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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

ES Abra-250 Tablet 120's is used in combination with prednisone or prednisolone to treat prostate cancer in adult men that has spread to other body parts. It contains Abiraterone, which works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer. It is not for use in women, children, and adolescents. In some cases, ES Abra-250 Tablet 120's may cause common side effects such as diarrhoea, urinary tract infection, high blood pressure, low blood potassium, and oedema. If any of the side effects persist or worsen, consult your doctor.

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Whats That

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Synonym :

ABIRATERONE ACETATE

Composition :

ABIRATERONE-250MG

Manufacturer/Marketer :

Esperer Bio Research Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About ES Abra-250 Tablet 120's

ES Abra-250 Tablet 120's belongs to the group of medicines called androgen biosynthesis inhibitors that is indicated in combination with prednisone or prednisolone to treat prostate cancer in adult men that have spread to other body parts.

ES Abra-250 Tablet 120's contains ‘Abiraterone’ that works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.

In some cases, ES Abra-250 Tablet 120's may cause common side effects such as diarrhoea, urinary tract infection, high blood pressure, low blood potassium, and oedema. If any of the side effects persist or worsen, consult your doctor.

ES Abra-250 Tablet 120's is not for use in women, children, and adolescents. ES Abra-250 Tablet 120's should not be given in combination with Ra-233 (a radioactive isotope used to treat prostate cancer) due to the increased risk of bone fracture or death. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of ES Abra-250 Tablet 120's

ES Abra-250 Tablet 120's is used in the treatment of prostate cancer. The detailed uses of ES Abra-250 Tablet 120's are as follows:<br/>• Treats advanced prostate cancer: ES Abra-250 Tablet 120's lowers levels of certain hormones (androgens) that fuel the growth of prostate cancer cells.<br/>• Slows cancer progression: ES Abra-250 Tablet 120's helps delay the spread and worsening of prostate cancer.<br/>• Improves overall management of prostate cancer: ES Abra-250 Tablet 120's is often used along with other medicines to enhance treatment effectiveness.<br/>

Directions for Use

• ES Abra-250 Tablet 120's can be taken on an empty stomach, i.e., 1 hour before or 2 hours after food. • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Swallow ES Abra-250 Tablet 120's as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

ES Abra-250 Tablet 120's belongs to the group of medicines called androgen biosynthesis inhibitors, indicated in combination with prednisone or prednisolone to treat prostate cancer in adult men that have spread to other body parts. ES Abra-250 Tablet 120's contains ‘Abiraterone’ that works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer. It is indicated in patients with metastatic castration-resistant prostate cancer (CRPC) who have received prior chemotherapy containing docetaxel and metastatic high-risk castration-sensitive prostate cancer (CSPC). ES Abra-250 Tablet 120's is prescribed in the early stages of the disease, where it is still responding to hormone therapy. It is used with androgen deprivation therapy (a treatment that lowers testosterone).

How ES Abra-250 Tablet 120's Works

ES Abra-250 Tablet 120's contains ‘Abiraterone’ that works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.

Storage

• Store in a cool and dry place away from sunlight.
• Keep ES Abra-250 Tablet 120's out of sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of ES Abra-250 Tablet
  • If you have discomfort, illness, or unease after taking medication, seek medical attention.
  • Your treatment plan may be modified, including adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage discomfort, follow your doctor's advice, like getting plenty of rest, or staying hydrated, and practising stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to manage the discomfort effectively.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

What if I have taken an overdose of ES Abra-250 Tablet 120's

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of ES Abra-250 Tablet 120's may include fast or irregular heartbeat, lightheadedness, dizziness, or fainting, shortness of breath or difficulty breathing, swelling of the feet, ankles, or lower legs, and unexplained weight gain. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take ES Abra-250 Tablet 120's if you are allergic to any of its components, if you have severe liver damage, or in combination with Ra-233 (used to treat prostate cancer). Inform your doctor if you have liver problems, high blood pressure, low blood potassium, heart failure, heart or blood vessel problems, irregular or rapid heartbeat, heart rhythm problems, shortness of breath, rapid weight gain, swelling in the legs, ankles, or feet, high blood sugar, bone problems, or if you have taken ketoconazole in the past for prostate cancer. ES Abra-250 Tablet 120's may cause libido (decreased sex drive), muscle weakness, decreased red blood cells, and/or muscle pain. ES Abra-250 Tablet 120's should not be given in combination with Ra-233 due to an increased risk of bone fracture or death.

Drug-Drug Interactions

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AbirateroneEliglustat
Critical
AbirateroneMesoridazine
Critical

Drug-Drug Interactions

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AbirateroneEliglustat
Critical
How does the drug interact with ES Abra-250 Tablet:
Coadministration of ES Abra-250 Tablet with Eliglustat can increase the levels of Eliglustat in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking ES Abra-250 Tablet with Eliglustat is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AbirateroneMesoridazine
Critical
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Mesoridazine can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking ES Abra-250 Tablet and Mesoridazine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between ES Abra-250 Tablet and ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking ES Abra-250 Tablet and Thioridazine together is not recommended and can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneSaquinavir
Critical
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking ES Abra-250 Tablet and Saquinavir together is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Gatifloxacin can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking ES Abra-250 Tablet with Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Sparfloxacin can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking ES Abra-250 Tablet and Sparfloxacin together can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneHydrocodone
Severe
How does the drug interact with ES Abra-250 Tablet:
Coadministration of ES Abra-250 Tablet with Hydrocodone can increase the levels of Hydrocodone in the body. This increases the risk or severity of side effects like low blood pressure, and low respiratory rate.

How to manage the interaction:
Taking ES Abra-250 Tablet with Hydrocodone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, difficulty concentrating, impairment in thinking and judgment, fainting, confusion, excessive drowsiness, slow heart rate, and shallow or difficult breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with ES Abra-250 Tablet:
Taking tamoxifen with ES Abra-250 Tablet may reduce the effectiveness of tamoxifen and increase the risk of side effects.

How to manage the interaction:
Although taking tamoxifen and ES Abra-250 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbirateronePasireotide
Severe
How does the drug interact with ES Abra-250 Tablet:
Taking ES Abra-250 Tablet with Pasireotide can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking ES Abra-250 Tablet with Pasireotide together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS
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Alcohol

Consult your doctor

It is unknown if alcohol affects ES Abra-250 Tablet 120's. Please consult your doctor.

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Pregnancy

Unsafe

ES Abra-250 Tablet 120's is not for use in women.

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Breast Feeding

Not applicable

ES Abra-250 Tablet 120's is not for use in women.

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Driving

Safe if prescribed

ES Abra-250 Tablet 120's is not likely to affect your ability to drive or operate machinery.

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Liver

Caution

Do not take ES Abra-250 Tablet 120's if you have severe liver damage. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns.

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Children

Not applicable

ES Abra-250 Tablet 120's is not for use in children and adolescents.

Have a query?

FAQs

ES Abra-250 Tablet 120's is used to treat Prostate cancer.

ES Abra-250 Tablet 120's works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.

Prednisolone/prednisone is prescribed along with ES Abra-250 Tablet 120's to lower the chances of getting high blood pressure, fluid retention (having too much water in the body), or low blood potassium levels.

ES Abra-250 Tablet 120's should not be given along with Ra-233 (a radioactive isotope used to treat prostate cancer) due to the increased risk of bone fracture or death. If you are prescribed to take Ra-233 following treatment with ES Abra-250 Tablet 120's and prednisolone/prednisone, you must wait five days before starting treatment with Ra-233.

No, ES Abra-250 Tablet 120's cannot cure prostate cancer. However, it is used to manage advanced or metastatic prostate cancer that works by inhibiting the production of testosterone, thereby preventing the growth and spread of cancer.

No, ES Abra-250 Tablet 120's is not a chemotherapy drug. It is a hormone therapy medication, which reduces testosterone levels to help manage prostate cancer.

Yes, ES Abra-250 Tablet 120's may affect the liver. Therefore, the doctor may advise regular blood tests to monitor its effects on the liver.

For patients taking ES Abra-250 Tablet 120's liver investigations are recommended. However, the frequency may differ for each individual and can be determined by the doctor based on your medical condition.

ES Abra-250 Tablet 120's can be taken orally on an empty stomach, either 1 hour before a meal or 2 hours after the meal. Swallow it as a whole with a glass of water. Do not chew or break it.

The side effects of ES Abra-250 Tablet 120's include oedema, urinary tract infection, high blood pressure, low blood potassium, and diarrhoea. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Office No. 4Ba, 4Th Floor, Gundecha Onclave, Kherani Road, Sakinaka, Kurla W Mumbai, India
Other Info - ESA0038

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