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compositionComposition:MEDROXYPROGESTERONE ACETATE-150MG
prescriptionPrescription Medicine
Depo-Provera 150 mg Injection 1 ml
Depo-Provera 150 mg Injection 1 ml

Depo-Provera 150 mg Injection 1 ml is used for contraception. It is also used in the treatment of amenorrhea (the unusual cessation of menstrual periods) and abnormal uterine bleeding, and the prevention of endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MEDROXYPROGESTERONE ACETATE-150MG

Manufacturer/Marketer :

DKT India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Depo-Provera 150 mg Injection 1 ml

Depo-Provera 150 mg Injection 1 ml is used as a long-acting contraceptive. It is also used in the treatment of abnormal uterine bleeding and the prevention of endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen.

Depo-Provera 150 mg Injection 1 ml contains medroxyprogesterone acetate, which prevents an egg from fully maturing and being discharged from the ovaries. If an egg is not released, it cannot be fertilised by sperm and result in pregnancy.

Depo-Provera 150 mg Injection 1 ml is administered by a doctor. In some cases, you may have nervousness, headache, stomach pain or discomfort, weight increase or decrease, reduced sex drive, dizziness, and feelings of sickness and depression. If the side effects are persistent, reach out to your doctor.

Let your doctor know if you have or have had migraine headaches, diabetes, liver or kidney disorders, osteoporosis, asthma, or epilepsy. And also inform your doctor if you are pregnant, expecting a pregnancy, or breastfeeding.

Uses of Depo-Provera 150 mg Injection 1 ml

Depo-Provera 150 mg Injection 1 ml is used in the treatment of contraception, amenorrhea and abnormal uterine bleeding, in the prevention of endometrial hyperplasia (thickening of the uterine or womb lining). The detailed uses of Depo-Provera 150 mg Injection 1 ml are as follows:

  • Prevent pregnancy: Depo-Provera 150 mg Injection 1 ml is primarily used as a long-acting contraceptive. A single intramuscular injection protects against pregnancy for up to 3 months by suppressing ovulation and altering the uterine lining.
  • Treat abnormal uterine bleeding: Depo-Provera 150 mg Injection 1 ml stabilises the endometrial lining and regulates menstrual cycles, making it effective in controlling heavy or irregular bleeding.
  • Address amenorrhea (absence of menstruation): Depo-Provera 150 mg Injection 1 ml is used to induce menstrual periods in individuals experiencing secondary amenorrhea due to hormonal imbalance.

Health Queries

I have a 2-month-old baby and am considering taking the Depo-Provera injection for contraception. Is it safe for my baby, especially if I am breastfeeding?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Depo-Provera (a progesterone-only contraceptive injection) is generally safe to use while breastfeeding, and it does not harm your baby or affect breast milk quality. In fact, this type of contraception is often preferred for nursing mothers because it does not contain estrogen, which can reduce milk supply. It is usually started after 6 weeks postpartum, so at 2 months after delivery, you can use it if there are no other medical concerns. Some women may notice mild side effects like irregular periods, spotting, or delayed return of normal cycles after stopping the injection, but these are usually not harmful. Before starting, it is still important to consult your doctor to confirm that it is suitable for you based on your health. Overall, Depo-Provera is a reliable and convenient option for contraception during breastfeeding.

Have a query?

Directions for Use

  • The timing and frequency of Depo-Provera 150 mg Injection 1 ml will be determined by your doctor, based on your medical condition and response to treatment.
  • This medication should only be administered by a qualified healthcare provider.
  • Do not attempt self-administration of the injection.

Key Benefits

When used as prescribed, Depo-Provera 150 mg Injection 1 ml may offer the following benefits:

For Contraception:

  • Offers long-acting birth control that lasts for almost three months.
  • Stops ovulation, or the release of eggs.
  • Thickens cervical mucus to prevent the introduction of sperm
  • Lowers the chance of unwanted pregnancy when taken as prescribed.

For Amenorrhea:

  • Corrects progesterone insufficiency, which aids in the restart of menstrual cycles.
  • Controls the menstrual cycle in hormonally imbalanced women.
  • Stops endometrial hyperplasia, an excessive thickening of the uterine lining brought on by unopposed estrogen.
  • Helpful in treating secondary amenorrhea once pregnancy and other reasons have been ruled out.

For Abnormal Uterine Bleeding:

  • Controls the menstrual cycle.
  • Helps reduce heavy or prolonged bleeding.
  • Stabilizes the endometrium, the lining of the uterus.
  • Helps correct progesterone deficiency.
  • Helps prevent abnormal bleeding from recurring.

For Endometriosis:

  • Blocks the development of endometrial tissue outside of the uterus.
  • Lowers menstrual cramps and pelvic discomfort.
  • Reduces uncomfortable or heavy periods.
  • Reduces the size of endometriotic lesions.
  • Enhances quality of life by reducing symptoms.

How Depo-Provera 150 mg Injection 1 ml Works

Depo-Provera 150 mg Injection 1 ml contains medroxyprogesterone acetate, which is similar to the natural hormone progesterone, which is produced in the ovaries during the second half of your menstrual cycle. During your menstrual cycle, Depo-Provera 150 mg Injection 1 ml prevents an egg from fully maturing and being discharged from the ovaries. If an egg is not released, it cannot be fertilised by sperm and result in pregnancy.

Storage

Store in a cool and dry place away from sunlight
Side effects of Depo-Provera 150 mg Injection 1 ml
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.

What if I have taken an overdose of Depo-Provera 150 mg Injection 1 ml

As Depo-Provera 150 mg Injection 1 ml is a parenteral formulation, the chance of overdose may be less. However, keep track of your medicine as an overdose of Depo-Provera 150 mg Injection 1 ml may cause serious side effects. Symptoms may include breathing problems, nausea, vomiting, and altered mental status. Seek immediate medical attention if you observe any of these side effects.

Drug Warnings

  • Depo-Provera 150 mg Injection 1 ml should not be used if you are allergic to any of its components.
  • Before taking Depo-Provera 150 mg Injection 1 ml, inform your healthcare provider if you have or have had migraine headaches, vaginal bleeding, blood disorders (such as deep vein thrombosis), diabetes, severe pain or swelling in the calf, eye diseases, depression, liver (such as jaundice) or kidney disorders, osteoporosis, asthma, or epilepsy and hormone-dependent cancer of the breast or sex organs.
  • Also, tell your doctor if you are pregnant, expecting a pregnancy, breastfeeding, or using certain medications, such as high-dose glucocorticoids (steroids).

Drug-Drug Interactions

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MedroxyprogesteroneAcitretin
Critical
MedroxyprogesteroneEtretinate
Critical

Drug-Drug Interactions

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MedroxyprogesteroneAcitretin
Critical
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Coadministration of Acitretin with Depo-Provera 150 mg Injection 1 ml can increase the risk and severity of birth defects when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with Depo-Provera 150 mg Injection 1 ml together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneEtretinate
Critical
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml and Etretinate may cause severe birth defects if the mother takes the medication during pregnancy.

How to manage the interaction:
Using etretinate and Depo-Provera 150 mg Injection 1 ml together is not recommended, but can be taken if prescribed by a doctor. However, if you experience unusual symptoms contact your doctor. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneTranexamic acid
Critical
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml acetate with Tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Taking Depo-Provera 150 mg Injection 1 ml with Tranexamic acid is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to your doctor.
MedroxyprogesteroneFosamprenavir
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Although there is a possible interaction between Depo-Provera 150 mg Injection 1 ml and Fosamprenavir, you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor right away. Do not stop using any medications without a doctor's advice.
MedroxyprogesteroneSugammadex
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
When Depo-Provera 150 mg Injection 1 ml is taken with sugammadex, the effect of Depo-Provera 150 mg Injection 1 ml in the blood may decrease.

How to manage the interaction:
Taking Sugammadex with Depo-Provera 150 mg Injection 1 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
MedroxyprogesteroneAmprenavir
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml with amprenavir may make amprenavir less effective.

How to manage the interaction:
There may be a possibility of interaction between Depo-Provera 150 mg Injection 1 ml and Amprenavir, but it can be taken if prescribed by a doctor. If you're having any unusual symptoms, it's important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
MedroxyprogesteroneGriseofulvin
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking griseofulvin with Depo-Provera 150 mg Injection 1 ml may reduce blood levels and the effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
There may be a possibility of interaction between Griseofulvin and Depo-Provera 150 mg Injection 1 ml, but it can be taken if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, or if you think you might be pregnant while using birth control, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneDabrafenib
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
When Dabrafenib is taken with Depo-Provera 150 mg Injection 1 ml acetate, the amount of Depo-Provera 150 mg Injection 1 ml acetate in the blood may decrease.

How to manage the interaction:
Co-administration of Dabrafenib with Depo-Provera 150 mg Injection 1 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience hot flashes(feeling of heat in the body), dryness, or unusual bleeding, don't hesitate to reach out to your doctor. Do not stop using any medications without a doctor's advice.
MedroxyprogesteroneBrigatinib
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml and Brigatinib may, reduce the blood levels and effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
Although taking Depo-Provera 150 mg Injection 1 ml and brigatinib together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience hot flashes(feeling of heat in the body), dryness, or unusual bleeding, don't hesitate to reach out to your doctor. Do not stop using any medications without a doctor's advice.
MedroxyprogesteroneTopiramate
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
When Depo-Provera 150 mg Injection 1 ml acetate is taken with Topiramate, it reduces the blood levels and effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
Co-administration of Depo-Provera 150 mg Injection 1 ml with Topiramate can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're taking birth control and experiencing symptoms like hot flashes, vaginal dryness, or abnormal bleeding, contact your doctor. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Healthy eating habits:

  • Consume a diet rich in fruits, vegetables, whole grains, and lean meats.
  • Reduce bloating and fluid retention by limiting processed foods and salt.
  • Add meals high in calcium and vitamin D to maintain healthy bones.
  • Avoid eating too many sweet or fatty foods and stay hydrated.

Lifestyle changes:

  • Regularly engage in mild exercise to maintain a healthy weight.
  • Use relaxation techniques, yoga, or meditation to reduce stress.
  • Avoid smoking and binge drinking since these might disrupt hormone balance.
  • Observe routine medical examinations and take medication as directed.

Stress management:

  • Every day, engage in relaxation exercises like yoga, meditation, or deep breathing.
  • To maintain hormonal balance, make sure you get enough sleep and rest.

Habit Forming

No

Therapeutic Class

[HORMONES, CONTRACEPTIVES]

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Alcohol

Consult your doctor

It is not known whether it is safe to consume alcohol with Depo-Provera 150 mg Injection 1 ml. However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Unsafe

Depo-Provera 150 mg Injection 1 ml must not be taken if you are pregnant, as hormonal medicines can affect the developing baby.

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Breast Feeding

Safe if prescribed

Depo-Provera 150 mg Injection 1 ml can be safely used by nursing mothers. Your doctor or healthcare professional may advise that you wait until at least 6 weeks after your baby has been born before you start using Depo-Provera 150 mg Injection 1 ml for contraception.

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Driving

Safe if prescribed

Depo-Provera 150 mg Injection 1 ml usually does not impact your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor before receiving Depo-Provera 150 mg Injection 1 ml if you have a history of liver impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor before receiving Depo-Provera 150 mg Injection 1 ml if you have a history of kidney impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Depo-Provera 150 mg Injection 1 ml is not recommended for children below 12 years of age.

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Heart

Caution

Inform your doctor before receiving Depo-Provera 150 mg Injection 1 ml if you have heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Depo-Provera 150 mg Injection 1 ml should be used with caution in elderly patients. Please consult your doctor before use.

FAQs

Depo-Provera 150 mg Injection 1 ml is used to treat amenorrhea (the unusual cessation of menstrual periods) and abnormal uterine bleeding. Besides that, it can also be used to prevent endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen.

Depo-Provera 150 mg Injection 1 ml prevents an egg from fully developing and being released from the ovaries during your menstrual cycle. An egg that is not released cannot be fertilised by sperm and result in pregnancy. On the other hand, it also induces changes in the lining of your womb, making conception less likely. It also thickens the mucus at the womb's opening, making sperm entry more difficult.

It is recommended not to take any other contraceptives with Depo-Provera 150 mg Injection 1 ml without a doctor's prescription.

Yes, the Depo-Provera 150 mg Injection 1 ml may cause hair loss. If you feel that you are experiencing a lot of hall falls while taking Depo-Provera 150 mg Injection 1 ml, please consult your doctor.

Do not use Depo-Provera 150 mg Injection 1 ml if you are allergic to medroxyprogesterone acetate, or any other similar hormonal medicines, if you have/had breast cancer, a blood clotting disorder such as deep vein thrombosis (blood clot in the legs) or pulmonary embolism (blood clot in the lung), severe liver disease such as jaundice, unexplained vaginal bleeding or if you are pregnant or think you may be pregnant or If you have not yet started your periods.

Depo-Provera 150 mg Injection 1 ml can be used for just one or two occasions in a few cases, such as if your partner is having a vasectomy, Depo-Provera 150 mg Injection 1 ml can be used to protect you until the vasectomy takes place, or if you are being immunised against rubella, to prevent conception during the virus's active phase, or if you are awaiting sterilisation.

Weight gain is a possible side effect of Depo-Provera 150 mg Injection 1 ml, but it can often be managed with diet and exercise. The weight gain can vary from person to person, and it's more likely to occur with higher doses. By maintaining a healthy lifestyle, you can minimize the impact of weight gain while taking Depo-Provera 150 mg Injection 1 ml.

Depo-Provera 150 mg Injection 1 ml is a generally safe and effective medication when used as directed. However, as with any medication, it may not be suitable for everyone and can cause side effects in some individuals. To ensure safe and effective use, following your healthcare provider's instructions is essential.

Withdrawal bleeding usually occurs within 3 to 7 days after you stop taking Depo-Provera 150 mg Injection 1 ml. Consult your doctor if your condition does not improve or if it worsens.

The common side effects of Depo-Provera 150 mg Injection 1 ml include headache, nausea, dizziness, hair loss, acne, and unusual vaginal bleeding or spotting. Most of these side effects of Depo-Provera 150 mg Injection 1 ml do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ?G? Block , Bandra Kurla Complex, Bandra East , Mumbai ? 400051.
Other Info - DEP0019

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