Apollo
logo
0
Select Delivery Location
compositionComposition:MEGESTROL-160MG
prescription
Prescription Medicine
info
Best Price

₹908 with coupons & bank offers*

View

Endace-160 Tablet is used as a symptomatic treatment in patients with breast cancer and endometrial cancer. It contains Megestrol, which works similarly to the female hormone progesterone. It interferes with the production or action of hormones involved in cancer growth. This effect helps to slow down the progression of cancer and reduce the symptoms associated with cancer.

Read more
Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
OffersOffers & Discounts

Get Free delivery (₹99) with circle icon

Join Circle
coupon
Get 18% Off with Coupons
coupon
Extra 10% Off with Bank Offers
bank offer
bank offer
bank offer

More about the Product

Composition :

MEGESTROL-160MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Endace-160 Tablet

Endace-160 Tablet is a tablet prescribed to treat severe appetite loss and significant weight loss in adults. It is primarily used for individuals experiencing advanced health conditions, such as cancer or HIV/AIDS, to help them regain lost body mass. It is also used to manage certain advanced, hormone-sensitive cancers.

To get the best results, you must take Endace-160 Tablet consistently at the same time every day, exactly as your doctor directs. You can take this tablet with or without food, but taking it with meals can help prevent stomach upset. Incorporating high-calorie foods and light physical activity into your daily routine can also help boost your overall progress.

While taking this medication, you may notice mild side effects like a larger appetite, weight gain, or slight fluid retention. However, you must contact your doctor immediately if you experience serious issues, such as sudden shortness of breath, chest pain, or painful swelling in your legs.

Talk to your doctor before starting Endace-160 Tablet if you have a history of blood clots, diabetes, kidney issues, or adrenal gland problems. Do not take this medicine if you are pregnant, as it can cause serious harm to an unborn baby.

This medicine can interact with other treatments. Smoking is an independent risk factor for blood clots and may add to the clotting risk already associated with Endace-160 Tablet , rather than directly interacting with the medicine. If you smoke, drink alcohol, are pregnant, breastfeeding, or are an older adult, discuss your individual risks and treatment needs with your doctor.

Uses of Endace-160 Tablet

Endace-160 Tablet is used to manage severe appetite and weight loss in certain chronic conditions and to treat selected hormone-sensitive cancers. Its main uses include:

  • Severe weight loss and appetite loss (Cachexia/Anorexia): Endace-160 Tablet helps stimulate the appetite and promotes healthy weight gain in adults experiencing extreme weight loss due to chronic illnesses.
  • Advanced breast cancer: It helps manage and slow down the growth of certain hormone-sensitive breast cancers in adults when other primary treatments are no longer working.
  • Advanced endometrial cancer: It is used to treat cancer of the lining of the uterus by helping to stop or slow the growth of cancer cells.

Key Benefits

Endace-160 Tablet helps improve appetite and support weight gain in people experiencing significant weight loss or wasting associated with certain medical conditions.

  • Stimulates Appetite: Helps increase the desire to eat, making it easier to consume enough calories and nutrients.
  • Supports Weight Gain: May promote weight gain in people with severe, unintended weight loss or reduced appetite.
  • Improves Nutritional Intake: Better appetite may help increase daily calorie and nutrient consumption, supporting overall nutritional status.
  • Supports Physical Strength: Regaining weight may help improve energy and reduce weakness associated with severe weight loss, although the weight gained may include body fat rather than muscle.
  • Supports Daily Functioning: Improved appetite and nutritional intake may help some patients manage daily activities and ongoing medical treatment more comfortably.

Directions for Use

  • Take Endace-160 Tablet with or without food as advised by your doctor.
  • Adhere to your doctor’s guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow Endace-160 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Endace-160 Tablet Works

Endace-160 Tablet contains megestrol, a man-made version of progesterone, a hormone naturally found in the body. The exact way it stimulates appetite is not fully understood. It may influence pathways involved in appetite regulation, including certain brain signals and inflammatory processes, helping increase food intake and support weight gain in some people. When used to treat advanced hormone-sensitive cancers, Endace-160 Tablet works in a different way. It blocks or alters the natural hormone pathways that cancer cells rely on to grow. By shutting down these signals, Endace-160 Tablet helps slow down or stop the spread of cancer cells in the body.
bannner image

Alcohol

Caution

Alcohol consumption may increase the risk of side effects and worsen the disease. So, avoid alcohol consumption while using this medicine.

bannner image

Pregnancy

Unsafe

Endace-160 Tablet should not be used in pregnant women as it may cause birth defects in the unborn baby. Women who are of childbearing potential should obtain a negative pregnancy test before using this medicine.

bannner image

Breast Feeding

Unsafe

Endace-160 Tablet is not recommended for use in breastfeeding as it may pass into breastmilk and harm your infant.

bannner image

Driving

Safe if prescribed

Endace-160 Tablet may not affect your ability to drive.

bannner image

Liver

Caution

Endace-160 Tablet should be used with caution if you have liver disease. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

bannner image

Kidney

Caution

Endace-160 Tablet should be used with caution if you have kidney disease. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Endace-160 Tablet is not recommended for use in children below 12 years of age.

bannner image

Heart

Unsafe

Endace-160 Tablet is not recommended for use in heart patients. This medicine has a block box warning- risk of blood clots.

bannner image

Geriatrics

Caution

Endace-160 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Endace-160 Tablet .

What if I have taken an overdose of Endace-160 Tablet

If you take more than your prescribed dose, seek immediate emergency medical care or call a poison control centre. Symptoms of an overdose may include severe nausea, vomiting, or confusion.

Diet & Lifestyle Advise

  • Eat Small, Frequent Meals: Have 5 to 6 smaller meals throughout the day if large meals feel difficult to manage.
  • Choose Nutrient-Dense Foods: Include energy- and protein-rich foods such as nuts, seeds, eggs, avocados, dairy products, pulses, and lean proteins according to your dietary needs.
  • Avoid Filling Up on Fluids Before Meals: If early fullness is a problem, limit large amounts of fluid immediately before or during meals while maintaining adequate hydration throughout the day.
  • Stay Active as Advised: If approved by your doctor, include gentle physical activity or resistance exercises to help maintain strength and muscle function.
health query

Have a query?

How Soon It Starts Working

  • The time required for Endace-160 Tablet to start to work: Endace-160 Tablet ideally shows its action within 2 to 3 hours after administration.
  • The time for which the effects of Endace-160 Tablet last: The effect of Endace-160 Tablet lasts for 24 hours.

What if you forget to take Endace-160 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your normal routine. Do not take two doses at once to make up for a missed one.

Storage

•Store Endace-160 Tablet tablets at room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the container tightly closed in a dry place to protect the medicine from moisture and direct light.

Drug Warnings

  • Do Not Stop Suddenly: Do not stop Endace-160 Tablet or reduce the dose on your own, especially after prolonged use. Your doctor may need to reduce the dose gradually because sudden discontinuation can contribute to adrenal gland problems.
  • Monitor Blood Sugar: If you have diabetes, check your blood glucose as advised because Endace-160 Tablet may raise blood sugar levels and affect diabetes control.
  • Watch for Signs of Blood Clots: Contact your doctor urgently if you develop unexplained pain, swelling, redness, or warmth in one leg. Seek immediate medical help for sudden chest pain, coughing up blood, or difficulty breathing.
  • Prevent Pregnancy During Treatment: Use effective contraception as advised by your doctor. Discuss suitable contraceptive options rather than assuming a non-hormonal method is required in every case.
  • Inform Healthcare Providers: Tell your doctor, dentist, surgeon, or anaesthetist that you are taking Endace-160 Tablet before any medical or dental procedure.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Endace-160 Tablet and require closer monitoring or treatment adjustments:

  • Corticosteroids: Medicines such as prednisone may add to effects on the adrenal glands or blood sugar control, particularly during prolonged treatment.
  • Diabetes Medicines: Endace-160 Tablet may raise blood glucose levels, which can reduce the effectiveness of insulin or oral blood sugar-lowering medicines and require adjustment of diabetes treatment.
  • Anticoagulants: Endace-160 Tablet may alter the effect of blood-thinning medicines such as warfarin. Your doctor may need to monitor blood-clotting tests more closely and adjust treatment if necessary.
MegestrolDofetilide
Severe

Drug-Drug Interactions

Login/Sign Up

How does the drug interact with Endace-160 Tablet:
Taking Thalidomide together with Endace-160 Tablet may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Endace-160 Tablet together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
MegestrolDofetilide
Severe
How does the drug interact with Endace-160 Tablet:
Co-administration of Endace-160 Tablet and Dofetilide can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions or electrolyte disturbances, you may be at higher risk.

How to manage the interaction:
Co-administration of Endace-160 Tablet with Dofetilide can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms like dizziness, fainting, lightheadedness, lack of breath, chest discomfort, or palpitations, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Endace-160 Tablet when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[PROGESTINS]

FAQs

Endace-160 Tablet is used for the treatment of Breast cancer and Endometrial cancer.
Endace-160 Tablet contains Megestrol, which works similarly to the female hormone progesterone. It interferes with the production or action of hormones involved in cancer growth. This effect helps to slow down the progression of cancer and reduce the symptoms associated with cancer.
Endace-160 Tablet may increase appetite and cause weight gain. You may gain weight, especially in the waist and the upper back. This effect usually decreases after discontinuing the treatment. However, opt for a healthy diet, exercise regularly, and maintain a normal weight while using this medicine.
Endace-160 Tablet may not affect fertility but may disrupt the menstrual cycle (periods). Though this medicine affects periods, you should take reliable contraceptive measures while using Endace-160 Tablet to prevent pregnancy as it may cause harmful effects to the unborn baby.
Endace-160 Tablet may increase blood glucose levels, so inform your doctor that you have diabetes before taking this medicine. If prescribed, you should monitor blood glucose levels regularly during the treatment.
No. Endace-160 Tablet is not a contraceptive and should not be used to prevent pregnancy. Although it may disrupt the menstrual cycle, you can still become pregnant. Use effective contraception during treatment and discuss suitable birth control options with your doctor.
It is recommended that you complete the course of Endace-160 Tablet even if you feel better. To treat your condition effectively, continue taking Endace-160 Tablet for as long as your doctor has prescribed it.
If you miss a dose of Endace-160 Tablet , take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take twice the dose to make up for a missed dose.
Take Endace-160 Tablet at around the same time(s) every day. Follow the directions on your prescription label or as directed by the physician.
Endace-160 Tablet is a hormonal therapy drug used to treat breast and womb cancer.
No, it is not recommended to use while pregnant. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking megestrol, call your doctor immediately. Megestrol may harm the foetus.
No, do not refrigerate. It should be stored in a cool and dry place away from sunlight.
No, there is no clinically proven indication to treat hot flushes with Endace-160 Tablet .
The common side-effects of Endace-160 Tablet are an increase in appetite, weight gain, shortness of breath, hot flushes (reddening of the face and neck), high blood pressure, increased blood sugar levels, a rounded face, constipation, and swelling of a vein due to a blood clot. If any of these side effects persist or get worse, inform your doctor immediately.
Yes, mild swelling in the ankles, feet, or hands due to fluid retention is a known side effect of this medicine. If the swelling becomes severe or is accompanied by shortness of breath, talk to your doctor right away.
There is no well-established direct interaction between alcohol and Endace-160 Tablet . However, alcohol may worsen certain side effects or add to other health risks depending on your medical condition and individual risk factors, including factors that affect blood clot risk. It is best to avoid or strictly limit alcohol while taking this medicine. Ask your doctor or pharmacist whether alcohol is safe for you during treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - END0108
whatsapp Floating Button

Recommended for a 30-day course: 2 Strips

Buy Now