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  3. ENDOXANN 500MG INJECTION

ENDOXANN 500MG INJECTION, Pack of 1 Injection
ENDOXANN 500MG INJECTION, Pack of 1 Injection
ENDOXANN 500MG INJECTION, Pack of 1 Injection
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
ENDOXANN 500MG INJECTION is used to treat Cancer. It contains 'Cyclophosphamide' that works by stopping or slowing the growth of cancer cells in the body. Thereby, It helps treat Cancer. Additionally, It is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients. It suppresses the body's immune system, thereby helping treat nephrotic syndrome. Common side effects of ENDOXANN 500MG INJECTION are nausea, vomiting, stomatitis (inflamed and sore mouth), weakness, malaise (general discomfort), fever, leukopenia (low white blood cell count), and alopecia (hair loss).
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Composition :

CYCLOPHOSPHAMIDE-500MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About ENDOXANN 500MG INJECTION

ENDOXANN 500MG INJECTION belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt's lymphoma, leukaemia,  neuroblastoma, retinoblastoma, adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma, small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Additionally, ENDOXANN 500MG INJECTION is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
ENDOXANN 500MG INJECTION contains 'Cyclophosphamide' that works by stopping or slowing the growth of cancer cells in the body. Thereby, ENDOXANN 500MG INJECTION helps treat cancer. ENDOXANN 500MG INJECTION suppresses the body's immune system and helps treat nephrotic syndrome.
 
In some cases, ENDOXANN 500MG INJECTION may cause nausea, vomiting, stomatitis (inflamed and sore mouth), weakness, malaise (general discomfort), fever, leukopenia (low white blood cell count), and alopecia (hair loss). You are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding. ENDOXANN 500MG INJECTION may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of ENDOXANN 500MG INJECTION

ENDOXANN 500MG INJECTION is used in the treatment of Cancer and nephrotic syndrome (kidney disease). The detailed uses of ENDOXANN 500MG INJECTION are as follows:<br/>• Treat various types of cancer: ENDOXANN 500MG INJECTION is a chemotherapy drug used to manage cancers such as breast cancer, ovarian cancer, leukemia, lymphoma (including Hodgkin’s and non-Hodgkin’s), multiple myeloma, and brain tumors by damaging the DNA of cancer cells and stopping their growth.<br/>• Manage autoimmune and kidney disorders: ENDOXANN 500MG INJECTION is also used in conditions like nephrotic syndrome and systemic lupus erythematosus, especially when other treatments have failed.<br/>

Have a query?

Directions for Use

• Your doctor will determine the dosage and frequency depending on your condition.• ENDOXANN 500MG INJECTION will be administered by a healthcare professional.• Do not self-administer.

Medicinal Benefits

ENDOXANN 500MG INJECTION belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease (cancer of the lymphatic system), mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma (cancer of plasma cells), Burkitt's lymphoma, leukaemia (blood cancer), neuroblastoma (cancer commonly found in the adrenal glands), retinoblastoma (eye cancer), adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma (cancer in and around the bones), small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. ENDOXANN 500MG INJECTION works by stopping or slowing the growth of cancer cells in the body. Thereby, ENDOXANN 500MG INJECTION helps treat cancer. Additionally, ENDOXANN 500MG INJECTION is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients. ENDOXANN 500MG INJECTION suppresses the body's immune system, thereby helping treat nephrotic syndrome.

How ENDOXANN 500MG INJECTION Works

ENDOXANN 500MG INJECTION contains 'Cyclophosphamide' that works by stopping or slowing the growth of cancer cells in the body. Thereby, ENDOXANN 500MG INJECTION helps treat cancer. ENDOXANN 500MG INJECTION suppresses the body's immune system and helps treat nephrotic syndrome.

Storage

• Store in a cool and dry place away from sunlight.
• Keep ENDOXANN 500MG INJECTION out of sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Endoxann 500mg Injection
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Your doctor may adjust the dose of the suspected medication based on your immune health; however, do not stop taking it suddenly without consulting them first.
  • Wash your hands often and handle food safely to avoid germs.
  • Get enough sleep and manage your stress levels to help your immune system stay strong.
  • Eat a balanced diet with plenty of vegetables, fruits, whole grains, dairy, and proteins.
  • Do not eat raw eggs, meat, fruits, unpasteurized milk, or uncooked vegetables.
  • Stay away from crowded places and individuals who are sick.
  • Have regular blood tests to check your immune system’s health.
  • Keep your vaccines up-to-date and ask your doctor about which vaccines you need.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
  • Stay hydrated to support kidney and bladder health.
  • Rest on your back as advised by your doctor.
  • Limit physical strain for 1-2 weeks.
  • Avoid strenuous activities like running and contact sports.
  • Quit smoking to improve overall health.
  • Use pain medication responsibly.
  • Avoid foods that can irritate the urinary track, such as spicy or acidic foods.
  • Remember to consult your doctor for personalized advice and guidance on managing your symptoms and developing a treatment plan.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of ENDOXANN 500MG INJECTION

As ENDOXANN 500MG INJECTION is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Do not take ENDOXANN 500MG INJECTION if you are allergic to any of its components. Inform your doctor if you have acute infections, bone marrow depression, urinary tract infections, urinary outflow/obstruction, liver or kidney problems, or urinary or respiratory symptoms. Consult your doctor if you are pregnant or breastfeeding. ENDOXANN 500MG INJECTION may cause myelosuppression, immunosuppression, bone marrow failure, and infections; consult your doctor if you have any concerns.

Drug-Drug Interactions

verifiedApollotooltip
CyclophosphamideCidofovir
Critical
CyclophosphamideNalidixic acid
Critical

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
How does the drug interact with Endoxann 500mg Injection:
Co-administration of Endoxann 500mg Injection and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideNalidixic acid
Critical
How does the drug interact with Endoxann 500mg Injection:
Co-administration of Nalidixic acid with Endoxann 500mg Injection may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Endoxann 500mg Injection and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideGolimumab
Severe
How does the drug interact with Endoxann 500mg Injection:
Co-administration of Golimumab with Endoxann 500mg Injection may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Endoxann 500mg Injection with Golimumab can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideDeferiprone
Severe
How does the drug interact with Endoxann 500mg Injection:
Co-administration of Endoxann 500mg Injection and Deferiprone may increase the risk of serious and potential infections.

How to manage the interaction:
Co-administration of Endoxann 500mg Injection with Deferiprone can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CyclophosphamideThalidomide
Severe
How does the drug interact with Endoxann 500mg Injection:
Taking Endoxann 500mg Injection with Thalidomide may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Endoxann 500mg Injection can be taken with Thalidomide if prescribed by the doctor. However, consult the doctor if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue any medications without a doctor's advice.
CyclophosphamideThiotepa
Severe
How does the drug interact with Endoxann 500mg Injection:
When Thiotepa is taken with Endoxann 500mg Injection, can increase the blood levels or add to the medication side effects of Endoxann 500mg Injection.

How to manage the interaction:
Although taking Thiotepa and Endoxann 500mg Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
CyclophosphamideClozapine
Severe
How does the drug interact with Endoxann 500mg Injection:
Taking Clozapine and Endoxann 500mg Injection may increase the risk of infection.

How to manage the interaction:
Taking Endoxann 500mg Injection with Clozapine can possibly lead to an interaction. However, they can be taken together if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideRopivacaine
Severe
How does the drug interact with Endoxann 500mg Injection:
Co-administration of Ropivacaine with Endoxann 500mg Injection can cause methemoglobinemia (low levels of oxygen in the blood).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Endoxann 500mg Injection, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
CyclophosphamideLevobupivacaine
Severe
How does the drug interact with Endoxann 500mg Injection:
Co-administration of Endoxann 500mg Injection with Levobupivacaine can increase the risk of methemoglobinemia (low level of oxygen in the blood).

How to manage the interaction:
Co-administration of Levobupivacaine with Endoxann 500mg Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. Keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray skin, feeling sick, headaches, dizziness, tiredness, or trouble breathing, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
CyclophosphamideBusulfan
Severe
How does the drug interact with Endoxann 500mg Injection:
Co-administration of Endoxann 500mg Injection with Busulfan can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Busulfan and Endoxann 500mg Injection, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your food.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

ENDOXANN 500MG INJECTION Substitute

Substitutes safety advice
bannner image

Alcohol

Caution

You are recommended to avoid alcohol consumption as it may worsen the risk of cyclophosphamide-induced nausea and vomiting.

bannner image

Pregnancy

Caution

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving ENDOXANN 500MG INJECTION. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

bannner image

Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving ENDOXANN 500MG INJECTION. Avoid breastfeeding during treatment with ENDOXANN 500MG INJECTION and for one week after the last dose.

bannner image

Driving

Caution

ENDOXANN 500MG INJECTION may cause dizziness. Do not drive or operate heavy machinery until you are alert.

bannner image

Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving ENDOXANN 500MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Kidney

Caution

If you have a history of kidney diseases, inform your doctor before receiving ENDOXANN 500MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Consult your doctor

Please consult your doctor. Your doctor will with the benefits and risks before prescribing this medicine based on your child's medical condition.

FAQs

ENDOXANN 500MG INJECTION is used to treat Cancer and nephrotic syndrome (kidney disease).

ENDOXANN 500MG INJECTION works by stopping or slowing down the growth of cancer cells in the body. Thereby, ENDOXANN 500MG INJECTION helps treat cancer. ENDOXANN 500MG INJECTION suppresses the body&#039;s immune system and helps treat nephrotic syndrome.

ENDOXANN 500MG INJECTION might impair fertility and interfere with oogenesis (development of ovum) and spermatogenesis (development of sperm). Please consult your doctor if you have any concerns.

Men should avoid fathering a child during the treatment and for six months following discontinuation of therapy.

ENDOXANN 500MG INJECTION might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding or bruising or if the wounds do not heal properly.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - END0006

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:23 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/3526/smpc
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/012142s109lbl.pdf
  3. https://www.drugs.com/pro/cyclophosphamide-injection.html
  4. https://fda.report/DailyMed/6bae5c14-9e87-4fb6-ae9c-4d875c1ecffe

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