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compositionComposition:LEFLUNOMIDE-20MG
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Prescription Medicine
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DM Lef 20 mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. This medicine may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Overseas Health Care Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About DM Lef 20 mg Tablet

DM Lef 20 mg Tablet is a prescription medication primarily used to treat active rheumatoid arthritis in adults. It belongs to a class of medicines known as disease-modifying antirheumatic drugs (DMARDs), which help control swelling, pain, and stiffness in your joints. By managing these chronic symptoms, this medicine helps prevent long-term joint damage and assists you in maintaining your daily physical function.

To get the most benefit, you must take DM Lef 20 mg Tablet consistently every day, exactly as prescribed by your healthcare provider. You can take this tablet with or without food, but taking it at the same time each day will help you build a reliable routine. Making healthy adjustments, such as eating a balanced diet and doing gentle, joint-friendly exercises, can support your treatment outcomes.

While taking DM Lef 20 mg Tablet , some people may experience mild side effects like diarrhoea, nausea, or temporary hair thinning. However, you must contact your doctor immediately if you notice serious symptoms such as yellowing of your eyes or skin, dark urine, or unusual tiredness, as these could indicate liver damage.

Do not take this if you are pregnant, planning to become pregnant, or breastfeeding, as this medicine can cause severe harm to an unborn baby. Before starting DM Lef 20 mg Tablet , talk to your doctor if you have a history of liver disease, severe infections, kidney problems, or a weakened immune system.

This medicine can interact with certain other drugs, alcohol, and live vaccinations, which may increase your risk of liver issues or serious infections. Because of these risks, elderly individuals and people with pre-existing medical conditions should talk to their doctor or pharmacist before starting treatment to ensure it is safe for them.

Uses of DM Lef 20 mg Tablet

DM Lef 20 mg Tablet may be prescribed for the following inflammatory joint conditions: 

  • Rheumatoid Arthritis: DM Lef 20 mg Tablet helps reduce inflammation, swelling, and stiffness in the joints, preventing progressive joint damage and preserving daily physical function.
  • Psoriatic Arthritis: In certain cases, doctors may prescribe this medication to help control joint symptoms and inflammatory skin plaques associated with this condition.
     

Key Benefits

DM Lef 20 mg Tablet helps control inflammation and slow disease progression in certain autoimmune joint disorders. Its benefits may include: 

  • Slowing Joint Damage: Unlike simple pain relievers that only mask symptoms, DM Lef 20 mg Tablet works deep within the immune system to slow down the progression of joint destruction, helping you preserve your joint health over the long term.
  • Improved Daily Mobility: By targeting chronic swelling and stiffness, this medicine makes daily physical activities, such as walking, bending, and reaching, much easier and more comfortable.
  • Long-lasting Inflammatory Relief: Regular use helps stabilise your body's overactive immune response, leading to fewer painful flare-ups and a more consistent level of physical comfort throughout your day.
     
Side effects of DM Lef 20 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

To use DM Lef 20 mg Tablet safely and effectively, follow these instructions: 

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed.
  • You can take DM Lef 20 mg Tablet with or without food. If you experience mild stomach upset, taking it with a meal may help.
  • Try to take your dose at the same time every day to maintain a steady level of the medication in your system.

Always follow your doctor's exact instructions. Do not stop taking this medication suddenly without consulting your doctor first, even if you begin to feel better.
 

How DM Lef 20 mg Tablet Works

DM Lef 20 mg Tablet contains the active drug leflunomide, which works by targeting the body's overactive immune system. In conditions like rheumatoid arthritis, certain white blood cells (called lymphocytes) multiply too quickly and attack healthy joint tissue, causing painful inflammation and wear. Leflunomide blocks a specific enzyme that these rapidly multiplying immune cells need to produce their DNA. By limiting the growth of these overactive cells, the medicine effectively tones down the autoimmune attack on your joints. This reduces swelling, eases pain, and helps protect your joint structures from permanent damage.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking DM Lef 20 mg Tablet . Alcohol intake, along with DM Lef 20 mg Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take DM Lef 20 mg Tablet while you are pregnant. DM Lef 20 mg Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take DM Lef 20 mg Tablet while you are breastfeeding. DM Lef 20 mg Tablet passes into breast milk.

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Driving

Caution

DM Lef 20 mg Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Please consult your doctor if you have liver impairment before taking DM Lef 20 mg Tablet .

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking DM Lef 20 mg Tablet .

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Children

Unsafe

DM Lef 20 mg Tablet is not approved for children under the age of 18 years.

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Heart

Unsafe

Avoid taking DM Lef 20 mg Tablet if you have any cardiac problems. If prescried, caution should be exercised while taking DM Lef 20 mg Tablet .

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Geriatrics

Consult your doctor

Please consult a doctor before giving DM Lef 20 mg Tablet to geriatric patients.

What if I have taken an overdose of DM Lef 20 mg Tablet

Do not take more than the prescribed dose of DM Lef 20 mg Tablet as it may cause an overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Since leflunomide can cause strain on your liver, drinking alcohol while taking this medicine significantly increases your risk of severe liver damage.
  • Protect yourself from infections: Because this medicine suppresses part of your immune system, wash your hands frequently, avoid close contact with people who are sick, and talk to your doctor before getting any vaccinations.
  • Eat an anti-inflammatory diet: Incorporate foods rich in omega-3 fatty acids, such as walnuts, flaxseeds, and fatty fish, which can naturally help support joint health and manage inflammation.
  • Engage in low-impact physical activity: Practice gentle exercises like swimming, walking, or stationary cycling to keep your joints flexible and strengthen the surrounding muscles without putting too much stress on them.
     
health query

Have a query?

How Soon It Starts Working

The time required for DM Lef 20 mg Tablet to start to work: DM Lef 20 mg Tablet starts working within 4 weeks of treatment. However, it might take four to six months to feel the full effect of the drug.

The time for which the effects of DM Lef 20 mg Tablet last: The duration of action for DM Lef 20 mg Tablet is unknown.

What if you forget to take DM Lef 20 mg Tablet

If you miss a dose of DM Lef 20 mg Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store DM Lef 20 mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Schedule regular blood tests: You will need regular blood tests to monitor your liver function and complete blood counts while taking this medicine. Do not skip these appointments.
  • Use effective birth control: Both men and women taking this medicine must use reliable birth control. The active drug can remain in your body for a long time, so talk to your doctor before trying to conceive, even after you stop taking the drug.
  • Be cautious with vaccines: Avoid live vaccines (such as the nasal spray flu vaccine or yellow fever vaccine) during your treatment, as your weakened immune system may not handle them safely.
  • Monitor your blood pressure: This medicine can sometimes increase your blood pressure, so it is important to check your blood pressure regularly at home or during your clinic visits.
  • Tell all healthcare providers: Always inform any dentist, surgeon, or specialist that you are taking DM Lef 20 mg Tablet before undergoing any medical procedures or starting new medications.
     

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with DM Lef 20 mg Tablet :

  • Other Liver-Affecting Medicines: Taking DM Lef 20 mg Tablet with medicines that can affect the liver, such as methotrexate or certain cholesterol-lowering medicines, may significantly increase the risk of liver damage.
  • Blood Thinners: Medicines such as warfarin may interact with DM Lef 20 mg Tablet and alter blood clotting, requiring closer monitoring.
  • Other Immunosuppressants: Using DM Lef 20 mg Tablet with other immunosuppressing medicines may increase the risk of serious infections.

Drug-Food Interactions

The following food and drink interactions may affect the safety of DM Lef 20 mg Tablet : 

  • Alcohol: Do not consume alcohol while taking DM Lef 20 mg Tablet , as this combination may greatly increase the risk of severe liver damage.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking DM Lef 20 mg Tablet , as it may worsen your condition or cause complications:

  • Liver Disease: Do not take this medicine if you have pre-existing liver disease, as it may worsen liver damage.
  • Severe Infections: Avoid using DM Lef 20 mg Tablet if you have an active or uncontrolled infection, as it may reduce your body's ability to fight infections.
  • Weakened Immune System: Use this medicine with caution if you have an immunodeficiency disorder, as it may further suppress immune function and increase the risk of infections.
     
LeflunomideGefitinib
Severe
LeflunomideTenofovir alafenamide
Severe

Drug-Drug Interactions

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LeflunomideGefitinib
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Gefitinib can cause higher levels of DM Lef 20 mg Tablet in the blood by reducing its excretion rate. This can increase the risk or severity of liver damage.

How to manage the interaction:
Taking DM Lef 20 mg Tablet with Gefitinib together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideTenofovir alafenamide
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking DM Lef 20 mg Tablet with tenofovir alafenamide can increase the risk of liver problems.

How to manage the interaction:
Taking DM Lef 20 mg Tablet and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
LeflunomideInfliximab
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Combining Infliximab with DM Lef 20 mg Tablet can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking DM Lef 20 mg Tablet with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, burning, paleness, fatigue, dizziness, lightheadedness, and bruising or bleeding when you pee, contact a doctor right away. Do not discontinue any medications without first consulting a doctor.
LeflunomideAfatinib
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking DM Lef 20 mg Tablet with afatinib can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between DM Lef 20 mg Tablet and afatinib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomidePrasterone
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking DM Lef 20 mg Tablet with prasterone may increase the risk of liver problems.

How to manage the interaction:
Taking Prasterone with DM Lef 20 mg Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideParacetamol
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Co-administration of Paracetamol and DM Lef 20 mg Tablet may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Paracetamol and DM Lef 20 mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideEfavirenz
Severe
How does the drug interact with DM Lef 20 mg Tablet:
When Efavirenz is taken with DM Lef 20 mg Tablet it can increase the risk or severity of liver damage.

How to manage the interaction:
Taking Efavirenz with DM Lef 20 mg Tablet together can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
LeflunomideCarboplatin
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Co-administration of DM Lef 20 mg Tablet with carboplatin can increase the risk of infections.

How to manage the interaction:
Co-administration of carboplatin with DM Lef 20 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
LeflunomideDeferasirox
Severe
How does the drug interact with DM Lef 20 mg Tablet:
DM Lef 20 mg Tablet may cause liver problems and using it with deferasirox may increase that risk.

How to manage the interaction:
Taking DM Lef 20 mg Tablet with Deferasirox together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - fever, joint pain, rash, or any other unusual signs, make sure to contact your doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideAmbrisentan
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking DM Lef 20 mg Tablet and ambrisentan can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is an interaction between DM Lef 20 mg Tablet and ambrisentan, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

DM Lef 20 mg Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.
DM Lef 20 mg Tablet is a disease-modifying antirheumatic drug (DMARD) which stops the DNA (genetic material) of the provoked immune system cells required for their survival. It thereby helps in treating inflammation, redness, and swelling at the damaged site (especially joints).
DM Lef 20 mg Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Inform your doctor if you have liver disease, kidney disease, a weak immune system and serious infections like pneumonia, or tuberculosis (TB).
The best time to take leflunomide is usually in the morning, with food, to help minimize stomach upset. However, following your doctor's specific instructions for taking leflunomide is essential, as the optimal timing may vary depending on your needs and health status.
DM Lef 20 mg Tablet is not a steroid. It contains leflunomide, which is an immunomodulatory medication used to treat rheumatoid arthritis and psoriatic arthritis. Leflunomide works by reducing inflammation and slowing the progression of the disease.
DM Lef 20 mg Tablet may cause weight loss as a side effect. This weight loss is usually insignificant and may be due to a loss of appetite. If you experience significant weight loss, it is essential to consult your doctor.
Patients taking leflunomide should notify their doctor if they experience any unusual symptoms, side effects, or concerns. They should also keep their doctor informed about any changes in their health or medications.
DM Lef 20 mg Tablet takes a long time to be eliminated from your body. It is generally recommended to wait at least 2 years after stopping DM Lef 20 mg Tablet before planning a pregnancy. It is essential to consult your healthcare provider for personalized advice and to discuss the best plan for pregnancy after stopping DM Lef 20 mg Tablet .
While taking leflunomide, it's reassuring to know that the risk of cancer is extremely low. Although there's a slight increase in the risk of certain types of cancer, such as lymphoma, this is very rare. Your healthcare provider will closely monitor you and address any concerns. Regular check-ups make you feel confident and safe while managing your condition with leflunomide.
It can take anywhere from 4 to 12 weeks to notice a significant improvement in your joint pain and swelling. Since this medicine works gradually to regulate your immune system, it is important to keep taking it consistently, even if you do not feel immediate relief. Talk to your doctor if you do not notice any changes after several weeks.
No, you should completely avoid alcohol while taking this medicine. Both alcohol and the active drug in DM Lef 20 mg Tablet are processed by the liver, and combining them can cause severe, potentially permanent liver damage. Talk to your doctor if you have concerns about avoiding alcohol.
Some people may experience mild, temporary hair thinning or loss while taking this medication. This is usually a temporary side effect that improves over time or after stopping the treatment. Talk to your doctor if the hair loss becomes severe or bothersome.
Your doctor will order regular blood tests to check your liver enzymes and monitor your complete blood counts. Because this medicine can affect your liver and your blood cells, these regular checks ensure the medication remains safe for you to continue. Talk to your doctor to understand your monitoring schedule.
No, you must not take this medicine if you are pregnant or planning to become pregnant, as it can cause serious birth defects. Because the drug stays in the body for a very long time, you must use effective birth control during treatment and undergo a specific drug washout procedure under medical supervision before trying to conceive. Talk to your doctor immediately if you plan to start a family.
Yes, this medicine works by calming an overactive immune system, which can make it slightly harder for your body to fight off infections. You should practice good hygiene, avoid close contact with sick individuals, and seek medical advice at the first sign of an infection, such as a fever or sore throat. Talk to your doctor if you get sick.
You should avoid receiving live vaccines while taking this medicine, as your immune system may not be able to process them safely. Non-live vaccines, such as the standard flu shot, are generally safe, but you should always confirm with your healthcare provider first. Talk to your doctor before scheduling any vaccinations.
Diarrhoea is a common side effect of this medicine, but if it becomes severe, persistent, or is accompanied by stomach pain, you should notify your healthcare provider right away. Do not try to treat severe diarrhoea with over-the-counter medicines without consulting a professional first. Talk to your doctor for guidance on managing this side effect safely.

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Country of origin

India

Manufacturer/Marketer address

335 KM. MILESTONE, NATIONAL HIGHWAY NO.1, P.O.BOX 25, PHILLAUR , (PUNJAB) INDIA-144 410
Other Info - DML0002
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