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compositionComposition:EPOETIN ALFA-2000IU
prescription
Prescription Medicine
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EPREX 2000IU PREFILLED SYRINGES is used to treat anaemia in cancer, chronic kidney disease, and HIV. It contains Epoetin alfa which works by stimulating the bone marrow to make more red blood cells. In some cases, this medicine may cause side effects such as diarrhoea, vomiting, fever, feeling sick, stuffy nose and sore throat. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

EPOETIN ALFA-2000IU

Manufacturer/Marketer :

Johnson & Johnson Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About EPREX 2000IU PREFILLED SYRINGES

EPREX 2000IU PREFILLED SYRINGES is a prescription injectable medication used to treat anemia, a condition where your body does not have enough healthy red blood cells. It is primarily prescribed for people with chronic kidney disease, cancer patients undergoing chemotherapy, or patients scheduled for major surgery. By boosting your red blood cell levels, EPREX 2000IU PREFILLED SYRINGES helps restore your body's ability to carry oxygen efficiently.

You will typically inject EPREX 2000IU PREFILLED SYRINGES either once a week, a few times a week, or once every few weeks, depending on your treatment plan. Since it is injected, it can be taken with or without food, as meals do not affect how it works in your body. Making sure you eat iron-rich foods and stay well-hydrated during treatment can significantly improve your results.

While using EPREX 2000IU PREFILLED SYRINGES, you may experience mild side effects like headaches, high blood pressure, or soreness at the injection site. However, you must contact your doctor immediately if you experience serious symptoms like sudden chest pain, shortness of breath, or severe dizziness.

Do not take this if you have uncontrolled high blood pressure or if you have ever had a rare blood condition called pure red cell aplasia after using this type of medicine. Talk to your doctor before starting this medication if you have a history of heart disease, seizures, or blood clots.

Certain medicines like cyclosporine can interact with EPREX 2000IU PREFILLED SYRINGES, and drinking alcohol or smoking can affect your blood pressure and overall heart health during treatment. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, you must consult your healthcare provider to ensure this treatment is safe for you.

Uses of EPREX 2000IU PREFILLED SYRINGES

EPREX 2000IU PREFILLED SYRINGES is used in the treatment of anemia in cancer, anemia in chronic kidney disease, and anemia in HIV. The detailed uses of EPREX 2000IU PREFILLED SYRINGES are as follows:

  • Anemia due to chronic kidney disease: Helps the body produce more red blood cells when the kidneys cannot make enough natural hormone.
  • Anemia caused by chemotherapy: Restores red blood cell levels in cancer patients undergoing chemotherapy, reducing the need for blood transfusions.
  • Anemia before major surgery: Boosts red blood cells prior to scheduled surgeries to reduce the risk of needing a blood transfusion during or after the procedure.
  • Anemia in HIV-infected patients: Treats low red blood cell counts caused by certain HIV medications.
     

Key Benefits

EPREX 2000IU PREFILLED SYRINGES helps treat anaemia by stimulating the production of red blood cells, improving oxygen delivery throughout the body. Increasing red blood cell levels helps reduce symptoms of anaemia and supports better daily functioning.

Benefits may include:

  • Helps increase red blood cell production and improve haemoglobin levels.
  • Reduces tiredness, weakness, and fatigue associated with anaemia.
  • Improves oxygen delivery to the body's tissues and organs.
  • May reduce the need for blood transfusions in appropriate patients.
  • Helps improve physical activity, exercise tolerance, and overall quality of life.
  • Supports long-term management of anaemia under medical supervision.
Side effects of Eprex 2000iu Prefilled Syringes
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of EPREX 2000IU PREFILLED SYRINGES. Typically, it is administered 3 times a week.
  • EPREX 2000IU PREFILLED SYRINGES will be administered subcutaneously (under the skin) or intravenously (through the vein) by the doctor or nurse in a medical setting.
  • Do not self-administer it.

How EPREX 2000IU PREFILLED SYRINGES Works

EPREX 2000IU PREFILLED SYRINGES is an erythropoietin, a hormone naturally produced by healthy kidneys. It sends signals directly to your bone marrow, which is the soft centre of your bones where blood cells are made. These signals instruct your bone marrow to produce more red blood cells. As these new red blood cells enter your bloodstream, they carry vital oxygen from your lungs to the rest of your body, resolving the symptoms of anaemia.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking EPREX 2000IU PREFILLED SYRINGES as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking EPREX 2000IU PREFILLED SYRINGES if you are pregnant unless prescribed by a doctor as EPREX 2000IU PREFILLED SYRINGES is a pregnancy category B drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks. If prescribed use only single-dose vials (the benzyl alcohol-free formulation) in pregnant women.

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Breast Feeding

Caution

Consult your doctor before taking EPREX 2000IU PREFILLED SYRINGES; your doctor will decide whether EPREX 2000IU PREFILLED SYRINGES can be taken by breastfeeding mothers or not.

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Driving

Caution

EPREX 2000IU PREFILLED SYRINGES causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

EPREX 2000IU PREFILLED SYRINGES should not be given to neonates as the safety and efficacy have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using EPREX 2000IU PREFILLED SYRINGES. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of EPREX 2000IU PREFILLED SYRINGES in elderly patients. Please consult your doctor.

What if I have taken an overdose of EPREX 2000IU PREFILLED SYRINGES

If you suspect an overdose, seek immediate medical attention or contact a poison control center right away. An overdose can lead to severe high blood pressure or life-threatening blood clotting issues.

Diet & Lifestyle Advise

  • Eat iron-rich foods: Your body needs iron to build red blood cells. Incorporate foods like lean meats, green leafy vegetables, and beans into your meals, as recommended by your doctor.
  • Track your blood pressure daily: Because EPREX 2000IU PREFILLED SYRINGES can raise your blood pressure, keep a daily record of your readings to share with your healthcare team.
  • Stay hydrated: Drink plenty of water throughout the day, unless your doctor has advised you to limit your fluid intake due to kidney problems.
  • Stand up slowly: If you feel dizzy or lightheaded, take your time when moving from a sitting or lying position to standing.
     
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How Soon It Starts Working

The time required for EPREX 2000IU PREFILLED SYRINGES to start to work: The time required for EPREX 2000IU PREFILLED SYRINGES to show its action is unknown. The time for which the effects of EPREX 2000IU PREFILLED SYRINGES last: The duration of action for EPREX 2000IU PREFILLED SYRINGES is clinically unknown.

What if you forget to take EPREX 2000IU PREFILLED SYRINGES

If you miss an injection, do not take a double dose to make up for the missed one. Contact your doctor or pharmacist immediately to get a safe, updated injection schedule.

Storage

• Store EPREX 2000IU PREFILLED SYRINGES in the refrigerator between 2°C and 8°C (36°F to 46°F).

Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Always inspect the vial before use: Never inject the liquid if it is cloudy, discolored, or has tiny floating specks in it.
  • Never shake the bottle: Shaking ruins the active protein inside the medicine. If you accidentally shake the vial, do not use it.
  • Rotate your injection sites: Avoid injecting into the exact same spot twice in a row to protect your skin from becoming hard, scarred, or irritated.
  • Practice strict needle safety: Always use a fresh, sterile needle and syringe for every injection, and never share them with anyone else.
  • Watch for signs of blood clots: Seek emergency care immediately if you notice sudden swelling, warmth, or deep pain in one leg, or sudden shortness of breath.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Immunosuppressive medicines (e.g., cyclosporine): Taking these medicines alongside EPREX 2000IU PREFILLED SYRINGES may affect the levels of both medicines in the body. Your doctor may monitor your blood tests closely and adjust the dose if needed.
  • Iron supplements: Iron supplements are often prescribed with EPREX 2000IU PREFILLED SYRINGES to support red blood cell production. Your doctor may monitor your iron levels and blood counts to ensure safe and effective treatment.
ErythropoietinLenalidomide
Severe
ErythropoietinPomalidomide
Severe

Drug-Drug Interactions

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ErythropoietinLenalidomide
Severe
How does the drug interact with Eprex 2000iu Prefilled Syringes:
Combining Eprex 2000iu Prefilled Syringes with Lenalidomide can increase the risk of Thrombosis(formation of a blood clot ).

How to manage the interaction:
Although there is an interaction between Eprex 2000iu Prefilled Syringes and Lenalidomide, it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
ErythropoietinPomalidomide
Severe
How does the drug interact with Eprex 2000iu Prefilled Syringes:
Pomalidomide can cause serious blood clots and taking it alongside Eprex 2000iu Prefilled Syringes may enhance the risk.

How to manage the interaction:
Co-administration of Eprex 2000iu Prefilled Syringes with Pomalidomide can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ErythropoietinCarfilzomib
Severe
How does the drug interact with Eprex 2000iu Prefilled Syringes:
Carfilzomib can cause serious blood clots and taking it alongside Eprex 2000iu Prefilled Syringes may enhance the risk.

How to manage the interaction:
Co-administration of Eprex 2000iu Prefilled Syringes with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ErythropoietinThalidomide
Severe
How does the drug interact with Eprex 2000iu Prefilled Syringes:
Taking thalidomide with Eprex 2000iu Prefilled Syringes may increase the risk or severity of thromboembolism(a circulating blood clot that gets stuck and causes an obstruction).

How to manage the interaction:
Although taking Eprex 2000iu Prefilled Syringes and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with EPREX 2000IU PREFILLED SYRINGES when used as directed.     
 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ERYTHROPOIESIS STIMULATING AGENTS (ESAs)]

FAQs

EPREX 2000IU PREFILLED SYRINGES is used to treat anaemia (low red blood cell count) in people with chronic kidney disease (CKD), patients affected with HIV, and those receiving chemotherapy for cancer (except for bone marrow or blood cells cancer).
EPREX 2000IU PREFILLED SYRINGES contains a protein "Epoetin alfa", which works by providing signals to the bone marrow to make more red blood cells. As in chronic kidney disease, the kidney gets damaged and doesn't filter the blood in the way it should be leading to anemia.
A person who is allergic to any chemical compound present in EPREX 2000IU PREFILLED SYRINGES or have uncontrolled/untreated high blood pressure, or ever had pure red cell aplasia (a type of anaemia) caused by using darbepoetin alfa, or epoetin alfa is not allowed to take a name.
It is suggested to store the EPREX 2000IU PREFILLED SYRINGES in the refrigerator between 2 and 8 ℃ and protect it from light. However, a person should not freeze it.
The common side-effects of EPREX 2000IU PREFILLED SYRINGES are headache and pain, redness at the injection site. These side-effects are usually mild and temporary. However, inform your doctor immediately if any of these side-effects persist or get worse.
EPREX 2000IU PREFILLED SYRINGES will be administered subcutaneously (under the skin) or intravenously (through the vein) by the doctor or nurse based on individual considerations.
Since EPREX 2000IU PREFILLED SYRINGES will be administered by the doctor it is unlikely to exceed the recommended dose. However, seek medical attention if you experience symptoms of overdose such as a fast or racing heartbeat.
Yes, EPREX 2000IU PREFILLED SYRINGES will be given to children by the doctor if needed. However, it should not be given to children under 1 month of age, as its safety and effectiveness have not been established for this age group. Consult the doctor if you have any concerns.
Yes, EPREX 2000IU PREFILLED SYRINGES may cause hypertension (high blood pressure). The doctor will control high blood pressure before and during treatment. However, it is not recommended for people with uncontrolled hypertension. Let the doctor know if you have hypertension before starting treatment with EPREX 2000IU PREFILLED SYRINGES.
Yes, you can learn to self-inject EPREX 2000IU PREFILLED SYRINGES at home after receiving proper training from your healthcare provider. Do not attempt to inject yourself until you are fully confident in the process. Talk to your doctor or pharmacist if you have any questions.
EPREX 2000IU PREFILLED SYRINGES can cause your blood pressure to rise, especially when your red blood cell count increases quickly. Regular checks help ensure your blood pressure stays within a safe range. Talk to your doctor if you notice high readings.
No, you must never freeze EPREX 2000IU PREFILLED SYRINGES. Freezing ruins the active ingredients, making the injection useless and unsafe. If a vial freezes, throw it away. Talk to your pharmacist if you need storage advice.
Many patients need iron supplements because the body uses up iron rapidly to make new red blood cells. Your doctor will test your iron levels and prescribe a supplement if necessary. Talk to your doctor before starting any over-the-counter iron pills.
Do not use the medicine if it is cloudy, discolored, or contains any floating particles. The liquid should always be clear and colorless. Talk to your pharmacist to get a replacement vial.
You should only use EPREX 2000IU PREFILLED SYRINGES during pregnancy or breastfeeding if the benefits clearly outweigh the potential risks. Talk to your doctor to discuss safer alternatives or special monitoring.
While there is no direct interaction between alcohol and EPREX 2000IU PREFILLED SYRINGES, drinking can affect your blood pressure and overall hydration, which are crucial when treating anemia. Talk to your doctor or pharmacist about safe alcohol limits for your specific condition.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Epoetin Alfa Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.1193 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 103234S5363S5366Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Saumil Patel, Jayesh B. Patel. Epoetin Alfa. Statpearls. NIH. National Library of Medicine, National center for biotechnology information. May 2022. [Accessed on 15th November 2022]Check here
  5. Janssen-Cilag (New Zealand) Ltd. New Zealand Medicines and Medical Devices Safety Authority [Revised in December 2021] [Accessed on 15th November 2022]Check here
  6. Biocon Biologics India Limited. Erythropoietin Alfa. [Revised in December 2019] [Accessed on 15th November 2022] SAFE PI.pdfCheck here

Country of origin

India

Manufacturer/Marketer address

Corporate Communications, Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Other Info - EPR0007

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