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compositionComposition:EPALRESTAT-50MG
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Prescription Medicine
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Epalridase 50 mg Tablet is used to treat diabetic neuropathy, a condition that causes nerve pain in people with diabetes. It helps reduce symptoms such as burning sensation, tingling, numbness, and pain in the hands and feet. Regular use can improve nerve function, enhance comfort, and support a better quality of life by relieving diabetes-related nerve discomfort. It also helps prevent the worsening of nerve damage when taken as prescribed along with proper blood sugar control.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

EPALRESTAT-50MG

Manufacturer/Marketer :

East West Pharma India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Epalridase 50 mg Tablet

Epalridase 50 mg Tablet is an oral prescription medicine used to treat diabetic neuropathy, which is nerve damage that frequently occurs in people with diabetes. It is specifically prescribed to relieve subjective symptoms such as burning pain, numbness, coldness, and abnormal sensations in the hands and feet. By targeting the underlying chemical pathway that causes nerve distress, this medication helps protect nerve function and improve your daily comfort.

For the best results, you must take Epalridase 50 mg Tablet consistently exactly as directed by your healthcare provider. It is typically taken before meals to ensure your body absorbs the medication properly and is usually prescribed for long-term management. Alongside taking this medicine, maintaining tight blood sugar control through a balanced, low-glycemic diet and regular physical activity can significantly improve your treatment outcomes.

While taking Epalridase 50 mg Tablet , some people may experience mild side effects, such as mild stomach discomfort, nausea, or a harmless reddish discolouration of the urine. However, in certain cases, this medication can affect liver function. It is important to monitor your health closely and consult your doctor immediately if you experience signs of liver damage, such as yellowing of the skin or eyes, dark urine, or unusual fatigue.

Talk to your doctor before starting this medicine if you have pre-existing liver or kidney conditions. Do not take this if you are allergic to Epalridase 50 mg Tablet or any of the inactive ingredients in the tablet. Because your safety is paramount, your healthcare provider will evaluate your medical history to confirm this medication is appropriate for you.

This medicine may interact with other diabetes medications, which can sometimes increase the risk of low blood sugar. If you are pregnant, breastfeeding, or an elderly individual, consult your doctor or pharmacist before starting treatment, as special monitoring or dose adjustments may be required.

Uses of Epalridase 50 mg Tablet

Epalridase 50 mg Tablet is used in the treatment of Diabetic neuropathy (diabetic nerve pain). The detailed use of Epalridase 50 mg Tablet is as follows:

  • Diabetic Peripheral Neuropathy: Epalridase 50 mg Tablet helps relieve distressing sensory symptoms, such as burning pain, prickling sensations, coldness, and numbness in the limbs, which are caused by nerve damage from chronic high blood sugar.
  • Nerve Function Preservation: It helps slow down the progression of diabetic nerve damage and supports overall nerve health by improving nerve conduction velocity and blood flow to nerve tissues.

Key Benefits

Epalridase 50 mg Tablet helps manage the symptoms of diabetic neuropathy, reducing nerve-related discomfort and improving everyday comfort.

Benefits may include:

  • Helps relieve pain caused by diabetic nerve damage.
  • Reduces tingling, burning, and numbness in the hands and feet.
  • Improves sensation and comfort in affected areas.
  • Supports safer movement and better balance.
  • Promotes better sleep by easing nerve-related discomfort.
  • Improves daily functioning and overall quality of life.
Side effects of Epalridase 50 mg Tablet
Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:
  • If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing.
  • Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the tablet, as this can affect how the medicine is released in your body.
  • Take the medicine before your meals, exactly as prescribed by your doctor, to ensure it is absorbed efficiently.
  • Always follow your doctor's exact instructions regarding your specific schedule. Do not stop taking the medicine or change your dose without consulting your healthcare provider first, even if you begin to feel better.

How Epalridase 50 mg Tablet Works

Epalridase 50 mg Tablet contains Epalrestat, which is an aldose reductase inhibitor. In people with diabetes, high blood sugar levels force the body to process excess glucose through an alternative pathway called the polyol pathway. An enzyme called aldose reductase converts this extra glucose into a sugar alcohol called sorbitol. When sorbitol accumulates in high amounts inside the nerve cells, it causes water retention, oxidative stress, and structural damage, which slows down nerve signals and restricts blood flow to the nerves. By blocking the aldose reductase enzyme, the medicine prevents the abnormal buildup of sorbitol in the nerve tissues. This action protects the nerves from cellular damage, improves blood supply to the nerve fibres, and allows the nervous system to transmit signals more effectively, relieving pain and restoring sensation.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Epalridase 50 mg Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Limited information is available regarding the use of Epalridase 50 mg Tablet in pregnant women. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited information is available regarding the use of Epalridase 50 mg Tablet in breastfeeding women. Consult your doctor before taking Epalridase 50 mg Tablet ; your doctor will decide whether Epalridase 50 mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Epalridase 50 mg Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Epalridase 50 mg Tablet should not be used in patients with severe liver disease. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Epalridase 50 mg Tablet should be used with caution in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Epalridase 50 mg Tablet should not be given to children as safety and efficacy have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Epalridase 50 mg Tablet . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Epalridase 50 mg Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Epalridase 50 mg Tablet

If you accidentally take more than your prescribed dose, seek immediate medical attention or contact your local emergency services right away. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Monitor blood sugar closely: Keeping your blood glucose levels within your target range is the most effective way to prevent further nerve damage and help Epalridase 50 mg Tablet work optimally.
  • Perform daily foot checks: Since neuropathy can reduce your ability to feel pain, inspect your feet daily for cuts, blisters, sores, or red spots to prevent serious, unnoticed infections.
  • Eat a nerve-supportive diet: Focus on whole foods rich in antioxidants and B-vitamins, such as leafy greens, nuts, seeds, and lean proteins, which naturally support nerve health.
  • Avoid alcohol: Limit or completely avoid alcohol consumption, as alcohol can worsen nerve damage (alcoholic neuropathy) and place extra stress on your liver.
  • Engage in low-impact exercise: Activities like walking, swimming, or stationary cycling can improve blood circulation to your extremities and support nerve repair without placing excessive stress on your feet.
health query

Have a query?

How Soon It Starts Working

  • The time required for Epalridase 50 mg Tablet to start to work: Epalridase 50 mg Tablet ideally shows its action within 1 hour after administration.
  • The time for which the effects of Epalridase 50 mg Tablet last: The duration of action for Epalridase 50 mg Tablet is clinically unknown.

What if you forget to take Epalridase 50 mg Tablet

If you miss a dose, take it as soon as you remember before your next meal. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Epalridase 50 mg Tablet out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check the packaging before use: Make sure the blister pack is sealed, and the tablets are not damaged or discoloured. Do not take the medicine if the packaging is torn or the tablets look unusual.
  • Do not worry about reddish urine: Your urine may turn reddish while taking this medicine. This is a harmless effect and does not mean there is blood in your urine.
  • Attend regular blood tests: Keep all appointments for blood tests. Your doctor may monitor your liver function to ensure the medicine is safe for you.
  • Monitor your blood sugar: Check your blood sugar regularly, especially when starting this medicine. It may increase the risk of low blood sugar if you are taking other diabetes medicines.
  • Share your medication list: Tell your doctor or pharmacist about all the medicines, supplements, and herbal products you use before starting this medicine. This helps prevent possible drug interactions.

Drug-Drug Interactions

verifiedApollotooltip
  • Antidiabetic medicines (e.g., metformin, glimepiride, insulin): Taking Epalridase 50 mg Tablet alongside other blood-sugar-lowering medications may increase the risk of low blood sugar (hypoglycemia). Your doctor may need to adjust your diabetes medication doses.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Food: Taking this medicine with or immediately after meals can reduce its absorption into your body. For best results, take it before meals as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Epalridase 50 mg Tablet is used to manage diabetic neuropathy, a chronic progressive nerve disease which causes nerve pain due to nerve damage in diabetic patients.
Epalridase 50 mg Tablet works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. Epalridase 50 mg Tablet prevents the accumulation of sorbitol, thereby helping in treating diabetic neuropathy.
Diarrhoea could be a side-effect of Epalridase 50 mg Tablet . Drink plenty of fluids to prevent dehydration and consume non-spicy meals if you experience diarrhoea. Consult your doctor if you have severe diarrhoea.
Epalridase 50 mg Tablet might cause high blood pressure. So, if you have hypertension, consult your doctor before taking Epalridase 50 mg Tablet . Regularly monitor blood pressure levels while taking Epalridase 50 mg Tablet .
Do not discontinue Epalridase 50 mg Tablet without consulting your doctor. To treat your condition effectively, continue taking Epalridase 50 mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Epalridase 50 mg Tablet .
Epalridase 50 mg Tablet may cause peripheral oedema. Peripheral oedema is the swelling of the hands and lower legs. Avoid sitting or standing for too long. Raise your legs by putting a pillow under them while lying down.
Epalridase 50 mg Tablet contains epalrestat, which is classified as an Aldose Reductase Inhibitor. It is used for the treatment of diabetic neuropathy.
Some individuals may experience specific common side effects, such as nausea, vomiting, diarrhoea, dizziness, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Follow your doctor's advice and take the right amount of medicine. Be aware of side effects and take care of yourself. If you're pregnant while on treatment, inform your doctor immediately. Don't take other medications unless instructed by the doctor. Alcohol consumption should be avoided. By following these precautions, you'll benefit most from your medicine and stay safe.
In some individuals, Epalridase 50 mg Tablet may cause vomiting as it is a common side effect of Epalridase 50 mg Tablet . This effect does not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Limited information is available regarding the use of Epalridase 50 mg Tablet in pregnant women. Please consult your doctor if you are pregnant or planning to become pregnant before taking Epalridase 50 mg Tablet , your doctor will prescribe only if the benefits outweigh the risks.
It is best to consult your doctor before taking any other medicines with Epalridase 50 mg Tablet , as some medications may interact with it. Inform your doctor about all the medicines you're currently taking to ensure safe and effective treatment.
It is common for your urine to turn a reddish colour while using Epalridase 50 mg Tablet . This is a harmless side effect caused by the way the medicine is processed and excreted by your body. It is not blood and is not a cause for concern. Talk to your doctor if you have any worries.
It is highly recommended to take Epalridase 50 mg Tablet before meals. Taking this medicine with or after food can reduce how much of it your body absorbs, making it less effective. Talk to your pharmacist or doctor for specific guidance on timing your doses.
Epalridase 50 mg Tablet does not cure diabetic neuropathy, but it helps manage the symptoms and slow down the progression of nerve damage by blocking the chemical processes that cause harm to nerve cells. Managing your blood sugar is also essential. Talk to your doctor about long-term nerve health.
You should avoid or strictly limit alcohol while taking Epalridase 50 mg Tablet . Alcohol can worsen diabetic nerve damage and increase the strain on your liver, which may raise the risk of side effects. Talk to your doctor about safe lifestyle habits.
Yellowing of the skin or eyes, dark urine, and unusual tiredness can be signs of liver damage. If you notice these symptoms, stop taking the medicine and contact your doctor immediately.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

No. 10, 2nd Cross, Maravaneri, Salem - 636007, Tamil Nadu.
Other Info - EPA0009
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