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compositionComposition:DORIPENEM-500MG
prescription
Prescription Medicine
info
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Dorikem 500 mg Injection Kit is used to treat bacterial infections, such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis). It contains doripenem, an antibacterial drug that works by inhibiting bacterial enzymes called penicillin-binding proteins (PBPs) and shows a bactericidal effect. Thus, it treats bacterial infections.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DORIPENEM-500MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Dorikem 500 mg Injection Kit

Dorikem 500 mg Injection Kit belongs to the group of antibiotic medicines called carbapenems. It is indicated in treating bacterial infections such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis). Bacterial infections are illnesses or conditions caused by bacterial growth or toxins (poisons).

Dorikem 500 mg Injection Kit contains doripenem. Doripenem is an antibacterial drug. It works by inhibiting bacterial enzymes called penicillin-binding proteins (PBPs) and shows a bactericidal effect. Thus, Dorikem 500 mg Injection Kit treats bacterial infections.

Dorikem 500 mg Injection Kit will be administered by a healthcare professional; do not self-administer. Sometimes, Dorikem 500 mg Injection Kit may cause injection site reactions, headaches, nausea, diarrhoea, rash, and phlebitis (vein inflammation). Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, consult your doctor.

Inform your doctor if you are allergic to any component in Dorikem 500 mg Injection Kit. If you are pregnant or breastfeeding, inform your doctor before taking Dorikem 500 mg Injection Kit. It is not recommended for use in children below 18 as safety and effectiveness have not been established. Keep your doctor up to date on your medical condition and medications to rule out any potential adverse effects or interactions.

Uses of Dorikem 500 mg Injection Kit

Dorikem 500 mg Injection Kit is used to treat bacterial infections. The detailed uses of Dorikem 500 mg Injection Kit are as follows:

  • Treats urinary tract and kidney infections: Dorikem 500 mg Injection Kit is used for complicated infections of the urinary tract and kidneys caused by bacteria.
  • Used for abdominal infections: Dorikem 500 mg Injection Kit helps manage serious intra-abdominal infections.
  • Effective against bacterial infections: Dorikem 500 mg Injection Kit works by killing bacteria responsible for these infections.

Key Benefits

Dorikem 500 mg Injection Kit contains doripenem. Doripenem is an antibacterial drug. It works by killing bacteria. Thus, Dorikem 500 mg Injection Kit helps treat bacterial infections. It is indicated in treating bacterial infections such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis).

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Dorikem 500 mg Injection Kit will be administered in the hospital setting by a trained healthcare professional.
  • Do not self-administer.

How Dorikem 500 mg Injection Kit Works

Dorikem 500 mg Injection Kit contains doripenem. Doripenem is an antibacterial drug. It works by inhibiting bacterial enzymes called penicillin-binding proteins (PBPs) and shows a bactericidal effect. Thus, Dorikem 500 mg Injection Kit treats bacterial infections.
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Alcohol

Caution

Consuming alcohol with Dorikem 500 mg Injection Kit is not advisable as it may cause unpleasant side effects.

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Pregnancy

Consult your doctor

Please visit your doctor. There are no adequate and well-controlled studies in pregnant women. Your doctor will only provide a prescription if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor; there has been no significant research on the use of Dorikem 500 mg Injection Kit in breastfeeding women.

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Driving

Caution

It is unclear whether Dorikem 500 mg Injection Kit affects driving abilities, so don't drive or operate machinery if you're having trouble concentrating or reacting.

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Liver

Caution

Limited information was available about using Dorikem 500 mg Injection Kit in patients with liver disease. Inform your doctor before receiving Dorikem 500 mg Injection Kit if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Dorikem 500 mg Injection Kit if you have had a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

It is not recommended for use in children below 18 years.

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Heart

Consult your doctor

Dorikem 500 mg Injection Kit should be avoided in individuals with heart problems due to potential risks and complications. Always consult your doctor for safer alternatives tailored to your cardiac condition.

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Geriatrics

Caution

Dorikem 500 mg Injection Kit can be used in geriatric patients, but caution is advised due to age-related kidney issues. Dose adjustments may be necessary, and close monitoring is recommended to ensure safety and effectiveness.

What if I have taken an overdose of Dorikem 500 mg Injection Kit

Since Dorikem 500 mg Injection Kit is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Diet & Lifestyle Advise

  • It would be best to take probiotics after taking the full course of Dorikem 500 mg Injection Kit to restore some healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread and brown rice, should be included in your diet.
  • Avoid taking too many calcium-enriched foods and drinks as it might affect the working of Dorikem 500 mg Injection Kit.
  • Avoid intake of alcoholic beverages with Dorikem 500 mg Injection Kit as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Dorikem 500 mg Injection Kit in fighting off infections.
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How Soon It Starts Working

The time required for Dorikem 500 mg Injection Kit to start to work: The onset of time for Dorikem 500 mg Injection Kit is unknown. The time for which the effects of Dorikem 500 mg Injection Kit last: The duration of Dorikem 500 mg Injection Kit effect is unknown.

What if you forget to take Dorikem 500 mg Injection Kit

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Dorikem 500 mg Injection Kit out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Dorikem 500 mg Injection Kit is contraindicated in patients with known serious hypersensitivity to doripenem, other drugs in the same class, or patients who have demonstrated anaphylactic reactions to beta-lactams. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Dorikem 500 mg Injection Kit should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. If symptoms worsen or persist or new symptoms appear, patients should stop using the medicine and consult a doctor. Valproic acid lowers serum valproic acid concentrations. Patients with seizure disorders treated with valproic acid or sodium valproate are at a higher risk of having a seizure.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Dorikem 500 mg Injection Kit may interact with vaccines (BCG vaccine, cholera vaccine live, typhoid vaccine live) and anticonvulsants (valproic acid, divalproex sodium).

Drug-Food Interactions: Avoid the consumption of alcohol or alcoholic beverages.

Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the colon's lining), renal dysfunction, CNS disorders (Seizures) and hemodialysis (dialysis).

DoripenemDivalproex
Severe
DoripenemSodium Valproate
Severe

Drug-Drug Interactions

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DoripenemDivalproex
Severe
How does the drug interact with Dorikem 500 mg Injection Kit:
Co-administration of Divalproex and Dorikem 500 mg Injection Kit can reduce the blood levels of divalproex sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Divalproex with Dorikem 500 mg Injection Kit can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
DoripenemSodium Valproate
Severe
How does the drug interact with Dorikem 500 mg Injection Kit:
Co-administration of sodium valproate with Dorikem 500 mg Injection Kit can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and sodium valproate can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

Dorikem 500 mg Injection Kit is used to treat Bacterial infections (Complicated intra-abdominal infections and complicated urinary tract infections including pyelonephritis).
Dorikem 500 mg Injection Kit contains doripenem. Doripenem is an antibacterial drug. It works by killing bacteria. Thus, Dorikem 500 mg Injection Kit helps treat bacterial infections.
Caution should be exercised. Patients with seizure disorders who are being treated with valproic acid or sodium valproate are at a higher risk of having a seizure. It has been demonstrated that administering Dorikem 500 mg Injection Kit together with valproic acid lowers its (valproic acid) serum levels.
In some cases, Dorikem 500 mg Injection Kit may lead to Clostridium difficile-associated diarrhoea (ranging from mild to fatal colitis): in major cases, it gradually resolves over time. In case this condition persists, consult your doctor immediately.
Inform your doctor if you do not feel better even after finishing the full course of treatment. If the symptoms worsen while using this medicine, consult your doctor.
To reduce the development of antibiotic resistance and maintain the effectiveness of Dorikem 500 mg Injection Kit, it should only be used to treat or prevent infections that are proven or highly suspected to be caused by bacteria.
Usually, Dorikem 500 mg Injection Kit starts working soon after taking it. However, it may take a few days to kill all the harmful bacteria and make you feel better.
A healthcare professional will administer Dorikem 500 mg Injection Kit through an intravenous (IV) infusion. It is given over a specific duration, depending on the infection being treated and the patient's condition. Do not self-administer it.
Yes, Dorikem 500 mg Injection Kit is an antibiotic medication. It belongs to the carbapenem class of antibiotics and is used to treat a variety of bacterial infections (such as complicated intra-abdominal infections and urinary tract infections) by inhibiting the growth of bacteria.
No, Dorikem 500 mg Injection Kit is an antibiotic used to treat bacterial infections, not viral infections. It does not directly targets the SARS-CoV-2 virus that causes COVID-19.
Dorikem 500 mg Injection Kit is not available as an over-the-counter medication. It is a prescription medication used to treat serious bacterial infections and must be prescribed by a healthcare provider.
Taking too much of Dorikem 500 mg Injection Kit may lead to an overdose, potentially causing serious side effects such as seizures, difficulty breathing, and severe allergic reactions (like itching, rash, or blisters on the skin, mouth, nose, and eyes). If an overdose is suspected, seek immediate medical help.
While taking Dorikem 500 mg Injection Kit, you should avoid certain medications that may interact with it, such as vaccines (e.g., BCG vaccine, live cholera vaccine, live typhoid vaccine) and anticonvulsants (e.g., valproic acid, divalproex sodium). Always consult your doctor before taking Dorikem 500 mg Injection Kit with other medications.
Dorikem 500 mg Injection Kit should be stored in a cool and dry place, away from direct sunlight. Do not freeze the medication. Keep it out of reach of children.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - DOR0117
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