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compositionComposition:MEDROXYPROGESTERONE ACETATE-10MG
prescription
Prescription Medicine
info
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Depomist 10mg Tablet is used to treat the absence of menstrual periods (amenorrhea) and abnormal uterine bleeding. Besides this, it also prevents endometrial hyperplasia (thickening of the uterine lining with the risk of cancer) and overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

MEDROXYPROGESTERONE ACETATE-10MG

Manufacturer/Marketer :

Werke Healthcare

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Depomist 10mg Tablet

Depomist 10mg Tablet is a prescription medication used to treat absent menstrual periods and abnormal bleeding from the uterus caused by a hormonal imbalance. It is also prescribed to reduce the risk of excessive growth in the lining of the uterus in women who are taking estrogens after menopause. By acting like a hormone your body produces naturally, it helps restore a regular cycle and manage uterine health.

To get the best results, you should take Depomist 10mg Tablet consistently at the same time every day. You can take this tablet with or without food, though taking it with a meal may help if you experience a mild upset stomach. Consistently taking your medication as prescribed is the most effective way to help regulate your body's hormone levels.

While taking Depomist 10mg Tablet, you may experience mild side effects like breast tenderness, headaches, or slight changes in your weight. However, you should consult your doctor immediately if you notice signs of serious complications, such as severe leg pain, sudden shortness of breath, severe headaches, or sudden changes in your vision.

Do not take this if you have active blood clots, liver damage, breast cancer, or unexplained vaginal bleeding. Before starting your treatment, talk to your doctor if you have a history of depression, high blood pressure, diabetes, or kidney problems so they can monitor your health closely.

Certain medications, such as seizure drugs, can speed up how your body processes Depomist 10mg Tablet, making it less effective. You should avoid smoking while taking this medication as it increases your risk of developing dangerous blood clots. If you are pregnant, planning to become pregnant, or breastfeeding, do not take this medicine, and always consult your doctor if you are managing other age-related health conditions.

Uses of Depomist 10mg Tablet

Depomist 10mg Tablet is used to treat absent menstrual periods and abnormal bleeding from the uterus caused by a hormonal imbalance. The detailed uses of Depomist 10mg Tablet are as follows:

  • Absent menstrual periods (amenorrhea): Depomist 10mg Tablet helps restart normal monthly menstrual cycles in women who have stopped having periods for several months due to low hormone levels.
  • Abnormal uterine bleeding: This medicine stops heavy, irregular, or prolonged bleeding from the uterus by restoring the proper hormonal balance.
  • Prevention of endometrial hyperplasia: It protects the lining of the uterus from overgrowing in postmenopausal women who are receiving estrogen replacement therapy.

Key Benefits

Depomist 10mg Tablet helps regulate the effects of progesterone in the body to manage menstrual disorders and protect the uterus in specific situations. With regular use as prescribed, it helps restore normal menstrual cycles, control abnormal bleeding, and support long-term uterine health.

  • Restores Regular Menstrual Cycles: By regulating hormonal changes, this medicine helps establish a more predictable menstrual cycle and reduces the distress associated with missed or irregular periods.
  • Controls Heavy or Irregular Bleeding: This medicine helps reduce heavy, prolonged, or irregular menstrual bleeding, relieving associated discomfort and lowering the risk of excessive blood loss and anaemia.
  • Protects the Uterine Lining: In women receiving estrogen therapy after menopause, this medicine helps prevent excessive thickening of the uterine lining, reducing the risk of abnormal changes and supporting uterine health.

Directions for Use

  • Depomist 10mg Tablet can be taken with or without food, but taking it with food helps reduce stomach upset.
  • Follow the recommended dosage and duration advised by the doctor to achieve optimal results.
  • Swallow Depomist 10mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Depomist 10mg Tablet Works

Depomist 10mg Tablet contains medroxyprogesterone acetate, which works as a replacement for progesterone, a natural female hormone that is essential for regulating ovulation and menstruation. When your body does not produce enough of this hormone, the uterine lining can grow continuously without shedding, leading to irregular bleeding or missed periods. This medication supplies the missing hormone to the body, signalling the lining of the uterus to stop growing and prepare to shed. When you finish your cycle of the medication, the sudden drop in hormone levels causes the uterine lining to shed, producing a normal menstrual period.
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Alcohol

Consult your doctor

There is not enough scientific data available for Depomist 10mg Tablet interaction with alcohol. Hence, it is best to consult a doctor.

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Pregnancy

Unsafe

Avoid taking Depomist 10mg Tablet if you are pregnant or think you may be pregnant, as Depomist 10mg Tablet might affect the developing baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Depomist 10mg Tablet. Consult your doctor if you have any concerns.

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Driving

Caution

It is advised to drive with caution after taking Depomist 10mg Tablet as it may cause dizziness.

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Liver

Caution

Depomist 10mg Tablet should be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Consult your doctor

There is not enough scientific data available regarding the use of Depomist 10mg Tablet in people with kidney problems. Hence, it is best to consult a doctor.

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Children

Unsafe

Depomist 10mg Tablet is not recommended for children below 12 years of age.

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Heart

Caution

Depomist 10mg Tablet should be taken with caution in patients with heart conditions. Please inform your doctor about any existing heart problems before starting Depomist 10mg Tablet.

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Geriatrics

Caution

Depomist 10mg Tablet should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform a healthcare professional before use.

What if I have taken an overdose of Depomist 10mg Tablet

If you take more than your prescribed dose, seek immediate medical attention. Symptoms of an overdose may include severe nausea, vomiting, or abnormal vaginal bleeding.

Diet & Lifestyle Advise

  • Avoid smoking completely: Smoking significantly increases the risk of serious cardiovascular side effects, including blood clots, stroke, and heart attacks while taking hormone therapies.
  • Support your bone health: Hormonal therapies can affect bone density. Ensure you eat a diet rich in calcium and vitamin D, including dairy products, leafy greens, or appropriate supplements.
  • Engage in regular exercise: Practice light weight-bearing exercises like walking or jogging to maintain bone strength and promote healthy blood circulation throughout your body.
  • Keep a symptom diary: Track your bleeding days, flow intensity, and any side effects in a logbook. This helps your doctor evaluate how well the treatment is working at your next checkup.
health query

Have a query?

How Soon It Starts Working

  • The time required for Depomist 10mg Tablet to start to work: The exact onset time of Depomist 10mg Tablet is clinically unknown.
  • The time for which the effects of Depomist 10mg Tablet last: The duration of action for Depomist 10mg Tablet is clinically unknown.

What if you forget to take Depomist 10mg Tablet

If you miss a dose of Depomist 10mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed tablet.

Storage

• Store Depomist 10mg Tablet at room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Confirm you are not pregnant: Always take a pregnancy test before starting a new cycle of this medication, as it should not be taken during pregnancy.
  • Perform regular breast self-exams: Check your breasts monthly for any lumps, dimpling, or unusual changes, and report anything unexpected to your healthcare provider.
  • Monitor your blood pressure: Have your blood pressure checked regularly by a healthcare professional, as hormone treatments can sometimes cause blood pressure to rise.
  • Watch for mood changes: If you have a history of depression, pay close attention to your mood. Tell your doctor immediately if you experience severe mood swings or feelings of deep sadness.
  • Inform surgical teams: If you have an upcoming surgery or need to be on prolonged bed rest, inform your doctor, as you may need to stop taking this medicine temporarily to lower blood clot risks.

verifiedApollotooltip
  • Seizure medications (such as carbamazepine, phenytoin, and phenobarbital): These medicines can speed up how your liver breaks down Depomist 10mg Tablet, reducing its levels in your blood and making it less effective.
  • Antibiotics (such as rifampin): Can lower the effectiveness of this medication by increasing its rate of elimination from your body.
  • Aminoglutethimide: May significantly lower the blood concentrations of Depomist 10mg Tablet, which can prevent it from working as intended.

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  • Grapefruit and grapefruit juice: May interfere with how your body processes this medication, potentially raising hormone levels in your blood and increasing the risk of side effects.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Depomist 10mg Tablet is used to treat heavy, painful, irregular or missed periods, absence of periods, and uterine bleeding. It is also used to treat mild to moderate endometriosis and to decrease the risk of endometrial hyperplasia (a condition that may lead to uterine cancer) while taking estrogens.
Depomist 10mg Tablet contains medroxyprogesterone acetate that works by replacing or supplementing the naturally produced female sex hormone called progesterone.
Abnormal uterine bleeding, irregular or missed periods (amenorrhea), abdominal pain during pregnancy, and frequent miscarriages are the signs of low progesterone. Additionally, low progesterone levels lead to high estrogen levels, and women can have decreased sex drive, weight gain, or gallbladder problems.
Yes, Depomist 10mg Tablet may cause weight gain. Eat healthy food and exercise regularly. If you feel that you are gaining a lot of weight while taking Depomist 10mg Tablet, please consult your doctor.
Do not use Depomist 10mg Tablet if you are allergic to medroxyprogesterone acetate, or any other similar hormonal medicines, if you have/had breast cancer, venous/arterial thrombosis, liver problems, porphyria, if you are pregnant or think you may be pregnant.
Continue taking Depomist 10mg Tablet for as long as it has been prescribed by the doctor. If you experience any difficulty while taking Depomist 10mg Tablet, consult a doctor.
Mild spotting or breakthrough bleeding can sometimes occur during the first few cycles of taking this medicine. However, if the bleeding is heavy, persistent, or concerns you, talk to your doctor.
No, oral Depomist 10mg Tablet tablets at the dosages prescribed for menstrual cycle regulation do not prevent pregnancy. You should use a reliable non-hormonal barrier method of birth control, like condoms, during treatment. Talk to your doctor.
Moderate alcohol consumption does not directly stop the medicine from working, but both alcohol and hormones can put extra strain on your liver and worsen fluid retention. Talk to your doctor.
Stop taking the medication immediately and contact your healthcare provider, as this medicine should not be used during pregnancy. Talk to your doctor.
Yes, hormonal fluctuations can cause moodiness, anxiety, or feelings of sadness in some patients. If you notice a severe change in your mood or worsening depression, talk to your doctor.
This medication can affect how your body manages blood sugar levels. You should monitor your blood glucose closely and talk to your doctor, as your diabetes medication may need to be adjusted.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.3547 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Medroxyprogesterone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. MedlinePlus. A604039 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  5. Medroxyprogesterone Acetate [Patient Information Leaflet]. 2007. [Accessed on 19 Feb. 2025]Check here
  6. Medroxyprogesterone Acetate [Patient Information Leaflet]. 2023. [Accessed on 19 Feb. 2025]Check here
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 04 Apr. 2019]Check here

Country of origin

India
Other Info - DE21137
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