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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Domi Up Spray is used in the prevention of vomiting and nausea that usually occur after cancer chemotherapy, radiation treatment, or surgery. It contains Ondanestron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. It may cause common side effects such as constipation, headache, diarrhea, drowsiness, flushing (a feeling of warmth), weakness, and tiredness. Before taking this medication, inform your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and any pre-existing medical conditions.

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Whats That

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Composition :

ONDANSETRON-2MG

Manufacturer/Marketer :

Lincoln Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Domi Up Spray

Domi Up Spray belongs to a group of medications called ' antiemetics,' primarily used in the prevention of vomiting (being sick) and nausea (feeling sick) that usually occur after cancer chemotherapy, radiation treatment, or surgery. Nausea is an uneasy feeling in which a person feels an urge to vomit, while vomiting is the natural response of the body to expel the stomach contents from the mouth forcefully.

Domi Up Spray contains Ondanestron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. As a result, Domi Up Spray prevents the sensation of nausea and vomiting caused by conditions like surgery, cancer chemotherapy, pregnancy, or motion sickness.

Take Domi Up Spray exactly as prescribed. Your doctor will advise you on how often you take Domi Up Spray based on your medical condition. You may experience common side effects such as constipation, headache, diarrhea, drowsiness, flushing (a feeling of warmth), weakness, and tiredness. However, not every person experiences these side effects, and some of the unpleasant effects of Domi Up Spray do not require medical attention. If the side effects persist or worsen, please consult your doctor.

Before using Domi Up Spray, inform your doctor if you are allergic to any of its ingredients. Do not use Domi Up Spray if you are taking apomorphine (a medicine used to treat Parkinson's disease), as it may cause a sharp drop in blood pressure and even fainting. Inform your doctor before using Domi Up Spray if you have any medical conditions, such as severe constipation, bowel obstruction, depression, electrolyte imbalance, irregular heartbeat, liver problems, or a history of tonsils or adenoid removal surgery. Domi Up Spray should be used during pregnancy and breastfeeding only if prescribed by a doctor.

Uses of Domi Up Spray

Domi Up Spray is used in the prevention of Nausea and Vomiting. The detailed uses of Domi Up Spray are as follows:<br/> • Chemotherapy-Induced Nausea and Vomiting: Domi Up Spray is frequently prescribed to alleviate nausea and vomiting caused by chemotherapy treatments.<br/> • Radiation Therapy Support: Domi Up Spray can help manage nausea and vomiting experienced by patients undergoing radiation therapy, improving treatment tolerance.<br/> • Postoperative Nausea and Vomiting Relief: Many patients experience nausea or vomiting after surgical procedures, and Domi Up Spray is effective in controlling and reducing these symptoms.<br/>

Directions for Use

  • Domi Up Spray can be taken with or without food, as advised by the doctor.
  • Typically, it is taken twice daily. However, follow your doctor's instructions on the dosage and timing of this medication. 
  • Swallow the tablet as a whole with a glass of water.
  • Do not crush, chew, break, or open it.

Medicinal Benefits

Domi Up Spray is an anti-emetic medication primarily used to prevent and treat nausea and vomiting associated with conditions such as cancer chemotherapy, radiation treatment, and surgery. When serotonin levels increase in the blood, it stimulates the CTZ receptor (chemoreceptor trigger zone) located in the brain responsible for controlling nausea and vomiting. Domi Up Spray contains Ondansetron, which works by inhibiting the release of serotonin, thereby preventing nausea and vomiting.

How Domi Up Spray Works

Domi Up Spray contains Ondanestron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. As a result, Domi Up Spray prevents the sensation of nausea and vomiting caused by conditions like surgery, cancer chemotherapy, pregnancy, or motion sickness.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Domi Up Spray 15ml
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Avoid rubbing or scratching the affected area, as this can cause further irritation and discomfort.
  • Consider using a humidifier to add moisture to the air and help reduce the sensation.
  • Seek medical attention if the sensation is severe, persistent, or worsens over time.
  • Avoid extreme temperatures, such as hot or cold showers, that can exacerbate the sensation.
  • Wear light, breathable clothing to help keep the body cool and reduce the sensation.
  • Avoid triggers that can cause the sensation, such as spicy foods or hot drinks.
  • Use cool compresses or fans to help lower body temperature and reduce the sensation.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

What if I have taken an overdose of Domi Up Spray

Do not take more than the prescribed dose of Domi Up Spray, as it may lead to an overdose. Symptoms of an overdose may include sudden loss of vision for a short time, irregular heartbeat, constipation, fainting, dizziness, or light-headedness. If you suspect that you have taken an overdose of this medication or notice any unusual symptoms, please consult a doctor immediately.

Drug Warnings

Do not use Domi Up Spray if you are allergic to any of its ingredients. Avoid using Domi Up Spray if you are taking apomorphine (a medicine used to treat Parkinson's disease), as it may cause a sharp drop in blood pressure and even fainting. Inform your doctor before using Domi Up Spray if you have any medical conditions, such as severe constipation, bowel obstruction, depression, electrolyte imbalance, heart or blood vessel problems (such as irregular heartbeats and high blood pressure), diabetes, liver problems, or a history of tonsils or adenoid removal surgery. Tell your doctor if you are taking any medications for depression, as using them alongside Domi Up Spray may increase the risk of serotonin syndrome, a potentially life-threatening condition. Domi Up Spray is not recommended for use during early pregnancy (first trimester), as it may increase the risk of birth defects in the mouth and face of the baby. Avoid breastfeeding while taking Domi Up Spray, as small amounts of the medicine may pass into breast milk. Avoid consuming alcohol while taking Domi Up Spray, as it may worsen the side effects like drowsiness.

Drug-Drug Interactions

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OndansetronMethadone
Severe

Drug-Drug Interactions

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How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Domi Up Spray 15ml with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
OndansetronMethadone
Severe
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with methadone increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with methadone can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronAnagrelide
Severe
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with anagrelide increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml alongside anagrelide can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Domi Up Spray 15ml:
When bupropion, is combined with Domi Up Spray 15ml it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with bupropion can lead to interaction, it can be taken if recommended by a doctor. If you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea consult a doctor. Do not discontinue any medications without consulting a doctor.
OndansetronVemurafenib
Severe
How does the drug interact with Domi Up Spray 15ml:
Although it is a very rare adverse effect, taking Domi Up Spray 15ml with vemurafenib increases the risk of an abnormal heart rhythm. If you're dealing with other heart illnesses or electrolyte imbalances (for example, magnesium or potassium loss likely due to serious or prolonged diarrhoea or vomiting), you may be at greater risk.

How to manage the interaction:
Although taking Domi Up Spray 15ml along with vemurafenib can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with cabozantinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with cabozantinib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Domi Up Spray 15ml:
Using Nortriptyline together with Domi Up Spray 15ml can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with nortriptyline can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, or diarrhea. while taking these medications. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Domi Up Spray 15ml:
When Vilazodone is taken with Domi Up Spray 15ml, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in body).

How to manage the interaction:
There may be a possibility of interaction between Vilazodone and Domi Up Spray 15ml, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml and Sotalol can increase the risk or severity of irregular heart rhythms which can be severe.

How to manage the interaction:
Although taking Domi Up Spray 15ml and Sotalol can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with ribociclib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with ribociclib can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat small meals throughout the day and eat slowly to help digestion.
  • If you are sensitive to food smells, try eating cold or room-temperature foods instead of hot ones.
  • Avoid acidic foods or drinks like orange or grapefruit juice.
  • After your meals, rest with your head elevated about 12 inches above your head.
  • Drink liquids or water between meals rather than during meals.
  • Eat when you are least nauseated to help prevent discomfort.
  • Avoid consuming greasy or oily foods, as these foods can trigger nausea and vomiting.
  • Include clear broths, non-fat yoghurt, fruit juice, sherbet, and sports drinks for fluid makeup that has been lost due to vomiting.

Habit Forming

No

Therapeutic Class

ANTIEMETICS
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Alcohol

Caution

Alcohol has no known direct interaction with Domi Up Spray. However, it is advisable to avoid consuming alcohol while taking Domi Up Spray, as it may worsen the side effects like drowsiness.

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Pregnancy

Caution

Domi Up Spray should be used during pregnancy only if prescribed by a doctor. It is generally not recommended for use during early pregnancy (first trimester), as it may increase the risk of birth defects in the mouth and face of the baby.

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Breast Feeding

Caution

Avoid breastfeeding while taking Domi Up Spray, as small amounts of the medicine may pass into breast milk.

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Driving

Caution

Domi Up Spray does not affect your ability to drive. However, if you experience drowsiness or blurred vision after taking Domi Up Spray, avoid driving or operating any heavy machinery.

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Liver

Caution

In individuals with liver problems, the use of Domi Up Spray is allowed if prescribed by a doctor. However, patients with severe liver impairment should take a low dose of Domi Up Spray as much as possible. Do not take more than 8 mg of Domi Up Spray per day in case of liver disease.

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Kidney

Safe if prescribed

The use of Domi Up Spray is considered safe in patients with kidney disorders. No dose adjustment is required.

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Children

Safe if prescribed

Domi Up Spray should not be given to children below 4 years of age, as its safety and effectiveness have not been established in this age group. The use of Domi Up Spray is safe in children above 4 years of age if prescribed by a doctor.

Have a query?

FAQs

Domi Up Spray is used in the prevention of vomiting and nausea that usually occur after cancer chemotherapy, radiation treatment, or surgery.

Domi Up Spray contains Ondanestron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting.

Domi Up Spray may cause drowsiness and changes in vision, so avoid driving or operating any machines that require mental alertness.

People with an irregular heartbeat (arrhythmia), and phenylketonuria (too much of the protein phenylalanine in the blood) should not take Domi Up Spray as it may cause serious conditions. The liver patient should not take more than 8 mg of Domi Up Spray daily. Taking Domi Up Spray with apomorphine can cause a sharp dip in blood pressure, even leading to death, so avoid its intake together.

Domi Up Spray contains Ondansetron, an antiemetic drug, used in the prevention of vomiting and nausea.

Domi Up Spray is ineffective in preventing nausea associated with motion sickness.

Before taking Domi Up Spray, inform your doctor about all your medical conditions, sensitivities, and medications you are using. Also, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Domi Up Spray usually works quickly, usually within 30 minutes, but it can take up to two hours for the full effect.

Common side effects of Domi Up Spray may include constipation, headache, diarrhea, drowsiness, flushing (a feeling of warmth), weakness, and tiredness. However, not every person experiences these side effects, and some of the unpleasant effects of Domi Up Spray do not require medical attention. If the side effects persist or worsen, please consult your doctor.

Domi Up Spray was not found to be beneficial in the treatment of seasickness.

Domi Up Spray works by blocking the action of a chemical in the body (serotonin) that is responsible for causing nausea and vomiting. As a result, Domi Up Spray prevents the sensation of nausea and vomiting caused by conditions like surgery, cancer chemotherapy, pregnancy, or motion sickness.

Yes, you can take Domi Up Spray half an hour to 1 hour before meals.

If you forget to take a dose of Domi Up Spray, take it as soon as you remember. However, if it is time for your next dose, skip the missed dose and take your regular dose. Never take a double dose to make up for a forgotten dose.

If you take more than the recommended dose of Domi Up Spray, it may result in an overdose. Signs and symptoms of an overdose of Domi Up Spray may include constipation, dizziness or lightheadedness, fainting, irregular heartbeat, and sudden loss of vision for a short time. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

No, Domi Up Spray is not a steroid. Domi Up Spray belongs to a class of drugs known as antiemetics.

While specific dosing instructions will vary depending on your individual needs and medical history. Always follow your doctor's prescribed dosage and timing for taking these medications.

Take Domi Up Spray exactly as prescribed by the doctor. Take it at the same time daily, as it will help you to remember taking the medication.

Yes, Domi Up Spray can be given during pregnancy if prescribed by a doctor. However, it is not recommended for use during early pregnancy (first trimester), as it may increase the risk of birth defects in the mouth and face of the baby.

Country of origin

INDIA

Manufacturer/Marketer address

LINCOLN HOUSE, B/h. Satyam Complex, Science City Road, Sola, Ahmedabad – 380 062., Gujarat, India,
Other Info - DOM0203

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