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compositionComposition:EFAVIRENZ-200MG
prescription
Prescription Medicine
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Efcure Tablet is used to treat HIV infection. It contains Efavirenz, which works by interfering with the normal working of enzymes that are essential for virus reproduction. In some cases, this medicine may cause side effects such as trouble sleeping, drowsiness, dizziness, unusual dreams and trouble concentrating. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

EFAVIRENZ-200MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Efcure Tablet

Efcure Tablet is an oral prescription medicine used in combination with other antiretroviral drugs to treat Human Immunodeficiency Virus Type 1 (HIV-1). It belongs to a class of medicines known as non-nucleoside reverse transcriptase inhibitors (NNRTIs), which work by preventing the virus from multiplying in your body. Efcure Tablet should never be used alone because HIV can quickly become resistant to treatment. It is commonly prescribed as part of a three-drug antiretroviral therapy (ART) regimen, often together with medicines such as tenofovir and emtricitabine.

To get the best results, you must take Efcure Tablet consistently every single day exactly as prescribed by your doctor. It is highly recommended to take this medicine on an empty stomach, preferably at bedtime, to help reduce dizziness and sleep-related side effects. Along with taking your medication, maintaining a balanced diet, staying hydrated, and avoiding recreational drugs are important lifestyle steps to support your immune health.

Many people taking this medicine experience temporary side effects such as dizziness, vivid dreams, or difficulty sleeping, which usually improve after a few weeks. However, you must contact your doctor immediately if you develop severe mood changes, depression, thoughts of self-harm, or a severe skin rash. Seeking timely medical advice for these serious symptoms is crucial for your safety.

Talk to your doctor before starting Efcure Tablet if you have a history of liver disease, mental health disorders, or seizures. Do not take this if you have severe liver damage or are taking certain other medications that can cause life-threatening drug interactions. Before starting treatment, your healthcare provider may recommend baseline blood tests, including HIV genotypic resistance testing when appropriate, to help ensure Efcure Tablet is likely to be effective as part of your treatment regimen.

This medicine interacts with several other medications, alcohol, and herbal supplements like St. John's wort, which can reduce its effectiveness or increase side effects. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, consult your doctor to discuss the risks and benefits of using this treatment. Your healthcare team can guide you on safe alternatives if needed.

Uses of Efcure Tablet

Efcure Tablet used in the treatment of Human immunodeficiency virus (HIV). The detailed use of Efcure Tablet is as follows:

  • HIV-1 Infection: Efcure Tablet is used in combination with other antiretroviral medications to treat Human Immunodeficiency Virus Type 1 (HIV-1). It helps lower the viral load in your blood, which strengthens your immune system and reduces the risk of active infections or complications.

Key Benefits

Efcure Tablet helps control HIV infection by lowering the amount of virus in the body and protecting the immune system.

Benefits may include:

  • Helps lower the amount of HIV in the body.
  • Supports a stronger immune system and overall health.
  • Reduces the risk of HIV-related infections and complications.
  • Promotes long-term management of HIV with consistent treatment.
  • Helps reduce the risk of passing HIV to others when used as prescribed with combination therapy.
Side effects of Efcure Tablet
  • Relieve inflammation with cool compresses, oatmeal baths, and fragrance-free moisturizers.
  • Wear loose, breathable clothing and keep nails trimmed to minimise irritation.
  • Use over-the-counter treatments like calamine lotion for relief.
  • Identify and avoid triggers like new soaps, detergents, or foods.
  • Seek medical help if the rash is severe, spreading, persistent, or accompanied by fever, swelling, or difficulty breathing.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
  • Take this medicine on an empty stomach, preferably at bedtime, as taking it with food (especially high-fat meals) can significantly increase the level of medicine in your body and make side effects like dizziness much worse.
  • Always follow your doctor's exact instructions regarding how and when to take your medication. Do not skip doses or stop taking it without consulting your healthcare provider, even if you feel well.

How Efcure Tablet Works

Efcure Tablet contains Efavirenz, which targets a specific protein inside the virus called reverse transcriptase. HIV needs this protein to make copies of its genetic material and infect new cells in your body. By binding directly to this protein, Efcure Tablet blocks its activity, stopping the virus from multiplying. Since the virus cannot replicate, its spread throughout your body is successfully controlled, allowing your immune system a chance to recover and rebuild its defences.
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Alcohol

Caution

It is advised to avoid consuming alcohol as it may worsen the condition.

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Pregnancy

Caution

Efcure Tablet is a category B medicine. It should be used with caution in pregnant women as Efcure Tablet may pass into breastmilk, which can transmit HIV to baby, so do not breastfeed your child.

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Breast Feeding

Caution

Efcure Tablet should only be used in breastfeeding females if prescribed by the doctor.

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Driving

Caution

Efcure Tablet may cause dizziness. So, avoid driving or refrain from any activities that require you to alert mentally.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Unsafe

Efcure Tablet should not be used in adolescents with kidney failure. In other people with severe kidney diseases, Efcure Tablet is given only if clinically needed and suggested by the doctor.

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Children

Safe if prescribed

Efcure Tablet is safe to be used in children only if suggested by the doctor depending upon the age and weight of the child.

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Heart

Caution

Efcure Tablet can be used in heart patients if prescribed by the physician.

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Geriatrics

Caution

Efcure Tablet can be given in elderly patients with extreme caution, if prescribed by the physician.

What if I have taken an overdose of Efcure Tablet

Symptoms of overdose may include uncontrolled body movements, dizziness, headache, difficulty concentrating, nervousness, confusion, forgetfulness, difficulty falling asleep or staying asleep, unusual dreams, drowsiness, hallucinations (seeing things or hearing voices that do not exist), abnormally happy mood, and strange thoughts. If you take too much of this medication, seek immediate emergency medical attention or contact a poison control centre right away, even if you do not feel any symptoms.

Diet & Lifestyle Advise

  • Avoid high-fat meals close to your dose: Do not eat high-fat foods within a few hours of taking Efcure Tablet , as this can cause your body to absorb too much of the medicine rapidly, worsening dizziness and sleep problems.
  • Limit or avoid alcohol: Alcohol can significantly worsen the dizziness, drowsiness, and concentration problems caused by this medicine, and it also increases the strain on your liver.
  • Eat a balanced diet: Focus on immune-supporting foods like lean proteins, whole grains, fruits, and vegetables to help your body fight off infections.
  • Prioritise sleep hygiene: Since this medicine can cause vivid dreams or insomnia, establish a relaxing bedtime routine and keep your bedroom dark and quiet to improve sleep quality.
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How Soon It Starts Working

  • The time required for Efcure Tablet to start to work: Efcure Tablet ideally shows its action within 3 to 5 hours after administration.
  • The time for which the effects of Efcure Tablet last: The effect of Efcure Tablet lasts for 56 to 72 hours.

What if you forget to take Efcure Tablet

If you miss a dose, take it as soon as you remember, provided your next scheduled dose is not due soon. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep this medicine out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Take it at bedtime: Taking your dose right before you go to sleep can help you sleep through the peak side effects, like dizziness or lightheadedness.
  • Monitor your skin closely: Watch for any signs of a skin rash during the first few weeks of starting treatment, and report any redness, peeling, or blistering to your doctor immediately.
  • Track your mood: Keep a close eye on your mental health and ask a trusted family member or friend to watch for changes in your mood, severe sadness, or unusual behaviour.
  • Do not skip doses: Skipping doses can allow the virus to become resistant to the medication, making it much harder to treat your infection in the future.
  • Check for interactions before starting new pills: Always consult your pharmacist or doctor before taking any new prescription drugs, over-the-counter medicines, or herbal supplements.
  • Seek immediate medical help: Contact your doctor or seek emergency care if you experience severe depression, anxiety, worsening seizures, or signs of liver problems (such as yellowing of your skin and dark urine).
  • Tell your doctor if HIV symptoms worsen: Contact your doctor if your HIV symptoms get worse despite taking your medicine regularly, or if you frequently miss your doses.
  • Inform your doctor about pregnancy: Tell your doctor immediately if you become pregnant, plan to become pregnant, or think you may be pregnant while taking this medicine.

Drug-Drug Interactions

verifiedApollotooltip
  • Certain cholesterol medicines (e.g., simvastatin, atorvastatin): Efcure Tablet may lower the levels of these drugs in your body, making them less effective.
  • Sedatives or sleep medicines (e.g., midazolam, triazolam): Combining these can lead to extreme sleepiness or serious breathing difficulties.
  • Antifungal medicines (e.g., voriconazole): Taking these together can alter the levels of both medications in your bloodstream, increasing side effects or reducing effectiveness.
  • Hormonal contraceptives (birth control pills, patches, or implants): Efcure Tablet can make hormonal birth control less effective, so you should use a reliable barrier method (like condoms) while on this medication.
EfavirenzRilpivirine
Critical
EfavirenzCisapride
Critical

Drug-Drug Interactions

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EfavirenzRilpivirine
Critical
How does the drug interact with Efcure Tablet:
Taking Rilpivirine with Efcure Tablet can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Rilpivirine with Efcure Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EfavirenzCisapride
Critical
How does the drug interact with Efcure Tablet:
Taking Efcure Tablet and Cisapride can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Efcure Tablet and Cisapride together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EfavirenzBepridil
Critical
How does the drug interact with Efcure Tablet:
Taking Bepridil with Efcure Tablet can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Bepridil with Efcure Tablet can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EfavirenzCarbamazepine
Critical
How does the drug interact with Efcure Tablet:
Using carbamazepine together with Efcure Tablet may reduce the effect of carbamazepine.

How to manage the interaction:
Taking Efcure Tablet with Carbamazepine can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to a doctor.
EfavirenzVoriconazole
Critical
How does the drug interact with Efcure Tablet:
Coadministration of Voriconazole with Efcure Tablet can alter the blood levels and effects of both medications.

How to manage the interaction:
Taking Voriconazole with Efcure Tablet can be taken if a doctor has advised it. Contact a doctor if you experience vomiting, dizziness, difficulty concentrating. Do not discontinue any medications without consulting a doctor.
EfavirenzErgometrine
Critical
How does the drug interact with Efcure Tablet:
When Efcure Tablet is taken with Ergometrine, the level of Ergometrine in the body can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Ergometrine with Efcure Tablet is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, abdominal pain, diarrhea, headache, dizziness, ringing of the ears, chest pain, palpitation, or irregular heartbeats contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EfavirenzDienogest
Critical
How does the drug interact with Efcure Tablet:
When Efcure Tablet is taken with Dienogest, it can lower the metabolism of Dienogest and increase the risk or severity of side effects.

How to manage the interaction:
Taking Efcure Tablet with Dienogest can possibly result in an interaction, however, it can be taken when advised by a doctor. Do not stop using any medications without talking to a doctor.
EfavirenzThioridazine
Critical
How does the drug interact with Efcure Tablet:
Taking Efcure Tablet with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Efcure Tablet with Thioridazine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EfavirenzRanolazine
Critical
How does the drug interact with Efcure Tablet:
When Efcure Tablet is taken with Ranolazine, it can lower the levels of Ranolazine.

How to manage the interaction:
Taking Ranolazine with Efcure Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medication without consulting a doctor.
EfavirenzLomitapide
Critical
How does the drug interact with Efcure Tablet:
When Efcure Tablet is taken with Lomitapide it can increase the risk or severity of liver damage.

How to manage the interaction:
Taking Efcure Tablet with Lomitapide is not recommended as it results in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • High-fat meals: Eating high-fat foods before or shortly after taking this medicine greatly increases its absorption, which can cause severe dizziness and nervous system side effects.
  • St. John's wort: This herbal supplement can significantly lower the levels of Efcure Tablet in your body, preventing it from working properly.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

Efcure Tablet is used to treat HIV infection.
Efcure Tablet is not a complete treatment of HIV infection however this medicine helps to reduce the HIV in the body so that the immune system of the body can protect the body from other infections associated with a weak immune system.
To reduce the chance of spreading HIV to others it is suggested to keep taking all the HIV medicines suggested by your doctor. Use an effective contraceptive method during sexual activity and never share your personal items like needles, syringes, toothbrushes with anyone as these products may have liquid with HIV.
Efcure Tablet contains Efavirenz, which is a nucleotide reverse transcriptase inhibitor and works by interfering with the normal working of enzymes (reverse transcriptase in HIV) that are essential for the production of viruses. It can effectively reduce the symptoms associated with HIV.
Efcure Tablet does not affect fertility. However, if you develop any side-effects while using Efcure Tablet , consult your doctor immediately.
Efcure Tablet should be taken as prescribed by your doctor. Abrupt stopping of this medicine may lead to resistance to other medications making the infection difficult to treat.
Efcure Tablet may cause dizziness. So, it would be best if you refrained from driving or operating heavy machinery that requires you to stay alert.
Efcure Tablet may alter kidney function. So, it is used with caution in patients with kidney failure, especially adolescents.
Efcure Tablet belongs to a group of medications known as 'antiretroviral drugs'. It is used to treat HIV infection in adults and children aged at least 3 months and weighing 3.5 kg or more. It contains 'Efavirenz,' a nucleotide reverse transcriptase inhibitor, which works by blocking the activity of the reverse transcriptase enzyme essential for HIV replication. This helps to reduce the symptoms associated with HIV and slows the progression of the infection.
Yes, Efcure Tablet is safe if taken in the dose and duration exactly as prescribed by the doctor.
Yes, Efcure Tablet is effective in managing HIV infection when used as part of a combination antiretroviral therapy (ART). It helps reduce the viral load in the body, increases the count of CD4 cells (a type of white blood cell that fights infections), and slows the progression of the disease. However, its effectiveness depends on following the prescribed treatment plan and regular follow-ups with the doctor.
If you forget to take a dose of Efcure Tablet , take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Efcure Tablet is generally not recommended during pregnancy, especially in the first trimester, as it may cause harm to the developing baby. Consult the doctor before taking Efcure Tablet , If you are pregnant, planning to become pregnant or think you might be pregnant. The doctor will evaluate the risks and benefits and may suggest alternative medications if necessary.
The side effects of Efcure Tablet include trouble sleeping, dizziness, drowsiness, unusual dreams and difficulty concentrating. Consult the doctor if any of these side effects persist or worsen.
No, you should take Efcure Tablet on an empty stomach, preferably at bedtime. Taking it with food, especially high-fat meals, can cause your body to absorb too much of the medicine, which increases the intensity of side effects like dizziness and confusion. Talk to your doctor or pharmacist if you have trouble scheduling your doses.
Taking this medicine at bedtime helps minimise the impact of common nervous system side effects, such as dizziness, drowsiness, and trouble concentrating, by allowing you to sleep through them. These symptoms are usually most noticeable in the first few weeks of treatment. Talk to your doctor if these symptoms persist or bother you.
Mild rashes are common when starting this medicine and often go away on their own. However, because a rash can sometimes be a sign of a severe, life-threatening skin reaction, you must report any new rash to your healthcare provider immediately. Talk to your doctor right away if the rash is accompanied by a fever, peeling skin, or mouth sores.
HIV treatment is lifelong, and Efcure Tablet should be taken every day as part of your complete antiretroviral therapy unless your doctor changes your treatment plan. During treatment, your healthcare provider will regularly monitor your viral load to ensure the medicine is controlling HIV, CD4 cell counts to assess your immune system, and may also perform liver function tests and other blood tests to check for side effects and confirm your treatment remains effective. Keep all scheduled medical appointments and laboratory tests.
No. Efcure Tablet is always used in combination with other antiretroviral medicines because using it alone can allow HIV to become resistant. It is commonly prescribed with medicines such as tenofovir and emtricitabine, and many people receive all three medicines together as a single fixed-dose combination tablet, making treatment simpler and helping improve adherence.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can worsen the dizziness, sleepiness, and concentration difficulties caused by the medication, and both substances are processed by your liver, which can increase the risk of liver damage. Talk to your doctor if you have questions about alcohol use.
Yes, this medication can reduce the effectiveness of hormonal birth control methods, such as pills, patches, implants, or vaginal rings. To prevent unplanned pregnancy, you should use a reliable barrier method of contraception, such as condoms, in addition to or instead of your hormonal birth control. Talk to your doctor to find the best contraceptive option for you.
Yes, this medicine is known to cause psychiatric side effects in some patients, including severe depression, anxiety, mood swings, or thoughts of self-harm. If you notice any changes in your mental health, or if your friends or family notice unusual changes in your behaviour, contact your healthcare provider immediately. Talk to your doctor if you have a history of depression or mental illness before starting treatment.
If you miss a dose, take it as soon as you remember, unless your next scheduled dose is due soon. Do not take two doses at the same time to make up for a missed one, as this can increase your risk of severe side effects. Skipping doses regularly can make the virus resistant to treatment. Talk to your doctor or pharmacist if you frequently forget to take your medication.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 020972S026,021360S013Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Efavirenz Efavirenz. 2014. [Accessed on 25 Jan. 2019]Check here
  3. Efavirenz Efavirenz. 1998. [Accessed on 31 Mar. 2019]Check here
  4. Ema. Atripla 600 mg/200 mg/245 mg film-coated tablets. [[Accessed on 17. Aug].2019] :Check here
  5. Webmd. Efavirenz.[[Accessed on 17 Aug].2019] :Check here
  6. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Efavirenz. [Updated 2018 Oct 31].:Check here
  7. Natella Y. Rakhmanina and John N. van den Anker. Efavirenz in the Therapy of HIV Infection. National Library of Medicine, National center for biotechnology information. PubMed Central. Revised in January 2011. [Accessed on 5th July 2022]Check here

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - EFC0011
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