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compositionComposition:DICLOFENAC-50MG+METAXALONE-400MG
prescription
Prescription Medicine
info
Dolfre MR Tablet 10's
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DICLOFENAC-50MG+METAXALONE-400MG

Manufacturer/Marketer :

Ravenbhel Pharmaceuticals

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Dolfre MR Tablet 10's

Dolfre MR Tablet 10's is a combination medication prescribed to treat pain and physical discomfort caused by muscle spasms and acute muscle injuries. It works by combining a pain-relieving medicine with a muscle relaxant to help you recover more comfortably from strains, sprains, or other muscle injuries. Your doctor will determine the appropriate duration of treatment based on your specific condition.

To get the best results, take Dolfre MR Tablet 10's exactly as prescribed by your doctor, keeping a consistent daily schedule. It is highly recommended to take this tablet with food or a glass of milk to protect your stomach from potential irritation. Combining this medical treatment with adequate rest, physical therapy, and gentle stretching exercises can significantly speed up your recovery process.

While taking Dolfre MR Tablet 10's, you may experience some mild side effects such as drowsiness, dizziness, or a mild upset stomach. However, you should stop taking the medicine and consult your doctor immediately if you experience serious symptoms, such as severe stomach pain, black or tarry stools, yellowing of your skin or eyes, or difficulty breathing.

Before you begin taking Dolfre MR Tablet 10's, tell your doctor if you have a history of stomach ulcers, asthma, high blood pressure, fluid retention, or kidney or liver damage. Do not take this if you have an active stomach ulcer, severe heart failure, or if you have ever had a severe allergic reaction or asthma attack triggered by aspirin or other pain relievers.

This medication can interact with other drugs, including blood thinners, other pain medicines, and certain blood pressure medications, which can increase the risk of side effects. Avoid drinking alcohol while taking Dolfre MR Tablet 10's, as it can worsen drowsiness and increase your risk of stomach bleeding. Pregnant women, breastfeeding mothers, and elderly patients should always consult their healthcare provider before using this medicine.

Uses of Dolfre MR Tablet 10's

Your doctor may prescribe this medicine to treat several conditions, including:

  • Muscle spasms: Dolfre MR Tablet 10's helps relax stiff, cramping muscles, allowing for improved flexibility and reduced discomfort during movement.
  • Acute musculoskeletal pain: Dolfre MR Tablet 10's targets inflammation and blocks pain signals in the body to relieve discomfort from strains, sprains, and muscle injuries.
  • Post-injury recovery: Dolfre MR Tablet 10's reduces localized pain and swelling following physical trauma, making it easier to participate in restorative physical therapy.
     

Key Benefits

Dolfre MR Tablet 10's provides dual-action relief that addresses both muscle tightness and underlying pain simultaneously, which helps you return to your normal daily activities faster.

  • Faster relief from pain: By targeting both pain pathways and muscle tension, it helps reduce the intensity of sharp, sudden pain more quickly than using a single-ingredient medication.
  • Improved mobility and movement: The muscle-relaxing effect helps decrease stiffness, making it easier for you to bend, walk, and perform physical therapy exercises without severe discomfort.
  • Better sleep and rest: Relieving painful muscle spasms prevents sudden nighttime cramps, allowing for more restful sleep, which is vital for healing.
     
Side effects of Dolfre MR Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

To ensure you get the full benefit of Dolfre MR Tablet 10's and minimise the risk of side effects, please follow these instructions carefully:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can alter how the medicine is absorbed into your body.
  • Take this medication with food or milk to help protect your stomach lining and prevent indigestion.
  • Try to take your doses at the same times each day to maintain a steady level of the medicine in your body.
  • Always follow your doctor's exact instructions regarding how many tablets to take and how long you should continue taking them. Do not stop taking the medicine early, even if you start to feel better, unless advised by your healthcare provider.
     

How Dolfre MR Tablet 10's Works

Dolfre MR Tablet 10's works through a combination of two active ingredients that target pain and muscle stiffness in different ways to provide comprehensive relief. The first active ingredient is diclofenac, which belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). When your body is injured, it produces chemical messengers called prostaglandins that cause pain, heat, and swelling. Diclofenac works by blocking the enzymes responsible for making these chemicals, which directly reduces inflammation and relieves pain at the site of the muscle injury. The second active ingredient is metaxalone, which is a muscle relaxant. Instead of acting directly on the muscles, metaxalone works on the central nervous system, specifically the brain and spinal cord, to block nerve impulses that cause painful muscle spasms. This helps soothe and relax tight muscles, making movement easier and less painful. Together, these two medicines provide a highly effective dual-action approach to recovery.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Dolfre MR Tablet 10's as it may cause increased drowsiness. It may also increase the risk of stomach bleeding.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Dolfre MR Tablet 10's; your doctor will decide whether Dolfre MR Tablet 10's can be taken by breastfeeding mothers or not.

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Driving

Caution

Dolfre MR Tablet 10's may cause drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Dolfre MR Tablet 10's should not be given to children as the safety and effectiveness were not established.

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Heart

Unsafe

Avoid taking Dolfre MR Tablet 10's if you have any cardiac problems. If prescried, caution should be exercised while taking Dolfre MR Tablet 10's.

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Geriatrics

Unsafe

Dolfre MR Tablet 10's should be avoided in geriatric patients as it can cause serious adverse effects.

What if I have taken an overdose of Dolfre MR Tablet 10's

An overdose of Dolfre MR Tablet 10's may cause unpleasant effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

Incorporating simple, targeted habits into your daily routine can support your recovery and help Dolfre MR Tablet 10's work more effectively:

  • Stay well-hydrated: Drink plenty of water throughout the day. Dehydration is a common cause of muscle cramps and spasms, so staying hydrated helps keep your muscles functioning smoothly.
  • Apply heat or cold therapy: Use an ice pack on the painful area for the first 48 hours to reduce inflammation, then switch to a warm heating pad to help relax tight muscle fibers.
  • Incorporate gentle stretching: Once the acute pain begins to ease, perform light, doctor-approved stretches to prevent the muscles from shortening and stiffening.
  • Eat magnesium-rich foods: Include foods like spinach, almonds, black beans, and avocados in your diet, as magnesium is a natural mineral that supports muscle relaxation and nerve function.
  • Avoid strenuous activities: Rest the affected muscle group and avoid heavy lifting or sudden, twisting movements that could re-injure the area.

 

Have a query?

How Soon It Starts Working

The time required for Dolfre MR Tablet 10's to start to work: Dolfre MR Tablet 10's ideally shows its action within 30 minutes after administration.

The time for which the effects of Dolfre MR Tablet 10's last: The effect of Dolfre MR Tablet 10's lasts for 8 hours.

What if you forget to take Dolfre MR Tablet 10's

If you miss a dose of Dolfre MR Tablet 10's, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store Dolfre MR Tablet 10's tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). Keep the bottle or blister pack tightly closed when not in use. •Keep the medicine in a dry place. Avoid storing it in humid environments like the bathroom cabinet, as

Drug Warnings

  • Avoid driving or operating machinery: This medication can make you drowsy or dizzy. Do not drive, cycle, or use heavy tools until you know exactly how Dolfre MR Tablet 10's affects you.
  • Check your packaging: Always inspect the blister pack or bottle seal before use. If the packaging is damaged, punctured, or the tablets appear discolored or crumbly, return them to the pharmacy.
  • Limit your treatment time: This medicine is typically meant for short-term use (usually up to two to three weeks). Taking it for longer periods can increase the risk of serious stomach and heart complications.
  • Do not combine with other pain relievers: Avoid taking other over-the-counter NSAIDs (like ibuprofen or naproxen) or prescription pain relievers unless specifically approved by your doctor, as this significantly increases the risk of stomach ulcers and bleeding.
  • Be careful when standing up: To prevent dizziness or falls, rise slowly from a sitting or lying position while taking this medication.
  • Avoid alcohol completely: Alcohol amplifies the sedating effects of the muscle relaxant and heightens the risk of severe liver damage and stomach bleeding.
     

Drug-Drug Interactions

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Drug-Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Blood thinners (like warfarin or aspirin): May significantly increase your risk of stomach irritation and bleeding.
  • Other NSAIDs (like ibuprofen, naproxen, or celecoxib): Can increase the risk of stomach ulcers and digestive tract bleeding when taken together.
  • Blood pressure medications (like ACE inhibitors or beta-blockers): Dolfre MR Tablet 10's may reduce the effectiveness of these medications and increase the risk of kidney strain.
  • Central nervous system depressants (like sleeping pills, anxiety medications, or narcotics): May cause extreme drowsiness, slow breathing, and coordination problems when combined with the muscle relaxant component.

Drug-Food Interactions:

  • Alcohol: Dramatically increases the sedating effects of this medication, causing severe drowsiness, and increases the risk of stomach bleeding.
  • High-fat meals: Taking this medication with a very high-fat meal may significantly increase the absorption of the muscle relaxant, which can lead to increased side effects like dizziness and sleepiness.

Drug-Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking Dolfre MR Tablet 10's, as it may worsen your condition or cause complications.

  • Stomach ulcers or bleeding: May cause serious irritation, bleeding, or perforation of the stomach or intestines.
  • Liver or kidney disease: Can worsen existing liver damage or kidney impairment, as both organs are responsible for processing and clearing this medication from your body.
  • Asthma: May trigger breathing difficulties or asthma attacks, especially in patients who are sensitive to aspirin or other NSAIDs.
  • Heart disease or high blood pressure: May cause fluid retention and swelling, potentially worsening heart failure or elevating blood pressure.
     
Metaxalone + DiclofenacMeloxicam
Critical
Metaxalone + DiclofenacIbuprofen
Severe

Drug-Drug Interactions

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Metaxalone + DiclofenacMeloxicam
Critical
How does the drug interact with Dolfre MR Tablet:
Co-administration of Meloxicam with Dolfre MR Tablet can increase the risk or severity of stomach inflammation, ulcer, or bleeding.

How to manage the interaction:
Taking Meloxicam with Dolfre MR Tablet is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience dizziness, tarry stools, coughing up or vomiting blood, and weakness. Do not stop any medication without a doctor's advice.
Metaxalone + DiclofenacIbuprofen
Severe
How does the drug interact with Dolfre MR Tablet:
Taking Ibuprofen with Dolfre MR Tablet can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Ibuprofen with Dolfre MR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, tarry stools, coughing up or vomiting blood, headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
Metaxalone + DiclofenacIbrutinib
Severe
How does the drug interact with Dolfre MR Tablet:
Taking Ibrutinib with Dolfre MR Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
There may be a possible interaction of Ibrutinib with Dolfre MR Tablet, it can be taken if a doctor has prescribed them. However, consult a doctor if you experience any unusual bleeding, tarry stools, coughing up or vomiting blood, or severe headaches. Do not discontinue any medications without consulting a doctor.
Metaxalone + DiclofenacPethidine
Severe
How does the drug interact with Dolfre MR Tablet:
Coadministration of Pethidine with Dolfre MR Tablet can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Pethidine with Dolfre MR Tablet can result in an interaction, it can be taken if your doctor has advised it. However, if you experience excessive sweating, shivering or shaking, blurred vision, muscle spasms, or shortness of breath, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Metaxalone + DiclofenacPonatinib
Severe
How does the drug interact with Dolfre MR Tablet:
Taking Ponatinib with Dolfre MR Tablet can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Ponatinib with Dolfre MR Tablet, it can be taken if your doctor has prescribed them. However, consult your doctor if you experience any unusual bleeding, tarry stools, coughing up or vomiting blood, or severe headaches. Do not discontinue any medications without consulting your doctor.
Metaxalone + DiclofenacWarfarin
Severe
How does the drug interact with Dolfre MR Tablet:
Taking Warfarin with Dolfre MR Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
There may be a possible interaction of Warfarin with Dolfre MR Tablet, it can be taken when a doctor has prescribed it. However, consult your doctor immediately if you experience unusual bleeding or bruising, blood in your urine or stools, or weakness, contact a doctor. Do not discontinue any medications without consulting a doctor.
Metaxalone + DiclofenacIndometacin
Severe
How does the drug interact with Dolfre MR Tablet:
The combined use of Indometacin with Dolfre MR Tablet can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Indometacin with Dolfre MR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, tarry stools, coughing up or vomiting bloof, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Metaxalone + DiclofenacAcalabrutinib
Severe
How does the drug interact with Dolfre MR Tablet:
Taking Acalabrutinib with Dolfre MR Tablet may increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Acalabrutinib with Dolfre MR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any unusual bruising, tarry stools, coughing up or vomiting blood, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
Metaxalone + DiclofenacRivaroxaban
Severe
How does the drug interact with Dolfre MR Tablet:
Co-administration of Rivaroxaban and Dolfre MR Tablet may increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Rivaroxaban and Dolfre MR Tablet can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like unusual bleeding or bruising, tarry stools, coughing up or vomiting blood, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
Metaxalone + DiclofenacKetamine
Severe
How does the drug interact with Dolfre MR Tablet:
Coadministration of Ketamine with Dolfre MR Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Coadministration of Ketamine with Dolfre MR Tablet can lead to an interaction, it can be taken when advised by a doctor. However, if you notice any symptoms of dizziness, difficulty concentrating, drowsiness, and shortness of breath, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESICS]

FAQs

Dolfre MR Tablet 10's is used to reduce and relieve pain due to muscle spasms (excessive tension in the muscles).

Dolfre MR Tablet 10's is a combination of two drugs: Diclofenac (Nonsteroidal Anti-Inflammatory Drug) and metaxalone (skeletal muscle relaxant). Diclofenac works by blocking the action of certain chemical messengers that cause pain. Metaxalone works by blocking the pain sensations and nerve impulses. Together, Dolfre MR Tablet 10's helps in relieving pain due to muscle spasm.

Do not take Dolfre MR Tablet 10's for longer durations unless prescribed by the doctor, as it might increase the risk of heart problems, liver problems and stomach bleeding/ulcer. Consult a doctor if you have any concerns.

To treat your condition effectively, continue taking Dolfre MR Tablet 10's for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Dolfre MR Tablet 10's.

Consult your doctor before taking Dolfre MR Tablet 10's if you have stomach ulcers, bleeding problems, liver problems or heart problems.

Dolfre MR Tablet 10's may cause nausea and vomiting. To help manage this, take your medication with food, eat small meals, and stay hydrated. You can also try ginger products to alleviate nausea. If your symptoms are severe or persistent, consult your doctor.

Dolfre MR Tablet 10's should be used with caution if you have a history of bleeding problems, kidney or liver disease, stomach ulcers, heart failure, high blood pressure, or swelling. Additionally, use with caution if you have asthma, gout, diabetes, porphyria, or are an elderly patient. Do not take Diclofenac Metaxalone unless prescribed by a doctor who has carefully weighed the potential risks and benefits and determined it is safe for you to use, considering your individual health needs and medical history.

Yes, Dolfre MR Tablet 10's can potentially damage kidneys, especially with long-term use or in people with pre-existing kidney disease. If you have kidney disease, use this medication cautiously and under medical supervision.

Taking more than the recommended dose of Dolfre MR Tablet 10's can be dangerous. It can lead to serious side effects like stomach ulcers, kidney damage, and seizures. Always follow the prescribed dosage and consult your doctor if you have concerns. They will adjust the dosage if necessary to ensure your safety.

Dolfre MR Tablet 10's should be stored in a cool, dry place away from sunlight. Keep Dolfre MR Tablet 10's out of reach and out of sight to children.

Only take Dolfre MR Tablet 10's with any other medications, including blood pressure medications, if recommended by your doctor. Use it as directed by your doctor and follow their instructions carefully. They will help you safely manage your blood pressure and minimize potential interactions.

Dolfre MR Tablet 10's is not recommended for use in children. Because the safety and efficacy of children have yet to be fully established. Please consult your doctor for proper diagnosis and safe treatment approaches.

Dolfre MR Tablet 10's may cause common side effects such as stomach pain, nausea, vomiting, diarrhoea, dizziness and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

It is highly recommended to take Dolfre MR Tablet 10's with food or a glass of milk rather than on an empty stomach. Taking it with food helps protect your stomach lining from irritation and reduces the risk of mild side effects like indigestion, nausea, or stomach upset. Talk to your doctor or pharmacist if you have a sensitive stomach.

Most patients begin to feel relief from pain and muscle stiffness within 1 to 2 hours after taking Dolfre MR Tablet 10's. However, the exact time can vary depending on your individual metabolism and whether you took the tablet with food. If you do not feel any improvement after a few days, talk to your doctor.

Yes, Dolfre MR Tablet 10's can cause drowsiness, sleepiness, or dizziness because of its muscle-relaxing component, which acts on the central nervous system. You should avoid driving, operating machinery, or performing any hazardous tasks until you know how this medication affects you. Talk to your doctor if the drowsiness is severe.

No, you should avoid drinking alcohol while taking Dolfre MR Tablet 10's. Alcohol can significantly worsen drowsiness, dizziness, and coordination issues caused by the medication. Additionally, combining alcohol with this drug increases the risk of serious stomach bleeding and liver damage. Talk to your doctor if you have concerns about alcohol use.

Dolfre MR Tablet 10's is generally not recommended during pregnancy, especially during the third trimester, as the pain-relieving component can cause harm to the unborn baby or lead to complications during delivery. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor to discuss safer alternatives.

No, Dolfre MR Tablet 10's is designed for short-term relief of acute, painful muscle conditions and is not recommended for long-term chronic pain management. Using this medication long-term increases your risk of serious heart, kidney, and stomach side effects. If you have chronic back pain, talk to your doctor about a safe, long-term treatment plan.

You should not combine Dolfre MR Tablet 10's with other pain medicines without professional medical advice. While paracetamol works differently, taking multiple pain relievers can sometimes strain your liver or kidneys. Always talk to your doctor or pharmacist before combining any over-the-counter or prescription medicines.

If your muscle pain and spasms do not start to improve after a few days of consistent use, or if they get worse, do not increase your dose on your own. Instead, talk to your doctor to re-evaluate your condition and adjust your treatment plan safely.

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Reference

  1. U.S. Food and Drug Administration (FDA). 019201S038Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Metaxalone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. Drugs.com Clinical Review Team. Diclofenac With Metaxalone 869 0 1572 0 Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Lorvatus Pharmapak Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. U.S. Food and Drug Administration (FDA). 013217S053Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  6. Diclofenac Diclofenac. 1997. [Accessed on 02 Apr. 2019] Check here
  7. Dexcel-Pharma Ltd; Electronic Medicines Compendium (EMC) [Revised in March 2022] [Accessed on 16th April 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Ravenbhel Pharmaceuticals (P) Ltd., 7, Baba Budha Ji Avenue, G.T. Road, Amritsar-Punjab (143001)
Other Info - DOL0665

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