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compositionComposition:RACECADOTRIL-100MG
prescription
Prescription Medicine
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Dotril 100mg Capsule is used to treat symptoms of acute (short-term) diarrhoea in adults and infants greater than 3 months of age. It can be administered as a complementary treatment when acute diarrhoea cannot be treated casually. It contains Racecadotril, which helps in decreasing the intestinal hypersecretion (losing) of electrolytes and water induced by the cholera toxin or inflammation. Thus, it exerts rapid antidiarrheal action, without changing the duration of intestinal transit (bowel transit time or time of food travel in the digestive tract). In some cases, you may experience certain common side effects such as headache, rash and skin redness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RACECADOTRIL-100MG

Manufacturer/Marketer :

Apex Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Dotril 100mg Capsule

Dotril 100mg Capsule is an oral prescription medication used to treat symptoms of sudden, short-term diarrhoea in adults. It works by reducing the excess secretion of water into your intestines, helping to firm up your stools and decrease the frequency of bathroom visits. This treatment is intended to address the symptoms of acute diarrhoea while you recover.

This medicine is typically taken three times a day, or as prescribed by your doctor, and should be used consistently until your bowel movements return to normal. You can take Dotril 100mg Capsule with or without food, though taking it at regular intervals helps maintain its efficacy. Alongside this medication, drinking plenty of fluids and oral rehydration solutions is essential to prevent dehydration.

Most people tolerate this medication very well, but some may experience mild side effects like headaches or skin rashes. If you experience severe reactions, such as swelling of your face, lips, or throat, stop taking the medicine and consult a doctor immediately.

Talk to your doctor before using Dotril 100mg Capsule if you have a history of kidney disease or liver damage, or if your diarrhoea is accompanied by a high fever, blood, or pus in your stools. Do not take this if you have a known allergy to any of its ingredients or if you are experiencing chronic diarrhoea.

Please inform your doctor about other medicines you are taking, especially blood pressure medications like ACE inhibitors, as combining them may increase the risk of allergic swelling. If you are pregnant, breastfeeding, or managing health conditions in an elderly patient, consult your healthcare provider before starting treatment.

Uses of Dotril 100mg Capsule

Dotril 100mg Capsule is used to treat symptoms of sudden, short-term diarrhoea. The detailed uses of Dotril 100mg Capsule are as follows:

  • Acute diarrhoea: Dotril 100mg Capsule helps manage sudden bouts of watery diarrhoea by decreasing the amount of excess fluid and salts released into the digestive tract, resulting in less frequent and more solid stools.
     

Key Benefits

Dotril 100mg Capsule helps manage acute diarrhoea by reducing excessive fluid and electrolyte secretion in the intestines, allowing stools to become less frequent and more formed. By targeting the underlying mechanism that contributes to diarrhoea, this medicine provides effective symptom relief while supporting the body's natural digestive function. It offers several key benefits:

  • Helps Reduce Frequent Loose Stools: By decreasing excess fluid secretion into the intestines, Dotril 100mg Capsule helps reduce the frequency and volume of loose stools. This can provide noticeable relief from the urgency and discomfort associated with acute diarrhoea.
  • Supports Fluid and Electrolyte Balance: Excessive diarrhoea can lead to significant fluid and electrolyte loss. By helping control diarrhoeal symptoms, Dotril 100mg Capsule supports the maintenance of hydration and reduces the risk of dehydration-related weakness and fatigue.
  • Promotes Comfortable Recovery: Unlike some anti-diarrhoeal medicines that slow intestinal movement, Dotril 100mg Capsule works without significantly affecting normal gut motility. This allows the digestive system to recover more naturally while helping you return to your daily activities sooner.
     

Directions for Use

To get the best results from your treatment, follow these simple steps:

  • Swallow the capsule or tablet whole with a full glass of water.
  • Do not crush, chew, or break the medication, as this can affect how it is absorbed.
  • You can take this medicine with or without food.
  • Continue taking the medicine until you have two normal, formed stools, or as directed by your healthcare provider. Do not exceed the recommended duration.
  • Always follow your doctor's exact instructions regarding how long to continue taking Dotril 100mg Capsule.
     

How Dotril 100mg Capsule Works

Dotril 100mg Capsule acts as an enkephalinase inhibitor. Inside your digestive tract, your body naturally produces chemical messengers called enkephalins, which help limit the amount of water and electrolytes secreted into your intestines. Under normal conditions, an enzyme called enkephalinase breaks these messengers down. When you have acute diarrhoea, your intestines secrete too much water. Dotril 100mg Capsule works by blocking the enkephalinase enzyme. This action protects the natural enkephalins, allowing them to keep working longer. As a result, excess water secretion in your intestines is significantly reduced, helping to firm up your stools without affecting the normal transit speed of food through your bowel.
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Alcohol

Unsafe

Avoid consuming alcohol while taking Dotril 100mg Capsule.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will decide whether pregnant women can take Dotril 100mg Capsule or not.

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Breast Feeding

Caution

Please consult your doctor if you any concerns regarding this, your doctor will decide whether Dotril 100mg Capsule can be taken by breastfeeding mothers or not.

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Driving

Safe

Dotril 100mg Capsule does not affect your ability to drive or handle machinery.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Dotril 100mg Capsule is safe for children over three months of age if prescribed by the doctor.

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Heart

Consult your doctor

Please consult your doctor before using Dotril 100mg Capsule if you have pre-existing heart problems. Your doctor will prescribe Dotril 100mg Capsule if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before giivng Dotril 100mg Capsule to geriatric patients. Your doctor will prescribe Dotril 100mg Capsule if the benefits outweigh the risks.

What if I have taken an overdose of Dotril 100mg Capsule

Do not take more than the prescribed dose of Dotril 100mg Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water and oral rehydration solutions (ORS) to replace lost fluids and essential minerals. This is the most crucial part of recovery.
  • Eat bland foods: Stick to easy-to-digest foods such as bananas, rice, applesauce, and plain toast (the BRAT diet) until your stomach settles.
  • Avoid gut irritants: Steer clear of spicy foods, greasy or fried items, dairy products, and high-fibre foods while recovering, as these can worsen diarrhoea.
  • Limit caffeine and alcohol: Avoid coffee, black tea, soda, and alcoholic drinks, which can stimulate your bowels and worsen fluid loss.
     
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How Soon It Starts Working

The time required for Dotril 100mg Capsule to start to work: Dotril 100mg Capsule ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Dotril 100mg Capsule last: The effect of Dotril 100mg Capsule lasts for 6 to 8 hours.

What if you forget to take Dotril 100mg Capsule

If you miss a dose of Dotril 100mg Capsule, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store Dotril 100mg Capsule tablets or capsules at room temperature, ideally below 30°C. •Keep the medication in its original blister pack or container to protect it from moisture and direct sunlight.

Drug Warnings

  • Do not take Dotril 100mg Capsule if your stools contain blood or pus, or if you have a high fever, as these may be signs of a bacterial infection that requires different treatment.
  • If your symptoms do not improve or if they get worse after 7 days of starting Dotril 100mg Capsule, consult your doctor immediately.
  • Do not take this medicine if you have chronic diarrhoea or diarrhoea caused by antibiotics.
  • Inspect the packaging before use; do not take the medication if the blister pack is torn or damaged.
     

Drug-Drug Interactions

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Drug-Drug Interactions

  • ACE Inhibitors: Taking Dotril 100mg Capsule alongside blood pressure medications such as lisinopril, enalapril, or ramipril may increase your risk of experiencing sudden allergic swelling of the face, throat, or limbs (angioedema).

Drug-Disease Interactions

  • Kidney or Liver Disease: If you have severe liver damage or kidney impairment, your body may process Dotril 100mg Capsule differently. Talk to your doctor before use, as dosage adjustments or alternative treatments may be needed.
  • Chronic Diarrhoea: Dotril 100mg Capsule is only designed to treat acute, short-term diarrhoea. Do not use this medicine for chronic, long-term diarrhoea without medical supervision.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIARRHEALS]

FAQs

Dotril 100mg Capsule is used to treat symptoms of acute (short-term) diarrhoea in adults and infants greater than 3 months of age. It can be used as a complementary treatment when acute diarrhoea cannot be treated casually.
Dotril 100mg Capsule works by decreasing the amount of salts (electrolytes) and fluids secreted into the intestine, thereby maintaining salt and water balance. Thus, it makes the stools less watery and helps in controlling diarrhoea.
Talk to your doctor if you do not feel better even after taking Dotril 100mg Capsule for 7 days. Do not take Dotril 100mg Capsule for longer durations unless prescribed by the doctor.
Although Dotril 100mg Capsule helps reduce the loss of salts and fluids into the intestine, it does not replace lost fluids and does not provide rehydration. Therefore, it should be taken along with oral rehydration solutions (ORS) to prevent dehydration during diarrhoea. You should also avoid alcohol while recovering from diarrhoea, as alcohol can worsen dehydration and delay recovery.
Acute diarrhoea occurs when there is a watery stool at least 3 times per day for at least 14 days. In contrast, Chronic diarrhoea lasts for more than 2-4 weeks.
No, you should not take Dotril 100mg Capsule if your diarrhoea is bloody or accompanied by pus and a high fever. These symptoms suggest an infectious or bacterial cause that requires a different medical evaluation. Talk to your doctor.
Dotril 100mg Capsule typically begins to work within 24 hours of starting treatment. If your symptoms do not improve after 7 days, you should consult your doctor.
Yes, you can take Dotril 100mg Capsule with or without food. It is highly effective either way. Talk to your doctor or pharmacist if you experience any stomach discomfort.
There is limited clinical safety data regarding the use of this medicine during pregnancy. For safety, it is generally not recommended. Talk to your doctor before taking this medication if you are pregnant or planning to become pregnant.
Unlike some other medications for diarrhea, Dotril 100mg Capsule reduces excess water secretion without slowing down the natural movement of your gut. This significantly lowers the risk of developing rebound constipation. Talk to your doctor if you experience persistent bowel changes.
While the active ingredient can be used for children in specific paediatric formulations, adult tablets or capsules of Dotril 100mg Capsule should not be given to children. Always talk to your doctor to get the correct paediatric diagnosis and treatment.
It is not recommended to use Dotril 100mg Capsule while breastfeeding as it is not fully known if the medicine passes into breast milk. Talk to your doctor to explore safer alternative treatments.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Racecadotril Children 30Mg Granules For Oral Suspension Leaflet Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Hidrasec 100 Mg Hard Capsules Leaflet Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Singh N, Narayan S. Racecadotril: A Novel Antidiarrheal. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. October 2008. [Accessed on 2nd July 2022]Check here
  4. Gordon M, Akobeng A. Racecadotril for acute diarrhoea in children: systematic review and meta-analyses. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. March 2016. [Accessed on 2nd July 2022]Check here
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 28 Mar. 2019]Check here
  6. Zedott Capsules [Internet]. Torrentian.com. 2025 [Accessed on 5 Dec 2025]Check here
  7. Se H 1342 002 Finalpi 4Of9. [Accessed on 02 Jun. 2026]Check here

Country of origin

India
Other Info - DO53009
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