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  3. Epalrica-M Tablet 10's

Epalrica-M Tablet 10's, Pack of 10 TABLETS
Epalrica-M Tablet 10's, Pack of 10 TABLETS
Epalrica-M Tablet 10's, Pack of 10 TABLETS
Epalrica-M Tablet 10's, Pack of 10 TABLETS
Epalrica-M Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Epalrica-M Tablet is used to treat diabetic neuropathy. It contains Epalrestat and Methylcobalamin which prevent the accumulation of sorbitol due to high blood sugar and promote the rejuvenation and protection of damaged nerve cells. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, dizziness, and headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

EPALRESTAT-150MG + METHYLCOBALAMIN-1500MCG

Manufacturer/Marketer :

Ordain Health Care Global Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Epalrica-M Tablet

Epalrica-M Tablet is a combination medicine indicated for the management of diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It primarily damages the nerves in the legs and feet. Diabetic neuropathic pain is common in patients with type 1 and type 2 diabetes.
 
Epalrica-M Tablet contains Epalrestat and Methylcobalamin. Epalrestat works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol, thereby preventing the accumulation of sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients suffering from diabetes which leads to nerve pain. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Epalrica-M Tablet helps in treating diabetic neuropathy.
 
You are advised to take Epalrica-M Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as nausea, vomiting, diarrhoea, dizziness, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Epalrica-M Tablet may cause drowsiness and dizziness, so drive only if you are alert. Epalrica-M Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Epalrica-M Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Epalrica-M Tablet

Treatment of Diabetic neuropathy (diabetic nerve pain)

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Directions for Use

• Epalrica-M Tablet can be taken with or without food as prescribed by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Swallow Epalrica-M Tablet as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Epalrica-M Tablet is a combination of two drugs, namely: Epalrestat and Methylcobalamin. Epalrica-M Tablet is indicated for the management of diabetic neuropathy. Epalrestat works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. This prevents the accumulation of sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients suffering from diabetes which leads to nerve pain. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Epalrica-M Tablet helps in treating diabetic neuropathy.

How Epalrica-M Tablet Works

Epalrica-M Tablet contains Epalrestat and Methylcobalamin. Epalrestat works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol, thereby preventing the accumulation of sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients suffering from diabetes which leads to nerve pain. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Epalrica-M Tablet helps in treating diabetic neuropathy.

Storage

Keep Epalrica-M Tablet out of reach and sight of children.
Side effects of Epalrica-M Tablet
  • Eat potassium-rich foods like avocados, bananas, spinach, and potatoes.
  • Stay hydrated by drinking plenty of water.
  • Exercise regularly and maintain healthy weight.
  • Manage stress.
  • Prioritize 7-9 hours of sleep each night to help your body and mind recharge.
  • Avoid smoking and limit intake of caffeine.
  • Practice stress-reducing activities like meditation, yoga, or deep breathing to help calm your mind and body.
  • Avoid stimulants and illegal drugs.
  • Call your doctor if it worsens.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

What if I have taken an overdose of Epalrica-M Tablet

Take Epalrica-M Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Epalrica-M Tablet if you are allergic to any of its components. Inform your doctor if you have liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Epalrica-M Tablet may cause drowsiness and dizziness, so drive only if you are alert. Epalrica-M Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Epalrica-M Tablet as it could lead to increased drowsiness and sleepiness. 

Drug-Drug Interactions

verifiedApollotooltip
MecobalaminChloramphenicol
Moderate
MecobalaminNeomycin
Moderate

Drug-Drug Interactions

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MecobalaminChloramphenicol
Moderate
How does the drug interact with Epalrica-M Tablet:
Coadministration of Epalrica-M Tablet with Chloramphenicol can impair absorption and increase the levels of Epalrica-M Tablet which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Epalrica-M Tablet with Chloramphenicol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of Vomiting, Diarrhoea, Nausea, Headache, or Loss of appetite, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MecobalaminNeomycin
Moderate
How does the drug interact with Epalrica-M Tablet:
Coadministration of Epalrica-M Tablet with Neomycin can impair the absorption of Epalrica-M Tablet and increase its levels which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Epalrica-M Tablet with Neomycin together is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of Vomiting, Diarrhoea, Nausea, Headache, or Loss of appetite you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain. 
  • Rest well, get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Epalrica-M Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

Avoid consumption of alcohol while taking Epalrica-M Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Epalrica-M Tablet ; your doctor will decide whether Epalrica-M Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Epalrica-M Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Limited information is available regarding the use of Epalrica-M Tablet in patients with liver disease. Please consult your doctor.

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Kidney

Caution

Limited information is available regarding the use of Epalrica-M Tablet in patients with kidney impairment. Please consult your doctor.

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Children

Caution

Epalrica-M Tablet should not be given to children as safety and efficacy have not been established.

FAQs

Epalrica-M Tablet is a combination of two drugs, namely: Epalrestat and Methylcobalamin. Epalrestat prevents the accumulation of sorbitol by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Epalrica-M Tablet helps in treating diabetic neuropathy.

Diarrhoea could be a side-effect of Epalrica-M Tablet . Drink plenty of fluids to prevent dehydration and consume non-spicy meals if you experience diarrhoea. Consult your doctor if you have severe diarrhoea.

Inform your doctor if you notice any cut/sore on your feet that is not healing or if you have a tingling/burning sensation in your feet/arms causing a hamper to the daily routine. If you experience trouble in sexual function, digestion, or urination, please consult a doctor. Examine your feet daily for lesions and wear proper footwear to prevent diabetic neuropathy.

Do not discontinue Epalrica-M Tablet without consulting your doctor. To treat your condition effectually, continue taking Epalrica-M Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Epalrica-M Tablet .

Epalrica-M Tablet may cause peripheral oedema. Peripheral oedema is the swelling of the hands and lower legs. Avoid sitting or standing for too long. Raise your legs by putting a pillow under the legs while lying down.

Epalrica-M Tablet does not help in controlling diabetes. Epalrica-M Tablet is indicated to treat neuropathic pain. It is recommended to adhere to your diabetic medicines to keep your blood sugar levels at normal.

Country of origin

INDIA

Manufacturer/Marketer address

Exeltis - Ordain Health Care Global Pvt Ltd , Khivraj Complex - II, 4th Floor, No: 480, Anna Salai, Nandanam, Chennai - 600 035, Tamil Nadu, India.
Other Info - EPA0012

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:51 AM IST

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Reference

  1. https://www.mims.com/malaysia/drug/info/epalrestat?mtype=generic
  2. https://www.medindia.net/doctors/drug_information/epalrestat.htm
  3. https://www.drugs.com/mtm/methylcobalamin-vitamin-b12.html

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