How does Denub 60 mg Injection 1 ml work?

Denub 60 mg Injection 1 ml binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreases bone breakdown, increases bone density, and strengthens the bone. Denub 60 mg Injection 1 ml makes the bones stronger and less likely to break.

Does Denub 60 mg Injection 1 ml cause osteonecrosis?

Osteonecrosis of the jaw (bone damage in the jaw) might be a side-effect of Denub 60 mg Injection 1 ml. The risk increases in people taking Denub 60 mg Injection 1 ml for longer durations. It might also occur upon discontinuation of the treatment. Maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Denub 60 mg Injection 1 ml. Inform your doctor if you have dental problems, gum disease, planned tooth extractions, cancer, if you smoke, or are taking bisphosphonates or corticosteroids.

Is Denub 60 mg Injection 1 ml used to treat high calcium levels?

Breakdown of bones releases calcium and causes hypercalcemia (high calcium levels in the blood). Denub 60 mg Injection 1 ml helps treat high calcium levels by decreasing bone breakdown.

Does Denub 60 mg Injection 1 ml cause unusual thigh bone fractures?

Unusual thigh bone fractures might occur whilst on treatment with Denub 60 mg Injection 1 ml. Consult your doctor if you experience new or unusual pain in the thigh, hip, or groin.

Is Denub 60 mg Injection 1 ml used to treat giant cell tumours of the bone?

Denub 60 mg Injection 1 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slows the tumour growth. Giant cell tumour of the bone is a non-cancerous tumour that typically grows at the ends of long bones.

Does Denub 60 mg Injection 1 ml cause skin infections?

Denub 60 mg Injection 1 ml might cause skin infections. Consult your doctor immediately if you notice symptoms such as swollen skin, redness, cellulitis (hot and tender skin), commonly in the lower leg with feverish symptoms.

How long can you stay on Denub 60 mg Injection 1 ml?

Denub 60 mg Injection 1 ml has been used safely for up to 8 years, showing substantial increases in bone density during that time. However, the optimal duration of therapy varies depending on individual health conditions and needs. Long-term use should be closely monitored by your healthcare provider to assess benefits, risks, and the need for continued therapy. Always consult the doctor for personalized guidance.

Does Denub 60 mg Injection 1 ml cause hair loss?

Some people may experience hair loss while using Denub 60 mg Injection 1 ml. However, individual reactions to medications can vary. If you experience hair loss or any unusual symptoms while taking Denub 60 mg Injection 1 ml, consult the doctor to determine the cause and discuss appropriate management options.

Is Denub 60 mg Injection 1 ml a chemotherapy drug?

No, Denub 60 mg Injection 1 ml is not a chemotherapy medication. It is a monoclonal antibody which is used to treat conditions like osteoporosis, and bone loss associated with certain cancers, and to prevent bone fractures in patients with metastatic bone disease. It targets a protein called RANKL to inhibit bone breakdown, thereby increasing bone strength and density.

How is Denub 60 mg Injection 1 ml given and how often?

Denub 60 mg Injection 1 ml is administered subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area by the doctor or nurse, usually given once every 6 months for osteoporosis. Your doctor will determine the exact schedule based on your condition. Always follow the doctor's instructions regarding dosage and scheduling, as it may vary based on your specific medical condition.

Can Denub 60 mg Injection 1 ml be taken during pregnancy?

You should inform your doctor before receiving Denub 60 mg Injection 1 ml, as it is not recommended during pregnancy due to the potential risk of harm to the foetus.

How should Denub 60 mg Injection 1 ml be stored?

Denub 60 mg Injection 1 ml should be stored in a refrigerator at a temperature between 2°C and 8°C. Do not freeze it. Keep the vial in its outer carton to protect it from light.

What are the side effects of Denub 60 mg Injection 1 ml?

The side effects of Denub 60 mg Injection 1 ml include abdominal discomfort, bone/joint/muscle pain, arm/leg pain, constipation, and painful/frequent urination. Consult the doctor if any of these side effects persist or worsen.

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Written By Santoshini Reddy G , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Denub 60 mg Injection 1 ml is used to treat osteoporosis, bone loss, giant cell tumours of the bone, high calcium levels and reduce the risk of fractures. It contains denosumab, which blocks a receptor that causes bone loss; thereby increasing bone density, and strengthening the bone. It slows the tumour growth by blocking certain receptors in the tumour cells. In some cases, this medicine may cause side effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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About Denub 60 mg Injection 1 ml

Denub 60 mg Injection 1 ml belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Denub 60 mg Injection 1 ml is also used to treat bone loss due to reduced testosterone level caused by surgery, due to the treatment with medicines such as glucocorticoids and in patients with prostate cancer. Denub 60 mg Injection 1 ml may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumour of the bone, and to treat high calcium levels caused by cancer.

Denub 60 mg Injection 1 ml contains Denosumab, which works by blocking a receptor in the body that causes bone loss, thereby treating bone loss. Denub 60 mg Injection 1 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the growth of the tumour. Denub 60 mg Injection 1 ml helps treat high calcium levels by decreasing bone breakdown, as a breakdown of the bones releases calcium. Denub 60 mg Injection 1 ml makes the bones stronger and less likely to break.

Denub 60 mg Injection 1 ml will be administered by a healthcare professional; do not self-administer. Sometimes, you may experience common side effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. You should talk to your doctor if the side effects persist or worsen.

Denub 60 mg Injection 1 ml might cause jaw osteonecrosis; therefore, maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Denub 60 mg Injection 1 ml. Avoid taking Denub 60 mg Injection 1 ml if you are pregnant. Consult your doctor before taking Denub 60 mg Injection 1 ml if you are breastfeeding. Denub 60 mg Injection 1 ml is not recommended for children below 18 years as safety and effectiveness have not been established. To rule out any interactions, keep your doctor informed about your health condition and medicines.

Uses of Denub 60 mg Injection 1 ml

Denub 60 mg Injection 1 ml used to treat osteoporosis, bone loss, giant cell tumour of the bone, and high calcium levels. The detailed uses of Denub 60 mg Injection 1 ml are as follows:
• Management of Osteoporosis: Denub 60 mg Injection 1 ml treats osteoporosis in postmenopausal women, increasing bone density and reducing fracture risk.
• Giant cell tumour of the bone treatment: Denub 60 mg Injection 1 ml is prescribed for the treatment of giant cell tumour of the bone, which helps by reducing tumour size and slowing its growth.
• Increases bone mass: Denub 60 mg Injection 1 ml increases bone mass in patients at high risk for fracture, including those undergoing androgen deprivation therapy for prostate cancer or adjuvant aromatase inhibitor therapy for breast cancer.
• Hypercalcemia Treatment: Denub 60 mg Injection 1 ml treats hypercalcemia caused by cancer, helping normalise calcium levels in the blood.
• Paget's Disease: Denub 60 mg Injection 1 ml treats Paget's disease by alleviating bone pain and complications caused by enlarged and deformed bones.

Directions for Use

Denub 60 mg Injection 1 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Denub 60 mg Injection 1 ml belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Denub 60 mg Injection 1 ml is also used to treat bone loss due to reduced hormone levels caused by surgery or due to treatment with medicines in patients with prostate cancer. It is also used to treat bone loss occurring due to long-term treatment with glucocorticoids in patients who are at an increased risk of fractures. Denub 60 mg Injection 1 ml may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone and to treat high calcium levels caused by cancer. Denub 60 mg Injection 1 ml binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. It decreases bone breakdown, increases bone density, and strengthens the bone. Denub 60 mg Injection 1 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the growth of the tumour. Denub 60 mg Injection 1 ml helps treat high calcium levels by decreasing bone breakdown, as the breakdown of the bones releases calcium. Denub 60 mg Injection 1 ml makes the bones stronger and less likely to break.

How Denub 60 mg Injection 1 ml Works

Denub 60 mg Injection 1 ml contains Denosumab, which works by blocking a receptor in the body that causes bone loss, thereby treating bone loss. Denub 60 mg Injection 1 ml treats giant cell tumours of bone (GCTB) by blocking specific receptors in the tumour cells, thereby slowing the growth of the tumour. Denub 60 mg Injection 1 ml helps treat high calcium levels by decreasing bone breakdown, as a breakdown of the bones releases calcium. Denub 60 mg Injection 1 ml makes the bones stronger and less likely to break.

Storage

Store in a cool and dry place away from sunlight

Side effects of Denub 60 mg Injection 1 ml

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Weakness

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Back Pain

Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:

Talk to your doctor about your back pain and potential medication substitutes or dose changes.
Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
To lessen the tension on your back, sit and stand upright and maintain proper posture.
To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
Back discomfort can worsen by bending, twisting, and heavy lifting.
Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

Joint Pain

Here are the steps to manage Joint Pain caused by medication usage:

Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

Pain In Arm Or Leg

Eat fatty fish rich in omega-3 fatty acids to reduce inflammation.
Add whole grains such as brown rice, quinoa, and whole wheat bread to your diet for a nutritional boost.
Add nuts and seeds like almonds, walnuts, chia seeds for anti-inflammatory benefits.
Eat dark leafy greens like spinach, kale, collard greens for antioxidants.
Include berries like blueberries, strawberries, raspberries for anti-inflammatory properties.
Rest and take a break from usual activities.
Apply ice for 15-20 minutes, 3 times a day to reduce pain and inflammation.
Use compression with a stretchable bandage or wrap to lessen swelling and provide support.
Avoid strenuous activities and rest the affected area.
Try light stretching with gentle exercises to maintain flexibility.
Consider OTC pain medications like ibuprofen or acetaminophen but consult a doctor before taking any medication.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Cough

Here are the steps to manage the medication-triggered Cough:

Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

What if I have taken an overdose of Denub 60 mg Injection 1 ml

It is unlikely to overdose on parenteral medication as a healthcare professional administers it. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Do not take Denub 60 mg Injection 1 ml if you are allergic to any of its components or have hypocalcaemia (low levels of calcium in the blood). Inform your doctor if you have low levels of calcium, kidney dysfunction, liver problems, poor dental health, gum problems, weak immune system, hypoparathyroidism (decreased function of the parathyroid gland), malabsorption, latex allergy, undergone thyroid surgery, planned dental procedure, if you are taking glucocorticoids, or cannot take calcium and vitamin D supplements. Avoid taking Denub 60 mg Injection 1 ml if you are pregnant. Consult your doctor if you are breastfeeding. Denub 60 mg Injection 1 ml is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

DenosumabEtelcalcetide

Severe

DenosumabCladribine

Severe

Drug-Drug Interactions

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DenosumabEtelcalcetide

Severe

How does the drug interact with Denub 60 mg Injection 1 ml:
Using Denub 60 mg Injection 1 ml together with etelcalcetide may significantly decrease the calcium levels in your blood.

How to manage the interaction:
Taking Denub 60 mg Injection 1 ml with Etelcalcetide together can possibly result in an interaction, but it can be taken if your doctor has advised it. "When taking Denub 60 mg Injection 1 ml with medications like cinacalcet and etelcalcetide, it's important to be cautious and regularly check your blood calcium levels. If you notice any symptoms like low blood calcium, numbness, tingling around your mouth, irritability, or feeling down, make sure to contact your doctor right away." Do not stop using any medications without first talking to your doctor.

DenosumabCladribine

Severe

How does the drug interact with Denub 60 mg Injection 1 ml:
Using cladribine together with Denub 60 mg Injection 1 ml may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Denub 60 mg Injection 1 ml and Cladribine, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, and pain or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
Snack on calcium-rich nuts like Brazil nuts or almonds.
Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
Avoid or reduce the intake of caffeine, soft drinks, and alcohol as they may inhibit calcium absorption.
Replace the meat with tofu or tempeh for extra calcium in your food.

Habit Forming

No

Therapeutic Class

MONOCLONAL ANTIBODIES

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Alcohol

Caution

It is not known if alcohol interacts with Denub 60 mg Injection 1 ml, so please consult a doctor.

Pregnancy

Unsafe

Denub 60 mg Injection 1 ml is not recommended during pregnancy as it might cause foetal harm. If you are a woman of child-bearing potential, use effective contraception during the treatment with Denub 60 mg Injection 1 ml and for 5 months after discontinuation. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide if breastfeeding mothers can take Denub 60 mg Injection 1 ml or not.

Driving

Safe if prescribed

Denub 60 mg Injection 1 ml generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

Children

Unsafe

Denub 60 mg Injection 1 ml is not recommended for children below 18 years as safety and effectiveness were not established.

FAQs

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.

Other Info - DEN0344

Keep Refrigerated. Do not freeze.Prepaid payment required.

Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

May 5, 2025 | 11:25 AM IST

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Denub 60 mg Injection 1 ml

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FAQs

What is the use of Denub 60 mg Injection 1 ml?

How does Denub 60 mg Injection 1 ml work?

Does Denub 60 mg Injection 1 ml cause osteonecrosis?

Is Denub 60 mg Injection 1 ml used to treat high calcium levels?

Does Denub 60 mg Injection 1 ml cause unusual thigh bone fractures?

Is Denub 60 mg Injection 1 ml used to treat giant cell tumours of the bone?

Does Denub 60 mg Injection 1 ml cause skin infections?

How long can you stay on Denub 60 mg Injection 1 ml?

Does Denub 60 mg Injection 1 ml cause hair loss?

Is Denub 60 mg Injection 1 ml a chemotherapy drug?

How is Denub 60 mg Injection 1 ml given and how often?

Can Denub 60 mg Injection 1 ml be taken during pregnancy?

How should Denub 60 mg Injection 1 ml be stored?

What are the side effects of Denub 60 mg Injection 1 ml?

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