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compositionComposition:DASATINIB-50MG
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Dyronib 50 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia and acute lymphoblastic leukaemia. It contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce their further spread to other parts of the body.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DASATINIB-50MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Dyronib 50 Tablet

Dyronib 50 Tablet is an oral prescription medication used to treat specific types of blood cancers, including chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL). It is prescribed to slow down or stop the growth of abnormal cancer cells in the bone marrow. This medication helps manage these complex blood conditions in both adults and, in some cases, children.

For the best results, you must take Dyronib 50 Tablet consistently at the same time every day. You can take this tablet with or without food, but you should stick to the same routine daily. Making healthy lifestyle choices, such as eating a well-balanced diet and drinking plenty of fluids, can help support your body during this treatment.

While taking Dyronib 50 Tablet , you may experience some common side effects, which are usually manageable. However, you must contact your doctor immediately if you experience serious symptoms, such as sudden shortness of breath, unexplained swelling, or unusual bleeding. Regular medical follow-ups and blood tests are required to ensure the medication is working safely.

Do not take this if you are allergic to any of its ingredients. Before starting Dyronib 50 Tablet , tell your doctor if you have a history of heart disease, liver damage, low potassium or magnesium levels in your blood, or a personal or family history of long QT syndrome. Pregnant women must not take this medication, as it can cause harm to an unborn baby.

Dyronib 50 Tablet can interact with several common medications, including stomach-acid reducers and certain antibiotics, which can prevent it from working properly. You should avoid drinking alcohol while taking this medicine as it may increase the risk of side effects, and talk to your doctor if you smoke. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, consult your doctor to discuss the risks and benefits of this treatment.

Uses of Dyronib 50 Tablet

Dyronib 50 Tablet is used to treat specific types of blood cancers. The detailed uses of Dyronib 50 Tablet are as follows:

  • Chronic Myeloid Leukaemia (CML): Dyronib 50 Tablet helps by targeting and blocking abnormal proteins that send signals to cancer cells to multiply, helping to control the overproduction of abnormal white blood cells.
  • Philadelphia Chromosome-Positive Acute Lymphoblastic Leukaemia (Ph+ ALL): Dyronib 50 Tablet stops the rapid growth of abnormal leukaemia cells, allowing the bone marrow to produce healthier, normally functioning blood cells.
     

Key Benefits

Dyronib 50 Tablet provides targeted action directly against the proteins causing cancer cell growth, which offers several practical benefits for patients:

  • Disease Control: It helps slow down or halt the progression of leukaemia, allowing many patients to achieve and maintain remission.
  • Symptom Relief: By reducing the number of abnormal white blood cells, it helps relieve common leukaemia symptoms like severe fatigue, night sweats, and bone pain, allowing you to feel stronger and more active.
  • Oral Convenience: Because it is taken as a simple daily tablet, it allows you to manage your treatment at home without requiring frequent, lengthy hospital stays for intravenous therapies.
Side effects of Dyronib 50 Tablet
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.

Directions for Use

  • Dyronib 50 Tablet can be taken with or without food, as food does not affect its absorption or effectiveness.
  • It is usually taken once a day, or as prescribed by your doctor.
  • Swallow Dyronib 50 Tablet as a whole with water.
  • Do not crush, chew or break Dyronib 50 Tablet .

How Dyronib 50 Tablet Works

Dyronib 50 Tablet contains dasatinib, which belongs to a class of medications called tyrosine kinase inhibitors. In certain leukaemias, an abnormal gene creates a protein that signals white blood cells to grow out of control. This medication works by specifically binding to and blocking these abnormal proteins. By cutting off these growth signals, Dyronib 50 Tablet stops the leukaemia cells from multiplying and surviving, which helps your bone marrow regain its normal balance of healthy blood cells.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Dyronib 50 Tablet to prevent serious adverse effects.

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Pregnancy

Unsafe

When given to a pregnant woman, Dyronib 50 Tablet may cause fetal harm. There have been no sufficient and well-controlled investigations of Dyronib 50 Tablet in pregnant women. Women of reproductive potential should avoid becoming pregnant while undergoing treatment with this medicine.

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Breast Feeding

Unsafe

It is not known if Dyronib 50 Tablet passes into your breast milk. Inform your doctor if you are breastfeeding. You should not breastfeed while taking this medicine and for 2 weeks of the treatment with Dyronib 50 Tablet . Your doctor may prescribe an alternative based on the symptoms and health condition.

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Driving

Unsafe

Dyronib 50 Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Dyronib 50 Tablet or until you become alert.

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Liver

Caution

Use Dyronib 50 Tablet with caution if you have liver disease. Your doctor may monitor your liver function while taking this medicine. No dose adjustments are necessary in patients with liver impairment.

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Kidney

Caution

There are presently no clinical investigations with Dyronib 50 Tablet in patients with compromised renal function. If you have kidney problems, inform your doctor before taking this medicine.

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Children

Consult your doctor

Dyronib 50 Tablet is safe for use in children above one year of age if prescribed by the doctor.

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Heart

Caution

Dyronib 50 Tablet may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Dyronib 50 Tablet .

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Geriatrics

Consult your doctor

Please consult a doctor before administering Dyronib 50 Tablet to geriatric patients. Your doctor will prescribe Dyronib 50 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Dyronib 50 Tablet

If you accidentally take more than your prescribed dose, seek immediate medical attention. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking Dyronib 50 Tablet , as it can dangerously increase the levels of the medicine in your body.
  • Manage infection risk: Wash your hands frequently and avoid close contact with people who have active infections, as this medicine can temporarily lower your white blood cell count.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys flush out waste products as tumour cells break down.
  • Track your weight: Weigh yourself regularly and report any sudden, unexplained weight gain to your doctor, as this can be an early sign of fluid retention.
health query

Have a query?

How Soon It Starts Working

The time required for Dyronib 50 Tablet to start to work: Dyronib 50 Tablet ideally shows its action within few hours after administration. The time for which the effects of Dyronib 50 Tablet last: The effect of Dyronib 50 Tablet lasts for 24 hours.

What if you forget to take Dyronib 50 Tablet

If you miss a dose, skip the missed dose and take your next dose at your regularly scheduled time. Do not take a double dose to make up for the missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Store Dyronib 50 Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Never crush or break Dyronib 50 Tablet tablets. If a tablet is broken, pregnant women must avoid handling it, as the active drug can be absorbed through the skin and harm an unborn baby.
  • Always carry a list of all your current medicines, vitamins, and herbal supplements, and show it to any doctor or dentist before receiving new treatments.
  • Check your body daily for any unusual bruising, red spots on your skin, or dark stools, and report these to your doctor immediately.
  • Make sure to attend all scheduled laboratory appointments so your doctor can check your blood counts and monitor your liver and heart health.

 

Drug-Drug Interactions

verifiedApollotooltip
  • Acid-reducers: Medicines like proton pump inhibitors (e.g., omeprazole) and H2 blockers can significantly lower the absorption of Dyronib 50 Tablet , making it less effective.
  • Blood thinners: Taking this medicine with anticoagulants (like warfarin) or antiplatelet drugs (like aspirin) can increase your risk of severe bleeding.
  • CYP3A4 inhibitors and inducers: Certain antibiotics, antifungals, and anti-seizure medicines can change how quickly your liver breaks down Dyronib 50 Tablet , causing levels to become dangerously high or too low.
DasatinibHalofantrine
Critical

Drug-Drug Interactions

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How does the drug interact with Dyronib 50 Tablet:
Using Pimozide together with Dyronib 50 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 50 Tablet with Pimozide is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibHalofantrine
Critical
How does the drug interact with Dyronib 50 Tablet:
Using Halofantrine together with Dyronib 50 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 50 Tablet with Halofantrine is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without doctor's advice.
How does the drug interact with Dyronib 50 Tablet:
Using dronedarone together with Dyronib 50 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 50 Tablet with Dronedarone is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medication without doctor's advice.
DasatinibMesoridazine
Critical
How does the drug interact with Dyronib 50 Tablet:
Using Mesoridazine together with Dyronib 50 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Dyronib 50 Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
How does the drug interact with Dyronib 50 Tablet:
Co-administration of Dyronib 50 Tablet with Haloperidol can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 50 Tablet with Haloperidol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms like dizziness, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DasatinibNelfinavir
Severe
How does the drug interact with Dyronib 50 Tablet:
taking Dyronib 50 Tablet with Nelfinavir may significantly increase the blood levels of Dyronib 50 Tablet.

How to manage the interaction:
Although taking Dyronib 50 Tablet and Nelfinavir together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - like dizziness, or shortness of breath, and pain while urinating - call a doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with Dyronib 50 Tablet:
Coadministration of Dyronib 50 Tablet and Ibuprofen can increase the risk of bleeding.

How to manage the interaction:
Using Dyronib 50 Tablet and Ibuprofen together can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising, headache, dizziness, or weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dyronib 50 Tablet:
Coadministration of Dyronib 50 Tablet with Voriconazole may significantly increase the blood levels of Dyronib 50 Tablet which increases risk of side effects.

How to manage the interaction:
Although taking Dyronib 50 Tablet and Voriconazole together may result in an interaction, they can be taken together if a doctor prescribes it. However, if you experience dizziness, shortness of breath, heart palpitations, muscle pain, pain or burning during urination consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Dyronib 50 Tablet:
Using Dyronib 50 Tablet together with Ketoprofen may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Dyronib 50 Tablet with Ketoprofen can result in an interaction, but it can be taken if a doctor has advised it. If you experience symptoms - like bruising, feeling dizzy or lightheaded, having red or black stools, severe headaches contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dyronib 50 Tablet:
Using Baricitinib together with Dyronib 50 Tablet may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Dyronib 50 Tablet, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms - fever, diarrhea, sore throat, muscle aches, difficulty breathing, pain, or burning while urinating, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit: Consuming grapefruit or its juice can block the enzymes that break down Dyronib 50 Tablet , leading to a high buildup of the medicine in your blood and increasing the risk of serious side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Dyronib 50 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Dyronib 50 Tablet contains Dasatinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.
Dyronib 50 Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.
Take antacids such as aluminium hydroxide/magnesium hydroxide, calcium carbonate, calcium carbonate, and magnesium 2 hours before or after taking Dyronib 50 Tablet as antacids may alter the absorption of this medicine.
Yes, you can take Dyronib 50 Tablet either with or without food. However, try to be consistent with how you take it each day to help keep drug levels steady in your body. Talk to your doctor if you have questions.
Contact your healthcare team immediately. A fever can be a sign of a serious infection, which requires prompt medical evaluation since this medicine can lower your white blood cell count. Talk to your doctor right away.
No, you must avoid grapefruit and grapefruit juice entirely while taking this medication. Grapefruit can dramatically increase the drug levels in your body, leading to severe side effects. Talk to your doctor if you have dietary concerns.
No, you must not crush, cut, or chew the tablets. They must be swallowed whole. If you have difficulty swallowing pills, talk to your doctor or pharmacist for alternative guidance.
Some patients may experience thinning of the hair or mild hair loss while taking Dyronib 50 Tablet , though it is usually temporary. If this concern is affecting your well-being, talk to your doctor or pharmacist for supportive care advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - DYR0018
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