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DEPOCILONE-40MG/1ML INJECTION is used to treat the pain of osteoarthritis (OA) in the knee. It helps to reduce the joint pain, stiffness, and swelling associated with inflammatory disorders. It contains triamcinolone acetonide, which belongs to the class of corticosteroids. It works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies. This effect helps reduce swelling, pain, and discomfort.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About DEPOCILONE-40MG/1ML INJECTION

DEPOCILONE-40MG/1ML INJECTION is an injectable corticosteroid used to reduce severe inflammation, swelling, and pain in various parts of the body. It is commonly prescribed to treat conditions affecting the joints, skin, eyes, and lungs, such as severe arthritis, asthma, skin disorders, and severe allergic reactions. By calming down the body's overactive immune response, it helps prevent tissue damage and relieves discomfort.

Because this medicine is given as an injection, the frequency of use depends entirely on your specific condition and how you respond to the treatment. It may be given as a single injection or spaced out several weeks or months apart. Since it is injected, it does not depend on meals or food intake. To get the best results, it is helpful to support your treatment with lifestyle adjustments, such as resting the affected area and following a balanced diet.

While DEPOCILONE-40MG/1ML INJECTION is highly effective, it can cause some side effects. Many people experience temporary pain or redness at the injection site, while others might notice mild stomach upset or headache. You should contact your doctor immediately if you experience severe side effects, such as sudden vision changes, severe swelling in your hands or ankles, or extreme mood shifts.

Do not take this if you have a systemic fungal infection or an untreated active infection. Before starting treatment, tell your healthcare provider if you have a history of diabetes, high blood pressure, osteoporosis, liver damage, or kidney issues. Your doctor will evaluate if this injection is safe for you based on your medical history.

This medicine can interact with other drugs, including blood thinners and certain vaccines. Let your doctor know about all medications you are currently taking, as well as if you smoke or regularly drink alcohol. If you are pregnant, breastfeeding, or an older adult, consult your doctor to discuss the risks and benefits before receiving this injection.

Uses of DEPOCILONE-40MG/1ML INJECTION

DEPOCILONE-40MG/1ML INJECTION is used to reduce severe inflammation, swelling, and pain in various parts of the body. The detailed uses of DEPOCILONE-40MG/1ML INJECTION are as follows:

  • Severe Inflammation and Allergic Reactions: DEPOCILONE-40MG/1ML INJECTION helps by calming the immune system to reduce severe swelling, redness, and itching associated with conditions like severe asthma, skin allergies, or lupus.
  • Osteoarthritis and Rheumatoid Arthritis: It is injected directly into affected joints to relieve intense joint pain, stiffness, and swelling, which helps restore joint movement.
  • Severe Skin Conditions: It is used to treat chronic, severe skin problems such as psoriasis, severe eczema, or raised scars (keloids) when topical creams do not provide enough relief.

Key Benefits

DEPOCILONE-40MG/1ML INJECTION provides fast and targeted relief from inflammation through injectable administration. By delivering the medicine directly to the affected area or into the bloodstream, it helps reduce pain, swelling, and inflammation quickly while supporting improved mobility and recovery.

  • Provides Targeted Relief from Inflammation: When injected into an affected joint or tissue, this medicine acts directly at the site of inflammation to reduce pain, swelling, and stiffness, allowing for more comfortable movement.
  • Offers Long-Lasting Symptom Control: Local injection into the affected area may provide prolonged relief from pain and inflammation, helping improve joint function and reduce discomfort for weeks or months, depending on your condition and treatment plan.
  • Controls Severe Inflammatory Flare-Ups: When administered for systemic inflammatory conditions, this medicine helps rapidly control severe symptoms, making it an effective option when oral medicines are not suitable or when faster relief is required.

Directions for Use

  • DEPOCILONE-40MG/1ML INJECTION must be given by a healthcare professional. It is usually administered through an intramuscular (IM) injection or directly into the joint (intra-articular). The healthcare provider will decide the appropriate dose and injection site for you.
  • Do not self-administer.
  • Be sure to inform your doctor of any other medications you are taking or any allergies you may have, especially to steroids.

How DEPOCILONE-40MG/1ML INJECTION Works

DEPOCILONE-40MG/1ML INJECTION contains triamcinolone acetonide, which is a corticosteroid that mimics the natural anti-inflammatory hormones produced by your body's adrenal glands. It works by entering cells and blocking the production of specific chemical messengers, such as prostaglandins and cytokines, which cause swelling, heat, pain, and redness. By suppressing these chemicals, it cools down the inflammatory response and prevents your immune system from accidentally attacking healthy tissues.
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Alcohol

Caution

Avoid consumption of alcohol while on treatment with DEPOCILONE-40MG/1ML INJECTION as it may increase adverse effects.

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Pregnancy

Caution

Inform your doctor if you are pregnant or planning to become pregnant before taking DEPOCILONE-40MG/1ML INJECTION. Your doctor will prescribe this medicine only if the benefits outweigh the potential risks.

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Breast Feeding

Caution

Limited information is available on the effects of DEPOCILONE-40MG/1ML INJECTION on breastfeeding. Hence, inform your doctor if you are a nursing or breastfeeding mother. Your doctor will administer this medicine only if the benefits outweigh the potential risks.

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Driving

Caution

DEPOCILONE-40MG/1ML INJECTION may cause dizziness. So, do not drive, operate heavy machinery or refrain from activities that require your alertness.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before receiving DEPOCILONE-40MG/1ML INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Before receiving $ name, let your doctor know if you have any history of kidney diseases. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

DEPOCILONE-40MG/1ML INJECTION is not recommended for use in children below 12 years of age. Please consult your doctor for more information.

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Heart

Consult your doctor

Please consult your doctor before using DEPOCILONE-40MG/1ML INJECTION if you have pre-existing heart problems. Your doctor will prescribe DEPOCILONE-40MG/1ML INJECTION if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering DEPOCILONE-40MG/1ML INJECTION to geriatric patients. Your doctor will prescribe DEPOCILONE-40MG/1ML INJECTION if the benefits outweigh the risks.

What if I have taken an overdose of DEPOCILONE-40MG/1ML INJECTION

An overdose is highly unlikely when the medicine is injected by a healthcare provider. However, if you suspect you have received too much or experience severe symptoms after your injection, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat a low-sodium diet: Corticosteroids can cause your body to retain salt and water, which raises blood pressure. Limit processed foods and extra table salt.
  • Increase potassium and calcium: Eat potassium-rich foods like bananas and calcium-rich foods like leafy greens to protect your bone health and balance fluids.
  • Rest the injected joint: If you received an injection into a joint, avoid strenuous physical activity or lifting heavy weights with that joint for 24 to 48 hours.
  • Monitor blood sugar: If you have diabetes, check your blood sugar more frequently, as this medicine can cause temporary spikes in glucose levels.
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How Soon It Starts Working

The time required for DEPOCILONE-40MG/1ML INJECTION to start to work: DEPOCILONE-40MG/1ML INJECTION can be observed within 24 to 48 hours based on the route of administration. The time for which the effects of DEPOCILONE-40MG/1ML INJECTION last: The duration of DEPOCILONE-40MG/1ML INJECTION’s effect is clinically not established.

What if you forget to take DEPOCILONE-40MG/1ML INJECTION

Since this medicine is scheduled and injected by a healthcare professional, it is unlikely you will miss a dose. If you miss an appointment for your injection, contact your doctor's office immediately to reschedule.

Storage

•Store the vials at room temperature, between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Check the liquid: Before the injection is given, ensure the solution is free of unusual clumps or discolouration.
  • Do not massage the area: Avoid rubbing or massaging the injection site after the treatment, as this can cause the medicine to spread to unintended tissues.
  • Watch for delayed infection: Tell your doctor immediately if you develop a fever, severe warmth, or increased swelling at the injection site after 48 hours.
  • Avoid live vaccines: This medicine can weaken your immune system. Talk to your doctor before receiving any live vaccines, such as those for shingles or measles.
  • Limit high-impact movements: Protect your treated joint from sudden, high-impact movements for several days following your injection.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (like warfarin): Combining these can alter how your blood clots, which may increase the risk of bleeding.
  • NSAIDs (like ibuprofen or aspirin): Taking these together can increase your risk of developing stomach ulcers or internal bleeding.
  • Diabetes medicines: DEPOCILONE-40MG/1ML INJECTION can raise your blood sugar, which may reduce the effectiveness of insulin or oral diabetes drugs.

Drug-Drug Interactions

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How does the drug interact with Depocilone 40 mg Injection 1 ml:
Co-administration of desmopressin together with Depocilone 40 mg Injection 1 ml may increase the risk of hyponatremia (a condition associated with low levels of salt in the blood).

How to manage the interaction:
Taking Depocilone 40 mg Injection 1 ml with Desmopressin is not recommended, but it should be taken if advised by a doctor. However, if you experience nausea, vomiting, headache, tiredness, irritability, difficulty concentrating, confusion, muscle spasm, weakness, , decreased urination and loss of appetite(less desire to eat), contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Depocilone 40 mg Injection 1 ml:
Using Mifepristone with Depocilone 40 mg Injection 1 ml can significantly reduce the effects of Depocilone 40 mg Injection 1 ml.

How to manage the interaction:
Taking Depocilone 40 mg Injection 1 ml with Mifepristone is not recommended but can be taken if prescribed by a doctor. However, if you notice any unusual symptoms contact a doctor. Do not discontinue any medications without consulting a doctor.
TriamcinoloneGrepafloxacin
Severe
How does the drug interact with Depocilone 40 mg Injection 1 ml:
Taking Depocilone 40 mg Injection 1 ml with grepafloxacin can increase the risk of tendinitis (tissue connecting muscle to bone becomes inflamed).

How to manage the interaction:
Although there is an interaction between Depocilone 40 mg Injection 1 ml and grepafloxacin, it can be taken together if prescribed by a doctor. Consult the doctor if you experience pain, or swelling on the back of the ankle, shoulder, biceps, hand, or thumb. Do not discontinue medications until the doctor recommends it
How does the drug interact with Depocilone 40 mg Injection 1 ml:
When Depocilone 40 mg Injection 1 ml is taken with Voriconazole may significantly increase the blood levels of Depocilone 40 mg Injection 1 ml.

How to manage the interaction:
Taking Depocilone 40 mg Injection 1 ml with Voriconazole together can result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of these symptoms - headache, feeling sick, trouble seeing, sensitivity to light, or ringing in your ears - make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Depocilone 40 mg Injection 1 ml:
Coadministration of Gatifloxacin with Depocilone 40 mg Injection 1 ml can increase the risk or severity of tendinitis (inflammation of the tendons attached to the muscle and bones).

How to manage the interaction:
Taking Gatifloxacin with Depocilone 40 mg Injection 1 ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience Stiff joints or difficulty moving your joints, joint pains, Swelling, or skin discoloration, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Depocilone 40 mg Injection 1 ml:
The use of Depocilone 40 mg Injection 1 ml together with ofloxacin may raise the risk of an abnormal heart rhythm. If you have other cardiac disorders, or electrolyte imbalances, you may be more at risk.

How to manage the interaction:
Although Ofloxacin and Depocilone 40 mg Injection 1 ml interact, they can be used if prescribed by a doctor. Consult a doctor if you have sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Depocilone 40 mg Injection 1 ml:
Taking levofloxacin with Depocilone 40 mg Injection 1 ml may increase the risk of tendinitis(inflammation of the thick fibrous cords that attach muscle to bone)

How to manage the interaction:
Although there is an interaction between levofloxacin and Depocilone 40 mg Injection 1 ml, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience pain, swelling, or inflammation in a tendon such as the back of the ankle, shoulder, biceps, hand, or thumb. Do not stop taking any medications without consulting your doctor.
How does the drug interact with Depocilone 40 mg Injection 1 ml:
Taking Ritonavir and Depocilone 40 mg Injection 1 ml may significantly increase the blood levels of Depocilone 40 mg Injection 1 ml.

How to manage the interaction:
Although taking Ritonavir and Depocilone 40 mg Injection 1 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as swelling, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat. Do not stop using any medications without consulting doctor.
TriamcinoloneDesirudin
Severe
How does the drug interact with Depocilone 40 mg Injection 1 ml:
Using desirudin together with Depocilone 40 mg Injection 1 ml may increase the risk of bleeding

How to manage the interaction:
Although taking Depocilone 40 mg Injection 1 ml and Desirudin together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Depocilone 40 mg Injection 1 ml:
Taking thalidomide together with Depocilone 40 mg Injection 1 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although there is an interaction between thalidomide and Depocilone 40 mg Injection 1 ml, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with DEPOCILONE-40MG/1ML INJECTION when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CORTICOSTEROIDS]

FAQs

DEPOCILONE-40MG/1ML INJECTION is used to treat the pain of osteoarthritis (OA) in the knee.
DEPOCILONE-40MG/1ML INJECTION works by blocking the release of certain chemical messengers involved in allergic and non-allergic-mediated inflammation. It also makes the nasal passages less sensitive to allergic triggers like pollen, animal dander or dust mites.
DEPOCILONE-40MG/1ML INJECTION works by blocking the release of certain chemical messengers involved in allergic and non-allergic-mediated inflammation. This helps reduce osteoarthritis symptoms such as pain, inflammation, swelling, and stiffness.
DEPOCILONE-40MG/1ML INJECTION weakens your immune system and increases the risk of getting infections. So, make sure you stay away from people who are sick or have infections. These conditions are life-threatening in people using steroids such as DEPOCILONE-40MG/1ML INJECTION.
Do not stop using DEPOCILONE-40MG/1ML INJECTION even if you feel better, as it may worsen your condition. However, if you experience any difficulty while using DEPOCILONE-40MG/1ML INJECTION, please consult a doctor.
Generally, doctors limit steroid injections in the same joint to 3 or 4 times a year. Overusing injections in a single joint can weaken the cartilage and joint structures. Talk to your doctor to determine the safest schedule for you.
It is highly recommended to limit or avoid alcohol. Alcohol can increase the risk of stomach irritation and bleeding when combined with corticosteroids. Talk to your doctor or pharmacist about what is safe for you.
Yes, this medicine can temporarily raise your blood sugar levels. If you have diabetes, you should monitor your blood glucose closely after your injection and talk to your doctor if you see a significant spike.
If the injection was given in a weight-bearing joint like your knee or ankle, or if you feel numb or weak, it is best to arrange for someone else to drive you home. Talk to your doctor before your appointment to plan safely.
A single injection is unlikely to cause noticeable weight gain. However, repeated injections or long-term use can lead to increased appetite and fluid retention, which may affect your weight. Talk to your doctor if you experience sudden swelling or rapid weight gain.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 208845S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Depocilone 40Mg Injection

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - DEP0250
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