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DESFERAL INJECTION 0.5GM

Manufacturer/Marketer

Novartis India Ltd

Consume Type

PARENTERAL

In Stock

Prescription Required
Product Details

About DESFERAL INJECTION 0.5GM

DESFERAL INJECTION 0.5GM belongs to the group of medicines called ‘chelating agents’ used to remove excess iron from the body in anemia or chronic iron overload due to blood transfusions in patients 2 years of age and older. It is also used with other medicines to treat acute iron poisoning, especially in small children. Besides this, DESFERAL INJECTION 0.5GM may also be used for high aluminum levels in dialysis patients and people with aluminum poisoning.

DESFERAL INJECTION 0.5GM contains Deferoxamine an iron-binding agent that belongs to a class of medicines called heavy metal antagonists. It works by binding trivalent (ferric) iron which has a strong affinity, forming ferrioxamine, a stable complex that prevents the iron from entering into further chemical reactions and also is eliminated from the body. It helps the kidneys and gallbladder get rid of the extra iron.

DESFERAL INJECTION 0.5GM will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side-effects such as flushing (sense of warmth in the face, ears, neck, and trunk), skin rash, hypotension (decreased pressure), change in color of urine to red, headache, upset stomach or throwing up, diarrhea, muscle or joint pain, irritation where the injection is given. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking DESFERAL INJECTION 0.5GM for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take DESFERAL INJECTION 0.5GM if you are pregnant or planning for pregnancy and breastfeeding unless prescribed by a doctor. Your doctor may advise you to undergo regular blood tests, kidney and liver tests, eye examinations, and hearing tests to monitor your condition. Avoid consuming alcohol along with DESFERAL INJECTION 0.5GM as it could lead to increased drowsiness and dizziness. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Uses of DESFERAL INJECTION 0.5GM

Iron Intoxication

Medicinal Benefits

DESFERAL INJECTION 0.5GM contains Deferoxamine an iron-chelating agent used for treating acute iron intoxication or emergency cases of iron poisoning. This medication can also be used to help get rid of iron in patients with high iron levels due to many blood transfusions. DESFERAL INJECTION 0.5GM works by forming a stable complex that prevents the iron and aluminum ions from entering into further chemical reactions and helping the kidneys and gallbladder eliminate the extra iron. This reduces the risk of organ damage.

Directions for Use

DESFERAL INJECTION 0.5GM will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of DESFERAL INJECTION 0.5GM

  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Skin rash
  • Hypotension (decreased blood pressure) 
  • Change in color of urine to red
  • Headache
  • Abdominal pain
  • Upset stomach or throwing up
  • Diarrhea
  • Muscle or joint pain
  • Irritation where the injection is given

In-Depth Precautions and Warning

Drug Warnings

Do not take DESFERAL INJECTION 0.5GM if you are allergic to Deferoxamine or any of the other ingredients in it. Inform your doctor if you have severe kidney problems and are on dialysis, liver disease, rheumatoid arthritis, diabetes, and any fungal infection. Do not take DESFERAL INJECTION 0.5GM if you are pregnant or planning to get pregnant and breastfeeding unless prescribed by a doctor. DESFERAL INJECTION 0.5GM may affect growth in children (especially those younger than 3 years of age) and teens in some cases. They may need regular growth checkups while taking DESFERAL INJECTION 0.5GM. Your doctor may recommend to you regular eye tests and hearing tests. DESFERAL INJECTION 0.5GM can affect your vision and your hearing.  Older adults (65 or older) may be more sensitive to the side effects of DESFERAL INJECTION 0.5GM, especially vision/hearing problems. Talk with your doctor before taking multivitamins, natural products, and diet aids. If you are using DESFERAL INJECTION 0.5GM to treat high iron levels, your doctor may advise you to take vitamin C (ascorbic acid) after using this medication for at least 1 month. Taking vitamin C will help replace vitamin C loss due to high iron levels and help the medication work to get rid of the iron. If you have a heart problem (heart failure), DESFERAL INJECTION 0.5GM should not be used with vitamin C (ascorbic acid) because severe interactions may occur. This medicine may affect certain lab tests. Inform your doctor and lab staff that you take DESFERAL INJECTION 0.5GM. If you are using DESFERAL INJECTION 0.5GM for aluminum poisoning, inform your doctor if you have seizures (fits), hypocalcemia (decreased calcium level in blood), and hyperparathyroidism.

Drug Interactions

Drug-Drug Interactions: DESFERAL INJECTION 0.5GM interacts with a medicine used to treat anxiety or schizophrenia (prochlorperazine), a medicine used to treat anemia (erythropoietin), antacids (aluminum hydroxide, aluminum carbonate), a medicine used to treat asthma (theophylline), antiviral (tenofovir, cidofovir), a contrast agent used during X-rays (diatrizoate), a medication used for the treatment of nerve damage (inotersen), radiocontrast agent (metrizamide), a diagnostic contrast agent (ioxilan), a medication used to treat epilepsy (vigabatrin).

Drug-Food Interactions: No interaction found.

Drug-Disease Interactions: DESFERAL INJECTION 0.5GM should not be used in people with renal dysfunction, auditory dysfunction, hepatic impairment, ocular dysfunction, or respiratory distress syndrome.

Drug-Drug Interactions Checker List:

  • PROCHLORPERAZINE
  • ERYTHROPOIETIN
  • ALUMINIUM HYDROXIDE
  • THEOPHYLLINE
  • TENOFOVIR DISOPROXIL
  • CIDOFOVIR
  • VIGABATRIN
  • INOTERSEN
  • DIATRIZOATE
  • IOXILAN
  • METRIZAMIDE
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      It is not known whether the DESFERAL INJECTION 0.5GM can interact with alcohol. However, you are recommended not to consume alcohol along with DESFERAL INJECTION 0.5GM to avoid unpleasant side-effects.

    • Safety Warning

      Pregnancy

      caution

      DESFERAL INJECTION 0.5GM is a pregnancy Category B medicine. It may not cause harm to an unborn fetus. However, DESFERAL INJECTION 0.5GM should be taken only when prescribed by a doctor only if he/she thinks benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      caution

      DESFERAL INJECTION 0.5GM should be used in breastfeeding mothers only if the benefits outweigh the risks as there is insufficient data available regarding the use of this medicine in breastfeeding mothers.

    • Safety Warning

      Driving

      caution

      After taking this drug, you can experience side effects like feeling dizzy, tired or alter your vision. If this occurs, do not drive or perform any work that requires a high level of concentration.

    • Safety Warning

      Liver

      caution

      DESFERAL INJECTION 0.5GM to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may have to adjust the dose if there are symptoms of nausea, vomiting, loss of appetite, dark-colored urine, or yellowing of skin/eye.

    • Safety Warning

      Kidney

      caution

      DESFERAL INJECTION 0.5GM should be used with caution in patients with renal impairment since the metal complexes are excreted via the kidneys. In these patients, dialysis will increase the elimination of chelated iron and aluminum. So, it should be used with caution in patients with kidney diseases. The dose may have to be adjusted by the doctor.

    • Safety Warning

      Children

      safe if prescribed

      In children below the age of 3 years, DESFERAL INJECTION 0.5GM may affect the growth. Regular checks on body weight and height are, therefore, recommended in children using DESFERAL INJECTION 0.5GM.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • It is essential to follow a specific diet plan created by your nutritionist to control health condition.
    • Avoid smoking and alcohol consumption.

    Special Advise

    • Your doctor may advise you to take blood and urine tests while using DESFERAL INJECTION 0.5GM to examine your health condition and ensure that this medicine treats your condition.
    • Eye examination and hearing tests are recommended while using DESFERAL INJECTION 0.5GM to affect your vision and hearing.
    • X-rays or scan results may be affected by treatment with DESFERAL INJECTION 0.5GM. Inform your doctor that you are being treated with DESFERAL INJECTION 0.5GM if an X-ray or scan is suggested.

    Other Information (DES0030)

    This item is Not Returnable.

    Expires on or after - Sep-23

    Patients Concern

    Disease/Condition Glossary

    Iron intoxication: Iron poisoning occurs from the ingestion of excess iron or increases iron levels in the blood that results in acute toxicity. Excessive iron can be damaging to the gastrointestinal system.  Iron is an essential mineral for blood production. Symptoms of iron toxicity include nausea, vomiting, diarrhea, and stomach pain. Iron can also accumulate in the organs and cause fatal damage to the liver or brain.

    FAQs

    DESFERAL INJECTION 0.5GM is an antidote that is used in the treatment of acute iron poisoning. It contains Deferoxamine which removes excess iron from the body, which is then excreted mainly in the stools. This reduces the risk of organ damage.

    DESFERAL INJECTION 0.5GM should not be used in people with any fungal infections, clouding the eye's lens (cataracts), ringing in the ears, liver disease, seizures, and heart problems. It should also be used with extreme caution in people with severe kidney impairment as this medicine may cause kidney damage.

    Iron poisoning is treatable, and you can survive this condition with a quick diagnosis and accurate treatment.

    DESFERAL INJECTION 0.5GM may cause side-effects such as pain, redness, swelling at the injection site, flushing (sense of warmth in the face, ears, neck, and trunk), rash, decreased blood pressure, abdominal pain. These side-effects are usually mild and temporary. However, if any of these side-effects persist or get worse, inform your doctor immediately.

    Yes, DESFERAL INJECTION 0.5GM can cause abnormal liver or renal function test results. X-rays or scans results may also be affected by treatment with DESFERAL INJECTION 0.5GM. Ensure that the doctor or nurse knows that you are being treated with DESFERAL INJECTION 0.5GM if a laboratory test and X-ray or scan is suggested.

    Country Of Origin

    Switzerland

    Manufacturer/Marketer address

    Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India

    Disclaimer

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    (Inclusive of all taxes)

    Provide Delivery Location

    Vial

    1

    1 Injection in 1 Vial