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compositionComposition:ACECLOFENAC-100MG+DIACEREIN-50MG
prescription
Prescription Medicine
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Diatril Ace 100mg/50mg Tablet is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It contains Aceclofenac and Diacerein which work by blocking the action of chemical messengers that cause pain and specific proteins that cause degradation of cartilage. This medicine may sometimes cause side effects such as nausea, vomiting, indigestion, heartburn, stomach pain, diarrhoea, and loss of appetite. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ACECLOFENAC-100MG+DIACEREIN-50MG

Manufacturer/Marketer :

Werke Healthcare

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Diatril Ace 100mg/50mg Tablet

Diatril Ace 100mg/50mg Tablet is an oral prescription medicine used to relieve pain, swelling, and stiffness caused by osteoarthritis. It combines a pain-relieving anti-inflammatory medicine with a medicine that helps slow the breakdown of joint cartilage, improving joint function and making everyday movements more comfortable over time.

For the best results, it is important to take Diatril Ace 100mg/50mg Tablet regularly and consistently exactly as your doctor has prescribed. This medication should be taken with food to reduce the chance of stomach irritation. Along with taking Diatril Ace 100mg/50mg Tablet, maintaining a healthy weight, staying physically active with low-impact exercises, and following a balanced diet can help improve joint health and mobility.

While taking Diatril Ace 100mg/50mg Tablet, some people may experience common side effects such as diarrhea, nausea, indigestion, stomach pain, or dizziness. These side effects are usually mild, but seek medical attention immediately if you develop severe stomach pain, black or bloody stools, vomiting blood, yellowing of the skin or eyes, or signs of a serious allergic reaction.

Before starting Diatril Ace 100mg/50mg Tablet, tell your doctor if you have a history of stomach ulcers, gastrointestinal bleeding, kidney disease, liver disease, heart disease, high blood pressure, or asthma. Do not take Diatril Ace 100mg/50mg Tablet if you have severe liver disease, active stomach or intestinal bleeding, or if you are allergic to aceclofenac, diacerein, or other NSAIDs. Your doctor will determine whether Diatril Ace 100mg/50mg Tablet is suitable for you.

Diatril Ace 100mg/50mg Tablet can interact with blood thinners, corticosteroids, diuretics, blood pressure medicines, and certain other pain relievers, which may increase the risk of side effects or affect treatment. Avoid drinking alcohol while taking Diatril Ace 100mg/50mg Tablet, as it can increase the risk of stomach irritation and bleeding. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor before using Diatril Ace 100mg/50mg Tablet.

Uses of Diatril Ace 100mg/50mg Tablet

Diatril Ace 100mg/50mg Tablet is used in the treatment of osteoarthritis and associated joint pain and inflammation. The detailed uses of Diatril Ace 100mg/50mg Tablet are as follows:

  •  Osteoarthritis: Diatril Ace 100mg/50mg Tablet helps reduce joint pain, swelling, and inflammation while supporting cartilage health, making it easier to move and perform daily activities.
  • Joint Pain and Stiffness: It helps relieve chronic joint pain, stiffness, and reduced mobility in conditions associated with osteoarthritis, improving overall joint function.
  • Inflammation of the Joints: It helps reduce inflammation in affected joints, providing long-lasting relief from pain and improving physical comfort and mobility.

Key Benefits

Diatril Ace 100mg/50mg Tablet helps relieve joint pain and inflammation while supporting long-term joint health in people with osteoarthritis. By improving comfort and mobility, it helps you perform daily activities more easily and maintain an active lifestyle.
Benefits may include:

  •  Helps relieve joint pain and stiffness associated with osteoarthritis.
  • Reduces inflammation and swelling in affected joints.
  • Improves joint mobility and flexibility for better daily functioning.
  • Supports long-term joint health by helping maintain healthy cartilage and slowing its breakdown.
  • Helps improve physical activity and overall quality of life.
  • Provides both symptomatic relief and long-term support for joint function.
Side effects of Diatril Ace 100mg/50mg Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Diatril Ace 100mg/50mg Tablet can be taken with meals to prevent stomach upset.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Diatril Ace 100mg/50mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Diatril Ace 100mg/50mg Tablet Works

Diatril Ace 100mg/50mg Tablet contains Aceclofenac and Diacerein. Aceclofenac: It helps relieve pain, swelling, and inflammation by reducing the substances in the body that cause these symptoms. This helps improve comfort and joint movement. Diacerein: It helps protect the cartilage in the joints and slows its breakdown. This helps reduce joint damage over time and supports better joint function in osteoarthritis.
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Alcohol

Caution

Consumption of alcohol with Diatril Ace 100mg/50mg Tablet is not recommended during treatment with Diatril Ace 100mg/50mg Tablet due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, nausea, joint pain, and fever. So please consult your doctor before taking Diatril Ace 100mg/50mg Tablet, if you have a habit of drinking alcohol.

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Pregnancy

Caution

Diatril Ace 100mg/50mg Tablet use during pregnancy is not recommended unless your doctor believes it is necessary. (It must not be used during the final three months of pregnancy.) Please consult your doctor before using this medicine if you are pregnant or planning a pregnancy.

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Breast Feeding

Caution

Diatril Ace 100mg/50mg Tablet is not recommended for use in breastfeeding as it is not known whether this medicine passes into breast milk. Your doctor may prescribe a safer alternative medicine based on the clinical condition.

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Driving

Caution

Diatril Ace 100mg/50mg Tablet may decrease alertness, affect your vision or make you sleepy and dizzy. Do not drive if these symptoms occur after taking Diatril Ace 100mg/50mg Tablet.

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Liver

Caution

Diatril Ace 100mg/50mg Tablet should be used with caution in patients with liver disease due to the increased risk of serious side effects. Close monitoring of liver function, appropriate dose adjustments or replacement with alternative medicine may be required based on your clinical condition.

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Kidney

Caution

Diatril Ace 100mg/50mg Tablet should be used with caution in patients with kidney diseases due to the increased risk of serious side effects. Close monitoring of kidney function, appropriate dose adjustments or replacement with alternative medicine may be required based on your clinical condition.

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Children

Caution

The safety and efficacy of Diatril Ace 100mg/50mg Tablet in children have not been established. Diatril Ace 100mg/50mg Tablet is not recommended for use in children.

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Heart

Unsafe

Diatril Ace 100mg/50mg Tablet is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

Diatril Ace 100mg/50mg Tablet can be given in elderly patients with extreme caution, due to the cause of adverse effects like liver/kidney problems,or gastrointestinal problems.

What if I have taken an overdose of Diatril Ace 100mg/50mg Tablet

In case of an accidental overdose, seek immediate medical attention or contact a poison control center right away. Do not wait for symptoms of discomfort to appear.

Diet & Lifestyle Advise

  •  Maintain a healthy weight: Aim for a healthy, stable weight to reduce pressure on weight-bearing joints such as your knees and hips.
  • Choose low-impact exercise: Engage in activities such as swimming, cycling, or walking to help strengthen the muscles around your joints and improve flexibility without placing excessive stress on them.
  • Follow an anti-inflammatory diet: Include foods rich in omega-3 fatty acids, whole grains, and a variety of fresh vegetables to help support joint health and overall wellbeing.
  • Stay well hydrated: Drink plenty of water throughout the day to help maintain joint lubrication and support kidney function while taking your medication.
  • Avoid high-impact activities: Limit activities such as running or heavy jumping, as they can place excessive strain on inflamed or painful joints.
health query

Have a query?

How Soon It Starts Working

The time required for Diatril Ace 100mg/50mg Tablet to start to work: Diatril Ace 100mg/50mg Tablet ideally shows its action within 2 hours after administration. The time for which the effects of Diatril Ace 100mg/50mg Tablet last: The duration of action for Diatril Ace 100mg/50mg Tablet is clinically unknown.

What if you forget to take Diatril Ace 100mg/50mg Tablet

If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Diatril Ace 100mg/50mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Avoid taking other pain relievers without medical advice: Do not use other NSAID pain medicines, such as ibuprofen or naproxen, while taking Diatril Ace 100mg/50mg Tablet unless specifically advised by your doctor, as this may increase the risk of stomach ulcers and bleeding.
  • Monitor your bowel movements: Contact your doctor promptly if you develop severe or persistent diarrhea, as your dose may need to be adjusted or treatment temporarily stopped.
  • Avoid alcohol during treatment: Drinking alcohol while taking Diatril Ace 100mg/50mg Tablet may increase the risk of stomach irritation, ulcers, and bleeding.
  • Inform healthcare providers before procedures: Tell your doctor, dentist, or surgeon that you are taking Diatril Ace 100mg/50mg Tablet before any medical, surgical, or dental procedure.
  • Attend regular monitoring appointments: If you are using Diatril Ace 100mg/50mg Tablet for a prolonged period, your doctor may recommend periodic blood tests to monitor your liver and kidney function.

Drug-Drug Interactions

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  • Blood thinners (e.g., warfarin): Taking these medicines alongside Diatril Ace 100mg/50mg Tablet may increase the risk of serious bleeding.
  • Other nonsteroidal anti-inflammatory drugs (NSAIDs) or pain relievers: Combining these with Diatril Ace 100mg/50mg Tablet may increase the risk of stomach ulcers, bleeding, and kidney problems.
  • Diuretics (water pills) and blood pressure medicines: Diatril Ace 100mg/50mg Tablet may reduce the effectiveness of these medicines and increase the risk of kidney damage.
  • Lithium or methotrexate: Taking these medicines alongside Diatril Ace 100mg/50mg Tablet may increase their levels in the body, raising the risk of toxicity.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Food: Take Diatril Ace 100mg/50mg Tablet with food or after a meal to help reduce the risk of stomach irritation.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- INFLAMMATORY AGENTS]

FAQs

Diatril Ace 100mg/50mg Tablet is used to relieve pain and inflammation (swelling) in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Diatril Ace 100mg/50mg Tablet is composed of two medicines: Aceclofenac and Diacerine. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Diacerine works by blocking the actions of a certain specific protein that causes swelling, and pain and reduces friction in the joints by the building of cartilage (the soft connective tissue in the bones near the joints) in the joints.
Diatril Ace 100mg/50mg Tablet may cause common side effects like nausea, vomiting, indigestion, heartburn, stomach pain, diarrhea, loss of appetite, and intense yellow urine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
No, Diatril Ace 100mg/50mg Tablet does not cure Rheumatoid arthritis, but instead, it helps in reducing the pain and inflammation caused by it as it is a pain killer.
No, do not stop taking Diatril Ace 100mg/50mg Tablet suddenly. If you want to stop taking this medicine, consult your doctor so that he/she might gradually reduce the dose to avoid an unwanted increase in pain or inflammation.
No, Diatril Ace 100mg/50mg Tablet should ideally not be taken for stomach pain without consulting a physician. This medication can increase the secretion of stomach acid, which may worsen gastritis or an unknown underlying stomach ulcer.
You may feel some pain relief within a few hours due to the fast-acting pain reliever component. However, the joint-protecting effects of the other component build up slowly and may take a few weeks of consistent use to show full benefits. Talk to your doctor if you do not notice any improvement after a few weeks.
Yes, mild diarrhea is a common side effect of one of the active components in Diatril Ace 100mg/50mg Tablet, especially during the first few days of starting the treatment. If the diarrhea is severe, persistent, or causes dehydration, stop taking Diatril Ace 100mg/50mg Tablet and talk to your doctor immediately.
It is safest to avoid alcohol while taking Diatril Ace 100mg/50mg Tablet. Alcohol can increase the risk of stomach irritation, bleeding, and liver strain when combined with this medication. Talk to your doctor if you have concerns about alcohol use.
You should avoid taking Diatril Ace 100mg/50mg Tablet if you are pregnant or breastfeeding unless specifically advised by your doctor, as it may not be safe for the baby. Always talk to your doctor or pharmacist to discuss safer alternatives.
Yes, this medication can cause your urine to appear a darker yellow or slightly brownish-yellow color. This is a completely harmless effect of Diatril Ace 100mg/50mg Tablet and is not a cause for concern. Talk to your doctor if you notice any other unusual symptoms.
You should avoid taking other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or diclofenac while taking Diatril Ace 100mg/50mg Tablet, as this significantly increases the risk of stomach ulcers and bleeding. Talk to your doctor before combining any pain medications.
Yes, it is often prescribed for long-term management of osteoarthritis, but it should only be used under the close supervision of your healthcare provider. Your doctor may monitor your kidney and liver health periodically. Talk to your doctor about the appropriate duration of your treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.4240 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Aceclofenac 100Mgs Leaflet Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. MIMS Drug Reference Compendium. Diacerein Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. ScienceDirect ScienceDirect. [Accessed on 22 Apr. 2019]Check here
  5. T S A Fidelix, B G D O Soares, V F M Trevisani. Diacerein for osteoarthritis. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. January 2006. [Accessed on 25th May 2022]Check here
  6. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021]. [Accessed on 25th May 2022]Check here
  7. Aceclofenac + Diacerein Tablet. Central Drugs Standard Control Organization. April 2008. [Accessed on 25th May 2022]Check here

Country of origin

India
Other Info - DI74941
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