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compositionComposition:ABIRATERONE-250MG
prescription
Prescription Medicine
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ES Abra-250 Tablet 120's is used in combination with prednisone or prednisolone to treat prostate cancer in adult men that has spread to other body parts. It contains Abiraterone, which works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer. It is not for use in women, children, and adolescents. In some cases, ES Abra-250 Tablet 120's may cause common side effects such as diarrhoea, urinary tract infection, high blood pressure, low blood potassium, and oedema. If any of the side effects persist or worsen, consult your doctor.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ABIRATERONE-250MG

Manufacturer/Marketer :

Esperer Bio Research Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About ES Abra-250 Tablet 120's

ES Abra-250 Tablet 120's is a prescription medication used to treat advanced prostate cancer that has spread to other parts of the body. It is typically prescribed for prostate cancer that no longer responds to medical or surgical treatments that lower testosterone, or for high-risk cancer that is still sensitive to hormone therapy. This medicine is almost always taken in combination with a low-dose steroid, such as prednisone, to help prevent certain side effects.

You should take ES Abra-250 Tablet 120's once a day, consistently at the same time each day, to keep a steady amount of the medicine in your body. It is vital to take this medication on an empty stomach (either at least one hour before eating or two hours after eating), as food can drastically change how your body absorbs it. Alongside your treatment, your doctor may recommend lifestyle changes such as a low-salt diet to help manage fluid levels and regular tracking of your blood pressure.

Many patients experience mild side effects while taking this medication, such as joint pain, hot flushes, or mild swelling in the legs. However, you must contact your doctor immediately if you experience serious side effects like severe muscle weakness, chest pain, or yellowing of your skin or eyes. Your healthcare team will monitor your health closely to ensure the treatment is working safely.

Before starting this treatment, tell your doctor if you have a history of heart disease, high blood pressure, low potassium levels, or liver damage. Do not take this if you are pregnant or planning to become pregnant, as it can cause severe harm to an unborn baby. In fact, women who are pregnant or of childbearing age should not handle these tablets without wearing protective gloves.

ES Abra-250 Tablet 120's can interact with other medicines, especially those processed by your liver, which may change how these treatments work or increase side effects. It is also wise to limit alcohol intake while taking this medicine to avoid putting extra stress on your liver. While this medicine is not intended for use in women, elderly individuals should discuss their heart health with their doctor, as they may be more sensitive to fluid retention and high blood pressure.

Uses of ES Abra-250 Tablet 120's

Your doctor may prescribe ES Abra-250 Tablet 120's to help manage the following conditions:

  • Advanced prostate cancer (metastatic castration-resistant prostate cancer): ES Abra-250 Tablet 120's helps treat prostate cancer that has spread to other parts of the body and no longer responds to standard treatments that lower testosterone.
  • High-risk sensitive prostate cancer (metastatic castration-sensitive prostate cancer): ES Abra-250 Tablet 120's is used early in the treatment of advanced prostate cancer that still responds to hormone therapy, helping to slow down the progression of the disease.

Key Benefits

ES Abra-250 Tablet 120's can help control advanced prostate cancer by reducing the hormones that support cancer growth. When used with the other treatments prescribed by your doctor, it can provide important long-term benefits.

  • Slows disease progression: By keeping androgen levels very low, ES Abra-250 Tablet 120's can delay the growth and spread of prostate cancer and help keep the disease under control for longer.
  • Helps people live longer: In appropriate patients with advanced prostate cancer, treatment with ES Abra-250 Tablet 120's has been shown to improve survival when used as part of the recommended treatment regimen.
  • Delays worsening of cancer-related problems: Controlling the cancer may delay complications and symptoms caused by disease progression, helping maintain daily functioning and quality of life for longer.
Side effects of ES Abra-250 Tablet
  • If you have discomfort, illness, or unease after taking medication, seek medical attention.
  • Your treatment plan may be modified, including adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage discomfort, follow your doctor's advice, like getting plenty of rest, or staying hydrated, and practising stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to manage the discomfort effectively.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Directions for Use

  • ES Abra-250 Tablet 120's can be taken on an empty stomach, i.e., 1 hour before or 2 hours after food.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Swallow ES Abra-250 Tablet 120's as a whole with a glass of water.
  • Do not chew, crush, or break it.

How ES Abra-250 Tablet 120's Works

ES Abra-250 Tablet 120's contains abiraterone. It works by blocking an enzyme called CYP17, which the body needs to make androgens (male sex hormones such as testosterone). Prostate cancer cells often depend on these hormones to grow and survive. Unlike treatments that mainly reduce testosterone production by the testicles, ES Abra-250 Tablet 120's reduces androgen production in the testicles, adrenal glands, and prostate tumour tissue. This lowers the amount of androgen available to stimulate prostate cancer cells and helps slow the progression of the disease. Blocking CYP17 also reduces the production of cortisol, a natural steroid hormone, and can cause the body to retain salt and water and lose potassium. For this reason, ES Abra-250 Tablet 120's is usually given with a corticosteroid such as prednisone or prednisolone. The corticosteroid helps maintain hormone balance and reduce side effects related to these changes.
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Alcohol

Consult your doctor

It is unknown if alcohol affects ES Abra-250 Tablet 120's. Please consult your doctor.

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Pregnancy

Unsafe

ES Abra-250 Tablet 120's is not for use in women.

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Breast Feeding

Not applicable

ES Abra-250 Tablet 120's is not for use in women.

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Driving

Safe if prescribed

ES Abra-250 Tablet 120's is not likely to affect your ability to drive or operate machinery.

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Liver

Caution

Do not take ES Abra-250 Tablet 120's if you have severe liver damage. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns.

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Children

Not applicable

ES Abra-250 Tablet 120's is not for use in children and adolescents.

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Heart

Caution

Avoid taking ES Abra-250 Tablet 120's if you have heart problems unless strictly prescribed by your doctor. It may cause or worsen hypertension, arrhythmias, fluid retention, and heart failure, requiring close cardiac monitoring.

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Geriatrics

Caution

Geriatric patients may take ES Abra-250 Tablet 120's, but only under close medical supervision. Age-related risks like high blood pressure, liver issues, and heart complications require regular monitoring.

What if I have taken an overdose of ES Abra-250 Tablet 120's

If you take more than your prescribed dose, seek emergency medical attention. Taking too much of this medicine can increase the risk of severe side effects, especially liver strain or heart issues.

Diet & Lifestyle Advise

  • Monitor your sodium intake: Stick to a low-salt diet to help minimise the risk of fluid retention and high blood pressure, which are common concerns during this treatment.
  • Support your bone health: Because hormone therapy can weaken bones, discuss taking calcium and vitamin D supplements with your doctor, and consume calcium-rich foods like leafy greens.
  • Stay active safely: Engage in regular, gentle weight-bearing exercises like walking or light strength training to preserve muscle mass, support bone strength, and fight fatigue.
  • Track your vitals: Keep a daily log of your blood pressure and weight. A sudden, unexplained weight gain can be a sign of fluid buildup and should be reported to your doctor.
health query

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How Soon It Starts Working

The time required for ES Abra-250 Tablet 120's to start to work: ES Abra-250 Tablet 120's ideally shows its action within 2 to 4 hours after administration. The time for which the effects of ES Abra-250 Tablet 120's last: The duration of action for ES Abra-250 Tablet 120's is clinically unknown.

What if you forget to take ES Abra-250 Tablet 120's

If you miss a dose of ES Abra-250 Tablet 120's or your steroid, skip the missed dose and take your usual dose the next day at your normal time. Do not take a double dose to make up for a missed one. If you miss more than one daily dose, contact your doctor or pharmacist immediately for instructions.

Storage

• Store ES Abra-250 Tablet 120's tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Never take with food: Taking this medicine with even a small amount of food can cause your body to absorb dangerous amounts of the medication, increasing your risk of severe side effects.
  • Do not stop your steroid: Never stop taking your prescribed prednisone or prednisolone suddenly, as this can cause your body's hormone balance to drop to dangerous levels.
  • Wear gloves if handling: If a family member or caregiver who is pregnant or of childbearing age must handle these tablets, they must wear protective gloves.
  • Keep up with blood tests: Attend all scheduled appointments for blood tests, as your doctor needs to regularly monitor your liver enzymes, potassium levels, and blood pressure.
  • Use protection during intimacy: You must use a condom during sexual activity if your partner is pregnant, and use a condom plus another highly effective birth control method if your partner can become pregnant, continuing this for at least one week after your last dose.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong CYP3A4 inducers (like rifampin, phenytoin, carbamazepine): May decrease the levels of ES Abra-250 Tablet 120's in your body, making the treatment less effective.
  • CYP2D6 substrates with a narrow safety range (like thioridazine): ES Abra-250 Tablet 120's can increase the levels of these drugs in your body, potentially causing dangerous side effects. Always tell your doctor about all other medicines you take.
AbirateroneMesoridazine
Critical
AbirateroneZiprasidone
Critical

Drug-Drug Interactions

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AbirateroneMesoridazine
Critical
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Mesoridazine can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking ES Abra-250 Tablet and Mesoridazine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneZiprasidone
Critical
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between ES Abra-250 Tablet and ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
AbirateroneThioridazine
Critical
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking ES Abra-250 Tablet and Thioridazine together is not recommended and can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneEliglustat
Critical
How does the drug interact with ES Abra-250 Tablet:
Coadministration of ES Abra-250 Tablet with Eliglustat can increase the levels of Eliglustat in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking ES Abra-250 Tablet with Eliglustat is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AbirateroneSaquinavir
Critical
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking ES Abra-250 Tablet and Saquinavir together is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneEscitalopram
Severe
How does the drug interact with ES Abra-250 Tablet:
Using escitalopram together with ES Abra-250 Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Escitalopram with ES Abra-250 Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience dizziness, irregular heartbeat, drowsiness, lightheadedness, shortness of breath, vomiting, or shortness of breath, consult a doctor immediately. Do not stop using any medications without consulting a doctor.
AbirateroneOxycodone
Severe
How does the drug interact with ES Abra-250 Tablet:
Coadministration of ES Abra-250 Tablet with Oxycodone can increase the levels of Oxycodone in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking ES Abra-250 Tablet with Oxycodone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience dizziness, fainting, confusion, excessive drowsiness, slow heart rate, and/or shallow or difficult breathing, contact a doctor immediately. Avoid activities requiring mental alertness such as driving or operating hazardous machinery while taking these medications. Do not discontinue any medications without consulting a doctor.
AbirateroneVenetoclax
Severe
How does the drug interact with ES Abra-250 Tablet:
Coadministration of ES Abra-250 Tablet with Venetoclax can increase the levels of Venetoclax in the body. This increases the risk or severity of side effects like bleeding problems, kidney injury, and the risk of developing serious infections.

How to manage the interaction:
Taking ES Abra-250 Tablet with Venetoclax together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneCeritinib
Severe
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Ceritinib can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking ES Abra-250 Tablet with Ceritinib together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateronePrimidone
Severe
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with primidone can significantly reduce the blood levels of ES Abra-250 Tablet, which may lower the treatment outcomes.

How to manage the interaction:
Taking ES Abra-250 Tablet with Primidone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience shortness of breath, chest pain or tightness, rapid heartbeat, bloating or swelling of the face, arms, hands, lower legs, or feet, low urine output, or blurred vision, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food: Must never be taken with food. Food significantly increases the absorption of this drug, which can lead to high blood pressure, low potassium, and severe fluid buildup.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

ES Abra-250 Tablet 120's is used to treat Prostate cancer.
ES Abra-250 Tablet 120's works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.
Prednisolone/prednisone is prescribed along with ES Abra-250 Tablet 120's to lower the chances of getting high blood pressure, fluid retention (having too much water in the body), or low blood potassium levels.
ES Abra-250 Tablet 120's should not be given along with Ra-233 (a radioactive isotope used to treat prostate cancer) due to the increased risk of bone fracture or death. If you are prescribed to take Ra-233 following treatment with ES Abra-250 Tablet 120's and prednisolone/prednisone, you must wait five days before starting treatment with Ra-233.
No, ES Abra-250 Tablet 120's cannot cure prostate cancer. However, it is used to manage advanced or metastatic prostate cancer that works by inhibiting the production of testosterone, thereby preventing the growth and spread of cancer.
No, ES Abra-250 Tablet 120's is not a chemotherapy drug. It is a hormone therapy medication, which reduces testosterone levels to help manage prostate cancer.
Yes, ES Abra-250 Tablet 120's may affect the liver. Therefore, the doctor may advise regular blood tests to monitor its effects on the liver.
For patients taking ES Abra-250 Tablet 120's liver investigations are recommended. However, the frequency may differ for each individual and can be determined by the doctor based on your medical condition.
ES Abra-250 Tablet 120's can be taken orally on an empty stomach, either 1 hour before a meal or 2 hours after the meal. Swallow it as a whole with a glass of water. Do not chew or break it.
The side effects of ES Abra-250 Tablet 120's include oedema, urinary tract infection, high blood pressure, low blood potassium, and diarrhoea. Consult the doctor if any of these symptoms persist or worsen.
Taking this medicine with food causes your body to absorb significantly more of the drug than it needs, which can lead to dangerous side effects like very high blood pressure or severe liver damage. Always take it at least one hour before or two hours after eating. Talk to your doctor if you have trouble managing this schedule.
This medicine is typically taken for as long as it continues to control your prostate cancer and does not cause unacceptable side effects. Your doctor will perform regular check-ups and blood tests to decide how long your treatment should continue. Talk to your doctor to understand your specific treatment plan.
No, this medication is only prescribed for men with advanced prostate cancer. It must not be taken by women, especially those who are pregnant or breastfeeding, as it can cause severe harm to an unborn baby or nursing infant. Talk to your doctor if you have questions about who can use this medication.
Muscle weakness, cramping, or a fluttering heartbeat can be signs of low potassium levels in your blood, which is a known side effect of this treatment. You should contact your healthcare provider right away so they can check your blood levels and advise you on the next steps. Talk to your doctor before taking any potassium supplements.
It is highly recommended to limit or avoid alcohol during your treatment, as both alcohol and ES Abra-250 Tablet 120's are processed by your liver. Combining them can increase the risk of liver strain or damage. Talk to your doctor or pharmacist to see if it is safe for you to consume alcohol in moderation.
You will need regular blood tests (usually at least once a month) to check your liver function and monitor your potassium and hormone levels. Your doctor will also check your blood pressure and monitor you for any signs of fluid retention. Talk to your doctor to schedule these essential health checks.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Office No. 4Ba, 4Th Floor, Gundecha Onclave, Kherani Road, Sakinaka, Kurla W Mumbai, India
Other Info - ESA0038
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