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compositionComposition:EPALRESTAT-150MG
prescription
Prescription Medicine
info
Epimeth 150mg SR Tablet 10's

Epimeth 150mg SR Tablet is used to treat diabetic neuropathy, a condition that causes nerve pain in people with diabetes. It helps reduce symptoms such as burning sensation, tingling, numbness, and pain in the hands and feet. Regular use can improve nerve function, enhance comfort, and support a better quality of life by relieving diabetes-related nerve discomfort. It also helps prevent the worsening of nerve damage when taken as prescribed along with proper blood sugar control.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

EPALRESTAT-150MG

Manufacturer/Marketer :

Zaiva Lifesciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Epimeth 150mg SR Tablet

Epimeth 150mg SR Tablet is used to manage diabetic neuropathy. Diabetic neuropathy is a chronic progressive nerve disease which causes nerve pain due to nerve damage in diabetic patients. It mostly affects the legs and feet.

Epimeth 150mg SR Tablet contains Epalrestat, which prevents the accumulation of sorbitol caused by hyperglycaemia in patients with diabetes, leading to nerve pain. Thus, it helps in treating diabetic neuropathy.

Common side effects include nausea, vomiting, diarrhoea, dizziness, and headache. Most of these side effects do not require medical attention and resolve gradually over time. However, consult your doctor if you experience these side effects persistently.

Consult your doctor before taking Epimeth 150mg SR Tablet if you are pregnant or breastfeeding. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Epimeth 150mg SR Tablet

Epimeth 150mg SR Tablet is used in the treatment of Diabetic neuropathy (diabetic nerve pain). The detailed use of Epimeth 150mg SR Tablet is as follows:

  • Diabetic Neuropathy: Epimeth 150mg SR Tablet helps relieve symptoms like pain, numbness, tingling, and burning sensations in the limbs caused by nerve damage due to prolonged high blood sugar.

Key Benefits

  • Helps manage diabetic neuropathy (nerve pain due to diabetes).
  • Reduces symptoms such as burning, tingling, numbness, and pricking sensations.
  • Helps prevent worsening of nerve damage caused by high blood sugar levels.
  • Improves nerve function and sensation over time.
  • Enhances comfort and quality of life in people with diabetes.

Directions for Use

  • Epimeth 150mg SR Tablet should be taken before meals.
  • It is usually taken 3 times a day, at the same time each day, or as prescribed by your doctor.
  • Swallow Epimeth 150mg SR Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Epimeth 150mg SR Tablet Works

Epimeth 150mg SR Tablet contains Epalrestat, which inhibits the aldose reductase enzyme that catalyses the conversion of glucose to sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients who have diabetes, which leads to nerve pain. Epimeth 150mg SR Tablet prevents the accumulation of sorbitol. Thus, it helps in treating diabetic neuropathy.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Epimeth 150mg SR Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Limited information is available regarding the use of Epimeth 150mg SR Tablet in pregnant women. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited information is available regarding the use of Epimeth 150mg SR Tablet in breastfeeding women. Consult your doctor before taking Epimeth 150mg SR Tablet ; your doctor will decide whether Epimeth 150mg SR Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Epimeth 150mg SR Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Epimeth 150mg SR Tablet should not be used in patients with severe liver disease. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Epimeth 150mg SR Tablet should be used with caution in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Epimeth 150mg SR Tablet should not be given to children as safety and efficacy have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Epimeth 150mg SR Tablet . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Epimeth 150mg SR Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Epimeth 150mg SR Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Diet & Lifestyle Advise

Healthy Diet:

  • Include foods rich in vitamin B and vitamin D to support nerve health.
  • Add cayenne pepper to your diet as it may help reduce neuropathic pain.

Physical Activity:

  • Exercise regularly to improve overall health and help manage pain.

Rest and Sleep:

  • Get adequate rest and plenty of sleep to support nerve recovery.

Heat Therapy:

  • Take a warm bath to help relax the body and soothe nerve discomfort.

Lifestyle Habits:

  • Avoid smoking and alcohol consumption, as they can worsen nerve pain.

Stress Management:

  • Practice meditation and yoga to reduce stress, lower pain sensitivity, and improve coping skills.

Alternative Therapies:

  • Acupuncture may help relieve pain by stimulating specific pressure points.
  • Massage with essential oils can help improve blood circulation and relaxation.

Have a query?

How Soon It Starts Working

The time required for Epimeth 150mg SR Tablet to start to work: Epimeth 150mg SR Tablet ideally shows its action within 1 hour after administration.

The time for which the effects of Epimeth 150mg SR Tablet last: The duration of action for Epimeth 150mg SR Tablet is clinically unknown.

What if you forget to take Epimeth 150mg SR Tablet

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose to make up for your missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Epimeth 150mg SR Tablet out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Epimeth 150mg SR Tablet if you are allergic to any of its contents.
  • Inform your doctor if you have liver or kidney problems.
  • Consult your doctor before taking Epimeth 150mg SR Tablet if you are pregnant or breastfeeding.
  • Epimeth 150mg SR Tablet may cause drowsiness and dizziness, so drive only if you are alert.
  • Epimeth 150mg SR Tablet is not recommended for children as safety and effectiveness have not been established.
  • Avoid consuming alcohol with Epimeth 150mg SR Tablet as it could lead to increased drowsiness and sleepiness.
  • Let your doctor know if you are taking any other medicines.

verifiedApollotooltip

Drug-Drug Interactions: No interactions found/established.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: No interactions found/established.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Epimeth 150mg SR Tablet is used to manage diabetic neuropathy, a chronic progressive nerve disease which causes nerve pain due to nerve damage in diabetic patients.
Epimeth 150mg SR Tablet works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. Epimeth 150mg SR Tablet prevents the accumulation of sorbitol, thereby helping in treating diabetic neuropathy.
Diarrhoea could be a side-effect of Epimeth 150mg SR Tablet . Drink plenty of fluids to prevent dehydration and consume non-spicy meals if you experience diarrhoea. Consult your doctor if you have severe diarrhoea.
Epimeth 150mg SR Tablet might cause high blood pressure. So, if you have hypertension, consult your doctor before taking Epimeth 150mg SR Tablet . Regularly monitor blood pressure levels while taking Epimeth 150mg SR Tablet .
Do not discontinue Epimeth 150mg SR Tablet without consulting your doctor. To treat your condition effectively, continue taking Epimeth 150mg SR Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Epimeth 150mg SR Tablet .
Epimeth 150mg SR Tablet may cause peripheral oedema. Peripheral oedema is the swelling of the hands and lower legs. Avoid sitting or standing for too long. Raise your legs by putting a pillow under them while lying down.
Epimeth 150mg SR Tablet contains epalrestat, which is classified as an Aldose Reductase Inhibitor. It is used for the treatment of diabetic neuropathy.
Some individuals may experience specific common side effects, such as nausea, vomiting, diarrhoea, dizziness, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Follow your doctor's advice and take the right amount of medicine. Be aware of side effects and take care of yourself. If you're pregnant while on treatment, inform your doctor immediately. Don't take other medications unless instructed by the doctor. Alcohol consumption should be avoided. By following these precautions, you'll benefit most from your medicine and stay safe.
In some individuals, Epimeth 150mg SR Tablet may cause vomiting as it is a common side effect of Epimeth 150mg SR Tablet . This effect does not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Limited information is available regarding the use of Epimeth 150mg SR Tablet in pregnant women. Please consult your doctor if you are pregnant or planning to become pregnant before taking Epimeth 150mg SR Tablet , your doctor will prescribe only if the benefits outweigh the risks.
It is best to consult your doctor before taking any other medicines with Epimeth 150mg SR Tablet , as some medications may interact with it. Inform your doctor about all the medicines you're currently taking to ensure safe and effective treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MIMS Drug Reference Compendium. Epalrestat Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Ramirez MA, Borja NL Epalrestat: An aldose reductase inhibitor for the treatment of diabetic neuropathy. Pharmacotherapy. 2008;28(5):646-55 Check here
  3. Verma, V., Singh, N., & Singh Jaggi, A. Pregabalin in neuropathic pain: Evidences and possible mechanisms. NIH National Library of Medicine, National center for biotechnology information. PubMed central. January 2014 [Accessed on 16th July 2022] Check here
  4. Laboratorios Lesvi, S.L. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 16th July 2022] Check here
  5. Epalrestat.Htm. [Accessed on 02 Jun. 2026] Check here
  6. Tripathi KD. Essentials of Medical pharmacology.7; 2013.296.[ Accessed on 23 Jan 2020]Check here

Country of origin

India

Manufacturer/Marketer address

A-502, Ashray Serene, TP-44, Chandkheda, Ahmedabad
Other Info - EPI0325

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