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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Divalpro XR 500 Tablet is used to treat epilepsy, seizures or fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. It contains Divalproex sodium, which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. It helps block the nerve transmission across the brain and provides a calming effect. Thereby, helps treat bipolar disorder. In some cases, it may cause common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

About Divalpro XR 500 Tablet

Divalpro XR 500 Tablet is used to treat epilepsy, seizures or fits. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Divalpro XR 500 Tablet contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures.

In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Inform your doctor about your health, allergies, and medicines to avoid side effects. Do not take Divalpro XR 500 Tablet if you are pregnant, as it could cause severe birth defects. Consult your doctor before taking Divalpro XR 500 Tablet if you are breastfeeding. Use Divalpro XR 500 Tablet cautiously in children under 2 years, due to higher liver risk in the first 6 months.

Uses of Divalpro XR 500 Tablet

Divalpro XR 500 Tablet is used in the treatment of seizures, bipolar disorder, and migraine. The detailed uses of Divalpro XR 500 Tablet are as follows:

  • Bipolar Disorder: Divalpro XR 500 Tablet treats manic episodes associated with bipolar disorder, stabilizes mood, and reduces symptoms.
  • Seizure Treatment: Divalpro XR 500 Tablet is used for treating complex partial seizures, absence seizures, and multiple seizure types by stabilizing electrical activity in the brain.
  • Migraine Prevention: Divalpro XR 500 Tablet prevents migraine headaches by reducing frequency and severity.

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Directions for Use

  • Divalpro XR 500 Tablet can be taken with or without food, or as advised by the doctor.
  • It is usually taken once daily; however, your doctor may adjust the dose and frequency based on your medical condition.
  • Swallow Divalpro XR 500 Tablet as a whole with a glass of water.
  • Do not crush, chew, break, or open it.

Key Benefits

  • Divalpro XR 500 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics.
  • Divalpro XR 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, Divalpro XR 500 Tablet is also used to treat mood disorders and to prevent migraine headaches.
  • Divalpro XR 500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.
  • Divalpro XR 500 Tablet treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect.
  • Divalpro XR 500 Tablet prevents migraine headaches by limiting the transmission of nerve pain.
  • Divalpro XR 500 Tablet is used alone or in combination to treat simple seizures, complex partial seizures, and complex absence seizures.
  • Divalpro XR 500 Tablet is used in combination to treat multiple seizures, such as absence seizures.

How Divalpro XR 500 Tablet Works

Divalpro XR 500 Tablet contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping in controlling seizures. Divalpro XR 500 Tablet increases the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect. Thereby, it helps treat bipolar disorder.

Storage

Store in a cool and dry place away from sunlight
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Divalpro XR 500 Tablet

Please do not take more than the prescribed dose of Divalpro XR 500 Tablet , as it may lead to serious side effects. The symptoms of an overdose may include heart block, excess sleepiness, and deep coma. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Divalpro XR 500 Tablet if you are allergic to any of its contents, have/had liver problems, or urea cycle disorders.
  • Inform your doctor before taking Divalpro XR 500 Tablet if you have pancreatitis, blood problems, or multi-organ hypersensitivity.
  • Consult your doctor immediately if you experience suicidal tendencies while taking Divalpro XR 500 Tablet .
  • Divalpro XR 500 Tablet may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature), and liver problems.
  • Please do not stop taking Divalpro XR 500 Tablet without consulting your doctor to avoid worsening of seizures.
  • Do not take Divalpro XR 500 Tablet if you are pregnant, as it could cause serious birth defects.
  • If you are of child-bearing age, use effective contraception while taking Divalpro XR 500 Tablet .
  • Avoid driving or operating machinery, as Divalpro XR 500 Tablet can cause dizziness and may affect thinking and motor skills.
  • Avoid consuming alcohol along with Divalpro XR 500 Tablet as it could lead to increased dizziness.
  • Care should be taken while giving Divalpro XR 500 Tablet to children below 2 years, as there is a higher risk of liver intoxication during the first 6 months of treatment.

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Divalpro XR 500 Tablet:
Coadministration of Glycerol phenylbutyrate and Divalpro XR 500 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Divalpro XR 500 Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Divalpro XR 500 Tablet:
Co-administration of Divalpro XR 500 Tablet and Meropenem can reduce the blood levels of Divalpro XR 500 Tablet sodium.

How to manage the interaction:
Co-administration of Divalpro XR 500 Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Divalpro XR 500 Tablet:
Co-administration of Sodium phenylbutyrate and Divalpro XR 500 Tablet can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Divalpro XR 500 Tablet with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexLomitapide
Severe
How does the drug interact with Divalpro XR 500 Tablet:
Co-administration of Divalpro XR 500 Tablet and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divalpro XR 500 Tablet and lomitapide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without the doctor's advice.
How does the drug interact with Divalpro XR 500 Tablet:
Co-administration of Divalpro XR 500 Tablet and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Divalpro XR 500 Tablet and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Divalpro XR 500 Tablet:
Co-administration of Divalpro XR 500 Tablet and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divalpro XR 500 Tablet and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexEsketamine
Severe
How does the drug interact with Divalpro XR 500 Tablet:
Coadministration of Esketamine and Divalpro XR 500 Tablet can increase the side effects of esketamine.

How to manage the interaction:
Although taking Divalpro XR 500 Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Divalpro XR 500 Tablet:
Coadministration of Divalpro XR 500 Tablet and Lamotrigine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Divalpro XR 500 Tablet and Lamotrigine, you can take these medicines together if prescribed by your doctor. However, contact your doctor if you experience restlessness, rash, or muscle weakness. Do not stop using any medications without a doctor's advice.
DivalproexVorinostat
Severe
How does the drug interact with Divalpro XR 500 Tablet:
Coadministration of Divalpro XR 500 Tablet and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Divalpro XR 500 Tablet and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.
DivalproexSodium oxybate
Severe
How does the drug interact with Divalpro XR 500 Tablet:
Co-administration of Sodium oxybate and Divalpro XR 500 Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Divalpro XR 500 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for energy generation.
  • The Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps maintain weight and improve overall health.
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.
  • Have a seizure response plan, and help those around you know what to do.
  • Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

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Alcohol

Safe if prescribed

Avoid consumption of alcohol while taking Divalpro XR 500 Tablet , as it may cause increased dizziness.

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Pregnancy

Consult your doctor

Divalpro XR 500 Tablet belongs to pregnancy category D. Avoid taking Divalpro XR 500 Tablet if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Consult your doctor

Divalpro XR 500 Tablet may pass into breastmilk. Consult your doctor before taking Divalpro XR 500 Tablet if you are breastfeeding.

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Driving

Safe if prescribed

Divalpro XR 500 Tablet causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery until you are mentally alert.

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Liver

Consult your doctor

Divalpro XR 500 Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this. Dose adjustment may be needed in patients with kidney impairment.

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Children

Safe if prescribed

Divalpro XR 500 Tablet can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below 2 years as they are at a higher risk of liver toxicity.

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Heart

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Divalpro XR 500 Tablet can be given in elderly patients with extreme caution due to the serious adverse effects.

FAQs

Divalpro XR 500 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Divalpro XR 500 Tablet is also used to treat manic episodes associated with bipolar disorder and to prevent migraine.

Divalpro XR 500 Tablet contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. Divalpro XR 500 Tablet increases the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect. Thereby, it helps treat bipolar disorder.

Divalpro XR 500 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.

Divalpro XR 500 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.

Do not discontinue Divalpro XR 500 Tablet without consulting your doctor. To treat your condition effectively, continue taking Divalpro XR 500 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Divalpro XR 500 Tablet . Your doctor will reduce the dose gradually to avoid worsening of seizures.

Divalpro XR 500 Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Use an effective method of contraception during the treatment with Divalpro XR 500 Tablet . Avoid getting pregnant while taking Divalpro XR 500 Tablet as it could lead to serious birth defects. Do not stop taking Divalpro XR 500 Tablet and consult your doctor immediately if you become pregnant.

Divalpro XR 500 Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Divalpro XR 500 Tablet .

Topiramate (anticonvulsant) should not be taken along with Divalpro XR 500 Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

It is crucial to consult with your doctor before discontinuing Divalpro XR 500 Tablet . Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.

Divalpro XR 500 Tablet is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.

Divalpro XR 500 Tablet can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, please consult your doctor.

Yes, Divalpro XR 500 Tablet can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Divalpro XR 500 Tablet , it's essential to consult with your doctor.

Yes, Divalpro XR 500 Tablet can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Divalpro XR 500 Tablet , seeking medical attention is crucial.

Avoid consumption of alcohol while taking Divalpro XR 500 Tablet , as it may cause increased dizziness.

If you experience abdominal pain, nausea, and anorexia while taking Divalpro XR 500 Tablet , it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.

An overdose of Divalpro XR 500 Tablet can be a severe medical emergency. The symptoms of an overdose may include heart block, excess sleepiness, and deep coma. If you or someone you know has taken an overdose of Divalpro XR 500 Tablet , please seek immediate medical attention.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - DIV0015

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