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  3. Entocom Tablet 10's

Entocom Tablet 10's, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Entocom Tablet is used to treat Parkinson's disease. It contains Entacapone which works by inhibiting a chemical messenger that supports increasing the amount of dopamine in the body; thereby, it helps the brain to control body movements. In some cases, this medicine may cause side effects such as nausea, fatigue, vomiting, confusion, constipation, diarrhoea, and abdominal pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

ENTACAPONE-200MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Entocom Tablet

Entocom Tablet is used alone or in combination with other drugs, such as levodopa, for the treatment of the signs and symptoms of Parkinson's disease. This drug can improve symptoms such as tremors, stiffness, poor muscle control and muscle spasms. Parkinson's disease is a medical disorder that affects the ability of a person to do regular tasks. This disease affects the nervous system of the body, which in turn, affects the person's ability to move or do the normal activities of the day. This is a chronic and progressive disorder, so if the right treatment is not provided to the patient at the initial stage of this disease, their symptoms may worsen with time.

Entocom Tablet contains entacapone, which is given in combination with levodopa. It works by inhibiting a chemical messenger that supports increasing the amount of dopamine (other chemical messengers) in the body. Thereby, enough dopamine controls the brain to organize body movements. This is how it works to survive Parkinson's disease.

Take Entocom Tablet as prescribed by your doctor. You are advised to take Entocom Tablet for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience nausea, fatigue, vomiting, confusion, constipation, increased sweating, falls, urine discolouration, dizziness, Insomnia (difficulty in sleeping), diarrhoea, impaired muscle coordination, heart disease, heart attack, dryness in the mouth and abdominal pain. Most of these side effects of Entocom Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not take Entocom Tablet if you are allergic to it or any other ingredients present in it. Avoid taking Entocom Tablet if you have heart disease or heart attack. Entocom Tablet causes low blood pressure, drowsiness and dizziness. It is advisable not to drive unless you are alert. Avoid drinking alcohol as it may cause drowsiness and dizziness and decrease the efficacy of Entocom Tablet . It is not recommended for use in children under 18 years of age as limited data are available. Tell your doctor if you are pregnant or breastfeeding.

Uses of Entocom Tablet

Treatment of Parkinson's disease.

Directions for Use

• Entocom Tablet can be taken with food or as directed by your doctor. • It is best advised to take Entocom Tablet at the same time each day to get effective results.• Swallow the tablet as a whole with a glass of water. • Do not chew, crush or break it.

Medicinal Benefits

Entocom Tablet increases levels of levodopa in the body. Entocom Tablet  is used together with levodopa and carbidopa to treat 'wearing-off' symptoms of Parkinson's disease, such as tremors, stiffness, poor muscle control and muscle spasms. It works by inhibiting a chemical messenger, which supports increasing the amount of dopamine (other chemical messengers) in the body. Thereby, enough dopamine controls the brain to organize body movements. This is how it works to survive Parkinson's disease.

How Entocom Tablet Works

Entocom Tablet contains entacapone, which is given in combination with levodopa. It works by inhibiting a chemical messenger that supports increasing the amount of dopamine (other chemical messengers) in the body. Thereby, enough dopamine controls the brain to organize body movements.

Storage

Keep this medicine out of the sight and reach of children.
Side effects of Entocom Tablet
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Wear loose, breathable clothing.
  • Stay in cool, well-ventilated areas.
  • Avoid strenuous activities.
  • Use fans or air conditioners.
  • Take cool showers or baths.
  • Use antiperspirants or deodorants.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Entocom Tablet

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include confusion, feeling sleepy, decreased activity, skin discolouration, decreased muscle tone, and hives/urticaria. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Avoid taking Entocom Tablet if you are allergic to Entocom Tablet or any other ingredients in it. If you have heart disease, heart attack, muscle pain, or weakness, consult your doctor before taking Entocom Tablet . Avoid taking Entocom Tablet if you experience diarrhea. Immediately inform your doctor if you notice weakness, loss of appetite and weight loss within a relatively short period. Entocom Tablet causes low blood pressure, drowsiness and dizziness. Do not drive unless you are alert. Avoid drinking alcohol as it may cause drowsiness and dizziness and decrease the efficacy of Entocom Tablet . It is not recommended for use in children under 18 years of age as limited data are available. Tell your doctor if you are pregnant or breastfeeding before taking Entocom Tablet .

Drug-Drug Interactions

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EntacaponePhenelzine
Critical
EntacaponeIsocarboxazid
Critical

Drug-Drug Interactions

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EntacaponePhenelzine
Critical
How does the drug interact with Entocom Tablet:
Combining Entocom Tablet with Phenelzine can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Entocom Tablet with Phenelzine is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeIsocarboxazid
Critical
How does the drug interact with Entocom Tablet:
Combining Entocom Tablet with Isocarboxazid can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Entocom Tablet with Isocarboxazid is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, Contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeLinezolid
Critical
How does the drug interact with Entocom Tablet:
Coadministration of Entocom Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Entocom Tablet with Linezolid is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeTranylcypromine
Critical
How does the drug interact with Entocom Tablet:
Coadministration of Entocom Tablet with Tranylcypromine can increase the risk of high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Entocom Tablet with Tranylcypromine can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
EntacaponeEsketamine
Severe
How does the drug interact with Entocom Tablet:
Combining Entocom Tablet with Esketamine can increase the risk and severity of side effects (drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination).

How to manage the interaction:
Although taking Entocom Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like feeling sleepy, having trouble concentrating, or feeling confused, it's important to let a doctor know right away. Do not stop using any medications without talking to a doctor.
EntacaponeProcarbazine
Severe
How does the drug interact with Entocom Tablet:
Combining Entocom Tablet with Procarbazine can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Entocom Tablet and Procarbazine together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like confusion, hallucinations, seizures, fast heartbeat, fever, sweating, shivering, blurred vision, muscle spasms, stiffness, trouble moving, cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeMethylene blue
Severe
How does the drug interact with Entocom Tablet:
Combining Entocom Tablet with Methylene blue can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Entocom Tablet with Methylene blue together can result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling confused or hallucinating, having a seizure, a fast heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty coordinating movements, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
EntacaponeFurazolidone
Severe
How does the drug interact with Entocom Tablet:
Combining Entocom Tablet with Furazolidone can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although there is a possible interaction between Entocom Tablet and Furazolidone, you can take these medicines together if prescribed by your doctor. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling really unwell, confusion, seeing or hearing things that aren't there, having a seizure, a faster heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty moving, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeSodium oxybate
Severe
How does the drug interact with Entocom Tablet:
Taking Entocom Tablet with Sodium oxybate can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Entocom Tablet and Sodium oxybate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like fatigue, dizziness, lightheaded, drowsiness, confusion, shortness of breath, chest pain or tightness, make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A balanced diet is essential to show improvement in Parkinson's disease that includes grains and leafy foods as this food is rich in vitamins, fibre and minerals. With this food, one should also include dairy items, protein-rich nourishments, for example, meat and beans and solid fats found in nuts, olive oil, fish and eggs in their diet. However, limit the consumption of sugar.

  • Constipation is a common issue for individuals with Parkinson's disease. Drinking more liquid and increasing the intake of fibre admission helps in overcoming this issue.

  • Parkinson's sickness is often caused by decreased bone thickness. In this manner, taking calcium and nutrient D enhancements may help. However, do not take any supplements before counselling a doctor.

  • One should drink a lot of water as a person dealing with this disease often feel dehydrated.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Entocom Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Taking the drug along with alcohol may increase the side effects such as confusion, drowsiness and trouble in concentration.

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Pregnancy

Caution

Entocom Tablet is generally not recommended for use in pregnancy. If you are pregnant, please consult your doctor before taking this medicine. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

No clinical use of Entocom Tablet during breastfeeding has been reported. The drug might reduce serum prolactin and may affect milk production. If you are breastfeeding, consult your doctor before taking Entocom Tablet .

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Driving

Caution

Entocom Tablet may cause low blood pressure that further cause drowsiness and dizziness. So, it is not recommended to drive or operate heavy machinery after taking Entocom Tablet .

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Liver

Caution

Entocom Tablet should be used with caution in patients with liver disease. If you have liver problems, your doctor may adjust the dose of Entocom Tablet or prescribe a suitable alternative based on your condition.

bannner image

Kidney

Caution

Entocom Tablet should be used with caution in patients with kidney disease. If you have kidney problems, your doctor may adjust the dose of Entocom Tablet or prescribe a suitable alternative based on your condition.

bannner image

Children

Caution

Entocom Tablet is not recommended for use in children under 18 years as the safety and effectiveness were not established. Consult a child specialist for further information.

Have a query?

FAQs

Entocom Tablet is used to treat signs and symptoms of Parkinson's disease. It works by inhibiting a chemical messenger that supports increasing the amount of dopamine (other chemical messengers) in the body.

Yes, Entocom Tablet may result in urine discolouration to a brownish-orange colour. This effect is common and is not dangerous.

The combined use of Entocom Tablet and levodopa has been related to unnecessary daytime sleepiness and unexpected sleep onset episodes. If you experience these symptoms, you should neither drive nor use other machinery. Inform your doctor if it becomes difficult.

If you take more than the prescribed doses of Entocom Tablet , you may experience confusion, sleepiness, decreased activity, decreased muscle tone, urticaria (skin rashes caused by a reaction of medicine) and skin discolouration. If such symptoms happen, you should take urgent medical attention in a nearby hospital or inform your doctor.

No, Entocom Tablet does not affect fertility. However, Entocom Tablet should be avoided by pregnant and breastfeeding women because there is not enough data to help the safety of this patient group.

Entocom Tablet contains entacapone, which works by blocking a chemical in the body that helps increase the amount of dopamine, a substance that plays an important role in controlling movement. By increasing dopamine levels, Entocom Tablet helps the brain control body movements, which is especially helpful for managing the symptoms of Parkinson's disease.

The common side effects of Entocom Tablet include nausea, fatigue, vomiting, confusion, constipation, increased sweating, falls, urine discolouration, dizziness, insomnia (difficulty in sleeping), diarrhoea, impaired muscle coordination, heart disease, heart attack, dryness in the mouth, and abdominal pain. If the side effects persist or worsen, please consult your doctor.

Entocom Tablet should not be crushed or split. Entocom Tablet should be swallowed whole with a glass of water. Always follow your doctor's instructions for proper use.

Impulse control disorder caused by Entocom Tablet refers to a side effect where patients may experience a loss of control over their behaviours. This happens because the medication can affect dopamine levels in the brain, which in turn impacts your ability to make decisions and regulate your actions.

No, Entocom Tablet does not cross the blood-brain barrier. It works outside the brain by preventing the breakdown of levodopa, allowing more levodopa to reach the brain.

No, Entocom Tablet does not affect fertility. However, if you have concerns about fertility or are planning to become pregnant, please consult your doctor.

Entocom Tablet is not a dopamine agonist. It is a COMT (catechol-O-methyltransferase) inhibitor used to enhance the effectiveness of levodopa in treating Parkinson's disease by preventing its breakdown.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ENT0035

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:46 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.8818.pdf
  2. https://www.drugs.com/cdi/entacapone.html

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