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compositionComposition:DULOXETINE-20MG+METHYLCOBALAMIN-750MCG
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Prescription Medicine
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Duloctus M 20mg/750mcg Tablet is used to treat neuropathic pain. It contains Duloxetine and Methylcobalamin, which work by increasing the levels of neurotransmitters (such as serotonin and noradrenaline) in the brain that are required to regulate pain. Also, it helps rejuvenate and protect damaged nerve cells. It may cause side effects such as drowsiness, nausea, constipation, headache, dry mouth, increased sweating, or loss of appetite. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DULOXETINE-20MG+METHYLCOBALAMIN-750MCG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Duloctus M 20mg/750mcg Tablet

Duloctus M 20mg/750mcg Tablet is a prescription oral medication used to treat chronic nerve pain, particularly diabetic neuropathy, which is nerve damage caused by diabetes. It helps relieve ongoing discomfort such as burning, stabbing, or tingling sensations in the hands and feet. By targeting pain signals in the brain and supporting nerve cell health, this medicine improves daily physical functioning.

You should take Duloctus M 20mg/750mcg Tablet regularly at the same time every day to maintain steady levels of the medicine in your body. It can be taken with or without food, though taking it with food may help reduce initial stomach upset. Incorporating a balanced diet rich in B-vitamins and managing your blood sugar levels can further enhance your treatment outcomes.

While taking Duloctus M 20mg/750mcg Tablet, you may experience mild side effects like dry mouth, nausea, sleepiness, or lightheadedness. These symptoms usually improve as your body adjusts to the medicine, but you must contact your doctor immediately if you experience severe mood changes, yellowing of your skin or eyes, or unusual bleeding.

Do not take this if you have severe kidney or liver disease, uncontrolled high blood pressure, or a history of heavy alcohol use. Talk to your doctor before starting Duloctus M 20mg/750mcg Tablet if you have a history of glaucoma, seizures, bleeding disorders, or depression.

Avoid drinking alcohol while taking this medicine because it significantly increases the risk of serious liver damage and drowsiness. You should also consult your doctor if you are pregnant, breastfeeding, or planning a pregnancy, as well as if you are an older adult, to ensure this treatment is safe for your specific health needs.

Uses of Duloctus M 20mg/750mcg Tablet

Duloctus M 20mg/750mcg Tablet is used to treat chronic nerve pain. The detailed uses of Duloctus M 20mg/750mcg Tablet are as follows:

  • Diabetic Peripheral Neuropathy: Duloctus M 20mg/750mcg Tablet helps relieve chronic nerve pain, burning, tingling, and numbness in the hands and feet caused by nerve damage in diabetic patients.
  • Neuropathic Pain: It manages various types of long-term nerve pain resulting from injury or nerve dysfunction, helping to calm overactive pain signals in the nervous system.
  • Nutritional Support for Nerve Health: It provides essential nutrients that aid in the regeneration and protection of damaged nerve fibres, promoting healthier nerve conduction.
     

Key Benefits

Duloctus M 20mg/750mcg Tablet helps relieve nerve pain while supporting healthy nerve function and repair. By reducing abnormal nerve signalling and promoting nerve health, it helps improve comfort, mobility, and overall quality of life.

  • Helps Relieve Nerve Pain: By calming overactive nerve signals, Duloctus M 20mg/750mcg Tablet helps reduce burning, stabbing, tingling, and other painful sensations associated with nerve damage, making daily activities more comfortable.
  • Supports Nerve Repair and Recovery: Duloctus M 20mg/750mcg Tablet helps nourish damaged nerves and supports the repair of their protective covering, promoting healthier nerve function and long-term recovery.
  • Improves Daily Comfort and Mobility: By reducing nerve pain and supporting nerve health, Duloctus M 20mg/750mcg Tablet helps improve physical coordination, sensation, sleep quality, and the ability to carry out everyday activities with greater ease.
     

Directions for Use

  • Take Duloctus M 20mg/750mcg Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How Duloctus M 20mg/750mcg Tablet Works

Duloctus M 20mg/750mcg Tablet is a combination of two active components that work together to address nerve pain from different angles. The first component, duloxetine, is a nerve-pain reliever that works in the brain and spinal cord. It increases the levels of natural chemical messengers (serotonin and norepinephrine) that stop pain signals from travelling to the brain, effectively lowering the pain you feel. The second component, methylcobalamin, is an active form of vitamin B12. This vitamin is crucial for producing myelin, the protective sheath that wraps around and insulates your nerves. By promoting myelin production, it helps repair damaged nerves, restores normal nerve signalling, and protects nerve cells from further degeneration.
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Alcohol

Unsafe

Alcohol may worsen the condition by increasing the risk of side effects

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Pregnancy

Unsafe

Duloctus M 20mg/750mcg Tablet is a category C medicine, so it is not recommended for use in pregnant women.

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Breast Feeding

Caution

Duloctus M 20mg/750mcg Tablet should be used with caution in breastfeeding mothers.

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Driving

Unsafe

Duloctus M 20mg/750mcg Tablet may cause drowsiness. So, avoid driving or operating heavy machinery while using Duloctus M 20mg/750mcg Tablet.

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Liver

Caution

Duloctus M 20mg/750mcg Tablet should be used with caution in patients with liver diseases.

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Kidney

Caution

Duloctus M 20mg/750mcg Tablet should be used with caution in patients with kidney diseases.

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Children

Unsafe

Duloctus M 20mg/750mcg Tablet is not recommended for children and anyone below 18 years. Please consult a medical professional for further information.

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Heart

Consult your doctor

Duloctus M 20mg/750mcg Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Duloctus M 20mg/750mcg Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Duloctus M 20mg/750mcg Tablet.

What if I have taken an overdose of Duloctus M 20mg/750mcg Tablet

In case of an accidental overdose, seek immediate medical attention. Symptoms of an overdose may include extreme sleepiness, severe dizziness, rapid heart rate, or vomiting.

Diet & Lifestyle Advise

  • Manage Blood Sugar Levels: Keep a close watch on your blood glucose levels, as stable blood sugar is key to preventing further nerve damage.
  • Eat a Balanced Diet: Focus on foods rich in B-complex vitamins, such as leafy greens, eggs, and lean meats, to support your nerve recovery.
  • Engage in Gentle Exercise: Regular, low-impact activities like walking or swimming can improve blood circulation to your hands and feet, easing neuropathic symptoms.
  • Protect Your Feet: Check your feet daily for cuts, blisters, or redness, as nerve pain can sometimes mask physical injuries.
  • Limit Alcohol Consumption: Restricting alcohol intake is crucial, as alcohol can worsen nerve damage and increase the risk of side effects.
     
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How Soon It Starts Working

The time required for Duloctus M 20mg/750mcg Tablet to start to work: Duloctus M 20mg/750mcg Tablet ideally shows its action within 4 hours after administration. The time for which the effects of Duloctus M 20mg/750mcg Tablet last: The duration of action for Duloctus M 20mg/750mcg Tablet is unknown.

What if you forget to take Duloctus M 20mg/750mcg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Duloctus M 20mg/750mcg Tablet at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the medication in its original container to protect it from direct light, moisture, and excess heat.

Drug Warnings

  • Avoid Sudden Discontinuation: Stopping this medicine abruptly can lead to withdrawal symptoms like dizziness, nausea, headache, and irritability.Always consult your doctor for a plan to gradually decrease the dose.
  • Monitor Mood Changes: Pay close attention to any sudden changes in mood, behaviour, or thoughts of self-harm, especially during the first few weeks of treatment.
  • Be Careful Driving: This medication can cause dizziness and drowsiness. Avoid driving or operating heavy machinery until you know how Duloctus M 20mg/750mcg Tablet affects you.
  • Limit Alcohol Intake: Combining this medicine with alcohol increases the risk of liver damage and severe drowsiness.
  • Check Blood Pressure Regularly: Since this medication can sometimes raise blood pressure, it is wise to monitor your readings periodically.

verifiedApollotooltip
  • Monoamine Oxidase Inhibitors (MAOIs): Taking Duloctus M 20mg/750mcg Tablet with MAOIs can cause a dangerous, life-threatening interaction. Allow at least 14 days between stopping an MAOI and starting Duloctus M 20mg/750mcg Tablet.
  • Blood Thinners: Combining this medicine with aspirin or other blood thinners can increase your risk of bleeding or bruising.
  • Other Serotonergic Drugs: Using other antidepressants or migraine medications alongside Duloctus M 20mg/750mcg Tablet can lead to a serious condition called serotonin syndrome.
     

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  • Alcohol: Avoid alcohol as it increases drowsiness and the risk of severe liver damage.

 

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANTICONVULSANT]

FAQs

Duloctus M 20mg/750mcg Tablet is used to treat neuropathic pain.
Duloctus M 20mg/750mcg Tablet is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine increases the number of neurotransmitters like serotonin and noradrenaline in the brain that can regulate pain. On the other hand, methylcobalamin (vitamin B12) can protect the nerve cells from further damage. Thus, Duloctus M 20mg/750mcg Tablet prevents nerve damage due to various conditions like injury or diabetic neuropathy and ensures smooth conduction of nerve signals throughout the body.
Duloctus M 20mg/750mcg Tablet should be taken either in the morning or evening. If you feel drowsy after taking Duloctus M 20mg/750mcg Tablet, consider taking it in the evening. Also, it is recommended to take Duloctus M 20mg/750mcg Tablet every day at the same time for the best results.
Duloctus M 20mg/750mcg Tablet should not be used with antidepressants, especially antidepressants like monoamine oxidase (MAO) inhibitors (moclobemide, linezolid) as they cause serious side-effects. It is advised to wait at least 14 days after stopping MAO inhibitors before taking Duloctus M 20mg/750mcg Tablet also wait at least 5 days after stopping Duloctus M 20mg/750mcg Tablet before taking any MAO inhibitors.
Seek medical attention immediately if you notice any depressive thoughts while using Duloctus M 20mg/750mcg Tablet. Your doctor may change the dose or medicine to treat your condition.
The common side effects of Duloctus M 20mg/750mcg Tablet include drowsiness, nausea, constipation, headache, dry mouth, increased sweating, anorexia (loss of appetite), and hot sensation (burning pain). Please inform your doctor if any of these side effects persist or worsen.
No, do not stop taking Duloctus M 20mg/750mcg Tablet, even if you start to feel better. Stopping the medication suddenly may cause withdrawal symptoms. If you need to stop the medication, your doctor will guide you on how to gradually reduce the dose safely.
Yes, you can take Duloctus M 20mg/750mcg Tablet with or without food. However, if you experience nausea or stomach upset, taking it with a meal can help reduce these side effects. Talk to your doctor if stomach issues persist.
Duloctus M 20mg/750mcg Tablet is designed to manage and significantly reduce nerve pain while supporting the repair of damaged nerve fibres. While it helps restore nerve function, it may not completely cure the underlying cause of the nerve damage. Talk to your doctor about your long-term treatment plan.
Dry mouth is a common side effect of Duloctus M 20mg/750mcg Tablet. You can manage this by sipping water frequently, chewing sugar-free gum, or sucking on sugar-free hard candies. If dry mouth becomes severe or causes dental issues, talk to your doctor or pharmacist.
Moderate intake of caffeine is generally fine, but excessive caffeine might increase anxiety or interfere with sleep, especially when starting Duloctus M 20mg/750mcg Tablet. Keep your caffeine intake moderate and talk to your doctor if you experience jitteriness or trouble sleeping.
The safety of Duloctus M 20mg/750mcg Tablet during pregnancy has not been fully established. It should only be used if the potential benefits outweigh the risks to the unborn baby. Talk to your doctor to discuss safer alternatives if you are pregnant or planning to become pregnant.
Some people may experience changes in weight or appetite while taking this medicine. These changes can vary, with some experiencing weight loss and others weight gain. Talk to your doctor if you notice significant, unexpected changes in your weight.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.8650 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Duloxetine hydrochloride. 2004. [Accessed on 23 Apr. 2019]Check here
  3. MedlinePlus MedlinePlus. [Accessed on 23 Apr. 2019]Check here
  4. Chetna Sharma, Inderpal Kaur, Harpreet Singh, Inderpal Singh Grover and Jatinder Singh. Uses of methylcobalamin plus duloxetine. Indian Journal of Pharmacology. September 2021. [Accessed on 14th June 2022]Check here
  5. Jaberpreet S. Dhaliwal, Benjamin C. Spurling, Mohammed Molla. Mechanism of duloxetine. National Institute of Health. NLM. National Centre for Biotechnology Information. Pubmed.gov. May 2022. [Accessed on 14th June 2022]Check here
  6. Eli Lilly and Company. U.S. Food & Drug Administration. [Revised in October 2010] [Accessed on 14th June 2022] docs/label/2010/022516lbl.pdfCheck here
  7. Eli Lilly and Company Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 14th June 2022]Check here

Country of origin

India

Manufacturer/Marketer address

A/3/1/3 Jawahar Market, Nangal, Punjab 140125
Other Info - DU65004
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