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  3. EPITHRA INJECTION 10MG

EPITHRA INJECTION 10MG , Pack of 1 INJECTION
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Synonym :

EPIRUBICIN HYDROCHLORIDE

Composition :

EPIRUBICIN-10MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About EPITHRA INJECTION 10MG

EPITHRA INJECTION 10MG is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer in people who have had tumor removal surgery. EPITHRA INJECTION 10MG is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast).

EPITHRA INJECTION 10MG contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

EPITHRA INJECTION 10MG may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer EPITHRA INJECTION 10MG . So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

EPITHRA INJECTION 10MG should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines, and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (eg, Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. EPITHRA INJECTION 10MG is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. EPITHRA INJECTION 10MG is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF.

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• EPITHRA INJECTION 10MG will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

EPITHRA INJECTION 10MG contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. It is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer.

How EPITHRA INJECTION 10MG Works

EPITHRA INJECTION 10MG contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Epithra Injection 10mg
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Eat a healthy balanced diet.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Keep track of your menstrual cycle any irregularities.
  • Have regular check ups to exclude other health problems.
  • Exercise but do not exercise to the extent of overheating.
  • Hydrate well, eat well (particularly iron and vitamins).
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.

What if I have taken an overdose of EPITHRA INJECTION 10MG

Since EPITHRA INJECTION 10MG is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of EPITHRA INJECTION 10MG may cause sores in the mouth and throat, fever, sore throat, chills, or other signs of infection, unusual bleeding or bruising, black and tarry stools, red blood in stools, and bloody vomit or vomited material that looks like coffee grounds.

Drug Warnings

EPITHRA INJECTION 10MG should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (e.g., Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. EPITHRA INJECTION 10MG is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. EPITHRA INJECTION 10MG is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF. Do not stop receiving EPITHRA INJECTION 10MG without a doctor’s advice, as it can cause serious health conditions. EPITHRA INJECTION 10MG is known to cause severe life-threatening haematological reactions, tissue necrosis, cardiomyopathy, secondary acute myelogenous leukaemia, and severe myelosuppression in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

verifiedApollotooltip
EpirubicinZiprasidone
Critical
EpirubicinHydroxychloroquine
Severe

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
How does the drug interact with Epithra Injection 10mg:
Using ziprasidone together with Epithra Injection 10mg can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Ziprasidone with Epithra Injection 10mg is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinHydroxychloroquine
Severe
How does the drug interact with Epithra Injection 10mg:
The combined use of Epithra Injection 10mg and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Epithra Injection 10mg and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
EpirubicinMoxifloxacin
Severe
How does the drug interact with Epithra Injection 10mg:
Using Moxifloxacin together with Epithra Injection 10mg can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Epithra Injection 10mg together can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heart rhythm, vomiting, dizziness, difficulty breathing, or irregular heartbeat call a doctor right away. Do not discontinue any medications without consulting a doctor.
EpirubicinCeritinib
Severe
How does the drug interact with Epithra Injection 10mg:
Taking Ceritinib with Epithra Injection 10mg can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Ceritinib and Epithra Injection 10mg together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinDisopyramide
Severe
How does the drug interact with Epithra Injection 10mg:
The combined use of Efavirenz and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Efavirenz and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
EpirubicinInfliximab
Severe
How does the drug interact with Epithra Injection 10mg:
Combining Infliximab with Epithra Injection 10mg can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Epithra Injection 10mg together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, contact a doctor right away. Do not stop using any medications without a doctor's advice.
EpirubicinGatifloxacin
Severe
How does the drug interact with Epithra Injection 10mg:
Taking Epithra Injection 10mg with Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Epithra Injection 10mg with Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EpirubicinChloroquine
Severe
How does the drug interact with Epithra Injection 10mg:
Using chloroquine together with Epithra Injection 10mg can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Chloroquine and Epithra Injection 10mg, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinMifepristone
Severe
How does the drug interact with Epithra Injection 10mg:
Co-administration of Epithra Injection 10mg with mifepristone can increase the risk of irregular heart rhythms. Prolonged treatment with Mifepristone may result in low potassium levels.

How to manage the interaction:
Taking Epithra Injection 10mg with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
EpirubicinHaloperidol
Severe
How does the drug interact with Epithra Injection 10mg:
Co-administration of Epithra Injection 10mg and Haloperidol can affect the rhythm of the heart.

How to manage the interaction:
Co-administration of Epithra Injection 10mg and Haloperidol can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to eat more healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.
  • Doing meditation and yoga for some time is very effective in helping cancer patients maintain a healthy attitude and body.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

EPITHRA INJECTION 10MG Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

EPITHRA INJECTION 10MG is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving EPITHRA INJECTION 10MG . Use reliable methods of birth control while on treatment with EPITHRA INJECTION 10MG .

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving EPITHRA INJECTION 10MG . Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Safe

EPITHRA INJECTION 10MG does not affect your ability to drive. However, drive only if you are alert.

bannner image

Liver

Caution

EPITHRA INJECTION 10MG should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

bannner image

Children

Unsafe

EPITHRA INJECTION 10MG is not recommended for use in children, as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF leading to serious side effects.

Have a query?

FAQs

EPITHRA INJECTION 10MG is used to treat Breast Cancer.

EPITHRA INJECTION 10MG contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

EPITHRA INJECTION 10MG can disrupt a woman&amp;#039;s natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with EPITHRA INJECTION 10MG .

Yes, EPITHRA INJECTION 10MG is considered a vesicant. This means it may cause tissue blistering and damage if it leaks out of the vein during administration in some individuals. Hence, this medication must be administered by a trained healthcare professional to reduce the risk of this complication.

EPITHRA INJECTION 10MG is effective in treating breast cancer by slowing or stopping the growth of cancer cells. It inhibits the topoisomerase II enzyme, interfering with DNA replication and destroying cancer cells. However, like all medications, it can have side effects and interact with other drugs, so it's essential to follow your doctor's instructions to maximize effectiveness and minimize side effects.

EPITHRA INJECTION 10MG is a chemotherapy medication that contains the active ingredient Epirubicin, a type of anthracycline topoisomerase inhibitor, used to treat breast cancer after tumor removal surgery.

The common side effects of EPITHRA INJECTION 10MG may include nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the injection site. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - EPI0071

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 17, 2025 | 10:56 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.mayoclinic.org/drugs-supplements/epirubicin-intravenous-route/side-effects/drg-20063685?p=1
  2. https://reference.medscape.com/drug/epirubicin-342251
  3. https://medlineplus.gov/druginfo/meds/a603003.html#
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/050778s021lbl.pdf

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