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compositionComposition:VALPROIC ACID-200MG
prescription
Prescription Medicine
info
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Dilpra 250Mg Tablet is used to treat seizures and manage manic episodes in bipolar disorder. It also helps prevent migraine attacks. It supports better brain stability and reduces symptom frequency. This helps improve daily functioning and overall quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

VALPROIC ACID-200MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Dilpra 250Mg Tablet

Dilpra 250Mg Tablet is an oral prescription medication used to control various types of seizures in people with epilepsy. It is also prescribed to treat the manic phase of bipolar disorder and to prevent migraine headaches from occurring. This medicine works by calming overactive nerve activity in the brain to help stabilise your mood and prevent abnormal brain signals.

To get the best results, you must take Dilpra 250Mg Tablet consistently every day at the same time as directed by your doctor. You can take this medicine with or without food, but taking it with meals can help prevent an upset stomach. Incorporating a regular sleep schedule, managing stress levels, and avoiding known seizure or migraine triggers can also support the effectiveness of your treatment.

While taking Dilpra 250Mg Tablet, you may experience some common side effects such as mild sleepiness, nausea, or temporary hair thinning. However, you must seek medical help immediately if you notice serious symptoms like severe abdominal pain, dark urine, yellowing of your skin or eyes, or unusual mood changes.

Before starting this medication, tell your doctor if you have a history of liver problems, kidney disease, or pancreatic disorders. Do not take this if you have a family history of severe liver damage or genetic mitochondrial disorders. Pregnant women, or those planning to become pregnant, should not take this medicine for migraine prevention, and should only use it for epilepsy or bipolar disorder if no other treatments are suitable, due to a high risk of birth defects.

Dilpra 250Mg Tablet can interact with alcohol, which can worsen drowsiness, and with other medicines like aspirin or certain antidepressants by changing how your body processes them. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss the risks and benefits before starting this medicine.

Uses of Dilpra 250Mg Tablet

Dilpra 250Mg Tablet is used for the treatment of epilepsy (seizures), bipolar disorder, and migraine. The detailed uses of Dilpra 250Mg Tablet are as follows:

  • Epilepsy and Seizure Control: Dilpra 250Mg Tablet helps prevent and control various types of seizures, including absence seizures, complex partial seizures, and generalised tonic-clonic seizures, by reducing abnormal electrical activity in the brain.
  • Bipolar Disorder (Manic Episodes): Dilpra 250Mg Tablet helps stabilise mood swings and manage manic episodes, which are periods of overly high, excited, or irritable mood.
  • Migraine Prevention: Dilpra 250Mg Tablet reduces the frequency and severity of migraine headaches when taken daily as a preventive treatment.

Key Benefits

Dilpra 250Mg Tablet helps manage seizures, stabilise mood in bipolar disorder, and prevent migraine headaches, helping you lead a more active and balanced life.

The following are the benefits of Dilpra 250Mg Tablet:

  • Helps reduce the frequency and severity of seizures.
  • Improves mood stability in people with bipolar disorder.
  • Reduces the occurrence of migraine headaches.
  • Supports better concentration and emotional well-being.
  • Promotes greater confidence in carrying out everyday activities.
  • Provides long-term control of symptoms with regular treatment.
Side effects of Dilpra 250Mg Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat eggs for zinc and other nutrients that support healthy vision.
  • Consume blueberries as antioxidants to combat eye strain.
  • Include broccoli in your diet for diverse eye-boosting nutrients.
  • Eat sweet potatoes as a natural source of vitamin A.
  • Snack on almonds for vitamin E and eye protection.
  • Add tomatoes to your diet for lycopene and vision protection.
  • Perform exercises that improve binocular vision, such as dot-to-dot cards, coloring within lines, and Brock string tests.
  • Wear an eye patch and perform tasks like playing games and solving puzzles.
  • Patching and eye exercises can improve symptoms.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Swallow the tablets or capsules whole with a full glass of water. Do not crush, chew, or break it.
  • Take this medicine with food if it causes an upset stomach.
  • Never change your dose or stop taking this medication suddenly without talking to your doctor first. Stopping abruptly can cause your seizures to return or worsen.
  • Always follow your doctor's exact instructions regarding your dosing schedule.

How Dilpra 250Mg Tablet Works

Dilpra 250Mg Tablet contains valproic acid, which works by stabilising electrical activity in the brain. In conditions like epilepsy, bipolar disorder, and migraines, brain cells can become overactive and send rapid, uncontrolled signals. To help restore balance, Dilpra 250Mg Tablet increases the levels of a natural calming chemical in the brain called gamma-aminobutyric acid (GABA), which helps slow excessive nerve activity. It also reduces abnormal electrical signalling by blocking certain sodium channels and T-type calcium channels in nerve cells. Together, these actions help keep nerve signals stable, thereby preventing seizures, managing mood shifts, and reducing processes that can trigger migraines.
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Alcohol

Unsafe

Do not consume alcohol while taking Dilpra 250Mg Tablet as alcohol can worsen the side effects of the Dilpra 250Mg Tablet, including sleepiness and dizziness.

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Pregnancy

Unsafe

Dilpra 250Mg Tablet is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with Dilpra 250Mg Tablet.

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Breast Feeding

Caution

Dilpra 250Mg Tablet passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking Dilpra 250Mg Tablet. Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

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Driving

Unsafe

Dilpra 250Mg Tablet may cause dizziness, drowsiness, or fatigue in some individuals. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking Dilpra 250Mg Tablet.

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Liver

Caution

Inform your doctor before taking the Dilpra 250Mg Tablet if you have a history of liver diseases. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing Dilpra 250Mg Tablet.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

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Children

Caution

Use is not recommended for children under 10 years old. Your doctor will decide the dose based on your child's condition if they are more than ten years old.

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Heart

Caution

Dilpra 250Mg Tablet can be used cautiously in patients with heart disease if prescribed by a physician.

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Geriatrics

Caution

Dilpra 250Mg Tablet can be given to elderly patients with extreme caution if prescribed by a physician.

What if I have taken an overdose of Dilpra 250Mg Tablet

If you suspect an overdose, seek immediate emergency medical attention or call your local poison control centre. Symptoms of an overdose may include severe drowsiness, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid alcohol: Do not drink alcohol while taking this medicine, as it can increase drowsiness, dizziness, and the risk of liver problems.
  • Maintain a healthy diet: Eat a balanced diet and check your weight regularly, as this medicine may increase your appetite and lead to weight gain.
  • Stay well hydrated: Drink plenty of water throughout the day to support kidney function and your overall health.
  • Care for your hair and skin: Use gentle hair care products and moisturising skin creams if you notice temporary hair thinning or dry skin while taking this medicine.
  • Keep a symptom diary: Record your seizures, mood changes, or migraine episodes to help your doctor monitor your progress and adjust your treatment if needed.
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Have a query?

How Soon It Starts Working

  • The time required for Dilpra 250Mg Tablet to start to work: Dilpra 250Mg Tablet ideally shows its action within 1 to 4 hours after administration.
  • The time for which the effects of Dilpra 250Mg Tablet last: The effect of Dilpra 250Mg Tablet lasts for 13 to 19 hours.

What if you forget to take Dilpra 250Mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Dilpra 250Mg Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Attend regular blood tests: Get the blood tests your doctor recommends to check your liver, pancreas, and the amount of medicine in your body. This helps ensure the medicine is working safely.
  • Use effective birth control: If you can become pregnant, use reliable birth control while taking this medicine. Dilpra 250Mg Tablet can seriously harm an unborn baby.
  • Watch for mood changes: Contact your doctor right away if you notice unusual changes in your mood, behaviour, or thoughts, including feelings of depression or thoughts of self-harm.
  • Tell healthcare providers about this medicine: Inform your doctor, dentist, or surgeon that you are taking this medicine before any procedure. It can affect how your blood clots.
  • Be careful with activities requiring alertness: Do not drive, operate heavy machinery, or do other dangerous activities until you know how this medicine affects you. It may cause drowsiness or reduce alertness.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g., phenytoin, carbamazepine): Taking these medicines alongside Dilpra 250Mg Tablet may affect how either medicine works and may increase the risk of side effects or reduce seizure control.
  • Blood thinners (e.g., warfarin): Taking these medicines with Dilpra 250Mg Tablet may increase the risk of bleeding and may require closer monitoring.
  • Certain antibiotics (e.g., meropenem, imipenem): These antibiotics may greatly reduce the amount of Dilpra 250Mg Tablet in the body, increasing the risk of breakthrough seizures.
DivalproexGlycerol phenylbutyrate
Critical
DivalproexMipomersen
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Dilpra 250Mg Tablet:
Coadministration of Glycerol phenylbutyrate and Dilpra 250Mg Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Dilpra 250Mg Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexMipomersen
Severe
How does the drug interact with Dilpra 250Mg Tablet:
Co-administration of Dilpra 250Mg Tablet and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Dilpra 250Mg Tablet and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Dilpra 250Mg Tablet:
Co-administration of Sodium phenylbutyrate and Dilpra 250Mg Tablet can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Dilpra 250Mg Tablet with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexDoripenem
Severe
How does the drug interact with Dilpra 250Mg Tablet:
Co-administration of Dilpra 250Mg Tablet and Doripenem can reduce the blood levels of Dilpra 250Mg Tablet sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Dilpra 250Mg Tablet with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
DivalproexErtapenem
Severe
How does the drug interact with Dilpra 250Mg Tablet:
Coadministration of Ertapenem with Dilpra 250Mg Tablet may reduce the blood levels of Dilpra 250Mg Tablet and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Dilpra 250Mg Tablet if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexEsketamine
Severe
How does the drug interact with Dilpra 250Mg Tablet:
Coadministration of Esketamine and Dilpra 250Mg Tablet can increase the side effects of esketamine.

How to manage the interaction:
Although taking Dilpra 250Mg Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexMeropenem
Severe
How does the drug interact with Dilpra 250Mg Tablet:
Co-administration of Dilpra 250Mg Tablet and Meropenem can reduce the blood levels of Dilpra 250Mg Tablet sodium.

How to manage the interaction:
Co-administration of Dilpra 250Mg Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexSodium oxybate
Severe
How does the drug interact with Dilpra 250Mg Tablet:
Co-administration of Sodium oxybate and Dilpra 250Mg Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Dilpra 250Mg Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexBuprenorphine
Severe
How does the drug interact with Dilpra 250Mg Tablet:
Co-administration of buprenorphine with Dilpra 250Mg Tablet may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Dilpra 250Mg Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexVorinostat
Severe
How does the drug interact with Dilpra 250Mg Tablet:
Coadministration of Dilpra 250Mg Tablet and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Dilpra 250Mg Tablet and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Carbonated beverages (e.g., soda, sparkling water): Consuming these drinks while taking Dilpra 250Mg Tablet may increase the risk of irritation to the mouth and throat.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Dilpra 250Mg Tablet is used to treat epilepsy/seizures/fits. In addition, it also helps treat manic episodes associated with bipolar disorder and prevent migraine symptoms (like a headache).
Dilpra 250Mg Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.
Dilpra 250Mg Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.
Dilpra 250Mg Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraines are a neurological condition characterised by intense headaches.
Dilpra 250Mg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Use an effective method of contraception during the treatment with Dilpra 250Mg Tablet. Avoid getting pregnant while taking Dilpra 250Mg Tablet as it could lead to serious birth defects. Do not stop taking Dilpra 250Mg Tablet and consult your doctor immediately if you become pregnant.
Dilpra 250Mg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Dilpra 250Mg Tablet may cause common side effects such as nausea, vomiting, headache, sleepiness, tremor, weakness, dizziness, stomach pain, and weight gain. If these side effects persist or worsen, please consult your doctor.
Dilpra 250Mg Tablet contains Valproic acid as its active ingredient.
Take Dilpra 250Mg Tablet with food to avoid stomach upset or as advised by your doctor.
You are recommended to avoid alcohol consumption while taking Dilpra 250Mg Tablet as it may worsen the side effects of the Dilpra 250Mg Tablet, including sleepiness and dizziness.
No, Dilpra 250Mg Tablet does not cause addiction. However, Dilpra 250Mg Tablet should be used as per the dose and duration prescribed by your doctor. Do not self-medicate.
Dilpra 250Mg Tablet does not cure epilepsy; it only helps prevent seizures. However, you must take Dilpra 250Mg Tablet for as long as your doctor advises. If you face any difficulty while taking Dilpra 250Mg Tablet, consult your doctor.
If you stop taking Dilpra 250Mg Tablet suddenly, it may increase the risk of recurrence of seizures. Therefore, it should be stopped gradually. If you feel the need to discontinue Dilpra 250Mg Tablet, please consult your physician.
Some birth control pills (oestrogen-containing birth control pills) may lower the levels of Dilpra 250Mg Tablet in blood. Thus, inform your doctor if you are using birth control pills and discuss with your doctor about a suitable method of contraception.
Dilpra 250Mg Tablet is safe for long-term use in many patients when prescribed by a physician. In rare cases, prolonged use of Dilpra 250Mg Tablet may weaken bones, thereby increasing the risk of fractures (osteopenia and osteoporosis). Get regular checkups for bone health if you have been taking Dilpra 250Mg Tablet for a long time.
Dilpra 250Mg Tablet may cause hair thinning, hair colour changes and even hair loss. If you have any concerns about this, please ask your doctor whether it is possible to reduce the dose of Dilpra 250Mg Tablet. Your hair may regrow after either lowering your dose or changing medication.
Your doctor will order regular blood tests to check the levels of Dilpra 250Mg Tablet in your body and to monitor how well your liver and blood cells are working. This ensures the medicine is working safely and effectively. Talk to your doctor if you have questions about your tests.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Valproic Acid Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.6102 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 018081S065 018082S048Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Valproic Acid - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Valporic acid. 1978. [Accessed on 19 Mar 2019]Check here
  6. Valproic acid. 2026. [Accessed on 21 Apr. 2026]Check here
  7. Sodium valproate: medicine to treat epilepsy and bipolar disorder [Internet]. nhs.uk. 2025 [Accessed on 10 Mar 2025]Check here

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - DIL0173

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