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compositionComposition:DOXOFYLLINE-400MG+MONTELUKAST-10MG
prescription
Prescription Medicine
info
Doxiflo-M Tablet 10's
Doxiflo-M Tablet 10's
Doxiflo-M Tablet 10's
Doxiflo-M Tablet 10's
Doxiflo-M Tablet 10's

Doxiflo-M Tablet is used to treat and prevent asthma and chronic obstructive pulmonary diseases (COPD). It contains Doxofylline and Montelukast, which works by relaxing muscles and widening the airways of the lungs. It treats the airflow obstruction in the lungs, thereby relieving chest tightness, wheezing and cough to make breathing easier. Also, it blocks the leukotrienes (chemicals released in response when a body comes in contact with an allergen), thereby reducing inflammation and swelling in the nose. It also inhibits bronchoconstriction (narrowing of airways in the lungs that lead to breathing difficulties). It may cause common side effects such as fever, nausea, vomiting, stomach pain/epigastric pain, headache, insomnia (difficulty in sleeping), irritation, sore throat, increased heart rate and flu-like symptoms.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

DOXOFYLLINE-400MG+MONTELUKAST-10MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Doxiflo-M Tablet

Doxiflo-M Tablet is a prescription medication used to prevent and manage the symptoms of asthma and chronic obstructive pulmonary disease (COPD). It is designed to relieve long-term breathing difficulties by keeping your airways open and reducing swelling in the lungs.

For this medicine to work effectively, you must take it consistently every day, even when you feel perfectly fine. It is typically taken once daily, with or without food, ideally at the same time each day. Making healthy adjustments, such as staying away from smoke and dust, can significantly improve how well this medicine works for you.

While taking Doxiflo-M Tablet , you might experience mild side effects like a mild headache, nausea, or an upset stomach. These symptoms usually fade as your body gets used to the medication, but if you experience a very fast heartbeat, severe dizziness, or breathing trouble, contact your doctor right away.

Do not take this if you have had a severe allergic reaction to similar airway-opening medicines in the past. You should discuss your medical history with your doctor before starting this medication, especially if you have heart rhythm issues, high blood pressure, active stomach ulcers, or severe liver disease.

This medicine can interact with certain substances; for instance, drinking alcohol or smoking can change how your body processes it, which may either reduce its effectiveness or increase the risk of side effects. Always let your doctor know if you are pregnant, planning to breastfeed, or are caring for an elderly patient, as they may require extra monitoring.

Uses of Doxiflo-M Tablet

Doxiflo-M Tablet is used to manage the following respiratory conditions:

  • Asthma: Doxiflo-M Tablet helps prevent asthma attacks by stopping the chemical triggers that cause sudden airway swelling and tightening, keeping your breathing stable over time.
  • Chronic Obstructive Pulmonary Disease (COPD): This medicine may be prescribed by your doctor to help manage symptoms of chronic bronchitis or emphysema in selected patients. However, montelukast is not routinely recommended for COPD, and the decision to use this combination depends on your individual clinical condition.

Key Benefits

The main benefit of Doxiflo-M Tablet is that it helps you breathe more comfortably throughout the day and night. By targeting two different causes of breathing trouble, it provides comprehensive, long-term relief.

  • Improves Breathing: Helps relax the airways, reducing chest tightness and making breathing easier.
  • Reduces Respiratory Flare-Ups: Regular use helps lower the frequency of asthma symptoms and COPD exacerbations.
  • Supports Better Sleep: Helps reduce nighttime breathing symptoms, allowing more restful sleep.
  • Improves Daily Activities: Better symptom control helps you stay active with less breathlessness and fatigue.
Side effects of Doxiflo-M Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.

Directions for Use

  • Doxiflo-M Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Doxiflo-M Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Doxiflo-M Tablet Works

Doxiflo-M Tablet contains doxofylline and montelukast, which work together to improve breathing and help manage asthma and other respiratory conditions. Doxofylline is a xanthine bronchodilator that works mainly by inhibiting phosphodiesterase (PDE) enzymes, increasing the level of cyclic AMP (cAMP) inside airway smooth muscle cells. This relaxes the muscles surrounding the airways, helping them remain open and making breathing easier. Montelukast is a selective leukotriene receptor antagonist that blocks the action of leukotrienes, natural chemicals responsible for airway inflammation, swelling, mucus production, and tightening of the airway muscles. By preventing these effects, montelukast helps reduce airway inflammation and keep the airways open. Together, these actions help improve airflow, reduce airway inflammation, and provide better long-term control of respiratory symptoms.
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Alcohol

Caution

Avoid drinking alcohol while taking Doxiflo-M Tablet to avail the maximum benefits and prevent the worsening of side-effects.

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Pregnancy

Caution

There is limited data on how Doxiflo-M Tablet affects pregnancy. Please consult your doctor if you are planning to conceive or already pregnant before starting Doxiflo-M Tablet .

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Breast Feeding

Caution

There is limited data on how Doxiflo-M Tablet affects breastfeeding. Please consult your doctor before starting Doxiflo-M Tablet .

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Driving

Caution

Do not drive or operate machinery if you experience drowsiness or difficulty in concentrating while using Doxiflo-M Tablet . Doxiflo-M Tablet may affect your ability to drive. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Doxiflo-M Tablet should be used with caution in patients with liver diseases. Let your doctor know if you have any history of hepatic impairment before taking Doxiflo-M Tablet .

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Kidney

Caution

Doxiflo-M Tablet should be used with caution in patients with kidney diseases. Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Doxiflo-M Tablet .

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Children

Caution

No information is available for use in children. Hence, consult your paediatrician before giving Doxiflo-M Tablet to your child.

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Heart

Caution

Doxiflo-M Tablet should be used in cardiac patients with caution.

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Geriatrics

Caution

Doxiflo-M Tablet should be given to elderly patients only if prescribed by a doctor. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Doxiflo-M Tablet

If you accidentally take more than your prescribed dose, seek emergency medical attention or contact a poison control centre immediately. Symptoms of an overdose may include extreme restlessness, vomiting, a rapid heartbeat, or severe dizziness.

Diet & Lifestyle Advise

  • Identify and avoid triggers: Keep a journal to track what triggers your breathing problems (such as pollen, pet dander, or strong perfumes) and try to limit your exposure.
  • Limit caffeine intake: Doxofylline is a xanthine derivative that is chemically related to caffeine. Consuming large amounts of coffee, tea, energy drinks, or other caffeinated products while taking this medicine may increase stimulant effects such as restlessness, tremors, palpitations, or a rapid heartbeat.
  • Stay hydrated: Drinking plenty of water helps keep the mucus in your lungs thin and easier to clear.
  • Avoid tobacco smoke: Avoid active smoking and secondhand smoke, as they damage your lungs and can severely reduce the effectiveness of this medication.

Have a query?

How Soon It Starts Working

The time required for Doxiflo-M Tablet to start to work: The time required for Doxiflo-M Tablet to show its action is not clinically established. The time for which the effects of Doxiflo-M Tablet last: The duration of action for Doxiflo-M Tablet is not clinically established.

What if you forget to take Doxiflo-M Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store this medication at room temperature, safely between 15°C and 30°C (59°F to 86°F). •Keep the tablets in their original packaging to protect them from direct sunlight, excess heat, and moisture. Do not store them in the bathroom cabinet.

Drug Warnings

  • Not a rescue medication: Do not use Doxiflo-M Tablet to treat a sudden, acute asthma attack. Always carry your quick-relief rescue inhaler for sudden breathing emergencies.
  • Watch your mood: Montelukast carries a regulatory boxed warning for serious neuropsychiatric side effects. Contact your doctor immediately if you, your family, or your caregivers notice changes in mood or behaviour, anxiety, agitation, depression, sleep disturbances, or suicidal thoughts while taking this medicine.
  • Do not stop suddenly: Even if your breathing improves completely, keep taking this medicine. Stopping it abruptly can cause your symptoms to return quickly.
  • Avoid self-medicating: Always check with your pharmacist before taking over-the-counter cough, cold, or allergy medicines, as they may interact poorly with Doxiflo-M Tablet .
  • Limit alcohol: Avoid drinking alcohol while on this medication, as it can increase the risk of dizziness and stress your liver.

Drug-Drug Interactions

verifiedApollotooltip

Some medicines may affect how Doxiflo-M Tablet works or increase the risk of side effects. Tell your doctor about all the medicines you are taking, including:

  • Certain antibiotics (like erythromycin): May increase the amount of this medicine in your body, raising the risk of side effects like a racing heart.

  • Seizure medicines (like phenobarbital or phenytoin): May lower the levels of this medicine in your blood, making it less effective.

  • Stomach acid reducers (like cimetidine): Can increase the concentration of the active ingredients in your blood, which might cause toxicity.

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

Certain foods and drinks may affect how Doxiflo-M Tablet works or increase the risk of side effects:

  • Caffeine-containing foods and drinks: Items like coffee, dark chocolate, tea, and colas can compound the stimulant-like side effects of this medicine, causing a fast heart rate or nervousness.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Doxiflo-M Tablet is a respiratory medication primarily used to treat and prevent asthma and chronic obstructive pulmonary diseases (COPD).
Doxiflo-M Tablet consists of Doxofylline and Montelukast. Doxofylline is a bronchodilator that works by relaxing muscles and widening the airways of the lungs. Montelukast is a leukotriene receptor antagonist that blocks leukotrienes (chemicals released in response when a body comes in contact with an allergen) and reduces inflammation and swelling in the nose.
Please take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.
Doxiflo-M Tablet is not recommended for use during a sudden asthma attack since it does not act right away. It is advised to please consult your doctor to prescribe a fast-acting inhaler for rescuing your sudden breathing problems.
Therapy with leukotriene receptor antagonists like Montelukast may worsen the symptoms of psychotic events in patients with a history of mental illness. Careful administration and monitoring are essential before taking Doxiflo-M Tablet in patients with neuropsychiatric disorders. Please consult your doctor before taking Doxiflo-M Tablet if you have been diagnosed or have a history of mental illness like depression, seizures (fits) etc.
It is essential to let your doctor know if you have any history of heart, liver, kidney, and lung diseases, neuropsychiatric disorders like seizures (fits) and depression, phenylketonuria (birth defect caused by the build-up of an amino acid called phenylalanine in the body), hyperthyroidism (overactive thyroid), high blood pressure, hypoxaemia (low levels of oxygen in the blood), stomach ulcers and viral infections before taking Doxiflo-M Tablet .
Doxiflo-M Tablet is usually taken in the evening for asthma and allergies, but the exact reason isn’t clear. Taking it in the evening helps control symptoms overnight and provides better relief throughout the next day.
No, the Doxiflo-M Tablet is not a steroid. It contains Doxofylline (bronchodilator) and Montelukast (leukotriene receptor antagonist) that relieves asthma and allergy symptoms.
No, Doxiflo-M Tablet doesn’t cause drowsiness, instead it causes insomnia (difficulty in sleep) as side effect. Consult the doctor if the side effect persists for long time.
Avoid alcohol consumption while using Doxiflo-M Tablet . Intake of alcohol may increase the side-effects like drowsiness. Consult the doctor if you have any concerns regarding this.
Take Doxiflo-M Tablet as advised by your physician. Swallow it with water. Do not chew, break or crush it.
Limited information is available on use of Doxiflo-M Tablet in children. Consult the children specialist before giving Doxiflo-M Tablet to child.
If you have any liver or kidney problems, inform your doctor before taking Doxiflo-M Tablet . You doctor will consider benefits and risks before prescribing Doxiflo-M Tablet . Do not self-medicate.
The side effects of Doxiflo-M Tablet include fever, nausea, vomiting, stomach pain, headache, insomnia (difficulty in sleeping), sore throat, and increased heart-rate. Most of these do not require any medical treatment. They will reduce by time. However, if these side effects persists, please consult the doctor.
If you think you have taken overdose of Doxiflo-M Tablet , consult your doctor immediately. Do not exceed recommended daily dose.
It is best to limit your intake of coffee, tea, and other caffeinated beverages. One of the active components in this medicine is closely related to caffeine, and combining them can cause side effects like a rapid heart rate, jitters, and sleep issues. Talk to your doctor about safe limits.
You should only take this medicine during pregnancy if your doctor determines that the benefits outweigh the risks. Always inform your healthcare provider if you are pregnant or planning to become pregnant before starting this medication. Talk to your doctor to discuss your treatment options.
Yes, in some cases, one of the active components in this medicine can cause mood changes, sleep problems, vivid dreams, or anxiety. If you or your family notice any changes in your mood or behaviour, you should contact your healthcare provider immediately. Talk to your doctor for guidance.
No, you should not stop taking this medication even if you feel completely healthy. This medicine is designed to prevent symptoms from starting, and stopping it suddenly can cause your breathing difficulties to return. Only stop or change your dose if directed by your healthcare provider. Talk to your doctor.
A fast or fluttering heartbeat is a known side effect that requires prompt medical attention. If you feel your heart racing or pounding, sit down, rest, and contact your healthcare provider right away. Talk to your doctor to see if your dosage needs adjustment.
Some over-the-counter cold and cough preparations contain stimulants or other ingredients that can interact poorly with Doxiflo-M Tablet , potentially worsening heart rate or blood pressure. Always check with a healthcare professional before combining any medicines. Talk to your doctor or pharmacist.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Montelukast Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  2. MIMS Drug Reference Compendium. Doxofylline Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026] Check here
  3. MIMS Drug Reference Compendium. Doxofylline+ +oral Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Montelukast sodium. 2014. [Accessed on 01 Apr. 2019] Check here
  5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC) [Revised in September 2020] [Accessed on 27th December 2022]. Check here
  6. Central Drugs Standard Control Organization (CDSCO). Doxofylline MR Tablet 650mg. Doxofylline Tablet (400mg), Doxofylline ER tablets 400mg/800mg (addl. Strength), Doxofylline tablets & Syrup. [Accessed on 27th December 2022].Check here

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - DOX0333

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