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  1. Home
  2. Medicine

  3. Disadex 500 Tablet ER

Prescription drug
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Disadex 500 Tablet ER, Pack of 1 Tablet
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Extra 15% Off with Bank Offers

Composition :

DIVALPROEX-500MG

Manufacturer/Marketer :

Dorris Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Disadex 500 Tablet ER

Disadex 500 Tablet ER is used to treat epilepsy/seizures/fits. Additionally, Disadex 500 Tablet ER is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain.

Disadex 500 Tablet ER contains 'Divalproex', which reduces excessive, abnormal nerve activity in the brain. Thereby helping in controlling seizures.

Disadex 500 Tablet ER increases the levels of the chemical substance GABA; this helps block nerve transmission in the brain and produces a calming effect. Thereby helping treat bipolar disorder.

In some cases, you may experience side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Talk to your doctor if you experience these side effects persistently.

Do not take Disadex 500 Tablet ER if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Disadex 500 Tablet ER. Consult your doctor if you are breastfeeding. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Disadex 500 Tablet ER

Disadex 500 Tablet ER is used in the treatment of epilepsy, bipolar disorder, and migraine. The detailed uses of Disadex 500 Tablet ER are as follows:

  • Seizure Management: Disadex 500 Tablet ER is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.
  • Bipolar Disorder Treatment: Disadex 500 Tablet ER can be utilised in the treatment of bipolar disorder, aiding in mood stabilisation and reducing the frequency of mood swings.
  • Migraine Prevention: Disadex 500 Tablet ER may also be prescribed to prevent migraines, providing relief from recurrent headaches.

Have a query?

Directions for Use

  • Disadex 500 Tablet ER can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Disadex 500 Tablet ER as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Disadex 500 Tablet ER is used to treat and prevent epilepsy, seizures, or fits by controlling abnormal electrical activity in the brain.
  • It helps manage various types of seizures, including simple partial, complex partial, and absence seizures.
  • Disadex 500 Tablet ER may be used alone or in combination with other anti-epileptic medicines for better seizure control.
  • It is also prescribed to treat mood disorders, such as bipolar disorder, by enhancing GABA (gamma-aminobutyric acid) activity in the brain, which produces a calming and stabilising effect.
  • Disadex 500 Tablet ER helps prevent migraine headaches by reducing abnormal nerve transmission and limiting the spread of pain signals.
  • By decreasing excessive nerve activity, Disadex 500 Tablet ER restores normal brain function and helps maintain emotional balance.
  • Disadex 500 Tablet ER provides broad neurological benefits by controlling seizures, stabilising mood, and reducing migraine frequency.

How Disadex 500 Tablet ER Works

Disadex 500 Tablet ER contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Disadex 500 Tablet ER increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Disadex 500 Tablet ER
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat eggs for zinc and other nutrients that support healthy vision.
  • Consume blueberries as antioxidants to combat eye strain.
  • Include broccoli in your diet for diverse eye-boosting nutrients.
  • Eat sweet potatoes as a natural source of vitamin A.
  • Snack on almonds for vitamin E and eye protection.
  • Add tomatoes to your diet for lycopene and vision protection.
  • Perform exercises that improve binocular vision, such as dot-to-dot cards, coloring within lines, and Brock string tests.
  • Wear an eye patch and perform tasks like playing games and solving puzzles.
  • Patching and eye exercises can improve symptoms.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Disadex 500 Tablet ER

Do not take more than the prescribed dose of Disadex 500 Tablet ER as it may cause overdose resulting in heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Disadex 500 Tablet ER if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders.
  • Inform your doctor before taking Disadex 500 Tablet ER if you have pancreatitis, blood problems or multi-organ hypersensitivity.
  • Consult your doctor immediately if you experience suicidal tendencies while taking Disadex 500 Tablet ER.
  • Disadex 500 Tablet ER may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems.
  • Please do not stop taking Disadex 500 Tablet ER without consulting your doctor to avoid worsening of seizures.
  • Do not take Disadex 500 Tablet ER if you are pregnant, as it could cause serious birth defects.
  • If you are of childbearing age, use effective contraception while taking Disadex 500 Tablet ER.
  • Consult your doctor before taking Disadex 500 Tablet ER if you are breastfeeding.
  • Avoid driving or operating machinery as Disadex 500 Tablet ER causes dizziness and may affect thinking and motor skills.
  • Avoid consuming alcohol along with Disadex 500 Tablet ER as it could lead to increased dizziness.
  • Care should be taken while giving Disadex 500 Tablet ER to children below 2 years, as there is a higher risk of liver intoxication during the first six months of treatment.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
DivalproexGlycerol phenylbutyrate
Critical
DivalproexKetamine
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Disadex 500 Tablet ER:
Coadministration of Glycerol phenylbutyrate and Disadex 500 Tablet ER can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Disadex 500 Tablet ER together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexKetamine
Severe
How does the drug interact with Disadex 500 Tablet ER:
Co-administration of Disadex 500 Tablet ER and Ketamine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Disadex 500 Tablet ER and Ketamine can lead to an interaction, it can be taken if advised by your doctor. If you have any symptoms such as dizziness, drowsiness, shortness of breath, or impairment in thinking and motor coordination, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
DivalproexTeriflunomide
Severe
How does the drug interact with Disadex 500 Tablet ER:
Co-administration of Disadex 500 Tablet ER and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Disadex 500 Tablet ER and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexEsketamine
Severe
How does the drug interact with Disadex 500 Tablet ER:
Coadministration of Esketamine and Disadex 500 Tablet ER can increase the side effects of esketamine.

How to manage the interaction:
Although taking Disadex 500 Tablet ER and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexErtapenem
Severe
How does the drug interact with Disadex 500 Tablet ER:
Coadministration of Ertapenem with Disadex 500 Tablet ER may reduce the blood levels of Disadex 500 Tablet ER and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Disadex 500 Tablet ER if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexLeflunomide
Severe
How does the drug interact with Disadex 500 Tablet ER:
Co-administration of Disadex 500 Tablet ER and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Disadex 500 Tablet ER and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DivalproexBexarotene
Severe
How does the drug interact with Disadex 500 Tablet ER:
Co-administration of Disadex 500 Tablet ER and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Disadex 500 Tablet ER and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexKetoconazole
Severe
How does the drug interact with Disadex 500 Tablet ER:
Coadministration of Ketoconazole and Disadex 500 Tablet ER may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Disadex 500 Tablet ER together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexBuprenorphine
Severe
How does the drug interact with Disadex 500 Tablet ER:
Co-administration of buprenorphine with Disadex 500 Tablet ER may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Disadex 500 Tablet ER can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexLomitapide
Severe
How does the drug interact with Disadex 500 Tablet ER:
Co-administration of Disadex 500 Tablet ER and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Disadex 500 Tablet ER and lomitapide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without the doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.
  • The Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan, help those around you know what to do.
  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Disadex 500 Tablet ER Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Disadex 500 Tablet ER as it may cause increased dizziness.

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Pregnancy

Unsafe

Disadex 500 Tablet ER belongs to pregnancy category D. Avoid taking Disadex 500 Tablet ER if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

Disadex 500 Tablet ER may pass into breastmilk. Consult your doctor before taking Disadex 500 Tablet ER if you are breastfeeding.

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Driving

Unsafe

Disadex 500 Tablet ER causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

Disadex 500 Tablet ER should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

Disadex 500 Tablet ER can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years, as they are at a higher risk of liver toxicity.

FAQs

Disadex 500 Tablet ER is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.

Disadex 500 Tablet ER decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.

Disadex 500 Tablet ER helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.

Disadex 500 Tablet ER limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.

Disadex 500 Tablet ER may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Disadex 500 Tablet ER only after consulting a doctor.

Disadex 500 Tablet ER may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.

Do not discontinue Disadex 500 Tablet ER without consulting your doctor. To treat your condition effectually, continue taking Disadex 500 Tablet ER for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Disadex 500 Tablet ER; your doctor will gradually reduce the dose to avoid worsening seizures.

Before taking Disadex 500 Tablet ER, certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.

Disadex 500 Tablet ER may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Disadex 500 Tablet ER.

Topiramate (anticonvulsant) should not be taken along with Disadex 500 Tablet ER as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

It's crucial to consult with your doctor before discontinuing Disadex 500 Tablet ER. Abruptly stopping this medication can lead to severe consequences, especially if it's prescribed to treat conditions like epilepsy.

Disadex 500 Tablet ER is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.

Disadex 500 Tablet ER can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.

Yes, Disadex 500 Tablet ER can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Disadex 500 Tablet ER, it's essential to consult with your doctor.

Yes, Disadex 500 Tablet ER can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Disadex 500 Tablet ER, seeking medical attention is crucial.

Avoid consumption of alcohol while taking Disadex 500 Tablet ER as it may cause increased dizziness.

If you experience abdominal pain, nausea, and anorexia while taking Disadex 500 Tablet ER, it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.

An overdose of Disadex 500 Tablet ER can be a severe medical emergency. If you or someone you know has taken an overdose of Disadex 500 Tablet ER, it's crucial to seek immediate medical attention.

Disadex 500 Tablet ER can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.

Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Country of origin

India
Other Info - DI34917

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Nov 4, 2025 | 9:20 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018723s037lbl.pdf
  2. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e26005ef-77f0-4393-a2dc-b5fe460cead8&type=display
  3. https://www.drugs.com/mtm/divalproex-sodium.html
  4. https://www.depakote.com/depakote-formulations
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