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compositionComposition:RECOMBINANT HUMAN ERYTHROPOIETIN ALFA-40000IU
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Prescription Medicine
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ERYPRO SAFE 40000IU INJECTION 4ML is used in the treatment of chronic anaemia and anaemic states seen in kidney disease, cancers, patients on chemotherapy, and bone marrow disorders. This medicine works by stimulating the bone marrow to produce more red blood cells, thereby correcting any low blood counts and anaemia. You may experience common side effects like vomiting, diarrhoea, fever, and nasal congestion.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RECOMBINANT HUMAN ERYTHROPOIETIN ALFA-40000IU

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ERYPRO SAFE 40000IU INJECTION 4ML

ERYPRO SAFE 40000IU INJECTION 4ML belongs to the group of hormones used in the treatment of chronic anaemia and anaemic states seen in kidney disease, cancers, patients on chemotherapy, bone marrow disorders, and those due to undergo major bone surgery. Anaemia refers to low blood counts due to a deficiency of the blood component haemoglobin, resulting in a reduced oxygen-carrying capacity of the blood.

ERYPRO SAFE 40000IU INJECTION 4ML contains Recombinant Human Erythropoietin Alfa, which works by stimulating the bone marrow to produce more red blood cells, thereby correcting low blood counts and anaemia.

In some cases, ERYPRO SAFE 40000IU INJECTION 4ML may cause specific common side effects such as vomiting, diarrhoea, fever, and nasal congestion. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to your doctor if you experience these side effects consistently.

Please inform the doctor of your detailed medical history, including hypertension, heart disease, heart attack, stroke, epilepsy, cancer, liver disease, thromboembolism, porphyria and/or pure red cell aplasia (where the bone marrow cannot produce enough RBCs). Consult your doctor before taking ERYPRO SAFE 40000IU INJECTION 4ML during pregnancy and nursing. Store this medicine at 2°C-8°C. Do not freeze.

Uses of ERYPRO SAFE 40000IU INJECTION 4ML

ERYPRO SAFE 40000IU INJECTION 4ML is used to treat anemia caused by chronic kidney illness, cancer, and HIV infection. The detailed uses of ERYPRO SAFE 40000IU INJECTION 4ML are as follows:

  • Anemia due to Chronic Kidney Disease (CKD): ERYPRO SAFE 40000IU INJECTION 4ML helps correct anemia in patients with CKD, especially those on dialysis, by replacing the deficient natural erythropoietin.
  • Anemia from Chemotherapy: ERYPRO SAFE 40000IU INJECTION 4ML is used in cancer patients undergoing chemotherapy to reduce the need for blood transfusions.
  • Pre-surgical Use: ERYPRO SAFE 40000IU INJECTION 4ML is sometimes given before major elective surgeries (like orthopedic procedures) to reduce the need for transfusions.
  • HIV-related Anemia: ERYPRO SAFE 40000IU INJECTION 4ML is used in patients receiving zidovudine (AZT), which can suppress bone marrow function.

Key Benefits

ERYPRO SAFE 40000IU INJECTION 4ML is a blood hormone. It contains Recombinant Human Erythropoietin Alfa used to treat anaemia caused by chronic diseases and anaemia related to kidney disease, cancers, bone marrow disorders, chemotherapy, children and adults on dialysis, and in those due to undergo major bone surgery. ERYPRO SAFE 40000IU INJECTION 4ML stimulates the bone marrow to produce more red blood cells. In addition, it also corrects any dysregulated erythropoiesis (RBC formation) and remedies the formation of any defunct precursors of RBC’s, paving the way for healthy red blood cell production. Clinically, ERYPRO SAFE 40000IU INJECTION 4ML causes a direct increase in haemoglobin values and reduces the rates and requirement of blood transfusion.

Side effects of Erypro Safe 40000iu Injection 4ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.

Directions for Use

  • It is usually injected one to three times weekly. However, follow your doctor's instructions regarding dosage and timing of ERYPRO SAFE 40000IU INJECTION 4ML for better results.
  • ERYPRO SAFE 40000IU INJECTION 4ML may be given by a doctor/nurse, or you may be told to inject the medication at home. In that case, a healthcare provider will show you how to inject the medication. Be sure that you understand the directions and use it exactly as advised.
  • Rotate the injection site each time. Do not inject into a spot that is tender, red, bruised, hard, or has scars or stretch marks.

How ERYPRO SAFE 40000IU INJECTION 4ML Works

ERYPRO SAFE 40000IU INJECTION 4ML contains Recombinant Human Erythropoietin Alfa that works by stimulating the bone marrow to produce more red blood cells, thereby correcting any low blood counts and anaemia.
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Alcohol

Caution

There is not enough literature to explain the effects of alcohol. Consult your doctor if you have any concerns.

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Pregnancy

Caution

If you are pregnant or planning to become pregnant, inform your doctor. Your doctor will weigh the benefits against the risks.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking ERYPRO SAFE 40000IU INJECTION 4ML; your doctor will decide whether breastfeeding mothers can use ERYPRO SAFE 40000IU INJECTION 4ML or not.

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Driving

Caution

It's unclear whether ERYPRO SAFE 40000IU INJECTION 4ML affects driving abilities, so don't drive or operate machinery if you're having trouble concentrating or reacting.

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Liver

Caution

ERYPRO SAFE 40000IU INJECTION 4ML should be used with caution in patients suffering from liver diseases. Please inform your doctor before receiving it.

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Kidney

Caution

ERYPRO SAFE 40000IU INJECTION 4ML should be used with caution in patients suffering from kidney diseases. Please inform your doctor before receiving it.

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Children

Safe if prescribed

ERYPRO SAFE 40000IU INJECTION 4ML can be used in children in prescribed paediatric doses.

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Heart

Caution

ERYPRO SAFE 40000IU INJECTION 4ML should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before receiving ERYPRO SAFE 40000IU INJECTION 4ML.

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Geriatrics

Caution

ERYPRO SAFE 40000IU INJECTION 4ML should be administered with caution in elderly patients due to an increased risk of side effects and dose adjustments may be required.

What if I have taken an overdose of ERYPRO SAFE 40000IU INJECTION 4ML

Overdose of ERYPRO SAFE 40000IU INJECTION 4ML increases blood viscosity and the risk of thrombosis by raising haemoglobin levels to dangerously high levels. Seek immediate medical help if you get an overdose of this medicine.

Diet & Lifestyle Advise

  • As nausea and vomiting may occur using ERYPRO SAFE 40000IU INJECTION 4ML, make sure to take it on light, small meals. 
  • To promote blood production, eat red fruits and vegetables, such as apples, pomegranates, dry fruits, beans, and nuts.
  • Avoid caffeine and alcohol as these can precipitate bleeding.
  • Take care of your mental health. Stress is a huge factor that can cause excessive bleeding. Make sure you meditate daily in the morning.
  • Yoga has also proven very effective in preventing excessive blood loss. The butterfly pose is one of the best poses for treating heavy periods.
  • Make sure you drink a lot of water and keep yourself hydrated. Fluid intake helps flush out toxins.
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How Soon It Starts Working

The time required for ERYPRO SAFE 40000IU INJECTION 4ML to start to work: The time required for ERYPRO SAFE 40000IU INJECTION 4ML to show its action is unknown. The time for which the effects of ERYPRO SAFE 40000IU INJECTION 4ML last: The duration of action for ERYPRO SAFE 40000IU INJECTION 4ML is clinically unknown.

What if you forget to take ERYPRO SAFE 40000IU INJECTION 4ML

Call your doctor to ask what to do if you miss a dose of ERYPRO SAFE 40000IU INJECTION 4ML. Do not use a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

Inform the doctor if you have an allergy to any of its components. Proceed with caution in case of a latex allergy. Please inform the doctor of your detailed medical history, including hypertension, heart disease, myocardial infarction, stroke, epilepsy, head and neck cancers, liver disease, thromboembolism, porphyria and/or pure red cell aplasia (where the bone marrow cannot produce enough RBCs). Inform your doctor of any medicines you may be taking especially if you are on any immunosuppressants, blood thinners or blood stimulants. Please consult your doctor before taking ERYPRO SAFE 40000IU INJECTION 4ML during pregnancy and nursing.

Drug-Drug Interactions

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Drug-Drug Interaction: ERYPRO SAFE 40000IU INJECTION 4ML may interact with blood thinners (warfarin, Coumarin), immunosuppressants (cyclosporine), anti-cancer (belzutifan, carfilzomib, lenalidomide, thalidomide, pomalidomide), antihypertensives (lisinopril, perindopril, ramipril) and hormones (conestat alfa, C1 esterase inhibitor). 

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: Inform your doctor if you have hypersensitivity disorder, thromboembolism and red cell aplasia.

ErythropoietinThalidomide
Severe
ErythropoietinCarfilzomib
Severe

Drug-Drug Interactions

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ErythropoietinThalidomide
Severe
How does the drug interact with Erypro Safe 40000iu Injection 4ml:
Taking thalidomide with Erypro Safe 40000iu Injection 4ml may increase the risk or severity of thromboembolism(a circulating blood clot that gets stuck and causes an obstruction).

How to manage the interaction:
Although taking Erypro Safe 40000iu Injection 4ml and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ErythropoietinCarfilzomib
Severe
How does the drug interact with Erypro Safe 40000iu Injection 4ml:
Carfilzomib can cause serious blood clots and taking it alongside Erypro Safe 40000iu Injection 4ml may enhance the risk.

How to manage the interaction:
Co-administration of Erypro Safe 40000iu Injection 4ml with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ErythropoietinLenalidomide
Severe
How does the drug interact with Erypro Safe 40000iu Injection 4ml:
Combining Erypro Safe 40000iu Injection 4ml with Lenalidomide can increase the risk of Thrombosis(formation of a blood clot ).

How to manage the interaction:
Although there is an interaction between Erypro Safe 40000iu Injection 4ml and Lenalidomide, it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
ErythropoietinPomalidomide
Severe
How does the drug interact with Erypro Safe 40000iu Injection 4ml:
Pomalidomide can cause serious blood clots and taking it alongside Erypro Safe 40000iu Injection 4ml may enhance the risk.

How to manage the interaction:
Co-administration of Erypro Safe 40000iu Injection 4ml with Pomalidomide can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[BLOOD DERIVATIVES]

FAQs

ERYPRO SAFE 40000IU INJECTION 4ML belongs to the group of hormones used in the treatment of chronic anaemia and anaemic states seen in kidney disease, cancers, patients on chemotherapy, bone marrow disorders and in those due to undergo major bone surgery.
ERYPRO SAFE 40000IU INJECTION 4ML works by stimulating the bone marrow to produce healthy red blood cells (RBC’s) and thus enhances blood production.
Consult your doctor before taking iron supplements along with ERYPRO SAFE 40000IU INJECTION 4ML as they might increase the effectiveness of ERYPRO SAFE 40000IU INJECTION 4ML when taken together.
ERYPRO SAFE 40000IU INJECTION 4ML might affect other treatments or tests. Therefore, inform the doctor/lab assistant that you are taking ERYPRO SAFE 40000IU INJECTION 4ML.
Not commonly. However, cases of Steven Johnson’s syndrome and Toxic Epidermal Necrosis (TEN), have been reported in rare instances. Consult your doctor immediately if you notice symptoms such as reddish-circular patches, skin peeling, fever, flu, ulcers of throat, mouth, nose, eyes or genitals.
ERYPRO SAFE 40000IU INJECTION 4ML may cause blood clots (deep vein thrombosis and embolism). Consult your doctor if you experience symptoms such as breathlessness, chest pain, painful swelling and redness in the legs.
The common side effects of ERYPRO SAFE 40000IU INJECTION 4ML may include vomiting, diarrhoea, fever, and nasal congestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects consistently.
ERYPRO SAFE 40000IU INJECTION 4ML contains Recombinant Human Erythropoietin Alfa. A hormone medication that stimulates the bone marrow to produce more red blood cells, correcting low blood counts and anaemia.
Don't stop taking your medication just because you're feeling better! This is a crucial moment in your recovery. Stopping too soon can lead to incomplete recovery and the return of symptoms. Instead, report your progress to your doctor and follow their advice. They will guide you on how to safely taper off the medication, if necessary, monitor for any potential side effects, and ensure the infection is fully cleared.
ERYPRO SAFE 40000IU INJECTION 4ML is usually given to you by a healthcare professional through an Intravenous(veins). In some cases, you may need to go to a local clinic or learn to self-inject, but only after proper training from a doctor or nurse.
You can store ERYPRO SAFE 40000IU INJECTION 4ML in the refrigerator or a cool, dry place away from sunlight. Do not freeze. Use at room temperature only.
Store ERYPRO SAFE 40000IU INJECTION 4ML in a refrigerator or in a cool, dry place away from sunlight. Keep it out of reach of children. Do not freeze it.
Taking more than the prescribed dose doesn't provide extra relief; instead, it may increase the risk of adverse effects, potentially harming your health.
Don't use ERYPRO SAFE 40000IU INJECTION 4ML if the solution is expired, frozen, or allergic to it. It's also not recommended for those with hypersensitivity disorders, thromboembolism, and red cell aplasia. Pregnant or breastfeeding women or children unless the doctor suggests it. Always consult your doctor before using.
ERYPRO SAFE 40000IU INJECTION 4ML can be used in children under a doctor's guidance and in prescribed pediatric doses.
ERYPRO SAFE 40000IU INJECTION 4ML may increase blood pressure or worsen existing high blood pressure, especially in patients with kidney failure, due to the rapid increase in red blood cells. Inform your doctor beforehand if you have any blood pressure issues. Your doctor will adjust the dose if the benefits outweigh the risks.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.3442 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. ScienceDirect Topics. Recombinant Erythropoietin - Research & Medical Applications Summary. Amsterdam, Netherlands: Elsevier; 2025. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Recombinant Human Erythropoietin Alfa Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Recombinant Human Erythropoietin Alfa/Epoetin Alfa. 2018. [Accessed on 07 Apr. 2019]Check here
  6. Recombinant Human Erythropoietin Alfa/Epoetin Alfa. 1989. [Accessed on 07 Apr. 2019]Check here
  7. Epoetin alfa [Prescribing Information]. 2017. [Accessed on 28 Mar. 2023]Check here

Country of origin

INDIA

Manufacturer/Marketer address

20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - ERY0045

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