breakdown, increases bone density, and strengthens the bone. Denotec 120 mg Injection 1.7 ml makes the bones stronger and less likely to break.

Osteonecrosis of the jaw (bone damage in the jaw) might be a side-effect of Denotec 120 mg Injection 1.7 ml. The risk increases in people taking Denotec 120 mg Injection 1.7 ml for longer durations. It might also occur upon discontinuation of the treatment. Maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Denotec 120 mg Injection 1.7 ml. Inform your doctor if you have dental problems, gum disease, planned tooth extractions, cancer, if you smoke, or are taking bisphosphonates or corticosteroids.

Breakdown of bones releases calcium and causes hypercalcemia (high calcium levels in the blood). Denotec 120 mg Injection 1.7 ml helps treat high calcium levels by decreasing bone breakdown.

Unusual thigh bone fractures might occur whilst on treatment with Denotec 120 mg Injection 1.7 ml. Consult your doctor if you experience new or unusual pain in the thigh, hip, or groin.

Denotec 120 mg Injection 1.7 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slows the tumour growth. Giant cell tumour of the bone is a non-cancerous tumour that typically grows at the ends of long bones.

Denotec 120 mg Injection 1.7 ml might cause skin infections. Consult your doctor immediately if you notice symptoms such as swollen skin, redness, cellulitis (hot and tender skin), commonly in the lower leg with feverish symptoms.

Denotec 120 mg Injection 1.7 ml has been used safely for up to 8 years, showing substantial increases in bone density during that time. However, the optimal duration of therapy varies depending on individual health conditions and needs. Long-term use should be closely monitored by your healthcare provider to assess benefits, risks, and the need for continued therapy. Always consult the doctor for personalized guidance.

Some people may experience hair loss while using Denotec 120 mg Injection 1.7 ml. However, individual reactions to medications can vary. If you experience hair loss or any unusual symptoms while taking Denotec 120 mg Injection 1.7 ml, consult the doctor to determine the cause and discuss appropriate management options.

No, Denotec 120 mg Injection 1.7 ml is not a chemotherapy medication. It is a monoclonal antibody which is used to treat conditions like osteoporosis, and bone loss associated with certain cancers, and to prevent bone fractures in patients with metastatic bone disease. It targets a protein called RANKL to inhibit bone breakdown, thereby increasing bone strength and density.

Denotec 120 mg Injection 1.7 ml is administered subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area by the doctor or nurse, usually given once every 6 months for osteoporosis. Your doctor will determine the exact schedule based on your condition. Always follow the doctor's instructions regarding dosage and scheduling, as it may vary based on your specific medical condition.

You should inform your doctor before receiving Denotec 120 mg Injection 1.7 ml, as it is not recommended during pregnancy due to the potential risk of harm to the foetus.

Denotec 120 mg Injection 1.7 ml should be stored in a refrigerator at a temperature between 2°C and 8°C. Do not freeze it. Keep the vial in its outer carton to protect it from light.

The side effects of Denotec 120 mg Injection 1.7 ml include abdominal discomfort, bone/joint/muscle pain, arm/leg pain, constipation, and painful/frequent urination. Consult the doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

HALL NO 3, BASEMENT, A37, MANGOLPURI, INDUSTRIALAREA, PHASE 11, NEW DELHI, DELHI, 110034.
Other Info - DEN0588

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Keep Refrigerated. Do not freeze.

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