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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Densucor PFS 60 mg Injection 1's is used to treat osteoporosis, bone loss, giant cell tumours of the bone, high calcium levels and reduce the risk of fractures. It contains denosumab, which blocks a receptor that causes bone loss; thereby increasing bone density, and strengthening the bone. It slows the tumour growth by blocking certain receptors in the tumour cells. In some cases, this medicine may cause side effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

DENOSUMAB-60MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Densucor PFS 60 mg Injection 1's

Densucor PFS 60 mg Injection 1's belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Densucor PFS 60 mg Injection 1's is also used to treat bone loss due to reduced testosterone level caused by surgery, due to the treatment with medicines such as glucocorticoids and in patients with prostate cancer. Densucor PFS 60 mg Injection 1's may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumour of the bone, and to treat high calcium levels caused by cancer.
 
Densucor PFS 60 mg Injection 1's contains Denosumab, which works by blocking a receptor in the body that causes bone loss, thereby treating bone loss. Densucor PFS 60 mg Injection 1's treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the growth of the tumour. Densucor PFS 60 mg Injection 1's helps treat high calcium levels by decreasing bone breakdown, as a breakdown of the bones releases calcium. Densucor PFS 60 mg Injection 1's makes the bones stronger and less likely to break.
 
Densucor PFS 60 mg Injection 1's will be administered by a healthcare professional; do not self-administer. Sometimes, you may experience common side effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. You should talk to your doctor if the side effects persist or worsen.
 
Densucor PFS 60 mg Injection 1's might cause jaw osteonecrosis; therefore, maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Densucor PFS 60 mg Injection 1's. Avoid taking Densucor PFS 60 mg Injection 1's if you are pregnant. Consult your doctor before taking Densucor PFS 60 mg Injection 1's if you are breastfeeding. Densucor PFS 60 mg Injection 1's is not recommended for children below 18 years as safety and effectiveness have not been established. To rule out any interactions, keep your doctor informed about your health condition and medicines.

Uses of Densucor PFS 60 mg Injection 1's

Densucor PFS 60 mg Injection 1's used to treat osteoporosis, bone loss, giant cell tumour of the bone, and high calcium levels. The detailed uses of Densucor PFS 60 mg Injection 1's are as follows:

  • Management of Osteoporosis: Densucor PFS 60 mg Injection 1's treats osteoporosis in postmenopausal women, increasing bone density and reducing fracture risk.
  • Giant cell tumour of the bone treatment: Densucor PFS 60 mg Injection 1's is prescribed for the treatment of giant cell tumour of the bone, which helps by reducing tumour size and slowing its growth.
  • Increases bone mass: Densucor PFS 60 mg Injection 1's increases bone mass in patients at high risk for fracture, including those undergoing androgen deprivation therapy for prostate cancer or adjuvant aromatase inhibitor therapy for breast cancer.
  • Hypercalcemia Treatment: Densucor PFS 60 mg Injection 1's treats hypercalcemia caused by cancer, helping normalise calcium levels in the blood.
  • Paget’s Disease: Densucor PFS 60 mg Injection 1's treats Paget’s disease by alleviating bone pain and complications caused by enlarged and deformed bones.

Have a query?

Directions for Use

  • Your doctor will determine the dosage and timing of Densucor PFS 60 mg Injection 1's based on your health condition. Usually, it is given once every 6 months.
  • Densucor PFS 60 mg Injection 1's is administered subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area by the doctor or nurse in a hospital setting.
  • Do not self-administer it.

Medicinal Benefits

Densucor PFS 60 mg Injection 1's belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Densucor PFS 60 mg Injection 1's is also used to treat bone loss due to reduced hormone levels caused by surgery or due to treatment with medicines in patients with prostate cancer. It is also used to treat bone loss occurring due to long-term treatment with glucocorticoids in patients who are at an increased risk of fractures. Densucor PFS 60 mg Injection 1's may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone and to treat high calcium levels caused by cancer. Densucor PFS 60 mg Injection 1's binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. It decreases bone breakdown, increases bone density, and strengthens the bone. Densucor PFS 60 mg Injection 1's treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the growth of the tumour. Densucor PFS 60 mg Injection 1's helps treat high calcium levels by decreasing bone breakdown, as the breakdown of the bones releases calcium. Densucor PFS 60 mg Injection 1's makes the bones stronger and less likely to break.

How Densucor PFS 60 mg Injection 1's Works

Densucor PFS 60 mg Injection 1's contains Denosumab, which works by blocking a receptor in the body that causes bone loss, thereby treating bone loss. Densucor PFS 60 mg Injection 1's treats giant cell tumours of bone (GCTB) by blocking specific receptors in the tumour cells, thereby slowing the growth of the tumour. Densucor PFS 60 mg Injection 1's helps treat high calcium levels by decreasing bone breakdown, as a breakdown of the bones releases calcium. Densucor PFS 60 mg Injection 1's makes the bones stronger and less likely to break.

Storage

• Store in a cool and dry place away from sunlight.• Keep Densucor PFS 60 mg Injection 1's out of reach and sight of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.

What if I have taken an overdose of Densucor PFS 60 mg Injection 1's

It is unlikely to overdose on parenteral medication as a healthcare professional administers it. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Do not take Densucor PFS 60 mg Injection 1's if you are allergic to any of its components or have hypocalcaemia (low levels of calcium in the blood). Inform your doctor if you have low levels of calcium, kidney dysfunction, liver problems, poor dental health, gum problems, weak immune system, hypoparathyroidism (decreased function of the parathyroid gland), malabsorption, latex allergy, undergone thyroid surgery, planned dental procedure, if you are taking glucocorticoids, or cannot take calcium and vitamin D supplements. Avoid taking Densucor PFS 60 mg Injection 1's if you are pregnant. Consult your doctor if you are breastfeeding. Densucor PFS 60 mg Injection 1's is not recommended for children below 18 years as safety and effectiveness have not been established.

Diet & Lifestyle Advise

  • Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
  • Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
  • Snack on calcium-rich nuts like Brazil nuts or almonds.
  • Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
  • Avoid or reduce the intake of caffeine, soft drinks, and alcohol as they may inhibit calcium absorption.
  • Replace the meat with tofu or tempeh for extra calcium in your food.

Habit Forming

No

Therapeutic Class

MONOCLONAL ANTIBODIES

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Alcohol

Caution

It is not known if alcohol interacts with Densucor PFS 60 mg Injection 1's, so please consult a doctor.

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Pregnancy

Unsafe

Densucor PFS 60 mg Injection 1's is not recommended during pregnancy as it might cause foetal harm. If you are a woman of child-bearing potential, use effective contraception during the treatment with Densucor PFS 60 mg Injection 1's and for 5 months after discontinuation. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide if breastfeeding mothers can take Densucor PFS 60 mg Injection 1's or not.

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Driving

Safe if prescribed

Densucor PFS 60 mg Injection 1's generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Densucor PFS 60 mg Injection 1's is not recommended for children below 18 years as safety and effectiveness were not established.

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Heart

Densucor PFS 60 mg Injection 1's should be administered with caution in patients with heart problems. Therefore, please talk to your doctor before receiving Densucor PFS 60 mg Injection 1's.

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Geriatrics

Caution

Densucor PFS 60 mg Injection 1's should be administered with caution in older adults. Always seek medical advice before receiving it.

FAQs

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India.
Other Info - DEN0577

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