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compositionComposition:CARBIDOPA-37.5MG+ENTACAPONE-200MG+LEVODOPA-150MG
prescriptionPrescription Medicine
Entacom Plus 150 Tablet 10's
Entacom Plus 150 Tablet 10's
Entacom Plus 150 Tablet 10's
Entacom Plus 150 Tablet 10's
Entacom Plus 150 Tablet 10's

Entacom Plus 150 Tablet is used in treating Parkinson's disease. It helps control movement and provides greater relief from the symptoms of Parkinson's disease. It may cause common side effects such as nausea, vomiting, loss of appetite, light-headedness, lowered blood pressure, confusion, and dyskinesia (uncontrolled/involuntary muscle movement). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CARBIDOPA-37.5MG+ENTACAPONE-200MG+LEVODOPA-150MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Entacom Plus 150 Tablet

Entacom Plus 150 Tablet is used in treating Parkinson's disease and its symptoms, including tremors, spasms, muscle stiffness and poor muscle control. Parkinson's disease is a disorder of the central nervous system that affects movement and locomotion.

Entacom Plus 150 Tablet contains Carbidopa, Levodopa, and Entacapone, which work by maintaining the levels of dopamine in the brain. Thereby, it helps reduce symptoms of Parkinson's disease, such as tremors and stiffness.

The most common side effects of Entacom Plus 150 Tablet are nausea, vomiting, loss of appetite, light-headedness, lowered blood pressure, confusion, and dyskinesia (uncontrolled/involuntary muscle movement). If the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to any of the components in Entacom Plus 150 Tablet , please tell your doctor. Consult your doctor if you are pregnant or breastfeeding. Keep your doctor informed about your medicines and health condition to rule out any side effects.

Uses of Entacom Plus 150 Tablet

Entacom Plus 150 Tablet is used in the treatment of Parkinson's disease. The detailed use of Entacom Plus 150 Tablet is as follows:

  • Treatment of Parkinson’s disease: Entacom Plus 150 Tablet is used in the treatment of Parkinson's disease. It improves motor function and enhances mobility.

Key Benefits

  • Entacom Plus 150 Tablet is used to treat Parkinson’s disease. It contains Carbidopa, Levodopa, and Entacapone.
  • Levodopa converts into dopamine in the brain, helping control movement and motor functions.
  • Carbidopa prevents the breakdown of Levodopa in the bloodstream, ensuring more reaches the brain for effective symptom relief.
  • Entacapone inhibits the enzyme COMT, prolonging the action of Levodopa and maintaining sustained dopamine levels.
  • Entacom Plus 150 Tablet reduces symptoms of Parkinson’s disease, including tremors, rigidity, stiffness, and slow movement.
  • It enhances overall mobility and quality of life by improving the effectiveness and duration of Levodopa therapy.
  • It supports overall neurological health, helping maintain a better quality of life for patients.
Side effects of Entacom Plus 150 Tablet
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Talk to your doctor about identifying the cause of the discoloration, adjusting your dose, or switching to a different medication.
  • Keep an eye on your urine colour and let your doctor know if you notice any unusual changes.
  • Increase your intake of water or other liquids to dilute your urine and restore its normal colour.
  • Avoid foods that can change your urine colour, such as beets, rhubarb, and berries.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Gently massage the affected area using your hands or a massager.
  • Light exercises such as walking or climbing stairs may help the muscles return to normal.
  • Apply heat/ice to the affected area.
  • Drink electrolyte-rich fluids.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

Directions for Use

  • Take Entacom Plus 150 Tablet with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Entacom Plus 150 Tablet Works

Entacom Plus 150 Tablet contains Carbidopa, Levodopa, and Entacapone. Levodopa belongs to the central nervous system agents, while Carbidopa is a decarboxylase inhibitor. The medicinal component Levodopa changes into dopamine in the brain and helps to control movement. Carbidopa prevents the breakdown of Levodopa in the bloodstream so that more Levodopa can reach the brain. On the other hand, Entacapone belongs to a class of COMT (catechol-o-methyltransferase enzyme) inhibitors, which cause higher and more sustained levels of Levodopa in the blood, so that more Levodopa can reach the brain, leading to greater relief from the symptoms of Parkinson's disease.
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Alcohol

Caution

Avoid consumption of alcohol with Entacom Plus 150 Tablet as it may increase the risk of adverse effects such as drowsiness, dizziness, or difficulty in concentrating.

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Pregnancy

Caution

Entacom Plus 150 Tablet is a pregnancy Category C medicine. It is unknown whether Entacom Plus 150 Tablet will affect pregnant women or the fetus. Hence, the intake of Entacom Plus 150 Tablet should be avoided if you are pregnant or planning to become pregnant, as it may harm the baby.

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Breast Feeding

Caution

Entacom Plus 150 Tablet is excreted in human milk, but the effect of Entacom Plus 150 Tablet on an infant is unknown. So, Entacom Plus 150 Tablet is given to a breastfeeding mother only if the doctor thinks the benefits outweigh the risks.

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Driving

Unsafe

Entacom Plus 150 Tablet may cause drowsiness and make you fall asleep suddenly. Therefore, avoid driving if you feel drowsy after taking Entacom Plus 150 Tablet .

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Liver

Caution

Take Entacom Plus 150 Tablet with caution if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Entacom Plus 150 Tablet with caution if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Entacom Plus 150 Tablet is not recommended for use in children, as safety and effectiveness have not been established.

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Heart

Caution

Entacom Plus 150 Tablet should be taken with extreme caution in patients with heart disease. Please consult your physician.

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Geriatrics

Safe if prescribed

Entacom Plus 150 Tablet can be given in elderly patients if prescribed by the doctor.

What if I have taken an overdose of Entacom Plus 150 Tablet

An overdose of Entacom Plus 150 Tablet may cause unpleasant side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Drink plenty of water to avoid headaches due to dehydration.
  • Limit the consumption of sugar-containing food or food with too many calories but few nutrients, as it may cause tooth decay.
  • Engaging in physical activity like dancing or exercising will boost the metabolism and make a person more energetic.
  • Avoid intake of alcoholic beverages with Entacom Plus 150 Tablet as it can make a person dehydrated and may affect their sleep. This can make it harder for a person’s body to aid the system in fighting off infections.

Have a query?

How Soon It Starts Working

The time required for Entacom Plus 150 Tablet to start to work: Entacom Plus 150 Tablet ideally shows its action within 1 to 2 hours after administration.

The time for which the effects of Entacom Plus 150 Tablet last: The effect of Entacom Plus 150 Tablet lasts for 3 to 6 hours.

What if you forget to take Entacom Plus 150 Tablet

If you miss a dose of Entacom Plus 150 Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Entacom Plus 150 Tablet if you are allergic to any of its ingredients.
  • The use of Entacom Plus 150 Tablet is not recommended if a person takes monoamine oxidase inhibitors (MAOs) or antidepressant drugs like isocarboxazid, phenelzine, selegiline, and tranylcypromine because it can lead to a high blood pressure (hypertension) crisis.
  • Do not stop taking Entacom Plus 150 Tablet suddenly without talking to your doctor. It may result in a serious neuroleptic malignant syndrome (NMS) that causes fever, muscle cramps or stiffness, unusual body movements, fast heartbeat, sweating, change in thinking, and confusion.
  • Tell your doctor if you have/had diabetes, a heart attack, a mental illness, stomach ulcers, heart disease, or have recently undergone a surgical procedure.
  • Entacom Plus 150 Tablet may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, especially when you start taking Entacom Plus 150 Tablet , so please get up gradually.
  • Prolonged intake of Entacom Plus 150 Tablet may lead to greater chances of neuropathy (nerve damage).
  • Entacom Plus 150 Tablet should be used with caution in patients with eye problems (narrow-angle glaucoma), irregular heartbeat (arrhythmia), gastrointestinal bleeding, and psychosis.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Entacom Plus 150 Tablet may have interaction with other antiparkinson’s drugs (rasagiline, selegiline, pramipexole, apomorphine), medicines used to treat depression (moclobemide, amitriptyline, desipramine, maprotiline, venlafaxine, paroxetine, rimiterole, isoprenaline), medicines used to treat respiratory diseases or allergic reactions (adrenaline, noradrenaline) medicines used to treat high blood pressure (methyldopa), water pills or diuretics (furosemide), high cholesterol-lowering drugs (atorvastatin), vitamins (pyridoxine), and anticonvulsants (phenytoin ), medicines used to relax the muscles (papaverine), dopamine D2 receptor blocker (metoclopramide, phenothiazines, butyrophenones, risperidone), antibiotics (erythromycin, rifampicin, ampicillin, chloramphenicol), a medicine used to treat TB (isoniazid).

Drug-Food Interactions: Entacom Plus 150 Tablet may interact with proteins in the food. Therefore, avoid intake of high-protein foods such as chicken, beef, pork, eggs, and fish, as they may reduce the effectiveness of Entacom Plus 150 Tablet . Do not take vitamin supplements with Entacom Plus 150 Tablet unless prescribed by a doctor. Also, avoid alcohol intake as it may increase side effects such as drowsiness, dizziness, or difficulty concentrating.

Drug-Disease Interactions: If you have glaucoma, asthma, nausea, dizziness, mental illness, breathing problems, daytime sleepiness, or involuntary muscle movements, inform your doctor before taking Entacom Plus 150 Tablet .

Entacapone + Carbidopa + LevodopaFurazolidone
Critical
Entacapone + Carbidopa + LevodopaMethylene blue
Critical

Drug-Drug Interactions

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Entacapone + Carbidopa + LevodopaFurazolidone
Critical
How does the drug interact with Entacom Plus 150 Tablet:
Taking levodopa and furazolidone together can lead to increased blood pressure.

How to manage the interaction:
Using levodopa and furazolidone together is not recommended. It can be taken if your doctor has suggested it. If you experience any symptoms like sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
Entacapone + Carbidopa + LevodopaMethylene blue
Critical
How does the drug interact with Entacom Plus 150 Tablet:
Combining Entacapone with Methylene Blue can increase the risk of increased blood pressure.

How to manage the interaction:
Taking Entacapone and Methylene Blue together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs—sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting—make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Entacapone + Carbidopa + LevodopaProcarbazine
Critical
How does the drug interact with Entacom Plus 150 Tablet:
Combining Levodopa with Procarbazine can increase the risk of increased blood pressure.

How to manage the interaction:
Taking Levodopa and Procarbazine together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs—sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting—make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Entacapone + Carbidopa + LevodopaLinezolid
Critical
How does the drug interact with Entacom Plus 150 Tablet:
Using levodopa together with linezolid can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking levodopa together with linezolid is not recommended, but it can be taken if your doctor has suggested it. However, if you experience a sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting, you should seek immediate medical attention. Do not stop using any medications without talking to a doctor.
Entacapone + Carbidopa + LevodopaPhenelzine
Critical
How does the drug interact with Entacom Plus 150 Tablet:
Using levodopa together with phenelzine can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking Levodopa with Phenelzine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
Entacapone + Carbidopa + LevodopaIsocarboxazid
Critical
How does the drug interact with Entacom Plus 150 Tablet:
Using levodopa together with isocarboxazid can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking isocarboxazid and levodopa together is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor right away if you experience symptoms like a severe headache, confusion, chest pain, or sudden weakness. Do not stop using any medications without a doctor's advice.
Entacapone + Carbidopa + LevodopaAmisulpride
Severe
How does the drug interact with Entacom Plus 150 Tablet:
Coadministration of levodopa with amisulpride may increase the risk and severity of side effects and also reduce the effectiveness of both drugs.

How to manage the interaction:
Although taking amisulpride and levodopa can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience drowsiness, low blood pressure, dizziness, and lightheadedness. Do not discontinue any medications without consulting a doctor.
Entacapone + Carbidopa + LevodopaEsketamine
Severe
How does the drug interact with Entacom Plus 150 Tablet:
Combining Entacapone+Levodopa with Esketamine can increase the risk and severity of side effects (drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination).

How to manage the interaction:
Although taking Entacapone+Levodopa and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms, like feeling sleepy, having trouble concentrating, or feeling confused, it's important to let a doctor know right away. Do not stop using any medications without talking to a doctor.
Entacapone + Carbidopa + LevodopaSodium oxybate
Severe
How does the drug interact with Entacom Plus 150 Tablet:
Taking Entacapone+Levodopa with sodium oxybate can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Entacapone+Levodopa and Sodium Oxybate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like fatigue, dizziness, lightheadedness, drowsiness, confusion, shortness of breath, chest pain, or tightness, make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPARKINSON AGENTS]

FAQs

Entacom Plus 150 Tablet is used in the treatment of Parkinson's disease and helps relieve symptoms, including tremors, spasms, muscle stiffness and poor muscle control.

Entacom Plus 150 Tablet works by maintaining the levels of dopamine in the brain. Thereby, it helps reduce symptoms of Parkinson's disease, such as tremors and stiffness.

Take Entacom Plus 150 Tablet at the same time every day, as this will help you remember to take the medicine.

In some cases, prolonged intake of Entacom Plus 150 Tablet may lead to autoimmune haemolytic anaemia (red blood cells in the blood are destroyed earlier than normal). Levodopa in Entacom Plus 150 Tablet can cause the immune system to mistake your own red blood cells for foreign substances. The body responds by making antibodies to attack the body's own red blood cells. The antibodies attach to red blood cells and cause them to break down too early. So, your doctor might recommend regular blood tests while using Entacom Plus 150 Tablet .

You are recommended to avoid taking protein-rich food (such as chicken, beef, pork, eggs, meats, fish, dairy products, seeds, and nuts), iron supplements, or multivitamin tablets while taking Entacom Plus 150 Tablet as it may delay and reduce the absorption of levodopa. Thus, it reduces the effectiveness of Entacom Plus 150 Tablet . Please consult your doctor and do as advised for the best results.

Yes, orthostatic hypotension could be a side-effect of Entacom Plus 150 Tablet . Orthostatic hypotension is a sudden lowering of blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Entacom Plus 150 Tablet are advised to regularly monitor their blood pressure levels to avoid unpleasant events.

Consult your doctor before taking Entacom Plus 150 Tablet if you have glaucoma. Entacom Plus 150 Tablet is contraindicated in patients with narrow-angle glaucoma. Entacom Plus 150 Tablet may cause blindness on long-term use in the case of patients with narrow-angle glaucoma.

Hallucination is a medical condition in which a person may feel, hear, or believe things that are not true, see things that are not there, or feel unusually suspicious or confused. Entacom Plus 150 Tablet may cause hallucinations in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Entacom Plus 150 Tablet , please talk to your doctor immediately.

It is advised not to stop taking Entacom Plus 150 Tablet without consulting your doctor, as it may lead to a severe condition called withdrawal-emergent hyperpyrexia with symptoms such as confusion, fever, muscle stiffness, changes in heartbeat, and breathing. Therefore, take Entacom Plus 150 Tablet for as long as your doctor has prescribed it, and if you experience any of these symptoms while taking Entacom Plus 150 Tablet , please consult your doctor so that the dose may be gradually reduced.

Entacom Plus 150 Tablet can be taken with or without food as advised by your doctor. Stay away from protein meals as it can delay the action of Entacom Plus 150 Tablet .

Yes, Entacom Plus 150 Tablet can turn the colour of your urine, sweat and saliva dark (brown, red, or black). Although it not harmful, it can sometimes stain your bedding and clothes.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ENT0012
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