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compositionComposition:RECOMBINANT HUMAN ERYTHROPOIETIN ALFA-4000IU
prescription
Prescription Medicine
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EPOTIN 4000IU INJECTION. is used in the treatment of chronic anaemia and anaemic states seen in kidney disease, cancers, patients on chemotherapy, and bone marrow disorders. This medicine works by stimulating the bone marrow to produce more red blood cells, thereby correcting any low blood counts and anaemia. You may experience common side effects like vomiting, diarrhoea, fever, and nasal congestion.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RECOMBINANT HUMAN ERYTHROPOIETIN ALFA-4000IU

Manufacturer/Marketer :

Core Claris Lifesciences Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About EPOTIN 4000IU INJECTION.

EPOTIN 4000IU INJECTION. is a prescribed injection used to treat anemia, a condition in which your body does not have enough healthy red blood cells. Living with anemia alongside chronic kidney disease, cancer treatment, or other long-term illnesses can be physically and emotionally challenging, often causing persistent tiredness, weakness, and reduced quality of life. This treatment is designed to help restore red blood cell levels and support improved energy and daily functioning.

This medication is injected either under the skin or directly into a vein, and it must be used consistently on a schedule determined by your doctor. Because it is an injection, its absorption is not affected by food, meaning you do not need to worry about meal timing. To support your body in building new red blood cells while using this medication, your doctor may recommend incorporating iron-rich foods like leafy greens and lean meats into your daily diet.

While taking EPOTIN 4000IU INJECTION., you may experience common side effects such as a temporary increase in blood pressure, mild headaches, or irritation at the injection site. However, you must contact your doctor immediately if you experience signs of severe complications, such as sudden chest pain, shortness of breath, severe leg pain, or sudden weakness on one side of your body.

Do not take this if you have uncontrolled high blood pressure or if you have ever developed a condition called pure red cell aplasia after using this type of medicine. Before starting treatment, tell your doctor if you have a history of heart disease, blood clots, stroke, seizures, or liver damage so they can evaluate if this medication is safe for you.

EPOTIN 4000IU INJECTION. can interact with other drugs that affect your immune system, such as cyclosporine. It is highly recommended to avoid smoking, as it can further raise your risk of blood clots. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, consult your healthcare provider to discuss the risks and benefits of this treatment.

Uses of EPOTIN 4000IU INJECTION.

EPOTIN 4000IU INJECTION. is used in the treatment of anemia. The detailed uses of EPOTIN 4000IU INJECTION. are as follows:

  • Anemia Due to Chronic Kidney Disease: EPOTIN 4000IU INJECTION. replaces the natural hormone that damaged kidneys cannot produce adequately, stimulating the bone marrow to produce red blood cells.
  • Anemia Caused by Chemotherapy: It helps increase red blood cell levels reduced by cancer treatment, helping to reduce fatigue and the need for blood transfusions.
  • Anemia in HIV Patients: It helps restore healthy red blood cell counts in patients receiving zidovudine therapy.
  • Reduction of Blood Transfusions Before Major Surgery: It is used before certain elective, non-cardiac surgeries to increase red blood cell levels and reduce the likelihood of requiring donor blood transfusions.

Key Benefits

EPOTIN 4000IU INJECTION. helps improve the symptoms of anemia by increasing the number of red blood cells in the body. As red blood cell levels improve, many people experience better energy, less tiredness, and improved ability to carry out everyday activities.
Benefits may include:

  • Helps reduce fatigue, weakness, and shortness of breath associated with anemia.
  • May improve energy levels, stamina, and overall quality of life.
  • Supports better oxygen delivery throughout the body by increasing red blood cell production.
  • Helps improve comfort and independence during daily activities.
  • May reduce the need for frequent blood transfusions in appropriate patients.
  • Helps lower the risks associated with repeated blood transfusions, such as iron overload and certain transfusion-related complications.
     
Side effects of Epotin 4000iu Injection.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.

Directions for Use

  • It is usually injected one to three times weekly. However, follow your doctor's instructions regarding dosage and timing of EPOTIN 4000IU INJECTION. for better results.
  • EPOTIN 4000IU INJECTION. may be given by a doctor/nurse, or you may be told to inject the medication at home. In that case, a healthcare provider will show you how to inject the medication. Be sure that you understand the directions and use it exactly as advised.
  • Rotate the injection site each time. Do not inject into a spot that is tender, red, bruised, hard, or has scars or stretch marks.

How EPOTIN 4000IU INJECTION. Works

EPOTIN 4000IU INJECTION. works like the natural hormone produced by the kidneys and helps stimulate the bone marrow to produce more red blood cells. This helps improve oxygen delivery throughout the body and relieves symptoms of anemia, such as fatigue, weakness, and shortness of breath.
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Alcohol

Caution

There is not enough literature to explain the effects of alcohol. Consult your doctor if you have any concerns.

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Pregnancy

Caution

If you are pregnant or planning to become pregnant, inform your doctor. Your doctor will weigh the benefits against the risks.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking EPOTIN 4000IU INJECTION.; your doctor will decide whether breastfeeding mothers can use EPOTIN 4000IU INJECTION. or not.

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Driving

Caution

It's unclear whether EPOTIN 4000IU INJECTION. affects driving abilities, so don't drive or operate machinery if you're having trouble concentrating or reacting.

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Liver

Caution

EPOTIN 4000IU INJECTION. should be used with caution in patients suffering from liver diseases. Please inform your doctor before receiving it.

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Kidney

Caution

EPOTIN 4000IU INJECTION. should be used with caution in patients suffering from kidney diseases. Please inform your doctor before receiving it.

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Children

Safe if prescribed

EPOTIN 4000IU INJECTION. can be used in children in prescribed paediatric doses.

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Heart

Caution

EPOTIN 4000IU INJECTION. should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before receiving EPOTIN 4000IU INJECTION..

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Geriatrics

Caution

EPOTIN 4000IU INJECTION. should be administered with caution in elderly patients due to an increased risk of side effects and dose adjustments may be required.

What if I have taken an overdose of EPOTIN 4000IU INJECTION.

If you inject more than your prescribed dose, seek emergency medical attention immediately, even if you do not have any symptoms. An overdose may cause dangerously high blood pressure or increase the risk of blood clots. Go to the nearest emergency room immediately if you develop chest pain, shortness of breath, severe headache, or sudden weakness. You may also contact your local poison information service for additional guidance.

Diet & Lifestyle Advise

  • Maintain adequate iron levels: EPOTIN 4000IU INJECTION. cannot produce red blood cells without sufficient iron. Eat iron-rich foods or take iron supplements as prescribed by your doctor.
  • Check your blood pressure daily: Keep a regular log of your blood pressure readings and share them with your doctor, as EPOTIN 4000IU INJECTION. can cause blood pressure to rise.
  • Stay well-hydrated: Unless you are on fluid restrictions due to kidney disease, drink plenty of water to support healthy circulation.
  • Limit alcohol and stop smoking: Avoid smoking and limit alcohol intake to help protect your cardiovascular system while your body is producing more red blood cells.
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Have a query?

How Soon It Starts Working

The time required for EPOTIN 4000IU INJECTION. to start to work: The time required for EPOTIN 4000IU INJECTION. to show its action is unknown. The time for which the effects of EPOTIN 4000IU INJECTION. last: The duration of action for EPOTIN 4000IU INJECTION. is clinically unknown.

What if you forget to take EPOTIN 4000IU INJECTION.

If you miss a dose, inject it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not inject a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Store EPOTIN 4000IU INJECTION. in the refrigerator between 2°C and 8°C (36°F to 46°F). •Do not freeze EPOTIN 4000IU INJECTION., and do not use it if it has been frozen. Keep the product in its original carton to protect it from light.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Handle the vial carefully: Never shake the vial, as this can damage the proteins in EPOTIN 4000IU INJECTION. and reduce its effectiveness.
  • Inspect the solution before use: Do not inject EPOTIN 4000IU INJECTION. if the liquid appears cloudy, discolored, or contains visible particles.
  • Never reuse needles: Always use a new, sterile needle and syringe for every injection to help prevent serious infections.
  • Attend regular monitoring appointments: Keep all scheduled blood tests and blood pressure checks so your doctor can monitor your hemoglobin levels and adjust treatment safely.
  • Monitor for signs of high blood pressure: Contact your doctor immediately if you develop severe headaches, dizziness, or changes in vision during treatment.
  • Use with caution in certain patients: EPOTIN 4000IU INJECTION. may increase the risk of serious cardiovascular events, including heart attack, stroke, and blood clots if hemoglobin levels become too high. EPOTIN 4000IU INJECTION. should not be used in patients with uncontrolled high blood pressure.
  • Be aware of rare but serious side effects: In rare cases, EPOTIN 4000IU INJECTION. may cause Pure Red Cell Aplasia (PRCA), a condition in which the body stops producing red blood cells.
  • Discuss your medical history with your doctor: Tell your healthcare provider about your complete medical history and treatment goals before starting therapy and attend all recommended follow-up appointments during treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Immunosuppressive medicines (e.g., cyclosporine): EPOTIN 4000IU INJECTION. may affect cyclosporine levels in the blood. Your doctor may monitor cyclosporine levels and adjust the dose if necessary.
  • Iron supplements: Iron supplements are often prescribed alongside EPOTIN 4000IU INJECTION. to support red blood cell production. Your doctor may monitor your iron levels to ensure appropriate supplementation.
ErythropoietinPomalidomide
Severe
ErythropoietinCarfilzomib
Severe

Drug-Drug Interactions

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ErythropoietinPomalidomide
Severe
How does the drug interact with Epotin 4000iu Injection.:
Pomalidomide can cause serious blood clots and taking it alongside Epotin 4000iu Injection. may enhance the risk.

How to manage the interaction:
Co-administration of Epotin 4000iu Injection. with Pomalidomide can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ErythropoietinCarfilzomib
Severe
How does the drug interact with Epotin 4000iu Injection.:
Carfilzomib can cause serious blood clots and taking it alongside Epotin 4000iu Injection. may enhance the risk.

How to manage the interaction:
Co-administration of Epotin 4000iu Injection. with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ErythropoietinLenalidomide
Severe
How does the drug interact with Epotin 4000iu Injection.:
Combining Epotin 4000iu Injection. with Lenalidomide can increase the risk of Thrombosis(formation of a blood clot ).

How to manage the interaction:
Although there is an interaction between Epotin 4000iu Injection. and Lenalidomide, it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
ErythropoietinThalidomide
Severe
How does the drug interact with Epotin 4000iu Injection.:
Taking thalidomide with Epotin 4000iu Injection. may increase the risk or severity of thromboembolism(a circulating blood clot that gets stuck and causes an obstruction).

How to manage the interaction:
Although taking Epotin 4000iu Injection. and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with EPOTIN 4000IU INJECTION. when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[BLOOD DERIVATIVES]

FAQs

EPOTIN 4000IU INJECTION. belongs to the group of hormones used in the treatment of chronic anaemia and anaemic states seen in kidney disease, cancers, patients on chemotherapy, bone marrow disorders and in those due to undergo major bone surgery.
EPOTIN 4000IU INJECTION. works by stimulating the bone marrow to produce healthy red blood cells (RBC’s) and thus enhances blood production.
Consult your doctor before taking iron supplements along with EPOTIN 4000IU INJECTION. as they might increase the effectiveness of EPOTIN 4000IU INJECTION. when taken together.
EPOTIN 4000IU INJECTION. might affect other treatments or tests. Therefore, inform the doctor/lab assistant that you are taking EPOTIN 4000IU INJECTION..
Not commonly. However, cases of Steven Johnson’s syndrome and Toxic Epidermal Necrosis (TEN), have been reported in rare instances. Consult your doctor immediately if you notice symptoms such as reddish-circular patches, skin peeling, fever, flu, ulcers of throat, mouth, nose, eyes or genitals.
EPOTIN 4000IU INJECTION. may cause blood clots (deep vein thrombosis and embolism). Consult your doctor if you experience symptoms such as breathlessness, chest pain, painful swelling and redness in the legs.
The common side effects of EPOTIN 4000IU INJECTION. may include vomiting, diarrhoea, fever, and nasal congestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects consistently.
EPOTIN 4000IU INJECTION. contains Recombinant Human Erythropoietin Alfa. A hormone medication that stimulates the bone marrow to produce more red blood cells, correcting low blood counts and anaemia.
Don't stop taking your medication just because you're feeling better! This is a crucial moment in your recovery. Stopping too soon can lead to incomplete recovery and the return of symptoms. Instead, report your progress to your doctor and follow their advice. They will guide you on how to safely taper off the medication, if necessary, monitor for any potential side effects, and ensure the infection is fully cleared.
EPOTIN 4000IU INJECTION. is usually given to you by a healthcare professional through an Intravenous(veins). In some cases, you may need to go to a local clinic or learn to self-inject, but only after proper training from a doctor or nurse.
You can store EPOTIN 4000IU INJECTION. in the refrigerator or a cool, dry place away from sunlight. Do not freeze. Use at room temperature only.
Store EPOTIN 4000IU INJECTION. in a refrigerator or in a cool, dry place away from sunlight. Keep it out of reach of children. Do not freeze it.
Taking more than the prescribed dose doesn't provide extra relief; instead, it may increase the risk of adverse effects, potentially harming your health.
Don't use EPOTIN 4000IU INJECTION. if the solution is expired, frozen, or allergic to it. It's also not recommended for those with hypersensitivity disorders, thromboembolism, and red cell aplasia. Pregnant or breastfeeding women or children unless the doctor suggests it. Always consult your doctor before using.
EPOTIN 4000IU INJECTION. can be used in children under a doctor's guidance and in prescribed pediatric doses.
EPOTIN 4000IU INJECTION. may increase blood pressure or worsen existing high blood pressure, especially in patients with kidney failure, due to the rapid increase in red blood cells. Inform your doctor beforehand if you have any blood pressure issues. Your doctor will adjust the dose if the benefits outweigh the risks.
No, the solution should be completely clear and colorless. If the liquid is discolored, cloudy, or contains particles, do not inject it. Talk to your pharmacist for a replacement.
Your doctor needs to monitor your hemoglobin levels to ensure they do not rise too quickly or reach levels that are too high, which can increase the risk of blood clots. Talk to your doctor about your blood test schedule.
Most people can drive safely, but you should avoid driving or operating machinery if you experience headaches, dizziness, or lightheadedness after your injection. Talk to your doctor if you experience these symptoms.
If the medication has been left at room temperature for an extended period, do not put it back in the refrigerator without checking first. Talk to your pharmacist to find out if EPOTIN 4000IU INJECTION. is still safe to use.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.3442 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. ScienceDirect Topics. Recombinant Erythropoietin - Research & Medical Applications Summary. Amsterdam, Netherlands: Elsevier; 2025. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Recombinant Human Erythropoietin Alfa Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Recombinant Human Erythropoietin Alfa/Epoetin Alfa. 2018. [Accessed on 07 Apr. 2019]Check here
  6. Recombinant Human Erythropoietin Alfa/Epoetin Alfa. 1989. [Accessed on 07 Apr. 2019]Check here
  7. Epoetin alfa [Prescribing Information]. 2017. [Accessed on 28 Mar. 2023]Check here

Country of origin

India

Manufacturer/Marketer address

Claris Corporate Headquarters, Nr. Parimal Crossing, Ellisbridge, Ahmedabad - 380 006, India.
Other Info - EPO0003

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