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compositionComposition:SODIUM VALPROATE-200MG+VALPROIC ACID-87MG
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Prescription Medicine
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Encorate Chrono 300 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat mood disorders and migraine. It contains Sodium valproate and Valproic acid, which works by decreasing the excessive and abnormal nerve activity in the brain. Thereby, it helps in controlling seizures. It blocks the nerve transmission across the brain and provides a calming effect. In some cases, it may cause common side effects such as headache, sleepiness, drowsiness, impaired coordination, apathy (lack of interest), irregular periods and weight gain. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SODIUM VALPROATE-200MG+VALPROIC ACID-87MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Encorate Chrono 300 Tablet

Encorate Chrono 300 Tablet is a prescription medicine primarily used to treat and control different types of seizures in people with epilepsy. It is also prescribed to manage manic episodes associated with bipolar disorder and to prevent migraine headaches from starting. It helps stabilise overactive electrical activity in the brain to keep these conditions under control.

For this medicine to work effectively, you must take it consistently at the same times every day. You can take Encorate Chrono 300 Tablet with or without food, but taking it with a meal can help prevent an upset stomach. Making positive lifestyle changes, such as maintaining a consistent sleep schedule and managing stress, can further support the success of your treatment.

While taking Encorate Chrono 300 Tablet , some people may experience mild side effects like drowsiness or temporary hair thinning. However, you must monitor your body closely and contact your doctor immediately if you notice signs of serious complications, such as severe upper stomach pain, persistent vomiting, or yellowing of your eyes or skin.

Do not take this if you have active liver disease, a personal or family history of severe liver problems, or genetic mitochondrial disorders. Before starting treatment, tell your doctor if you have kidney problems, a history of depression or suicidal thoughts, or a urea cycle disorder. It is highly important to discuss these conditions to ensure the medicine is safe for you.

This medicine can interact with other substances; for instance, drinking alcohol while taking Encorate Chrono 300 Tablet can lead to extreme drowsiness and increase the strain on your liver. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, you must consult your healthcare provider before taking this medication. Encorate Chrono 300 Tablet can cause serious birth defects and developmental disorders in an unborn baby and should generally be avoided during pregnancy unless no suitable alternative treatment is available. Women who can become pregnant should use effective contraception and discuss pregnancy planning with their doctor before starting or continuing treatment.

Uses of Encorate Chrono 300 Tablet

Encorate Chrono 300 Tablet is used to manage neurological and psychiatric conditions by helping stabilise electrical activity in the brain. It is commonly prescribed for the following conditions:

  • Epilepsy and Seizures: Encorate Chrono 300 Tablet helps control and prevent various types of seizures by calming hyperactive nerve signals in the brain.
  • Bipolar Disorder (Manic Episodes): Encorate Chrono 300 Tablet helps stabilise mood swings, reducing periods of extreme high energy, excitement, or irritability.
  • Migraine Prevention: Encorate Chrono 300 Tablet reduces the frequency and severity of migraine attacks, though it is not used to treat a migraine headache that has already started.
     

Key Benefits

By helping stabilise brain activity, Encorate Chrono 300 Tablet provides several important benefits that improve long-term symptom control and quality of life, including:

  • Reduces Seizure Frequency: Helps prevent seizures, allowing better day-to-day functioning and reducing the risk of seizure-related injuries.
  • Supports Mood Stability: Helps control manic episodes and promotes more stable moods in people with bipolar disorder.
  • Prevents Migraine Attacks: Reduces the number and severity of migraine episodes, helping minimise disruption to daily activities.
  • Promotes Better Quality of Life: Improved control of seizures, mood swings, or migraines helps support a more consistent and independent lifestyle.
  • Provides Long-Term Symptom Control: When taken regularly as prescribed, it helps maintain stable brain function and reduces the likelihood of symptom recurrence.
  • Convenient Dual-Component Therapy: Combines sodium valproate and valproic acid to provide effective and sustained therapeutic levels for ongoing management of eligible conditions.
     
Side effects of Encorate Chrono 300 Tablet
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.

Directions for Use

  • Take Encorate Chrono 300 Tablet with food to avoid stomach upset or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Encorate Chrono 300 Tablet Works

Encorate Chrono 300 Tablet works by calming overactive electrical signals in your brain through several complementary mechanisms. It increases the activity of a natural chemical messenger called GABA (gamma-aminobutyric acid), which acts as a natural 'brake' in the nervous system. It also helps stabilise overactive nerve cells by affecting sodium and calcium channels involved in transmitting electrical signals. Together, these actions help prevent the uncontrolled nerve activity that can lead to seizures, manic episodes, and migraine attacks.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Encorate Chrono 300 Tablet as it may increase the risk of seizures.

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Pregnancy

Unsafe

Encorate Chrono 300 Tablet belongs to pregnancy category D. Avoid taking Encorate Chrono 300 Tablet if you are pregnant unless prescribed by a doctor, as it could lead to serious birth defects.

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Breast Feeding

Consult your doctor

Encorate Chrono 300 Tablet may pass into breastmilk. Consult your doctor before taking Encorate Chrono 300 Tablet if you are breastfeeding.

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Driving

Unsafe

Encorate Chrono 300 Tablet causes dizziness, sleepiness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Encorate Chrono 300 Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Encorate Chrono 300 Tablet can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Caution

Encorate Chrono 300 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Encorate Chrono 300 Tablet .

What if I have taken an overdose of Encorate Chrono 300 Tablet

If you take too much of this medicine, seek immediate emergency medical attention or contact a poison control center right away. Symptoms of an overdose can include extreme sleepiness, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid alcohol: Drinking alcohol while taking this medicine can cause severe drowsiness and significantly increases the risk of liver damage.
  • Track your symptoms: Keep a daily diary of your seizures, mood changes, or migraine episodes to share with your doctor at your next visit.
  • Prioritize sleep: Lack of sleep can trigger seizures and migraines. Aim for 7 to 9 hours of quality sleep every night.
  • Eat consistent meals: Taking your medicine with food can protect your stomach lining and reduce nausea.

Health Queries

I feel shivering in my hands and I'm being treated for a mental illness. Is this related to my treatment?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Handshaking can occur with some mental health medicines. Keep taking your treatment medication and tell your psychiatrist so they can check or adjust the dose. Get help fast if the shaking gets very strong or you also get a fever, stiffness, or weakness.
health query

Have a query?

How Soon It Starts Working

  • The time required for Encorate Chrono 300 Tablet to start to work: The time required for Encorate Chrono 300 Tablet to show its action is not clinically established.
  • The time for which the effects of Encorate Chrono 300 Tablet last: The duration of action for Encorate Chrono 300 Tablet is not clinically established.

What if you forget to take Encorate Chrono 300 Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store Encorate Chrono 300 Tablet at room temperature, between 15°C and 30°C, in a dry place away from direct heat, moisture, and light. •Do not store this medicine in the bathroom.

Drug Warnings

  • Do not stop taking Encorate Chrono 300 Tablet suddenly, as doing so can trigger continuous, life-threatening seizures.
  • If you are of childbearing age, use highly effective birth control, as this medicine can cause severe birth defects in an unborn baby.
  • Avoid driving, riding a bike, or operating heavy machinery until you are certain that this medicine does not make you dizzy or sleepy.
  • Carry a medical ID card or wear a medical alert bracelet to let emergency responders know you are taking this medication.
  • Regular blood tests may be required to monitor your liver function, complete blood count (including platelet levels), and, when appropriate, the level of medicine in your body. Your doctor may also check your blood ammonia level if you develop unexplained drowsiness, vomiting, or confusion during treatment. 

Important Warning: This medicine carries a risk of severe liver damage, particularly in children younger than 2 years of age and those taking multiple seizure medicines. Contact your doctor immediately if you develop persistent vomiting, unusual sleepiness, severe stomach pain, or yellowing of the skin or eyes. 

Drug-Drug Interactions

verifiedApollotooltip

Encorate Chrono 300 Tablet can interact with certain medicines, affecting how they work or increasing the risk of side effects. Inform your doctor about all prescription, over-the-counter, and herbal medicines you are taking, including:

  • Aspirin: May increase the level of Encorate Chrono 300 Tablet in your blood, raising the risk of side effects.
  • Other seizure medicines: Medications like carbamazepine, phenytoin, or phenobarbital can alter how Encorate Chrono 300 Tablet is processed, or vice versa.
  • Lamotrigine: Encorate Chrono 300 Tablet can significantly increase lamotrigine levels, raising the risk of serious skin reactions and other side effects. Your doctor may prescribe a lower lamotrigine dose and monitor you closely.
  • Carbapenem antibiotics (such as meropenem or imipenem): These antibiotics can rapidly reduce valproate levels in your blood, increasing the risk of breakthrough seizures. Alternative antibiotics may be recommended whenever possible.
  • Blood thinners: Taking this medicine with blood thinners can increase your risk of bleeding or bruising.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

Certain foods and beverages may increase the side effects of Encorate Chrono 300 Tablet . Keep the following in mind during treatment:

  • Alcohol: Greatly increases the sedating effects of Encorate Chrono 300 Tablet , leading to dangerous drowsiness, and increases the risk of liver damage.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Encorate Chrono 300 Tablet is primarily used to treat epilepsy/seizures/fits. It is also used to treat mood disorders and migraine.
Encorate Chrono 300 Tablet decreases the excessive and abnormal nerve activity in the brain. Encorate Chrono 300 Tablet increases the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect. Thereby helps in controlling seizures.
Do not discontinue Encorate Chrono 300 Tablet without consulting your doctor. To treat your condition effectually, continue taking Encorate Chrono 300 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Encorate Chrono 300 Tablet ; your doctor will reduce the dose gradually to avoid worsening of seizures.
Encorate Chrono 300 Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising.
Encorate Chrono 300 Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.
Encorate Chrono 300 Tablet may increase the effect of aspirin when taken together. Please consult your doctor before taking Encorate Chrono 300 Tablet with aspirin to avoid unpleasant side-effects. Encorate Chrono 300 Tablet and aspirin should not be given together to children below 3 years as it could lead to liver intoxication.
Encorate Chrono 300 Tablet contains sodium valproate and valproic acid as the active ingredients. It is used for the treatment of all types of epilepsy.
Take Encorate Chrono 300 Tablet with or after food as advised by your doctor.
No, Encorate Chrono 300 Tablet does not cause addiction. However, it should be taken as per dose and duration prescribed by your doctor. Avoid self-medication as it may have severe unwanted effects.
Encorate Chrono 300 Tablet does not cure epilepsy, it only prevents the seizures from occurring. Therefore, you may need to continue taking it for years. If you experience any problems while taking Encorate Chrono 300 Tablet , please consult your doctor.
Yes, Encorate Chrono 300 Tablet has no influence on the working of birth control pills. However, contraceptives (birth control pills) may interfere with the working of Encorate Chrono 300 Tablet and seizures may occur. Thus, it is essential to inform your doctor if you are using birth control pills. Your doctor will monitor your response to the treatment and Encorate Chrono 300 Tablet levels in your blood.
Long term use of Encorate Chrono 300 Tablet is safe for large number of patients. Rarely, using Encorate Chrono 300 Tablet for long term may weaken your bones, thereby increasing their chances of breaking easily (osteopenia and osteoporosis). Get regular check-ups done for bone health if you are taking Encorate Chrono 300 Tablet for a prolonged time.
Encorate Chrono 300 Tablet may cause change of hair colour, thinning of hair, and even hair loss. If you have any concerns, discuss with your doctor if it is possible to reduce the dose of Encorate Chrono 300 Tablet . Your hair may regrow after either switching to a different medicine or reducing your dose.
Encorate Chrono 300 Tablet may cause side effects such as nausea, diarrhoea, hair loss, weight gain, headache and irregular periods. If these side effects persist or worsen, please consult your doctor.
You are recommended to avoid taking Encorate Chrono 300 Tablet if you have known hypersensitivity to valproic acid, have liver disease, or are pregnant. It should be used with caution in kidney impairment patients.
Encorate Chrono 300 Tablet overdose can cause serious symptoms such as metabolic acidosis and deep coma. If you suspect you have taken overdose of Encorate Chrono 300 Tablet , seek medical help immediately.
This medicine carries a high risk of causing birth defects and developmental issues in unborn babies. If you are pregnant or planning to become pregnant, talk to your doctor immediately about alternative treatments.
Mild sleepiness is common when starting this medicine. Avoid driving or operating machinery until you know how it affects you, and talk to your doctor if the sleepiness does not go away.
No, you should avoid alcohol. Mixing alcohol with this medication can cause extreme drowsiness and put extra stress on your liver. Talk to your doctor for more advice.
Regular blood tests help your doctor monitor your liver function, blood cell counts (including platelets), and, when appropriate, the amount of medicine in your bloodstream. If you develop symptoms such as unexplained drowsiness, vomiting, or confusion, your doctor may also check your blood ammonia level. These tests help ensure the medicine remains both safe and effective.
Yes, increased appetite and weight gain are recognised side effects of this medicine. Maintaining a balanced diet and regular exercise can help manage this. Talk to your doctor if weight gain becomes a concern.
No, you should swallow the tablets or capsules whole. Crushing or chewing them can destroy their protective coating, leading to stomach irritation or a bitter taste. Talk to your pharmacist if you have difficulty swallowing pills.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A682412 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Valproic Acid,Valproate Sodium Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Masum Rahman, Hoang Nguyen. Valproic Acid. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. [Revised in October 2021] [Assessed 29th April 2025]Check here
  4. E Perucca, R Grimaldi, G Gatti, S Pirracchio, F Crema, G M Frigo. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. June 1984. [Assessed 29th April 2025]Check here
  5. Sanofi-Aventis. Electronic Medicine Compendium (EMC). [Revised in January 2022] [Assessed 29th April 2025]Check here
  6. Sodium Valproate and Valproic Acid [Package Information]. 2022. [Accessed on 17 Jan. 2026]Check here
  7. Nlh 0678 001. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - ENC0011

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